Search

Your search keyword '"Palmqvist, Richard"' showing total 1,046 results
Start Over Author "Palmqvist, Richard"
1,046 results on '"Palmqvist, Richard"'

1. Prognostic genome and transcriptome signatures in colorectal cancers

Author

Nunes, Luís, Li, Fuqiang, Wu, Meizhen, Luo, Tian, Hammarström, Klara, Torell, Emma, Ljuslinder, Ingrid, Mezheyeuski, Artur, Edqvist, Per-Henrik, Löfgren-Burström, Anna, Zingmark, Carl, Edin, Sofia, Larsson, Chatarina, Mathot, Lucy, Osterman, Erik, Osterlund, Emerik, Ljungström, Viktor, Neves, Inês, Yacoub, Nicole, Guðnadóttir, Unnur, Birgisson, Helgi, Enblad, Malin, Ponten, Fredrik, Palmqvist, Richard, Xu, Xun, Uhlén, Mathias, Wu, Kui, Glimelius, Bengt, Lin, Cong, and Sjöblom, Tobias

Published
2024
Full Text
View/download PDF

7. Implementing precision medicine in a regionally organized healthcare system in Sweden

Author

Fioretos, Thoas, Wirta, Valtteri, Cavelier, Lucia, Berglund, Eva, Friedman, Mikaela, Akhras, Michael, Botling, Johan, Ehrencrona, Hans, Engstrand, Lars, Helenius, Gisela, Fagerqvist, Therese, Gisselsson, David, Gruvberger-Saal, Sofia, Gyllensten, Ulf, Heidenblad, Markus, Höglund, Kina, Jacobsson, Bo, Johansson, Maria, Johansson, Åsa, Soller, Maria Johansson, Landström, Maréne, Larsson, Pär, Levin, Lars-Åke, Lindstrand, Anna, Lovmar, Lovisa, Lyander, Anna, Melin, Malin, Nordgren, Ann, Nordmark, Gunnel, Mölling, Paula, Palmqvist, Lars, Palmqvist, Richard, Repsilber, Dirk, Sikora, Per, Stenmark, Bianca, Söderkvist, Peter, Stranneheim, Henrik, Strid, Tobias, Wheelock, Craig E., Wadelius, Mia, Wedell, Anna, Edsjö, Anders, and Rosenquist, Richard

Published
2022
Full Text
View/download PDF

9. Sporadic deficient mismatch repair in colorectal cancer increases the risk for non‐colorectal malignancy: A European multicenter cohort study

Author

Gkekas, Ioannis, primary, Jan, Novotny, additional, Kaprio, Tuomas, additional, Beilmann‐Lehtonen, Ines, additional, Fabian, Pavel, additional, Tavelin, Björn, additional, Böckelman, Camilla, additional, Edin, Sofia, additional, Strigård, Karin, additional, Svoboda, Tomas, additional, Hagström, Jaana, additional, Barsova, Lucie, additional, Jirasek, Tomas, additional, Haglund, Caj, additional, Palmqvist, Richard, additional, and Gunnarsson, Ulf, additional

Published
2024
Full Text
View/download PDF

10. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations

Author

Mandle, Hannah B, primary, Jenab, Mazda, additional, Gunter, Marc J, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Zhang, Jie, additional, Sugier, Pierre-Emmanuel, additional, Rothwell, Joseph, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena A, additional, Schulze, Matthias B, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Sacerdote, Carlotta, additional, Bonet, Catalina, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Huerta, José María, additional, Guevara, Marcela, additional, Palmqvist, Richard, additional, Löwenmark, Thyra, additional, Perez-Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Heath, Alicia K, additional, Cross, Amanda J, additional, Vineis, Paolo, additional, Hughes, David J, additional, and Fedirko, Veronika, additional

Published
2024
Full Text
View/download PDF

11. Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

Author

Chuang, Shu-Chun, Boeing, Heiner, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Bueno-de-Mesquita, Bas, Lajous, Martin, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Küehn, Tilman, Pischon, Tobias, Drogan, Dagmar, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Agudo, Antonio, Molina-Montes, Esther, Dorronsoro, Miren, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H, Weiderpass, Elisabete, Palmqvist, Richard, Ljuslinder, Ingrid, Gunter, Marc, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, Vineis, Paolo, and Aleksandrova, Krasimira

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Cardiovascular, Nutrition, Aging, Clinical Research, Cell-mediated immunity, Metabolic syndrome, Neopterin, Clinical Sciences, Immunology, Clinical sciences
Abstract

BackgroundIncreased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).ResultsHigher total neopterin concentrations were associated with reduced HDLC (9.7 %, p

Published
2016

12. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations

Author

Mandle, Hannah B., Jenab, Mazda, Gunter, Marc J., Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Zhang, Jie, Sugier, Pierre-Emmanuel, Rothwell, Joseph, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Bonet, Catalina, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Guevara, Marcela, Palmqvist, Richard, Löwenmark, Thyra, Perez-Cornago, Aurora, Weiderpass, Elisabete, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Hughes, David J., Fedirko, Veronika, Mandle, Hannah B., Jenab, Mazda, Gunter, Marc J., Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Zhang, Jie, Sugier, Pierre-Emmanuel, Rothwell, Joseph, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Bonet, Catalina, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Guevara, Marcela, Palmqvist, Richard, Löwenmark, Thyra, Perez-Cornago, Aurora, Weiderpass, Elisabete, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Hughes, David J., and Fedirko, Veronika

Abstract

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn's disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871, rectum = 503) were matched 1:1 to controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. Previously measured serum concentrations of gut barrier function and inflammation biomarkers (flagellin/LPS-specific immunoglobulins and C-reactive protein [CRP]) were available for a sub-set of participants (Ncases = 1001; Ncontrols = 667). Forty-two unique SNPs from 19 different genes were associated with serum biomarkers at Punadjusted <= 0.05 among controls. Among SNPs associated with a gut permeability score, 24 SNPs were in genes related to LPS sensing and mucin synthesis. Nine out of 12 SNPs associated with CRP were in genes related to inflammation or Crohn's disease. TLR4 was associated with colon cancer at the SNP level (nine SNPs, all Punadjusted <= 0.04) and at the gene level (Punadjusted <= 0.01). TLR4 rs10759934 was associated with rectal cancer but not colon cancer. Similarly, IL10 was associated with rectal cancer risk at an SNP and gene level (both Punadjusted <= 0.01), but not colon cancer. Genes and SNPs were selected a priori; therefore, we present unadjusted P-values. However, no association was statistically significant after multiple testing correction. This large and comprehensive study has identified gut barrier function and inflammation-related genes possibly contributing to CRC risk in European populations and is consistent with potential etiological links between host genetic background, gut barrier permeability, microbial endotoxemia, and CRC development.

Published
2024
Full Text
View/download PDF

13. Sporadic deficient mismatch repair in colorectal cancer increases the risk for non-colorectal malignancy : a European multicenter cohort study

Author

Gkekas, Ioannis, Novotny, Jan, Kaprio, Tuomas, Beilmann-Lehtonen, Ines, Fabian, Pavel, Tavelin, Björn, Böckelman, Camilla, Edin, Sofia, Strigård, Karin, Svoboda, Tomas, Hagström, Jaana, Barsova, Lucie, Jirasek, Tomas, Haglund, Caj, Palmqvist, Richard, Gunnarsson, Ulf, Gkekas, Ioannis, Novotny, Jan, Kaprio, Tuomas, Beilmann-Lehtonen, Ines, Fabian, Pavel, Tavelin, Björn, Böckelman, Camilla, Edin, Sofia, Strigård, Karin, Svoboda, Tomas, Hagström, Jaana, Barsova, Lucie, Jirasek, Tomas, Haglund, Caj, Palmqvist, Richard, and Gunnarsson, Ulf

Abstract

Background and Objectives: Disparities between tumors arising via different sporadic carcinogenetic pathways have not been studied systematically. This retrospective multicenter cohort study evaluated the differences in the risk for non-colorectal malignancy between sporadic colorectal cancer (CRC) patients from different DNA mismatch repair status. Methods: A retrospective European multicenter cohort study including in total of 1706 CRC patients treated between 1996 and 2019 in three different countries. The proficiency (pMMR) or deficiency (dMMR) of mismatch repair was determined by immunohistochemistry. Cases were analyzed for tumor BRAFV600E mutation, and BRAF mutated tumors were further analyzed for hypermethylation status in the promoter region of MLH1 to distinguish between sporadic and hereditary cases. Swedish and Finish patients were matched with their respective National Cancer Registries. For the Czech cohort, thorough scrutiny of medical files was performed to identify any non-colorectal malignancy within 20 years before or after the diagnosis of CRC. Poisson regression analysis was performed to identify the incidence rates of non-colorectal malignancies. For validation purposes, standardized incidence ratios were calculated for the Swedish cases adjusted for age, year, and sex. Results: Of the 1706 CRC patients included in the analysis, 819 were female [48%], median age at surgery was 67 years [interquartile range: 60–75], and sporadic dMMR was found in 188 patients (11%). Patients with sporadic dMMR CRC had a higher incidence rate ratio (IRR) for non-colorectal malignancy before and after diagnosis compared to patients with a pMMR tumor, in both uni- (IRR = 2.49, 95% confidence interval [CI] = 1.89–3.31, p = 0.003) and multivariable analysis (IRR = 2.24, 95% CI = 1.67–3.01, p = 0.004). This association applied whether or not the non-colorectal tumor developed before or after the diagnosis of CRC in both uni- (IRR = 1.91, 95% CI = 1.28–2.98, p = 0.004)

Published
2024
Full Text
View/download PDF

15. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk

Author

Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, and Vineis, Paolo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Cancer, Clinical Research, Digestive Diseases, Adult, Aged, Biomarkers, Tumor, Case-Control Studies, Chromatography, Liquid, Colonic Neoplasms, Colorectal Neoplasms, Europe, Female, Humans, Immunity, Cellular, Male, Middle Aged, Neopterin, Odds Ratio, Prospective Studies, Rectal Neoplasms, Sensitivity and Specificity, T-Lymphocytes, Helper-Inducer, Tandem Mass Spectrometry, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years. These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

Published
2015

18. Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis

Author

Kerdreux, Maïwenn, Edin, Sofia, Löwenmark, Thyra, Bronnec, Vicky, Löfgren Burström, Anna, Zingmark, Carl, Ljuslinder, Ingrid, Palmqvist, Richard, and Ling, Agnes

Subjects
Cancer och onkologi, Oncology, Cancer and Oncology, microbiota, colorectal cancer, Porphyromonas gingivalis, survival
Abstract

Microbiota dysbiosis may affect both the development and progression of colorectal cancer (CRC). Large metagenomic studies have highlighted specific oral bacteria linked to CRC including Porphyromonas gingivalis. Few studies have however analysed the implications of this bacterium in CRC progression and survival. In this study, we investigated the intestinal presence of P. gingivalis by qPCR in both faecal and mucosal samples from two different patient cohorts, including patients with precancerous dysplasia or CRC, as well as controls. P. gingivalis was detected in 2.6-5.3% of CRC patients and significantly different levels of P. gingivalis were found in faeces of CRC patients compared to controls (P = 0.028). Furthermore, an association was found between the presence of P. gingivalis in faeces and tumour tissue (P < 0.001). Our findings further suggested a potential link between mucosal P. gingivalis and tumours of MSI subtype (P = 0.040). Last but not least, patients with faecal P. gingivalis were found to have a significantly decreased cancer-specific survival (P = 0.040). In conclusion, P. gingivalis could be linked to patients with CRC and to a worse patient prognosis. Further studies are needed to elucidate the role of P. gingivalis in CRC pathogenesis.

Published
2023

26. Data from Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bas Bueno-de-Mesquita, H., primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J.B., primary, Fedirko, Veronika, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Romaguera, Dora, primary, Overvad, Kim, primary, Østergaard, Jane Nautrup, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Morois, Sophie, primary, Masala, Giovanna, primary, Agnoli, Claudia, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Naska, Androniki, primary, Bamia, Christina, primary, Peeters, Petra H., primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Dorronsoro, Miren, primary, Huerta, Jose-María, primary, Barricarte, Aurelio, primary, Hallmans, Göran, primary, Palmqvist, Richard, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Allen, Naomi E., primary, Tsilidis, Konstantinos K, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

27. Supplementary Table 1 from Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bas Bueno-de-Mesquita, H., primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J.B., primary, Fedirko, Veronika, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Romaguera, Dora, primary, Overvad, Kim, primary, Østergaard, Jane Nautrup, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Morois, Sophie, primary, Masala, Giovanna, primary, Agnoli, Claudia, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Naska, Androniki, primary, Bamia, Christina, primary, Peeters, Petra H., primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Dorronsoro, Miren, primary, Huerta, Jose-María, primary, Barricarte, Aurelio, primary, Hallmans, Göran, primary, Palmqvist, Richard, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Allen, Naomi E., primary, Tsilidis, Konstantinos K, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Tables 1-2 from Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations

Author

Fedirko, Veronika, primary, Riboli, Elio, primary, Tjønneland, Anne, primary, Ferrari, Pietro, primary, Olsen, Anja, primary, Bueno-de-Mesquita, H. Bas, primary, van Duijnhoven, Fränzel J.B., primary, Norat, Teresa, primary, Jansen, Eugène H.J.M., primary, Dahm, Christina C., primary, Overvad, Kim, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Racine, Antoine, primary, Lukanova, Annekatrin, primary, Teucher, Birgit, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Benetou, Vassiliki, primary, Trichopoulos, Dimitrios, primary, Grioni, Sara, primary, Vineis, Paolo, primary, Panico, Salvatore, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Siersema, Peter D., primary, Peeters, Petra H., primary, Skeie, Guri, primary, Brustad, Magritt, primary, Chirlaque, Maria-Dolores, primary, Barricarte, Aurelio, primary, Ramón Quirós, Jose, primary, Sánchez, Maria José, primary, Dorronsoro, Miren, primary, Bonet, Catalina, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Key, Timothy J., primary, Crowe, Francesca, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Romieu, Isabelle, primary, McKay, James, primary, Wark, Petra A., primary, Romaguera, Dora, primary, and Jenab, Mazda, primary

Published
2023
Full Text
View/download PDF

31. Data from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

32. Data from Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort

Author

Kaaks, Rudolf, primary, Stattin, Pär, primary, Villar, Stéphanie, primary, Poetsch, Anna R., primary, Dossus, Laure, primary, Nieters, Alexandra, primary, Riboli, Elio, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Plass, Christoph, primary, and Friesen, Marlin D., primary

Published
2023
Full Text
View/download PDF

33. Supplementary Materials from Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort

Author

Kaaks, Rudolf, primary, Stattin, Pär, primary, Villar, Stéphanie, primary, Poetsch, Anna R., primary, Dossus, Laure, primary, Nieters, Alexandra, primary, Riboli, Elio, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Plass, Christoph, primary, and Friesen, Marlin D., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Figure 1 from Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort

Author

Kaaks, Rudolf, primary, Stattin, Pär, primary, Villar, Stéphanie, primary, Poetsch, Anna R., primary, Dossus, Laure, primary, Nieters, Alexandra, primary, Riboli, Elio, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Plass, Christoph, primary, and Friesen, Marlin D., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Table 3 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

36. Supplementary Figure 2 from Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort

Author

Kaaks, Rudolf, primary, Stattin, Pär, primary, Villar, Stéphanie, primary, Poetsch, Anna R., primary, Dossus, Laure, primary, Nieters, Alexandra, primary, Riboli, Elio, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Plass, Christoph, primary, and Friesen, Marlin D., primary

Published
2023
Full Text
View/download PDF

37. Supplementary Figure 3 from Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort

Author

Kaaks, Rudolf, primary, Stattin, Pär, primary, Villar, Stéphanie, primary, Poetsch, Anna R., primary, Dossus, Laure, primary, Nieters, Alexandra, primary, Riboli, Elio, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Plass, Christoph, primary, and Friesen, Marlin D., primary

Published
2023
Full Text
View/download PDF

38. Supplementary Table 1 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

39. Supplementary Table 5 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Table 4 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

42. Supplementary Table 2 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author

Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bueno-de-Mesquita, H. Bas, primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J. B., primary, Rinaldi, Sabina, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Gunter, Marc J., primary, Westphal, Sabine, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Halkjær, Jytte, primary, Racine, Antoine, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Mattiello, Amalia, primary, Pala, Valeria, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Amiano, Pilar, primary, Huerta, José María, primary, Barricarte, Aurelio, primary, Menéndez, Virginia, primary, Peeters, Petra H., primary, Söderberg, Stefan, primary, Palmqvist, Richard, primary, Allen, Naomi E., primary, Crowe, Francesca L., primary, Khaw, Kay-Tee, primary, Wareham, Nickolas, primary, and Pischon, Tobias, primary

Published
2023
Full Text
View/download PDF

43. Plasma concentrations of gut hormones acyl ghrelin and peptide YY and subsequent risk of colorectal cancer and molecular tumor subtypes

Author

Bodén, Stina, Harbs, Justin, Sundkvist, Anneli, Fuchs, Klara, Myte, Robin, Gylling, Björn, Zingmark, Carl, Löfgren Burström, Anna, Palmqvist, Richard, Harlid, Sophia, van Guelpen, Bethany, Bodén, Stina, Harbs, Justin, Sundkvist, Anneli, Fuchs, Klara, Myte, Robin, Gylling, Björn, Zingmark, Carl, Löfgren Burström, Anna, Palmqvist, Richard, Harlid, Sophia, and van Guelpen, Bethany

Abstract

Obesity and metabolic dysfunction are implicated in colorectal cancer development. Appetite-regulating gut hormones might have a role in colorectal cancer risk. We investigated whether circulating levels of the gut hormones ghrelin (analyzed as acyl ghrelin) and Peptide YY (PYY) were associated with subsequent colorectal cancer risk, including clinical and molecular tumor subtypes. We also provide descriptive data on these hormones in relation to background participant characteristics and metabolic biomarkers. This population-based study included 1,010 matched case-control pairs with a median of 12.3 years of follow-up. Acyl ghrelin and PYY were measured by multiplex immunoassay. Data on KRAS and BRAF mutations and microsatellite instability (MSI) status were available for 704 and 708 cases, respectively. Conditional logistic regression models estimated association to colorectal cancer risk. Partial correlation and linear regression were used to investigate relationships between background and metabolic variables and variation in plasma gut hormone concentrations. Acyl ghrelin was not clearly associated with colorectal cancer risk (multivariable OR per 1 SD increase: 1.11; 95% CI, 1.00-1.23). Positive associations were observed for specific subtypes, in particular BRAF-mutated colorectal cancer and right-sided colon cancer, although with nonsignificant heterogeneity. PYY was not related to colorectal cancer risk (multivariable OR per 1 SD: 1.04; 95% CI, 0.95-1.14) or any tumor subtype. In the control participants, ghrelin was inversely correlated with BMI, and PYY was positively correlated with C-peptide and insulin levels. These findings provide limited support for a possible role for ghrelin in colorectal cancer development, primarily in specific anatomical and molecular tumor subtypes. PREVENTION RELEVANCE: The findings of this study do not support a major role for the metabolic gut hormones ghrelin and PYY in colorectal cancer development but suggest the possibi

Published
2023
Full Text
View/download PDF

44. An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples

Author

Harbs, Justin, Rinaldi, Sabina, Keski-Rahkonen, Pekka, Liu, Xijia, Palmqvist, Richard, van Guelpen, Bethany, Harlid, Sophia, Harbs, Justin, Rinaldi, Sabina, Keski-Rahkonen, Pekka, Liu, Xijia, Palmqvist, Richard, van Guelpen, Bethany, and Harlid, Sophia

Abstract

Endogenous sex hormones and DNA methylation both play important roles in various diseases. However, their interplay is largely unknown. A deeper understanding of their interrelationships could provide new insights into the pathology of disease development. We, therefore, investigated associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood, using samples from 77 men (65 with repeated samples), from the population-based Northern Sweden Health and Disease Study (NSHDS). DNA methylation was measured in buffy coat using the Infinium Methylation EPIC BeadChip (Illumina). Sex hormone (oestradiol, oestrone, testosterone, androstenedione, dehydroepiandrosterone, and progesterone) and SHBG concentrations were measured in plasma using a high-performance liquid chromatography tandem mass spectrometry (LC/MS-MS) method and an enzyme-linked immunoassay, respectively. Associations between sex hormones, SHBG, and DNA methylation were estimated using both linear regression and mixed-effects models. Additionally, we used the comb-p method to identify differentially methylated regions based on nearby P values. We identified one novel CpG site (cg14319657), at which DNA methylation was associated with dehydroepiandrosterone, surpassing a genome-wide significance level. In addition, more than 40 differentially methylated regions were associated with levels of sex hormones and SHBG and several of these mapped to genes involved in hormone-related diseases. Our findings support a relationship between circulating sex hormones and DNA methylation and suggest that further investigation is warranted, both for validation, further exploration and to gain a deeper understanding of the mechanisms and potential consequences for health and disease., Originally included in thesis in manuscript form.

Published
2023
Full Text
View/download PDF

49. Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes

Author

Bodén, Stina, primary, Harbs, Justin, additional, Sundkvist, Anneli, additional, Fuchs, Klara, additional, Myte, Robin, additional, Gylling, Björn, additional, Zingmark, Carl, additional, Löfgren Burström, Anna, additional, Palmqvist, Richard, additional, Harlid, Sophia, additional, and Van Guelpen, Bethany, additional

Published
2022
Full Text
View/download PDF

50. Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Aleksandrova, Krasimira, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Fedirko, Veronika, Kaaks, Rudolf, Lukanova, Annekatrin, van Duijnhoven, Fränzel J. B., Jansen, Eugene, Rinaldi, Sabina, Romieu, Isabelle, Ferrari, Pietro, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Westhpal, Sabine, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Agnoli, Claudia, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Duell, Eric J., Molina-Montes, Esther, Quirós, J. Ramón, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Ljuslinder, Ingrid, Palmqvist, Richard, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nicholas, Pischon, Tobias, and Boeing, Heiner

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results