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1. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Author

Graff, Mariaelisa, Justice, Anne E., Young, Kristin L., Marouli, Eirini, Zhang, Xinruo, Fine, Rebecca S., Lim, Elise, Buchanan, Victoria, Rand, Kristin, Feitosa, Mary F., Wojczynski, Mary K., Yanek, Lisa R., Shao, Yaming, Rohde, Rebecca, Adeyemo, Adebowale A., Aldrich, Melinda C., Allison, Matthew A., Ambrosone, Christine B., Ambs, Stefan, Amos, Christopher, Arnett, Donna K., Atwood, Larry, Bandera, Elisa V., Bartz, Traci, Becker, Diane M., Berndt, Sonja I., Bernstein, Leslie, Bielak, Lawrence F., Blot, William J., Bottinger, Erwin P., Bowden, Donald W., Bradfield, Jonathan P., Brody, Jennifer A., Broeckel, Ulrich, Burke, Gregory, Cade, Brian E., Cai, Qiuyin, Caporaso, Neil, Carlson, Chris, Carpten, John, Casey, Graham, Chanock, Stephen J., Chen, Guanjie, Chen, Minhui, Chen, Yii-Der I., Chen, Wei-Min, Chesi, Alessandra, Chiang, Charleston W.K., Chu, Lisa, Coetzee, Gerry A., Conti, David V., Cooper, Richard S., Cushman, Mary, Demerath, Ellen, Deming, Sandra L., Dimitrov, Latchezar, Ding, Jingzhong, Diver, W. Ryan, Duan, Qing, Evans, Michele K., Falusi, Adeyinka G., Faul, Jessica D., Fornage, Myriam, Fox, Caroline, Freedman, Barry I., Garcia, Melissa, Gillanders, Elizabeth M., Goodman, Phyllis, Gottesman, Omri, Grant, Struan F.A., Guo, Xiuqing, Hakonarson, Hakon, Haritunians, Talin, Harris, Tamara B., Harris, Curtis C., Henderson, Brian E., Hennis, Anselm, Hernandez, Dena G., Hirschhorn, Joel N., McNeill, Lorna Haughton, Howard, Timothy D., Howard, Barbara, Hsing, Ann W., Hsu, Yu-Han H., Hu, Jennifer J., Huff, Chad D., Huo, Dezheng, Ingles, Sue A., Irvin, Marguerite R., John, Esther M., Johnson, Karen C., Jordan, Joanne M., Kabagambe, Edmond K., Kang, Sun J., Kardia, Sharon L., Keating, Brendan J., Kittles, Rick A., Klein, Eric A., Kolb, Suzanne, Kolonel, Laurence N., Kooperberg, Charles, Kuller, Lewis, Kutlar, Abdullah, Lange, Leslie, Langefeld, Carl D., Le Marchand, Loic, Leonard, Hampton, Lettre, Guillaume, Levin, Albert M., Li, Yun, Li, Jin, Liu, Yongmei, Liu, Youfang, Liu, Simin, Lohman, Kurt, Lotay, Vaneet, Lu, Yingchang, Maixner, William, Manson, JoAnn E., McKnight, Barbara, Meng, Yan, Monda, Keri L., Monroe, Kris, Moore, Jason H., Mosley, Thomas H., Mudgal, Poorva, Murphy, Adam B., Nadukuru, Rajiv, Nalls, Mike A., Nathanson, Katherine L., Nayak, Uma, N’Diaye, Amidou, Nemesure, Barbara, Neslund-Dudas, Christine, Neuhouser, Marian L., Nyante, Sarah, Ochs-Balcom, Heather, Ogundiran, Temidayo O., Ogunniyi, Adesola, Ojengbede, Oladosu, Okut, Hayrettin, Olopade, Olufunmilayo I., Olshan, Andrew, Padhukasahasram, Badri, Palmer, Julie, Palmer, Cameron D., Palmer, Nicholette D., Papanicolaou, George, Patel, Sanjay R., Pettaway, Curtis A., Peyser, Patricia A., Press, Michael F., Rao, D.C., Rasmussen-Torvik, Laura J., Redline, Susan, Reiner, Alex P., Rhie, Suhn K., Rodriguez-Gil, Jorge L., Rotimi, Charles N., Rotter, Jerome I., Ruiz-Narvaez, Edward A., Rybicki, Benjamin A., Salako, Babatunde, Sale, Michele M., Sanderson, Maureen, Schadt, Eric, Schreiner, Pamela J., Schurmann, Claudia, Schwartz, Ann G., Shriner, Daniel A., Signorello, Lisa B., Singleton, Andrew B., Siscovick, David S., Smith, Jennifer A., Smith, Shad, Speliotes, Elizabeth, Spitz, Margaret, Stanford, Janet L., Stevens, Victoria L., Stram, Alex, Strom, Sara S., Sucheston, Lara, Sun, Yan V., Tajuddin, Salman M., Taylor, Herman, Taylor, Kira, Tayo, Bamidele O., Thun, Michael J., Tucker, Margaret A., Vaidya, Dhananjay, Van Den Berg, David J., Vedantam, Sailaja, Vitolins, Mara, Wang, Zhaoming, Ware, Erin B., Wassertheil-Smoller, Sylvia, Weir, David R., Wiencke, John K., Williams, Scott M., Williams, L. Keoki, Wilson, James G., Witte, John S., Wrensch, Margaret, Wu, Xifeng, Yao, Jie, Zakai, Neil, Zanetti, Krista, Zemel, Babette S., Zhao, Wei, Zhao, Jing Hua, Zheng, Wei, Zhi, Degui, Zhou, Jie, Zhu, Xiaofeng, Ziegler, Regina G., Zmuda, Joe, Zonderman, Alan B., Psaty, Bruce M., Borecki, Ingrid B., Cupples, L. Adrienne, Liu, Ching-Ti, Haiman, Christopher A., Loos, Ruth, Ng, Maggie C.Y., and North, Kari E. more...

Published
2021
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2. rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Author

Vreugdenhil, Anita, Alisi, Anna, Socha, Piotr, Jańczyk, Wojciech, Baumann, Ulrich, Rajwal, Sanjay, van Mourik, Indra, Lacaille, Florence, Dabbas, Myriam, Kelly, Deirdre A., Nobili, Valerio, Eiriksdottir, Gudny, Garcia, Melissa E., Gudnason, Vilmundur, Harris, Tamara B., Kim, Lauren J., Launer, Lenore J., Nalls, Michael A., Smith, Albert V., Clark, Jeanne M., Hernaez, Ruben, Kao, W.H. Linda, Mitchell, Braxton D., Shuldiner, Alan R., Yerges-Armstrong, Laura M., Borecki, Ingrid B., Carr, J. Jeffrey, Feitosa, Mary F., Wu, Jun, Butler, Johannah L., Fox, Caroline S., Hirschhorn, Joel N., Hoffmann, Udo, Hwang, Shih-Jen, Massaro, Joseph M., O'Donnell, Christopher J., Palmer, Cameron D., Sahani, Dushyant V., Speliotes, Elizabeth K., Teo, Kevin, Abeysekera, Kushala W.M., Adams, Leon, Aigner, Elmar, Anstee, Quentin M., Banales, Jesus M., Banerjee, Rajarshi, Basu, Priyadarshi, Berg, Thomas, Bhatnagar, Pallav, Buch, Stephan, Canbay, Ali, Caprio, Sonia, Chatterjee, Ankita, Ida Chen, Yii-Der, Chowdhury, Abhijit, Daly, Ann K., Datz, Christian, de Gracia Hahn, Dana, DiStefano, Johanna K., Dong, Jiawen, Duret, Amedine, Emdin, Connor, Fairey, Madison, Gerhard, Glenn S., Guo, Xiuqing, Hampe, Jochen, Hickman, Matthew, Heintz, Lena, Hudert, Christian, Hunter, Harriet, Kelly, Matt, Kozlitina, Julia, Krawczyk, Marcin, Lammert, Frank, Langenberg, Claudia, Lavine, Joel, Li, Lin, Lim, Hong Kai, Loomba, Rohit, Luukkonen, Panu K., Melton, Phillip E., Mori, Trevor A., Palmer, Nicholette D., Parisinos, Constantinos A., Pillai, Sreekumar G., Qayyum, Faiza, Reichert, Matthias C., Romeo, Stefano, Rotter, Jerome I., Im, Yu Ri, Santoro, Nicola, Schafmayer, Clemens, Stender, Stefan, Stickel, Felix, Still, Christopher D., Strnad, Pavel, Taylor, Kent D., Tybjærg-Hansen, Anne, Umano, Giuseppina Rosaria, Utukuri, Mrudula, Valenti, Luca, Wagenknecht, Lynne E., Wareham, Nicholas J., Watanabe, Richard M., Wattacheril, Julia, Yaghootkar, Hanieh, Yki-Järvinen, Hannele, Young, Kendra A., and Mann, Jake P. more...

Published
2021
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3. New genetic loci link adipose and insulin biology to body fat distribution

Author

Shungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Mägi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph MW, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C, Scherag, André, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M, Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L, Buyske, Steven, Demirkan, Ayse, Ehret, Georg B, Feitosa, Mary F, Goel, Anuj, Jackson, Anne U, Johnson, Toby, Kleber, Marcus E, Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J, Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V, Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M, Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B, Caspersen, Ida H, Clarke, Robert, Warwick Daw, E, Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex SF, Eklund, Niina, Erdos, Michael R, Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S, Golay, Alain, Grallert, Harald, Grammer, Tanja B, Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J, Haller, Toomas, and Hallmans, Goran more...

Subjects
Genetics, Human Genome, Diabetes, Obesity, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Cardiovascular, Stroke, Adipocytes, Adipogenesis, Adipose Tissue, Age Factors, Body Fat Distribution, Body Mass Index, Epigenesis, Genetic, Europe, Female, Genome, Human, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Neovascularization, Physiologic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Racial Groups, Sex Characteristics, Transcription, Genetic, Waist-Hip Ratio, ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, GLGC, ICBP, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, General Science & Technology
Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P more...

Published
2015

4. Genetic studies of body mass index yield new insights for obesity biology

Author

Locke, Adam E, Kahali, Bratati, Berndt, Sonja I, Justice, Anne E, Pers, Tune H, Day, Felix R, Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L, Yang, Jian, Croteau-Chonka, Damien C, Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian’an, Mägi, Reedik, Randall, Joshua C, Winkler, Thomas W, Wood, Andrew R, Workalemahu, Tsegaselassie, Faul, Jessica D, Smith, Jennifer A, Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K, Karjalainen, Juha, Schmidt, Ellen M, Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L, Bragg-Gresham, Jennifer L, Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B, Feenstra, Bjarke, Feitosa, Mary F, Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U, Kanoni, Stavroula, Kleber, Marcus E, Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E, Nalls, Michael A, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J, Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V, Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M, Attwood, Antony P, Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L, Böttcher, Yvonne, Boyd, Heather A, Bruinenberg, Marcel, Caspersen, Ida H, Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E, de Craen, Anton JM, Delgado, Graciela, and Dimitriou, Maria more...

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Obesity, Pediatric, Nutrition, Biotechnology, Human Genome, Childhood Obesity, Prevention, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Metabolic and endocrine, Stroke, Oral and gastrointestinal, Adipogenesis, Adiposity, Age Factors, Body Mass Index, Energy Metabolism, Europe, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glutamic Acid, Humans, Insulin, Insulin Secretion, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Racial Groups, Synapses, LifeLines Cohort Study, ADIPOGen Consortium, AGEN-BMI Working Group, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GLGC, ICBP, MAGIC Investigators, MuTHER Consortium, MIGen Consortium, PAGE Consortium, ReproGen Consortium, GENIE Consortium, International Endogene Consortium, General Science & Technology
Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. more...

Published
2015

5. Defining the role of common variation in the genomic and biological architecture of adult human height

Author

Wood, Andrew R, Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H, Gustafsson, Stefan, Chu, Audrey Y, Estrada, Karol, Luan, Jian'an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L, Croteau-Chonka, Damien C, Day, Felix R, Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U, Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E, Mägi, Reedik, Mihailov, Evelin, Porcu, Eleonora, Randall, Joshua C, Scherag, André, Vinkhuyzen, Anna AE, Westra, Harm-Jan, Winkler, Thomas W, Workalemahu, Tsegaselassie, Zhao, Jing Hua, Absher, Devin, Albrecht, Eva, Anderson, Denise, Baron, Jeffrey, Beekman, Marian, Demirkan, Ayse, Ehret, Georg B, Feenstra, Bjarke, Feitosa, Mary F, Fischer, Krista, Fraser, Ross M, Goel, Anuj, Gong, Jian, Justice, Anne E, Kanoni, Stavroula, Kleber, Marcus E, Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Lui, Julian C, Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Nalls, Michael A, Nyholt, Dale R, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Prokopenko, Inga, Ried, Janina S, Ripke, Stephan, Shungin, Dmitry, Stancáková, Alena, Strawbridge, Rona J, Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V, Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Afzal, Uzma, Ärnlöv, Johan, Arscott, Gillian M, Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blüher, Matthias, Bolton, Jennifer L, Böttcher, Yvonne, Boyd, Heather A, Bruinenberg, Marcel, Buckley, Brendan M, Buyske, Steven, Caspersen, Ida H, Chines, Peter S, Clarke, Robert, Claudi-Boehm, Simone, Cooper, Matthew, Daw, E Warwick, De Jong, Pim A, Deelen, Joris, and Delgado, Graciela more...

Subjects
Biological Sciences, Genetics, Human Genome, 2.1 Biological and endogenous factors, Adult, Analysis of Variance, Body Height, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Humans, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, White People, Electronic Medical Records and Genomics (eMEMERGEGE) Consortium, MIGen Consortium, PAGEGE Consortium, LifeLines Cohort Study, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. more...

Published
2014

6. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans

Author

Ellis, Jaclyn, Lange, Ethan M, Li, Jin, Dupuis, Josee, Baumert, Jens, Walston, Jeremy D, Keating, Brendan J, Durda, Peter, Fox, Ervin R, Palmer, Cameron D, Meng, Yan A, Young, Taylor, Farlow, Deborah N, Schnabel, Renate B, Marzi, Carola S, Larkin, Emma, Martin, Lisa W, Bis, Joshua C, Auer, Paul, Ramachandran, Vasan S, Gabriel, Stacey B, Willis, Monte S, Pankow, James S, Papanicolaou, George J, Rotter, Jerome I, Ballantyne, Christie M, Gross, Myron D, Lettre, Guillaume, Wilson, James G, Peters, Ulrike, Koenig, Wolfgang, Tracy, Russell P, Redline, Susan, Reiner, Alex P, Benjamin, Emelia J, and Lange, Leslie A more...

Subjects
Biological Sciences, Genetics, Human Genome, Heart Disease, Aging, Cardiovascular, Adult, Black or African American, Aged, Biomarkers, C-Reactive Protein, CD36 Antigens, Cardiovascular Diseases, Female, Genetic Loci, Genetic Predisposition to Disease, Genetics, Population, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract

C-reactive protein (CRP) is a heritable biomarker of systemic inflammation and a predictor of cardiovascular disease (CVD). Large-scale genetic association studies for CRP have largely focused on individuals of European descent. We sought to uncover novel genetic variants for CRP in a multiethnic sample using the ITMAT Broad-CARe (IBC) array, a custom 50,000 SNP gene-centric array having dense coverage of over 2,000 candidate CVD genes. We performed analyses on 7,570 African Americans (AA) from the Candidate gene Association Resource (CARe) study and race-combined meta-analyses that included 29,939 additional individuals of European descent from CARe, the Women's Health Initiative (WHI) and KORA studies. We observed array-wide significance (p < 2.2 × 10(-6)) for four loci in AA, three of which have been reported previously in individuals of European descent (IL6R, p = 2.0 × 10(-6); CRP, p = 4.2 × 10(-71); APOE, p = 1.6 × 10(-6)). The fourth significant locus, CD36 (p = 1.6 × 10(-6)), was observed at a functional variant (rs3211938) that is extremely rare in individuals of European descent. We replicated the CD36 finding (p = 1.8 × 10(-5)) in an independent sample of 8,041 AA women from WHI; a meta-analysis combining the CARe and WHI AA results at rs3211938 reached genome-wide significance (p = 1.5 × 10(-10)). In the race-combined meta-analyses, 13 loci reached significance, including ten (CRP, TOMM40/APOE/APOC1, HNF1A, LEPR, GCKR, IL6R, IL1RN, NLRP3, HNF4A and BAZ1B/BCL7B) previously associated with CRP, and one (ARNTL) previously reported to be nominally associated with CRP. Two novel loci were also detected (RPS6KB1, p = 2.0 × 10(-6); CD36, p = 1.4 × 10(-6)). These results highlight both shared and unique genetic risk factors for CRP in AA compared to populations of European descent. more...

Published
2014

7. Discovery and refinement of loci associated with lipid levels

Author

Willer, Cristen J, Schmidt, Ellen M, Sengupta, Sebanti, Peloso, Gina M, Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L, Mora, Samia, Beckmann, Jacques S, Bragg-Gresham, Jennifer L, Chang, Hsing-Yi, Demirkan, Ayşe, Den Hertog, Heleen M, Do, Ron, Donnelly, Louise A, Ehret, Georg B, Esko, Tõnu, Feitosa, Mary F, Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Fraser, Ross M, Freitag, Daniel F, Gurdasani, Deepti, Heikkilä, Kauko, Hyppönen, Elina, Isaacs, Aaron, Jackson, Anne U, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E, Li, Xiaohui, Luan, Jian’an, Lyytikäinen, Leo-Pekka, Magnusson, Patrik KE, Mangino, Massimo, Mihailov, Evelin, Montasser, May E, Müller-Nurasyid, Martina, Nolte, Ilja M, O’Connell, Jeffrey R, Palmer, Cameron D, Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Service, Susan K, Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thorleifsson, Gudmar, Van den Herik, Evita G, Voight, Benjamin F, Volcik, Kelly A, Waite, Lindsay L, Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Inês, Been, Latonya F, Bolton, Jennifer L, Bonnycastle, Lori L, Brambilla, Paolo, Burnett, Mary S, Cesana, Giancarlo, Dimitriou, Maria, Doney, Alex SF, Döring, Angela, Elliott, Paul, Epstein, Stephen E, Ingi Eyjolfsson, Gudmundur, Gigante, Bruna, Goodarzi, Mark O, Grallert, Harald, Gravito, Martha L, Groves, Christopher J, Hallmans, Göran, Hartikainen, Anna-Liisa, Hayward, Caroline, Hernandez, Dena, Hicks, Andrew A, Holm, Hilma, Hung, Yi-Jen, Illig, Thomas, Jones, Michelle R, Kaleebu, Pontiano, Kastelein, John JP, Khaw, Kay-Tee, and Kim, Eric more...

Subjects
Biological Sciences, Genetics, Human Genome, Cardiovascular, 2.1 Biological and endogenous factors, Asian People, Black People, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Lipids, Triglycerides, White People, Global Lipids Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research. more...

Published
2013

8. Common variants associated with plasma triglycerides and risk for coronary artery disease

Author

Do, Ron, Willer, Cristen J, Schmidt, Ellen M, Sengupta, Sebanti, Gao, Chi, Peloso, Gina M, Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L, Mora, Samia, Beckmann, Jacques S, Bragg-Gresham, Jennifer L, Chang, Hsing-Yi, Demirkan, Ayşe, Den Hertog, Heleen M, Donnelly, Louise A, Ehret, Georg B, Esko, Tõnu, Feitosa, Mary F, Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Fraser, Ross M, Freitag, Daniel F, Gurdasani, Deepti, Heikkilä, Kauko, Hyppönen, Elina, Isaacs, Aaron, Jackson, Anne U, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E, Li, Xiaohui, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Magnusson, Patrik KE, Mangino, Massimo, Mihailov, Evelin, Montasser, May E, Müller-Nurasyid, Martina, Nolte, Ilja M, O'Connell, Jeffrey R, Palmer, Cameron D, Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Service, Susan K, Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thorleifsson, Gudmar, Van den Herik, Evita G, Voight, Benjamin F, Volcik, Kelly A, Waite, Lindsay L, Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Inês, Been, Latonya F, Bolton, Jennifer L, Bonnycastle, Lori L, Brambilla, Paolo, Burnett, Mary S, Cesana, Giancarlo, Dimitriou, Maria, Doney, Alex SF, Döring, Angela, Elliott, Paul, Epstein, Stephen E, Eyjolfsson, Gudmundur Ingi, Gigante, Bruna, Goodarzi, Mark O, Grallert, Harald, Gravito, Martha L, Groves, Christopher J, Hallmans, Göran, Hartikainen, Anna-Liisa, Hayward, Caroline, Hernandez, Dena, Hicks, Andrew A, Holm, Hilma, Hung, Yi-Jen, Illig, Thomas, Jones, Michelle R, Kaleebu, Pontiano, Kastelein, John JP, and Khaw, Kay-Tee more...

Subjects
Agricultural, Veterinary and Food Sciences, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Agricultural Biotechnology, Atherosclerosis, Heart Disease, Heart Disease - Coronary Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Biological Transport, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Triglycerides, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. more...

Published
2013

9. Evidence of widespread selection on standing variation in Europe at height-associated SNPs

Author

Turchin, Michael C, Chiang, Charleston WK, Palmer, Cameron D, Sankararaman, Sriram, Reich, David, and Hirschhorn, Joel N

Subjects
Adult, Body Height, Cohort Studies, Europe, Female, Gene Frequency, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Humans, Likelihood Functions, Male, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Selection, Genetic, White People, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Strong signatures of positive selection at newly arising genetic variants are well documented in humans(1-8), but this form of selection may not be widespread in recent human evolution(9). Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation(10-12). By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome wide, are systematically elevated in Northern Europeans compared with Southern Europeans (P < 4.3 × 10(-4)). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients ∼10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)). more...

Published
2012

10. The landscape of recombination in African Americans

Author

Hinch, Anjali G, Tandon, Arti, Patterson, Nick, Song, Yunli, Rohland, Nadin, Palmer, Cameron D, Chen, Gary K, Wang, Kai, Buxbaum, Sarah G, Akylbekova, Ermeg L, Aldrich, Melinda C, Ambrosone, Christine B, Amos, Christopher, Bandera, Elisa V, Berndt, Sonja I, Bernstein, Leslie, Blot, William J, Bock, Cathryn H, Boerwinkle, Eric, Cai, Qiuyin, Caporaso, Neil, Casey, Graham, Adrienne Cupples, L, Deming, Sandra L, Ryan Diver, W, Divers, Jasmin, Fornage, Myriam, Gillanders, Elizabeth M, Glessner, Joseph, Harris, Curtis C, Hu, Jennifer J, Ingles, Sue A, Isaacs, William, John, Esther M, Linda Kao, WH, Keating, Brendan, Kittles, Rick A, Kolonel, Laurence N, Larkin, Emma, Le Marchand, Loic, McNeill, Lorna H, Millikan, Robert C, Murphy, Musani, Solomon, Neslund-Dudas, Christine, Nyante, Sarah, Papanicolaou, George J, Press, Michael F, Psaty, Bruce M, Reiner, Alex P, Rich, Stephen S, Rodriguez-Gil, Jorge L, Rotter, Jerome I, Rybicki, Benjamin A, Schwartz, Ann G, Signorello, Lisa B, Spitz, Margaret, Strom, Sara S, Thun, Michael J, Tucker, Margaret A, Wang, Zhaoming, Wiencke, John K, Witte, John S, Wrensch, Margaret, Wu, Xifeng, Yamamura, Yuko, Zanetti, Krista A, Zheng, Wei, Ziegler, Regina G, Zhu, Xiaofeng, Redline, Susan, Hirschhorn, Joel N, Henderson, Brian E, Taylor Jr, Herman A, Price, Alkes L, Hakonarson, Hakon, Chanock, Stephen J, Haiman, Christopher A, Wilson, James G, Reich, David, and Myers, Simon R more...

Subjects
Biological Sciences, Genetics, Biotechnology, Human Genome, Africa, Western, Black or African American, Alleles, Amino Acid Motifs, Base Sequence, Chromosome Mapping, Crossing Over, Genetic, Europe, Evolution, Molecular, Female, Gene Frequency, Genetics, Population, Genome, Human, Genomics, Haplotypes, Histone-Lysine N-Methyltransferase, Humans, Male, Molecular Sequence Data, Pedigree, Polymorphism, Single Nucleotide, Probability, White People, General Science & Technology
Abstract

Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P value more...

Published
2011

11. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

Author

Reiner, Alexander P, Lettre, Guillaume, Nalls, Michael A, Ganesh, Santhi K, Mathias, Rasika, Austin, Melissa A, Dean, Eric, Arepalli, Sampath, Britton, Angela, Chen, Zhao, Couper, David, Curb, J David, Eaton, Charles B, Fornage, Myriam, Grant, Struan FA, Harris, Tamara B, Hernandez, Dena, Kamatini, Naoyuki, Keating, Brendan J, Kubo, Michiaki, LaCroix, Andrea, Lange, Leslie A, Liu, Simin, Lohman, Kurt, Meng, Yan, Mohler, Emile R, Musani, Solomon, Nakamura, Yusuke, O'Donnell, Christopher J, Okada, Yukinori, Palmer, Cameron D, Papanicolaou, George J, Patel, Kushang V, Singleton, Andrew B, Takahashi, Atsushi, Tang, Hua, Taylor, Herman A, Taylor, Kent, Thomson, Cynthia, Yanek, Lisa R, Yang, Lingyao, Ziv, Elad, Zonderman, Alan B, Folsom, Aaron R, Evans, Michele K, Liu, Yongmei, Becker, Diane M, Snively, Beverly M, and Wilson, James G more...

Subjects
Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 16, Humans, Microfilament Proteins, Receptors, Cell Surface, Duffy Blood-Group System, Leukocyte Count, Artifacts, Reproducibility of Results, DNA Replication, Phenotype, Polymorphism, Single Nucleotide, African Americans, Asian Continental Ancestry Group, European Continental Ancestry Group, Chemokine CXCL2, Genome-Wide Association Study, Molecular Epidemiology, Genetic Loci, Chromosomes, Human, Pair 1, Pair 4, Pair 16, Receptors, Cell Surface, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P more...

Published
2011

12. Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium.

Author

Pasaniuc, Bogdan, Zaitlen, Noah, Lettre, Guillaume, Chen, Gary K, Tandon, Arti, Kao, WH Linda, Ruczinski, Ingo, Fornage, Myriam, Siscovick, David S, Zhu, Xiaofeng, Larkin, Emma, Lange, Leslie A, Cupples, L Adrienne, Yang, Qiong, Akylbekova, Ermeg L, Musani, Solomon K, Divers, Jasmin, Mychaleckyj, Joe, Li, Mingyao, Papanicolaou, George J, Millikan, Robert C, Ambrosone, Christine B, John, Esther M, Bernstein, Leslie, Zheng, Wei, Hu, Jennifer J, Ziegler, Regina G, Nyante, Sarah J, Bandera, Elisa V, Ingles, Sue A, Press, Michael F, Chanock, Stephen J, Deming, Sandra L, Rodriguez-Gil, Jorge L, Palmer, Cameron D, Buxbaum, Sarah, Ekunwe, Lynette, Hirschhorn, Joel N, Henderson, Brian E, Myers, Simon, Haiman, Christopher A, Reich, David, Patterson, Nick, Wilson, James G, and Price, Alkes L more...

Subjects
Humans, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2, Odds Ratio, Chromosome Mapping, Genetics, Population, Gene Frequency, Genotype, Linkage Disequilibrium, Phenotype, Polymorphism, Single Nucleotide, Genome, Human, Algorithms, Principal Component Analysis, Software, African Americans, Female, Male, Receptor, Fibroblast Growth Factor, Type 2, Genetic Variation, Genome-Wide Association Study, Diabetes Mellitus, Type 2, Genetics, Population, Polymorphism, Single Nucleotide, Genome, Human, Receptor, Fibroblast Growth Factor, Developmental Biology
Abstract

While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans and Latinos. In admixed populations, linkage disequilibrium (LD) exists both at a fine scale in ancestral populations and at a coarse scale (admixture-LD) due to chromosomal segments of distinct ancestry. Disease association statistics in admixed populations have previously considered SNP association (LD mapping) or admixture association (mapping by admixture-LD), but not both. Here, we introduce a new statistical framework for combining SNP and admixture association in case-control studies, as well as methods for local ancestry-aware imputation. We illustrate the gain in statistical power achieved by these methods by analyzing data of 6,209 unrelated African Americans from the CARe project genotyped on the Affymetrix 6.0 chip, in conjunction with both simulated and real phenotypes, as well as by analyzing the FGFR2 locus using breast cancer GWAS data from 5,761 African-American women. We show that, at typed SNPs, our method yields an 8% increase in statistical power for finding disease risk loci compared to the power achieved by standard methods in case-control studies. At imputed SNPs, we observe an 11% increase in statistical power for mapping disease loci when our local ancestry-aware imputation framework and the new scoring statistic are jointly employed. Finally, we show that our method increases statistical power in regions harboring the causal SNP in the case when the causal SNP is untyped and cannot be imputed. Our methods and our publicly available software are broadly applicable to GWAS in admixed populations. more...

Published
2011

13. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.

Author

Speliotes, Elizabeth K, Yerges-Armstrong, Laura M, Wu, Jun, Hernaez, Ruben, Kim, Lauren J, Palmer, Cameron D, Gudnason, Vilmundur, Eiriksdottir, Gudny, Garcia, Melissa E, Launer, Lenore J, Nalls, Michael A, Clark, Jeanne M, Mitchell, Braxton D, Shuldiner, Alan R, Butler, Johannah L, Tomas, Marta, Hoffmann, Udo, Hwang, Shih-Jen, Massaro, Joseph M, O'Donnell, Christopher J, Sahani, Dushyant V, Salomaa, Veikko, Schadt, Eric E, Schwartz, Stephen M, Siscovick, David S, NASH CRN, GIANT Consortium, MAGIC Investigators, Voight, Benjamin F, Carr, J Jeffrey, Feitosa, Mary F, Harris, Tamara B, Fox, Caroline S, Smith, Albert V, Kao, WH Linda, Hirschhorn, Joel N, Borecki, Ingrid B, and GOLD Consortium more...

Subjects
NASH CRN, GIANT Consortium, MAGIC Investigators, GOLD Consortium, Humans, Fatty Liver, Insulin, Lipase, Blood Glucose, Adaptor Proteins, Signal Transducing, Lectins, C-Type, Membrane Proteins, Nerve Tissue Proteins, Tomography, X-Ray Computed, Case-Control Studies, Cohort Studies, Mutation, Missense, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Adult, Aged, Aged, 80 and over, Middle Aged, Male, Genome-Wide Association Study, Chondroitin Sulfate Proteoglycans, Non-alcoholic Fatty Liver Disease, Prevention, Human Genome, Digestive Diseases, Liver Disease, Hepatitis, Chronic Liver Disease and Cirrhosis, Genetics, Clinical Research, 2.1 Biological and endogenous factors, Developmental Biology
Abstract

Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ∼2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p more...

Published
2011

14. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmüller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O’Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, André G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L. more...

Published
2018
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15. Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system

Author

Jaime, Maria D L A, primary, Salem, Ghadi H, additional, Martinez, Daniel J, additional, Karott, Sean, additional, Flores, Alejandra, additional, Palmer, Cameron D, additional, Mahadevaraju, Sharvani, additional, Krynitsky, Jonathan, additional, Garmendia-Cedillos, Marcial, additional, Anderson, Sarah, additional, Harbison, Susan, additional, Pohida, Thomas J, additional, Ludington, William B, additional, and Oliver, Brian, additional more...

Published
2023
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17. Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection

Author

Bhatia, Gaurav, Patterson, Nick, Pasaniuc, Bogdan, Zaitlen, Noah, Genovese, Giulio, Pollack, Samuela, Mallick, Swapan, Myers, Simon, Tandon, Arti, Spencer, Chris, Palmer, Cameron D., Adeyemo, Adebowale A., Akylbekova, Ermeg L., Cupples, L. Adrienne, Divers, Jasmin, Fornage, Myriam, Kao, W.H. Linda, Lange, Leslie, Li, Mingyao, Musani, Solomon, Mychaleckyj, Josyf C., Ogunniyi, Adesola, Papanicolaou, George, Rotimi, Charles N., Rotter, Jerome I., Ruczinski, Ingo, Salako, Babatunde, Siscovick, David S., Tayo, Bamidele O., Yang, Qiong, McCarroll, Steve, Sabeti, Pardis, Lettre, Guillaume, De Jager, Phil, Hirschhorn, Joel, Zhu, Xiaofeng, Cooper, Richard, Reich, David, Wilson, James G., and Price, Alkes L. more...

Published
2011
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18. Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans

Author

Tang, Weihong, Cushman, Mary, Green, David, Rich, Stephen S., Lange, Leslie A., Yang, Qiong, Tracy, Russell P., Tofler, Geoffrey H., Basu, Saonli, Wilson, James G., Keating, Brendan J., Weng, Lu-Chen, Taylor, Herman A., Jacobs, David R., Jr., Delaney, Joseph A., Palmer, Cameron D., Young, Taylor, Pankow, James S., OʼDonnell, Christopher J., Smith, Nicholas L., Reiner, Alexander P., and Folsom, Aaron R. more...

Published
2015
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19. Replication and fine mapping of asthma-associated loci in individuals of African ancestry

Author

Kantor, David B., Palmer, Cameron D., Young, Taylor R., Meng, Yan, Gajdos, Zofia K., Lyon, Helen, Price, Alkes L., Pollack, Samuela, London, Stephanie J., Loehr, Laura R., Smith, Lewis J., Kumar, Rajesh, Jacobs Jr., David R., Petrini, Marcy F., O’Connor, George T., White, Wendy B., Papanicolaou, George, Burkart, Kristin M., Heckbert, Susan R., Barr, R. Graham, and Hirschhorn, Joel N. more...

Published
2013
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21. rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Author

Teo, Kevin, primary, Abeysekera, Kushala W.M., additional, Adams, Leon, additional, Aigner, Elmar, additional, Anstee, Quentin M., additional, Banales, Jesus M., additional, Banerjee, Rajarshi, additional, Basu, Priyadarshi, additional, Berg, Thomas, additional, Bhatnagar, Pallav, additional, Buch, Stephan, additional, Canbay, Ali, additional, Caprio, Sonia, additional, Chatterjee, Ankita, additional, Ida Chen, Yii-Der, additional, Chowdhury, Abhijit, additional, Daly, Ann K., additional, Datz, Christian, additional, de Gracia Hahn, Dana, additional, DiStefano, Johanna K., additional, Dong, Jiawen, additional, Duret, Amedine, additional, Emdin, Connor, additional, Fairey, Madison, additional, Gerhard, Glenn S., additional, Guo, Xiuqing, additional, Hampe, Jochen, additional, Hickman, Matthew, additional, Heintz, Lena, additional, Hudert, Christian, additional, Hunter, Harriet, additional, Kelly, Matt, additional, Kozlitina, Julia, additional, Krawczyk, Marcin, additional, Lammert, Frank, additional, Langenberg, Claudia, additional, Lavine, Joel, additional, Li, Lin, additional, Lim, Hong Kai, additional, Loomba, Rohit, additional, Luukkonen, Panu K., additional, Melton, Phillip E., additional, Mori, Trevor A., additional, Palmer, Nicholette D., additional, Parisinos, Constantinos A., additional, Pillai, Sreekumar G., additional, Qayyum, Faiza, additional, Reichert, Matthias C., additional, Romeo, Stefano, additional, Rotter, Jerome I., additional, Im, Yu Ri, additional, Santoro, Nicola, additional, Schafmayer, Clemens, additional, Speliotes, Elizabeth K., additional, Stender, Stefan, additional, Stickel, Felix, additional, Still, Christopher D., additional, Strnad, Pavel, additional, Taylor, Kent D., additional, Tybjærg-Hansen, Anne, additional, Umano, Giuseppina Rosaria, additional, Utukuri, Mrudula, additional, Valenti, Luca, additional, Wagenknecht, Lynne E., additional, Wareham, Nicholas J., additional, Watanabe, Richard M., additional, Wattacheril, Julia, additional, Yaghootkar, Hanieh, additional, Yki-Järvinen, Hannele, additional, Young, Kendra A., additional, Mann, Jake P., additional, Vreugdenhil, Anita, additional, Alisi, Anna, additional, Socha, Piotr, additional, Jańczyk, Wojciech, additional, Baumann, Ulrich, additional, Rajwal, Sanjay, additional, van Mourik, Indra, additional, Lacaille, Florence, additional, Dabbas, Myriam, additional, Kelly, Deirdre A., additional, Nobili, Valerio, additional, Eiriksdottir, Gudny, additional, Garcia, Melissa E., additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Kim, Lauren J., additional, Launer, Lenore J., additional, Nalls, Michael A., additional, Smith, Albert V., additional, Clark, Jeanne M., additional, Hernaez, Ruben, additional, Kao, W.H. Linda, additional, Mitchell, Braxton D., additional, Shuldiner, Alan R., additional, Yerges-Armstrong, Laura M., additional, Borecki, Ingrid B., additional, Carr, J. Jeffrey, additional, Feitosa, Mary F., additional, Wu, Jun, additional, Butler, Johannah L., additional, Fox, Caroline S., additional, Hirschhorn, Joel N., additional, Hoffmann, Udo, additional, Hwang, Shih-Jen, additional, Massaro, Joseph M., additional, O'Donnell, Christopher J., additional, Palmer, Cameron D., additional, and Sahani, Dushyant V., additional more...

Published
2021
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22. Genome-wide association of anthropometric traits in African- and African-derived populations

Author

Kang, Sun J., Chiang, Charleston W.K., Palmer, Cameron D., Tayo, Bamidele O., Lettre, Guillaume, Butler, Johannah L., Hackett, Rachel, Adeyemo, Adebowale A., Guiducci, Candace, Berzins, Ilze, Nguyen, Thutrang T., Feng, Tao, Luke, Amy, Shriner, Daniel, Ardlie, Kristin, Rotimi, Charles, Wilks, Rainford, Forrester, Terrence, McKenzie, Colin A., Lyon, Helen N., Cooper, Richard S., Zhu, Xiaofeng, and Hirschhorn, Joel N. more...

Published
2010
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23. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Author

Ehret, Georg B., Ferreira, Teresa, Chasman, Daniel I., Jackson, Anne U., Schmidt, Ellen M., Johnson, Toby, Thorleifsson, Gudmar, Luan, Jian'an, Donnelly, Louise A., Kanoni, Stavroula, Petersen, Ann -Kristin, Pihurl, Vasyl, Strawbridge, Rona J., Shungin, Dmitry, Hughes, Maria F., Meirelles, Osorio, Kaakinen, Marika, Bouatia-Naji, Nabila, Kristiansson, Kati, Shah, Sonia, Kleber, Marcus E., Guo, Xiuqing, Lyytikainen, Leo-Pekka, Fava, Cristiano, Eriksson, Niclas, Nolte, Ilja M., Magnusson, Patrik K., Salfati, Elias L., Rallidis, Loukianos S., Theusch, Elizabeth, Smith, Andrew J. P., Folkersen, Lasse, Witkowska, Kate, Pers, Tune H., Joehanes, Roby, Kim, Stuart K., Lataniotis, Lazaros, Jansen, Rick, Johnson, Andrew D., Warren, Helen, Kim, Young Jin, Zhao, Wei, Wu, Ying, Tayo, Bamidele O., Bochud, Murielle, Absher, Devin, Adair, Linda S., Amin, Najaf, Arkingl, Dan E., Axelsson, Tomas, Baldassarre, Damian, Balkau, Beverley, Bandinelli, Stefania, Barnes, Michael R., Barroso, Ines, Bevan, Stephen, Bis, Joshua C., Bjornsdottir, Gyda, Boehnke, Michael, Boerwinkle, Eric, Bonnycastle, Lori L., Boomsma, Dorret I., Bornstein, Stefan R., Brown, Morris J., Burnier, Michel, Cabrera, Claudia P., Chambers, John C., Chang, I-Shou, Cheng, Ching-Yu, Chines, Peter S., Chung, Ren-Hua, Collins, Francis S., Connell, John M., Doring, Angela, Dallongeville, Jean, Danesh, John, de Faire, Ulf, Delgado, Graciela, Dominiczak, Anna F., Doney, Alex S. F., Drenos, Fotios, Edkins, Sarah, Eicher, John D., Elosua, Roberto, Enroth, Stefan, Erdmann, Jeanette, Eriksson, Per, Esko, Tonu, Evangelou, Evangelos, Evans, Alun, Fall, Tove, Farra, Martin, Felixl, Janine F., Ferrieres, Jean, Ferrucci, Luigi, Fornage, Myriam, Forrester, Terrence, Franceschinil, Nora, Franco, Oscar H., Franco-Cereceda, Anders, Fraser, Ross M., Ganesh, Santhi K., Gao, He, Gertow, Karl, Gianfagna, Francesco, Gigante, Bruna, Giulianini, Franco, Goe, Anuj, Goodall, Alison H., Goodarzi, Mark, Gorski, Mathias, Grassler, Jurgen, Groves, Christopher J., Gudnason, Vilmundur, Gyllensten, Ulf, Hallmans, Göran, Hartikainen, Anna-Liisa, Hassinen, Maija, Havulinna, Aki S., Hayward, Caroline, Hercberg, Serge, Herzig, Karl-Heinz, Hicks, Andrew A., Hingorani, Aroon D., Hirschhorn, Joel N., Hofmanl, Albert, Holmen, Jostein, Holmen, Oddgeir Lingaas, Hottenga, Jouke-Jan, Howard, Phil, Hsiung, Chao A., Hunt, Steven C., Ikram, M. Arfan, Illig, Thomas, Iribarren, Carlos, Jensen, Richard A., Kahonen, Mika, Kang, Hyun Min, Kathiresan, Sekar, Keating, Brendan J., Khaw, Kay-Tee, Kim, Yun Kyoung, Kim, Eric, Kivimaki, Mika, Klopp, Norman, Kolovou, Genovefa, Komulainen, Pirjo, Kooner, Jaspal S., Kosova, Gulum, Krauss, Ronald M., Kuh, Diana, Kutalik, Zoltan, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Lee, Nanette R., Lee, I-Te, Lee, Wen-Jane, Levy, Daniel, Li, Xiaohui, Liang, Kae-Woei, Lin, Honghuang, Lin, Li, Lindstrom, Jaana, Lobbens, Stephane, Mannisto, Satu, Muller, Gabriele, Muller-Nurasyid, Martina, Mach, Francois, Markus, Hugh S., Marouli, Eirini, McCarthy, Mark I., McKenzie, Colin A., Meneton, Pierre, Menni, Cristina, Metspalu, Andres, Mijatovic, Vladan, Moilanen, Leena, Montasser, May E., Morris, Andrew D., Morrison, Alanna C., Mulas, Antonella, Nagaraja, Ramaiah, Narisu, Narisu, Nikus, Kjell, O'Donnell, Christopher J., O'Reilly, Paul F., Ong, Ken K., Paccaud, Fred, Palmer, Cameron D., Parsa, Afshin, Pedersen, Nancy L., Penninx, Brenda W., Perola, Markus, Peters, Annette, Poulter, Neil, Pramstaller, Peter P., Psaty, Bruce M., Quertermous, Thomas, Rao, Dabeeru C., Rasheed, Asif, Rayner, N. William, Renstrom, Frida, Rettig, Rainer, Rice, Kenneth M., Roberts, Robert, Rose, Lynda M., Rossouw, Jacques, Samani, Nilesh J., Sanna, Serena, Saramies, Jouko, Schunkert, Heribert, Sebert, Sylvain, Sheu, Wayne H-H, Shin, Young-Ah, Sim, Xueling, Smit, Johannes H., Smith, Albert V., Sosa, Maria X., Spector, Tim D., Stancakova, Alena, Stanton, Alice V., Stirrups, Kathleen E., Stringham, Heather M., Sundström, Johan, Swift, Amy J., Syvänen, Ann-Christine, Tai, E-Shyong, Tanaka, Toshiko, Tarasov, Kirill V., Teumer, Alexander, Thorsteinsdottir, Unnur, Tobin, Martin D., Tremoli, Elena, Uitterlinden, Andre G., Uusitupa, Matti, Vaez, Ahmad, Vaidya, Dhananjay, van Duijn, Cornelia M., van Iperen, Erik P. A., Vasan, Ramachandran S., Verwoert, Germaine C., Virtamo, Jarmo, Vitart, Veronique, Voight, Benjamin F., Vollenweider, Peter, Wagner, Aline, Wain, Louise V., Wareham, Nicholas J., Watldns, Hugh, Weder, Alan B., Westra, Harm Jan, Wilks, Rainford, Wilsgaard, Tom, Wilson, James F., Wong, Tien Y., Yang, Tsun-Po, Yao, Jie, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zhu, Xiaofeng, Bovet, Pascal, Cooper, Richard S., Mohlke, Karen L., Saleheen, Danish, Lee, Jong-Young, Elliott, Paul, Gierman, Hinco J., Willer, Cristen J., Franke, Lude, Hovingh, G. Kees, Taylor, Kent D., Dedoussis, George, Sever, Peter, Wong, Andrew, Lind, Lars, Assimes, Themistocles L., Njolstad, Inger, Schwarz, Peter E. H., Langenberg, Claudia, Snieder, Harold, Caulfield, Mark J., Melander, E., Laakso, Markku, Saltevo, Juha, Rauramaa, Rainer, Tuomilehto, Jaakko, Ingelsson, Erik, Lehtimaki, Terho, Hveem, Kristian, Palmas, Walter, Marz, Winfried, Kumar, Meena, Salomaa, Veikko, Chen, Yii-Der I., Rotter, Jerome I., Froguel, Philippe, Jarvelin, Marjo-Riitta, Lakatta, Edward G., Kuulasmaa, Kari, Franks, Paul W., Hamsten, Anders, Wichmann, H-Erich, Palmer, Colin N. A., Stefansson, Kari, Ridker, Paul M., Loos, Ruth J. F., Chalcravarti, Aravinda, Deloukas, Panos, Morris, Andrew P., Newton-Cheh, Christopher, Munroe, Patricia B., Ehret, Georg B., Ferreira, Teresa, Chasman, Daniel I., Jackson, Anne U., Schmidt, Ellen M., Johnson, Toby, Thorleifsson, Gudmar, Luan, Jian'an, Donnelly, Louise A., Kanoni, Stavroula, Petersen, Ann -Kristin, Pihurl, Vasyl, Strawbridge, Rona J., Shungin, Dmitry, Hughes, Maria F., Meirelles, Osorio, Kaakinen, Marika, Bouatia-Naji, Nabila, Kristiansson, Kati, Shah, Sonia, Kleber, Marcus E., Guo, Xiuqing, Lyytikainen, Leo-Pekka, Fava, Cristiano, Eriksson, Niclas, Nolte, Ilja M., Magnusson, Patrik K., Salfati, Elias L., Rallidis, Loukianos S., Theusch, Elizabeth, Smith, Andrew J. P., Folkersen, Lasse, Witkowska, Kate, Pers, Tune H., Joehanes, Roby, Kim, Stuart K., Lataniotis, Lazaros, Jansen, Rick, Johnson, Andrew D., Warren, Helen, Kim, Young Jin, Zhao, Wei, Wu, Ying, Tayo, Bamidele O., Bochud, Murielle, Absher, Devin, Adair, Linda S., Amin, Najaf, Arkingl, Dan E., Axelsson, Tomas, Baldassarre, Damian, Balkau, Beverley, Bandinelli, Stefania, Barnes, Michael R., Barroso, Ines, Bevan, Stephen, Bis, Joshua C., Bjornsdottir, Gyda, Boehnke, Michael, Boerwinkle, Eric, Bonnycastle, Lori L., Boomsma, Dorret I., Bornstein, Stefan R., Brown, Morris J., Burnier, Michel, Cabrera, Claudia P., Chambers, John C., Chang, I-Shou, Cheng, Ching-Yu, Chines, Peter S., Chung, Ren-Hua, Collins, Francis S., Connell, John M., Doring, Angela, Dallongeville, Jean, Danesh, John, de Faire, Ulf, Delgado, Graciela, Dominiczak, Anna F., Doney, Alex S. F., Drenos, Fotios, Edkins, Sarah, Eicher, John D., Elosua, Roberto, Enroth, Stefan, Erdmann, Jeanette, Eriksson, Per, Esko, Tonu, Evangelou, Evangelos, Evans, Alun, Fall, Tove, Farra, Martin, Felixl, Janine F., Ferrieres, Jean, Ferrucci, Luigi, Fornage, Myriam, Forrester, Terrence, Franceschinil, Nora, Franco, Oscar H., Franco-Cereceda, Anders, Fraser, Ross M., Ganesh, Santhi K., Gao, He, Gertow, Karl, Gianfagna, Francesco, Gigante, Bruna, Giulianini, Franco, Goe, Anuj, Goodall, Alison H., Goodarzi, Mark, Gorski, Mathias, Grassler, Jurgen, Groves, Christopher J., Gudnason, Vilmundur, Gyllensten, Ulf, Hallmans, Göran, Hartikainen, Anna-Liisa, Hassinen, Maija, Havulinna, Aki S., Hayward, Caroline, Hercberg, Serge, Herzig, Karl-Heinz, Hicks, Andrew A., Hingorani, Aroon D., Hirschhorn, Joel N., Hofmanl, Albert, Holmen, Jostein, Holmen, Oddgeir Lingaas, Hottenga, Jouke-Jan, Howard, Phil, Hsiung, Chao A., Hunt, Steven C., Ikram, M. Arfan, Illig, Thomas, Iribarren, Carlos, Jensen, Richard A., Kahonen, Mika, Kang, Hyun Min, Kathiresan, Sekar, Keating, Brendan J., Khaw, Kay-Tee, Kim, Yun Kyoung, Kim, Eric, Kivimaki, Mika, Klopp, Norman, Kolovou, Genovefa, Komulainen, Pirjo, Kooner, Jaspal S., Kosova, Gulum, Krauss, Ronald M., Kuh, Diana, Kutalik, Zoltan, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Lee, Nanette R., Lee, I-Te, Lee, Wen-Jane, Levy, Daniel, Li, Xiaohui, Liang, Kae-Woei, Lin, Honghuang, Lin, Li, Lindstrom, Jaana, Lobbens, Stephane, Mannisto, Satu, Muller, Gabriele, Muller-Nurasyid, Martina, Mach, Francois, Markus, Hugh S., Marouli, Eirini, McCarthy, Mark I., McKenzie, Colin A., Meneton, Pierre, Menni, Cristina, Metspalu, Andres, Mijatovic, Vladan, Moilanen, Leena, Montasser, May E., Morris, Andrew D., Morrison, Alanna C., Mulas, Antonella, Nagaraja, Ramaiah, Narisu, Narisu, Nikus, Kjell, O'Donnell, Christopher J., O'Reilly, Paul F., Ong, Ken K., Paccaud, Fred, Palmer, Cameron D., Parsa, Afshin, Pedersen, Nancy L., Penninx, Brenda W., Perola, Markus, Peters, Annette, Poulter, Neil, Pramstaller, Peter P., Psaty, Bruce M., Quertermous, Thomas, Rao, Dabeeru C., Rasheed, Asif, Rayner, N. William, Renstrom, Frida, Rettig, Rainer, Rice, Kenneth M., Roberts, Robert, Rose, Lynda M., Rossouw, Jacques, Samani, Nilesh J., Sanna, Serena, Saramies, Jouko, Schunkert, Heribert, Sebert, Sylvain, Sheu, Wayne H-H, Shin, Young-Ah, Sim, Xueling, Smit, Johannes H., Smith, Albert V., Sosa, Maria X., Spector, Tim D., Stancakova, Alena, Stanton, Alice V., Stirrups, Kathleen E., Stringham, Heather M., Sundström, Johan, Swift, Amy J., Syvänen, Ann-Christine, Tai, E-Shyong, Tanaka, Toshiko, Tarasov, Kirill V., Teumer, Alexander, Thorsteinsdottir, Unnur, Tobin, Martin D., Tremoli, Elena, Uitterlinden, Andre G., Uusitupa, Matti, Vaez, Ahmad, Vaidya, Dhananjay, van Duijn, Cornelia M., van Iperen, Erik P. A., Vasan, Ramachandran S., Verwoert, Germaine C., Virtamo, Jarmo, Vitart, Veronique, Voight, Benjamin F., Vollenweider, Peter, Wagner, Aline, Wain, Louise V., Wareham, Nicholas J., Watldns, Hugh, Weder, Alan B., Westra, Harm Jan, Wilks, Rainford, Wilsgaard, Tom, Wilson, James F., Wong, Tien Y., Yang, Tsun-Po, Yao, Jie, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zhu, Xiaofeng, Bovet, Pascal, Cooper, Richard S., Mohlke, Karen L., Saleheen, Danish, Lee, Jong-Young, Elliott, Paul, Gierman, Hinco J., Willer, Cristen J., Franke, Lude, Hovingh, G. Kees, Taylor, Kent D., Dedoussis, George, Sever, Peter, Wong, Andrew, Lind, Lars, Assimes, Themistocles L., Njolstad, Inger, Schwarz, Peter E. H., Langenberg, Claudia, Snieder, Harold, Caulfield, Mark J., Melander, E., Laakso, Markku, Saltevo, Juha, Rauramaa, Rainer, Tuomilehto, Jaakko, Ingelsson, Erik, Lehtimaki, Terho, Hveem, Kristian, Palmas, Walter, Marz, Winfried, Kumar, Meena, Salomaa, Veikko, Chen, Yii-Der I., Rotter, Jerome I., Froguel, Philippe, Jarvelin, Marjo-Riitta, Lakatta, Edward G., Kuulasmaa, Kari, Franks, Paul W., Hamsten, Anders, Wichmann, H-Erich, Palmer, Colin N. A., Stefansson, Kari, Ridker, Paul M., Loos, Ruth J. F., Chalcravarti, Aravinda, Deloukas, Panos, Morris, Andrew P., Newton-Cheh, Christopher, and Munroe, Patricia B. more...

Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation. more...

Published
2016
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24. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Author

Lu, Yingchang, Day, Felix R, Gustafsson, Stefan, Buchkovich, Martin L, Na, Jianbo, Bataille, Veronique, Cousminer, Diana L, Dastani, Zari, Drong, Alexander W, Esko, Tõnu, Evans, David M, Falchi, Mario, Feitosa, Mary F, Ferreira, Teresa, Hedman, Åsa K, Haring, Robin, Hysi, Pirro G, Iles, Mark M, Justice, Anne E, Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Mägi, Reedik, Perry, John R B, Pers, Tune H, Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M, Scott, William R, Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A E, Walker, Ryan W, Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J L, Bellis, Claire, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S, Cederholm, Tommy, Choh, Audrey C, Choi, Hyung Jin, Curran, Joanne E, de Groot, Lisette C P G M, De Jager, Philip L, Dhonukshe-Rutten, Rosalie A M, Enneman, Anke W, Eury, Elodie, Evans, Daniel S, Forsen, Tom, Friedrich, Nele, Fumeron, Frédéric, Garcia, Melissa E, Gärtner, Simone, Han, Bok-Ghee, Havulinna, Aki S, Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W, Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Mateo Leach, Irene, Lee, Christine G, Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stéphane, Loh, Marie, Lyytikäinen, Leo-Pekka, Medina-Gomez, Carolina, Michaëlsson, Karl, Nalls, Mike A, Nielson, Carrie M, Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polašek, Ozren, Ripatti, Samuli, Sarzynski, Mark A, Shin, Chan Soo, Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M A, Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M, Verweij, Niek, Wright, Alan F, Yu, Lei, Zmuda, Joseph M, Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U, Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Männistö, Satu, Palmer, Cameron D, Ried, Janina S, Scott, Robert A, Stancáková, Alena, Wagner, Peter J, Demirkan, Ayse, Döring, Angela, Gudnason, Vilmundur, Kiel, Douglas P, Kühnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R, Oostra, Ben A, Shuldiner, Alan R, Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M, Vollenweider, Peter, White, Charles C, Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S, Forouhi, Nita G, Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jørgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A, Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O, Wareham, Nicholas J, Bennett, David A, Bertram, Lars, Blangero, John, Blüher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H, Cummings, Steven R, Czerwinski, Stefan A, Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G, Ferrucci, Luigi, Franco, Oscar H, Froguel, Philippe, Gansevoort, Ron T, Hansen, Torben, Harris, Tamara B, Hastie, Nicholas, Heliövaara, Markku, Hofman, Albert, Jordan, Joanne M, Jula, Antti, Kähönen, Mika, Kajantie, Eero, Knekt, Paul B, Koskinen, Seppo, Kovacs, Peter, Lehtimäki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S, Osmond, Clive, Perola, Markus, Pérusse, Louis, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rice, Treva K, Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sørensen, Thorkild I A, Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J, Tremblay, Angelo, Uitterlinden, André G, van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S, Vitart, Veronique, Vohl, Marie-Claude, Völzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F, Yengo, Loïc, Bishop, D Timothy, Borecki, Ingrid B, Chambers, John C, Cupples, L Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S, Franke, Lude, Han, Jiali, Hunter, David J, Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C, Kooner, Jaspal S, McCarthy, Mark I, Murabito, Joanne M, Morris, Andrew P, Bishop, Julia A N, North, Kari E, Ohlsson, Claes, Ong, Ken K, Prokopenko, Inga, Richards, J Brent, Schadt, Eric E, Spector, Tim D, Widén, Elisabeth, Willer, Cristen J, Yang, Jian, Ingelsson, Erik, Mohlke, Karen L, Hirschhorn, Joel N, Pospisilik, John Andrew, Zillikens, M Carola, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari, Loos, Ruth J F, Lu, Yingchang, Day, Felix R, Gustafsson, Stefan, Buchkovich, Martin L, Na, Jianbo, Bataille, Veronique, Cousminer, Diana L, Dastani, Zari, Drong, Alexander W, Esko, Tõnu, Evans, David M, Falchi, Mario, Feitosa, Mary F, Ferreira, Teresa, Hedman, Åsa K, Haring, Robin, Hysi, Pirro G, Iles, Mark M, Justice, Anne E, Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Mägi, Reedik, Perry, John R B, Pers, Tune H, Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M, Scott, William R, Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A E, Walker, Ryan W, Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J L, Bellis, Claire, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S, Cederholm, Tommy, Choh, Audrey C, Choi, Hyung Jin, Curran, Joanne E, de Groot, Lisette C P G M, De Jager, Philip L, Dhonukshe-Rutten, Rosalie A M, Enneman, Anke W, Eury, Elodie, Evans, Daniel S, Forsen, Tom, Friedrich, Nele, Fumeron, Frédéric, Garcia, Melissa E, Gärtner, Simone, Han, Bok-Ghee, Havulinna, Aki S, Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W, Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Mateo Leach, Irene, Lee, Christine G, Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stéphane, Loh, Marie, Lyytikäinen, Leo-Pekka, Medina-Gomez, Carolina, Michaëlsson, Karl, Nalls, Mike A, Nielson, Carrie M, Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polašek, Ozren, Ripatti, Samuli, Sarzynski, Mark A, Shin, Chan Soo, Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M A, Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M, Verweij, Niek, Wright, Alan F, Yu, Lei, Zmuda, Joseph M, Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U, Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Männistö, Satu, Palmer, Cameron D, Ried, Janina S, Scott, Robert A, Stancáková, Alena, Wagner, Peter J, Demirkan, Ayse, Döring, Angela, Gudnason, Vilmundur, Kiel, Douglas P, Kühnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R, Oostra, Ben A, Shuldiner, Alan R, Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M, Vollenweider, Peter, White, Charles C, Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S, Forouhi, Nita G, Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jørgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A, Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O, Wareham, Nicholas J, Bennett, David A, Bertram, Lars, Blangero, John, Blüher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H, Cummings, Steven R, Czerwinski, Stefan A, Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G, Ferrucci, Luigi, Franco, Oscar H, Froguel, Philippe, Gansevoort, Ron T, Hansen, Torben, Harris, Tamara B, Hastie, Nicholas, Heliövaara, Markku, Hofman, Albert, Jordan, Joanne M, Jula, Antti, Kähönen, Mika, Kajantie, Eero, Knekt, Paul B, Koskinen, Seppo, Kovacs, Peter, Lehtimäki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S, Osmond, Clive, Perola, Markus, Pérusse, Louis, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rice, Treva K, Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sørensen, Thorkild I A, Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J, Tremblay, Angelo, Uitterlinden, André G, van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S, Vitart, Veronique, Vohl, Marie-Claude, Völzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F, Yengo, Loïc, Bishop, D Timothy, Borecki, Ingrid B, Chambers, John C, Cupples, L Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S, Franke, Lude, Han, Jiali, Hunter, David J, Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C, Kooner, Jaspal S, McCarthy, Mark I, Murabito, Joanne M, Morris, Andrew P, Bishop, Julia A N, North, Kari E, Ohlsson, Claes, Ong, Ken K, Prokopenko, Inga, Richards, J Brent, Schadt, Eric E, Spector, Tim D, Widén, Elisabeth, Willer, Cristen J, Yang, Jian, Ingelsson, Erik, Mohlke, Karen L, Hirschhorn, Joel N, Pospisilik, John Andrew, Zillikens, M Carola, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari, and Loos, Ruth J F more...

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. more...

Published
2016
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25. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Author

University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Hospital for Children and Adolescents, Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amelie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frederic, Garcia, Melissa E., Gartner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stephane, Loh, Marie, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Michaelsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polasek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narancic, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Pellikka, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Mannisto, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancakova, Alena, Wagner, Peter J., Demirkan, Ayse, Doring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kuhnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jorgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Bluher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliovaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kahonen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimaki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Perusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sorensen, Thorkild I. A., Stumvoll, Michael, Tonjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, Andre G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Volzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loic, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widen, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpelainen, Tuomas Oskari, Loos, Ruth J. F., University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Hospital for Children and Adolescents, Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amelie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frederic, Garcia, Melissa E., Gartner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stephane, Loh, Marie, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Michaelsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polasek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narancic, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Pellikka, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Mannisto, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancakova, Alena, Wagner, Peter J., Demirkan, Ayse, Doring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kuhnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jorgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Bluher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliovaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kahonen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimaki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Perusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sorensen, Thorkild I. A., Stumvoll, Michael, Tonjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, Andre G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Volzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loic, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widen, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpelainen, Tuomas Oskari, and Loos, Ruth J. F. more...

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. more...

Published
2016

26. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans

Author

Pankow, James S., Gabriel, Stacey B., Martin, Lisa W., Farlow, Deborah N., Lange, Ethan M., Ramachandran, Vasan S., Ballantyne, Christie M., Fox, Ervin R., Tracy, Russell P., Larkin, Emma, Durda, Peter, Keating, Brendan J., Dupuis, Josee, Gross, Myron D., Lettre, Guillaume, Ellis, Jaclyn, Schnabel, Renate B., Rotter, Jerome I., Palmer, Cameron D., Willis, Monte S., Wilson, James G., Auer, Paul, Baumert, Jens, Walston, Jeremy D., Papanicolaou, George J., Peters, Ulrike, Koenig, Wolfgang, Young, Taylor, Li, Jin, Bis, Joshua C., Meng, Yan A., and Marzi, Carola S. more...

Abstract

C-reactive protein (CRP) is a heritable biomarker of systemic inflammation and a predictor of cardiovascular disease (CVD). Large-scale genetic association studies for CRP have largely focused on individuals of European descent. We sought to uncover novel genetic variants for CRP in a multi-ethnic sample using the ITMAT Broad-CARe (IBC) array, a custom 50,000 SNP gene-centric array having dense coverage of over 2,000 candidate CVD genes. We performed analyses on 7570 African Americans (AA) from the Candidate gene Association Resource (CARe) study and race-combined meta-analyses that included 29,939 additional individuals of European descent from CARe, the Women’s Health Initiative (WHI) and KORA studies. We observed array-wide significance (p more...

Published
2014
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27. Novel Loci Associated with PR Interval in a Genome-Wide Association Study of Ten African American Cohorts

Author

Butler, Anne M., Yin, Xiaoyan, Evans, Daniel S., Nalls, Michael A., Smith, Erin N., Tanaka, Toshiko, Li, Guo, Buxbaum, Sarah G., Whitsel, Eric A., Alonso, Alvaro, Arking, Dan E., Benjamin, Emelia J., Berenson, Gerald S., Bis, Josh C., Chen, Wei, Deo, Rajat, Ellinor, Patrick T., Heckbert, Susan R., Heiss, Gerardo, Hsueh, Wen-Chi, Keating, Brendan J., Kerr, Kathleen F., Li, Yun, Limacher, Marian C., Liu, Yongmei, Lubitz, Steven A., Marciante, Kristin D., Mehra, Reena, Meng, Yan A., Newman, Anne B., Newton-Cheh, Christopher, North, Kari E., Palmer, Cameron D., Psaty, Bruce M., Quibrera, P. Miguel, Redline, Susan, Reiner, Alex P., Rotter, Jerome I., Schnabel, Renate B., Schork, Nicholas J., Singleton, Andrew B., Smith, J. Gustav, Soliman, Elsayed Z., Srinivasan, Sathanur R., Zhang, Zhu-ming, Zonderman, Alan B., Ferrucci, Luigi, Murray, Sarah S., Evans, Michele K., Sotoodehnia, Nona, Magnani, Jared W., and Avery, Christy L. more...

Subjects
Adult, Black or African American, Cohort Studies, Male, Electrocardiography, Meta-Analysis as Topic, Genetic Loci, Humans, Female, Middle Aged, Polymorphism, Single Nucleotide, Article, Genome-Wide Association Study
Abstract

The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci associated with PR in African Americans.We present results from the largest genome-wide association study to date of PR in 13 415 adults of African descent from 10 cohorts. We tested for association between PR (ms) and ≈2.8 million genotyped and imputed single-nucleotide polymorphisms. Imputation was performed using HapMap 2 YRI and CEU panels. Study-specific results, adjusted for global ancestry and clinical correlates of PR, were meta-analyzed using the inverse variance method. Variation in genome-wide test statistic distributions was noted within studies (λ range: 0.9-1.1), although not after genomic control correction was applied to the overall meta-analysis (λ: 1.008). In addition to generalizing previously reported associations with MEIS1, SCN5A, ARHGAP24, CAV1, and TBX5 to African American populations at the genome-wide significance level (P5.0 × 10(-8)), we also identified a novel locus: ITGA9, located in a region previously implicated in SCN5A expression. The 3p21 region harboring SCN5A also contained 2 additional independent secondary signals influencing PR (P5.0 × 10(-8)).This study demonstrates the ability to map novel loci in African Americans as well as the generalizability of loci associated with PR across populations of African, European, and Asian descent. more...

Published
2012

28. Novel Loci Associated With PR Interval in a Genome-Wide Association Study of 10 African American Cohorts

Author

Zhang, Zhu Ming, Li, Yun, Marciante, Kristin D., Deo, Rajat, Evans, Michele K., North, Kari E., Newton-Cheh, Christopher, Singleton, Andrew B., Rotter, Jerome I., Psaty, Bruce M., Reiner, Alex P., Yin, Xiaoyan, Berenson, Gerald S., Redline, Susan, Alonso, Alvaro, Lubitz, Steven A., Smith, J. Gustav, Smith, Erin N., Mehra, Reena, Arking, Dan E., Avery, Christy L., Butler, Anne M., Sotoodehnia, Nona, Benjamin, Emelia J., Whitsel, Eric A., Keating, Brendan J., Tanaka, Toshiko, Meng, Yan A., Heckbert, Susan R., Hsueh, Wen Chi, Zonderman, Alan B., Buxbaum, Sarah G., Ellinor, Patrick T., Palmer, Cameron D., Heiss, Gerardo, Quibrera, P. Miguel, Murray, Sarah S., Schork, Nicholas J., Bis, Josh C., Chen, Wei, Li, Guo, Newman, Anne B., Limacher, Marian C., Ferrucci, Luigi, Srinivasan, Sathanur R., Schnabel, Renate B., Soliman, Elsayed Z., Kerr, Kathleen F., Liu, Yongmei, Nalls, Michael A., Evans, Daniel S., and Magnani, Jared W. more...

Abstract

BACKGROUND: The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci associated with PR in African Americans. METHODS AND RESULTS: We present results from the largest genome-wide association study to date of PR in 13 415 adults of African descent from 10 cohorts. We tested for association between PR (ms) and ≈2.8 million genotyped and imputed single-nucleotide polymorphisms. Imputation was performed using HapMap 2 YRI and CEU panels. Study-specific results, adjusted for global ancestry and clinical correlates of PR, were meta-analyzed using the inverse variance method. Variation in genome-wide test statistic distributions was noted within studies (λ range: 0.9-1.1), although not after genomic control correction was applied to the overall meta-analysis (λ: 1.008). In addition to generalizing previously reported associations with MEIS1, SCN5A, ARHGAP24, CAV1, and TBX5 to African American populations at the genome-wide significance level (P more...

Published
2012
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29. Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection

Author

McCarroll, Steve, Sabeti, Pardis, Lange, Leslie, Mychaleckyj, Josyf C., Papanicolaou, George, Zaitlen, Noah, Cupples, L. Adrienne, Akylbekova, Ermeg L., Salako, Babatunde, Mallick, Swapan, Yang, Qiong, Rotter, Jerome I., Rotimi, Charles N., Myers, Simon, Genovese, Giulio, Patterson, Nick, Musani, Solomon, Tandon, Arti, Tayo, Bamidele O., Adeyemo, Adebowale A., Pasaniuc, Bogdan, Divers, Jasmin, Ruczinski, Ingo, Li, Mingyao, Bhatia, Gaurav, Spencer, Chris, Fornage, Myriam, Ogunniyi, Adesola, Siscovick, David S., Pollack, Samuela, Palmer, Cameron D., and Kao, W.H. Linda more...

Abstract

The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the increase in beneficial alleles and plays a role in explaining diversity across human populations. By discovering traits subject to positive selection, we can better understand the population level response to environmental pressures including infectious disease. Our study examines unusual population differentiation between three large data sets to detect natural selection. The populations examined, African Americans, Nigerians, and Gambians, are genetically close to one another (FST < 0.01 for all pairs), allowing us to detect selection even with moderate changes in allele frequency. We also develop a tree-based method to pinpoint the population in which selection occurred, incorporating information across populations. Our genome-wide significant results corroborate loci previously reported to be under selection in Africans including HBB and CD36. At the HLA locus on chromosome 6, results suggest the existence of multiple, independent targets of population-specific selective pressure. In addition, we report a genome-wide significant (p = 1.36 × 10−11) signal of selection in the prostate stem cell antigen (PSCA) gene. The most significantly differentiated marker in our analysis, rs2920283, is highly differentiated in both Africa and East Asia and has prior genome-wide significant associations to bladder and gastric cancers. more...

Published
2011
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30. The landscape of recombination in African Americans

Author

Gillanders, Elizabeth M., Ryan Diver, W., Buxbaum, Sarah G., Ingles, Sue A., Berndt, Sonja I., Boerwinkle, Eric, Rohland, Nadin, Patterson, Nick, Caporaso, Neil, Blot, William J., Harris, Curtis C., Song, Yunli, Deming, Sandra L., Hinch, Anjali G., Palmer, Cameron D., Glessner, Joseph, Casey, Graham, Divers, Jasmin, Hu, Jennifer J., Chen, Gary K., Fornage, Myriam, Adrienne Cupples, L., Bock, Cathryn H., Aldrich, Melinda C., Wang, Kai, Bandera, Elisa V., Tandon, Arti, Akylbekova, Ermeg L., Bernstein, Leslie, Ambrosone, Christine B., Cai, Qiuyin, and Amos, Christopher more...

Abstract

Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P more...

Published
2011
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31. Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)

Author

Kubo, Michiaki, Couper, David, Grant, Struan F. A., Harris, Tamara B., Ganesh, Santhi K., Arepalli, Sampath, Austin, Melissa A., Lettre, Guillaume, Chen, Zhao, Kamatini, Naoyuki, Hernandez, Dena, Britton, Angela, Okada, Yukinori, Nakamura, Yusuke, Fornage, Myriam, Keating, Brendan J., Dean, Eric, Palmer, Cameron D., LaCroix, Andrea, Reiner, Alexander P., Mathias, Rasika, Liu, Simin, O'Donnell, Christopher J., Papanicolaou, George J., Lange, Leslie A., Eaton, Charles B., Nalls, Michael A., Curb, J. David, Meng, Yan, Mohler, Emile R., Musani, Solomon, and Lohman, Kurt more...

Abstract

Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived “null” variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P more...

Published
2011
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32. Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

Author

Fox, Caroline, Britton, Angela, Hu, Jennifer J., Ambrosone, Christine B., Atwood, Larry, Demerath, Ellen, Palmer, Cameron D., John, Esther M., Chanock, Stephen J., Adoue, Véronique, Ding, Jingzhong, Keating, Brendan, Boerwinkle, Eric, Deming, Sandra L., Tayo, Bamidele, N'Diaye, Amidou, Johnson, Craig, Nalls, Michael A., Ge, Bing, Bernstein, Leslie, Harris, Tamara B., Diver, W. Ryan, Casey, Graham, Berndt, Sonja I., Mathias, Rasika A., Blot, William J., Chen, Gary K., Becker, Lewis C., Bandera, Elisa V., Ingles, Sue A., Hernandez, Dena G., and Adeyemo, Adebowale more...

Abstract

Adult height is a classic polygenic trait of high heritability (h 2 ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10−12 and 2p14-rs4315565, P = 1.2×10−8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10−4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P more...

Published
2011
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33. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Author

Lu, Yingchang, primary, Day, Felix R., additional, Gustafsson, Stefan, additional, Buchkovich, Martin L., additional, Na, Jianbo, additional, Bataille, Veronique, additional, Cousminer, Diana L., additional, Dastani, Zari, additional, Drong, Alexander W., additional, Esko, Tõnu, additional, Evans, David M., additional, Falchi, Mario, additional, Feitosa, Mary F., additional, Ferreira, Teresa, additional, Hedman, Åsa K., additional, Haring, Robin, additional, Hysi, Pirro G., additional, Iles, Mark M., additional, Justice, Anne E., additional, Kanoni, Stavroula, additional, Lagou, Vasiliki, additional, Li, Rui, additional, Li, Xin, additional, Locke, Adam, additional, Lu, Chen, additional, Mägi, Reedik, additional, Perry, John R. B., additional, Pers, Tune H., additional, Qi, Qibin, additional, Sanna, Marianna, additional, Schmidt, Ellen M., additional, Scott, William R., additional, Shungin, Dmitry, additional, Teumer, Alexander, additional, Vinkhuyzen, Anna A. E., additional, Walker, Ryan W., additional, Westra, Harm-Jan, additional, Zhang, Mingfeng, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhu, Zhihong, additional, Afzal, Uzma, additional, Ahluwalia, Tarunveer Singh, additional, Bakker, Stephan J. L., additional, Bellis, Claire, additional, Bonnefond, Amélie, additional, Borodulin, Katja, additional, Buchman, Aron S., additional, Cederholm, Tommy, additional, Choh, Audrey C., additional, Choi, Hyung Jin, additional, Curran, Joanne E., additional, de Groot, Lisette C. P. G. M., additional, De Jager, Philip L., additional, Dhonukshe-Rutten, Rosalie A. M., additional, Enneman, Anke W., additional, Eury, Elodie, additional, Evans, Daniel S., additional, Forsen, Tom, additional, Friedrich, Nele, additional, Fumeron, Frédéric, additional, Garcia, Melissa E., additional, Gärtner, Simone, additional, Han, Bok-Ghee, additional, Havulinna, Aki S., additional, Hayward, Caroline, additional, Hernandez, Dena, additional, Hillege, Hans, additional, Ittermann, Till, additional, Kent, Jack W., additional, Kolcic, Ivana, additional, Laatikainen, Tiina, additional, Lahti, Jari, additional, Leach, Irene Mateo, additional, Lee, Christine G., additional, Lee, Jong-Young, additional, Liu, Tian, additional, Liu, Youfang, additional, Lobbens, Stéphane, additional, Loh, Marie, additional, Lyytikäinen, Leo-Pekka, additional, Medina-Gomez, Carolina, additional, Michaëlsson, Karl, additional, Nalls, Mike A., additional, Nielson, Carrie M., additional, Oozageer, Laticia, additional, Pascoe, Laura, additional, Paternoster, Lavinia, additional, Polašek, Ozren, additional, Ripatti, Samuli, additional, Sarzynski, Mark A., additional, Shin, Chan Soo, additional, Narančić, Nina Smolej, additional, Spira, Dominik, additional, Srikanth, Priya, additional, Steinhagen-Thiessen, Elisabeth, additional, Sung, Yun Ju, additional, Swart, Karin M. A., additional, Taittonen, Leena, additional, Tanaka, Toshiko, additional, Tikkanen, Emmi, additional, van der Velde, Nathalie, additional, van Schoor, Natasja M., additional, Verweij, Niek, additional, Wright, Alan F., additional, Yu, Lei, additional, Zmuda, Joseph M., additional, Eklund, Niina, additional, Forrester, Terrence, additional, Grarup, Niels, additional, Jackson, Anne U., additional, Kristiansson, Kati, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Lichtner, Peter, additional, Luan, Jian'an, additional, Mahajan, Anubha, additional, Männistö, Satu, additional, Palmer, Cameron D., additional, Ried, Janina S., additional, Scott, Robert A., additional, Stancáková, Alena, additional, Wagner, Peter J., additional, Demirkan, Ayse, additional, Döring, Angela, additional, Gudnason, Vilmundur, additional, Kiel, Douglas P., additional, Kühnel, Brigitte, additional, Mangino, Massimo, additional, Mcknight, Barbara, additional, Menni, Cristina, additional, O'Connell, Jeffrey R., additional, Oostra, Ben A., additional, Shuldiner, Alan R., additional, Song, Kijoung, additional, Vandenput, Liesbeth, additional, van Duijn, Cornelia M., additional, Vollenweider, Peter, additional, White, Charles C., additional, Boehnke, Michael, additional, Boettcher, Yvonne, additional, Cooper, Richard S., additional, Forouhi, Nita G., additional, Gieger, Christian, additional, Grallert, Harald, additional, Hingorani, Aroon, additional, Jørgensen, Torben, additional, Jousilahti, Pekka, additional, Kivimaki, Mika, additional, Kumari, Meena, additional, Laakso, Markku, additional, Langenberg, Claudia, additional, Linneberg, Allan, additional, Luke, Amy, additional, Mckenzie, Colin A., additional, Palotie, Aarno, additional, Pedersen, Oluf, additional, Peters, Annette, additional, Strauch, Konstantin, additional, Tayo, Bamidele O., additional, Wareham, Nicholas J., additional, Bennett, David A., additional, Bertram, Lars, additional, Blangero, John, additional, Blüher, Matthias, additional, Bouchard, Claude, additional, Campbell, Harry, additional, Cho, Nam H., additional, Cummings, Steven R., additional, Czerwinski, Stefan A., additional, Demuth, Ilja, additional, Eckardt, Rahel, additional, Eriksson, Johan G., additional, Ferrucci, Luigi, additional, Franco, Oscar H., additional, Froguel, Philippe, additional, Gansevoort, Ron T., additional, Hansen, Torben, additional, Harris, Tamara B., additional, Hastie, Nicholas, additional, Heliövaara, Markku, additional, Hofman, Albert, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Kähönen, Mika, additional, Kajantie, Eero, additional, Knekt, Paul B., additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Lehtimäki, Terho, additional, Lind, Lars, additional, Liu, Yongmei, additional, Orwoll, Eric S., additional, Osmond, Clive, additional, Perola, Markus, additional, Pérusse, Louis, additional, Raitakari, Olli T., additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rice, Treva K., additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Sørensen, Thorkild I. A., additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Towne, Bradford, additional, Tranah, Gregory J., additional, Tremblay, Angelo, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Vartiainen, Erkki, additional, Viikari, Jorma S., additional, Vitart, Veronique, additional, Vohl, Marie-Claude, additional, Völzke, Henry, additional, Walker, Mark, additional, Wallaschofski, Henri, additional, Wild, Sarah, additional, Wilson, James F., additional, Yengo, Loïc, additional, Bishop, D. Timothy, additional, Borecki, Ingrid B., additional, Chambers, John C., additional, Cupples, L. Adrienne, additional, Dehghan, Abbas, additional, Deloukas, Panos, additional, Fatemifar, Ghazaleh, additional, Fox, Caroline, additional, Furey, Terrence S., additional, Franke, Lude, additional, Han, Jiali, additional, Hunter, David J., additional, Karjalainen, Juha, additional, Karpe, Fredrik, additional, Kaplan, Robert C., additional, Kooner, Jaspal S., additional, McCarthy, Mark I., additional, Murabito, Joanne M., additional, Morris, Andrew P., additional, Bishop, Julia A. N., additional, North, Kari E., additional, Ohlsson, Claes, additional, Ong, Ken K., additional, Prokopenko, Inga, additional, Richards, J. Brent, additional, Schadt, Eric E., additional, Spector, Tim D., additional, Widén, Elisabeth, additional, Willer, Cristen J., additional, Yang, Jian, additional, Ingelsson, Erik, additional, Mohlke, Karen L., additional, Hirschhorn, Joel N., additional, Pospisilik, John Andrew, additional, Zillikens, M. Carola, additional, Lindgren, Cecilia, additional, Kilpeläinen, Tuomas Oskari, additional, and Loos, Ruth J. F., additional more...

Published
2016
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34. New genetic loci link adipose and insulin biology to body fat distribution

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., O’Connell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, L. Adrienne, Morris, Andrew P., Lindgren, Cecilia M., Mohlke, Karen L, Devuyst, Olivier, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., O’Connell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, L. Adrienne, Morris, Andrew P., Lindgren, Cecilia M., Mohlke, Karen L, and Devuyst, Olivier more...

Published
2015

35. A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups

Author

Weng, Lu-Chen, primary, Tang, Weihong, additional, Rich, Stephen S., additional, Smith, Nicholas L., additional, Redline, Susan, additional, O'Donnell, Christopher J., additional, Basu, Saonli, additional, Reiner, Alexander P., additional, Delaney, Joseph A., additional, Tracy, Russell P., additional, Palmer, Cameron D., additional, Young, Taylor, additional, Yang, Qiong, additional, Folsom, Aaron R., additional, and Cushman, Mary, additional more...

Published
2014
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36. Discovery and refinement of loci associated with lipid levels

Author

Willer, Cristen J., Schmidt, Ellen M., Sengupta, Sebanti, Peloso, Gina M., Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L., Mora, Samia, Beckmann, Jacques S., Bragg-Gresham, Jennifer L., Chang, Hsing-Yi, Demirkan, Ayse, Den Hertog, Heleen M., Do, Ron, Donnelly, Louise A., Ehret, Georg B., Esko, Tonu, Feitosa, Mary F., Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Fraser, Ross M., Freitag, Daniel F., Gurdasani, Deepti, Heikkila, Kauko, Hyppoenen, Elina, Isaacs, Aaron, Jackson, Anne U., Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E., Li, Xiaohui, Luan, Jian'an, Lyytikainen, Leo-Pekka, Magnusson, Patrik K. E., Mangino, Massimo, Mihailov, Evelin, Montasser, May E., Mueller-Nurasyid, Martina, Nolte, Ilja M., O'Connell, Jeffrey R., Palmer, Cameron D., Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Service, Susan K., Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J., Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M., Thorleifsson, Gudmar, Van den Herik, Evita G., Voight, Benjamin F., Volcik, Kelly A., Waite, Lindsay L., Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Ines, Been, Latonya F., Bolton, Jennifer L., Bonnycastle, Lori L., Brambilla, Paolo, Burnett, Mary S., Cesana, Giancarlo, Dimitriou, Maria, Doney, Alex S. F., Doering, Angela, Elliott, Paul, Epstein, Stephen E., Eyjolfsson, Gudmundur Ingi, Gigante, Bruna, Goodarzi, Mark O., Grallert, Harald, Gravito, Martha L., Groves, Christopher J., Hallmans, Goran, Hartikainen, Anna-Liisa, Hayward, Caroline, Hernandez, Dena, Hicks, Andrew A., Holm, Hilma, Hung, Yi-Jen, Illig, Thomas, Jones, Michelle R., Kaleebu, Pontiano, Kastelein, John J. P., Khaw, Kay-Tee, Kim, Eric, Klopp, Norman, Komulainen, Pirjo, Kumari, Meena, Langenberg, Claudia, Lehtimaki, Terho, Lin, Shih-Yi, Lindstrom, Jaana, Loos, Ruth J. F., Mach, Francois, McArdle, Wendy L., Meisinger, Christa, Mitchell, Braxton D., Mueller, Gabrielle, Nagaraja, Ramaiah, Narisu, Narisu, Nieminen, Tuomo V. M., Nsubuga, Rebecca N., Olafsson, Isleifur, Ong, Ken K., Palotie, Aarno, Papamarkou, Theodore, Pomilla, Cristina, Pouta, Anneli, Rader, Daniel J., Reilly, Muredach P., Ridker, Paul M., Rivadeneira, Fernando, Rudan, Igor, Ruokonen, Aimo, Samani, Nilesh, Scharnagl, Hubert, Seeley, Janet, Silander, Kaisa, Stancakova, Alena, Stirrups, Kathleen, Swift, Amy J., Tiret, Laurence, Uitterlinden, Andre G., van Pelt, L. Joost, Vedantam, Sailaja, Wainwright, Nicholas, Wijmenga, Cisca, Wild, Sarah H., Willemsen, Gonneke, Wilsgaard, Tom, Wilson, James F., Young, Elizabeth H., Zhao, Jing Hua, Adair, Linda S., Arveiler, Dominique, Assimes, Themistocles L., Bandinelli, Stefania, Bennett, Franklyn, Bochud, Murielle, Boehm, Bernhard O., Boomsma, Dorret I., Borecki, Ingrid B., Bornstein, Stefan R., Bovet, Pascal, Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C., Chen, Yii-Der Ida, Collins, Francis S., Cooper, Richard S., Danesh, John, Dedoussis, George, de Faire, Ulf, Feranil, Alan B., Ferrieres, Jean, Ferrucci, Luigi, Freimer, Nelson B., Gieger, Christian, Groop, Leif C., Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hingorani, Aroon, Hirschhorn, Joel N., Hofman, Albert, Hovingh, G. Kees, Hsiung, Chao Agnes, Humphries, Steve E., Hunt, Steven C., Hveem, Kristian, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Jula, Antti, Kahonen, Mika, Kaprio, Jaakko, Kesaniemi, Antero, Kivimaki, Mika, Kooner, Jaspal S., Koudstaal, Peter J., Krauss, Ronald M., Kuh, Diana, Kuusisto, Johanna, Kyvik, Kirsten O., Laakso, Markku, Lakka, Timo A., Lind, Lars, Lindgren, Cecilia M., Martin, Nicholas G., Maerz, Winfried, McCarthy, Mark I., McKenzie, Colin A., Meneton, Pierre, Metspalu, Andres, Moilanen, Leena, Morris, Andrew D., Munroe, Patricia B., Njolstad, Inger, Pedersen, Nancy L., Power, Chris, Pramstaller, Peter P., Price, Jackie F., Psaty, Bruce M., Quertermous, Thomas, Rauramaa, Rainer, Saleheen, Danish, Salomaa, Veikko, Sanghera, Dharambir K., Saramies, Jouko, Schwarz, Peter E. H., Sheu, Wayne H-H, Shuldiner, Alan R., Siegbahn, Agneta, Spector, Tim D., Stefansson, Kari, Strachan, David P., Tayo, Bamidele O., Tremoli, Elena, Tuomilehto, Jaakko, Uusitupa, Matti, van Duijn, Cornelia M., Vollenweider, Peter, Wallentin, Lars, Wareham, Nicholas J., Whitfield, John B., Wolffenbuttel, Bruce H. R., Ordovas, Jose M., Boerwinkle, Eric, Palmer, Colin N. A., Thorsteinsdottir, Unnur, Chasman, Daniel I., Rotter, Jerome I., Franks, Paul W., Ripatti, Samuli, Cupples, L. Adrienne, Sandhu, Manjinder S., Rich, Stephen S., Boehnke, Michael, Deloukas, Panos, Kathiresan, Sekar, Mohlke, Karen L., Ingelsson, Erik, Abecasis, Goncalo R., Willer, Cristen J., Schmidt, Ellen M., Sengupta, Sebanti, Peloso, Gina M., Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L., Mora, Samia, Beckmann, Jacques S., Bragg-Gresham, Jennifer L., Chang, Hsing-Yi, Demirkan, Ayse, Den Hertog, Heleen M., Do, Ron, Donnelly, Louise A., Ehret, Georg B., Esko, Tonu, Feitosa, Mary F., Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Fraser, Ross M., Freitag, Daniel F., Gurdasani, Deepti, Heikkila, Kauko, Hyppoenen, Elina, Isaacs, Aaron, Jackson, Anne U., Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E., Li, Xiaohui, Luan, Jian'an, Lyytikainen, Leo-Pekka, Magnusson, Patrik K. E., Mangino, Massimo, Mihailov, Evelin, Montasser, May E., Mueller-Nurasyid, Martina, Nolte, Ilja M., O'Connell, Jeffrey R., Palmer, Cameron D., Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Service, Susan K., Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J., Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M., Thorleifsson, Gudmar, Van den Herik, Evita G., Voight, Benjamin F., Volcik, Kelly A., Waite, Lindsay L., Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Ines, Been, Latonya F., Bolton, Jennifer L., Bonnycastle, Lori L., Brambilla, Paolo, Burnett, Mary S., Cesana, Giancarlo, Dimitriou, Maria, Doney, Alex S. F., Doering, Angela, Elliott, Paul, Epstein, Stephen E., Eyjolfsson, Gudmundur Ingi, Gigante, Bruna, Goodarzi, Mark O., Grallert, Harald, Gravito, Martha L., Groves, Christopher J., Hallmans, Goran, Hartikainen, Anna-Liisa, Hayward, Caroline, Hernandez, Dena, Hicks, Andrew A., Holm, Hilma, Hung, Yi-Jen, Illig, Thomas, Jones, Michelle R., Kaleebu, Pontiano, Kastelein, John J. P., Khaw, Kay-Tee, Kim, Eric, Klopp, Norman, Komulainen, Pirjo, Kumari, Meena, Langenberg, Claudia, Lehtimaki, Terho, Lin, Shih-Yi, Lindstrom, Jaana, Loos, Ruth J. F., Mach, Francois, McArdle, Wendy L., Meisinger, Christa, Mitchell, Braxton D., Mueller, Gabrielle, Nagaraja, Ramaiah, Narisu, Narisu, Nieminen, Tuomo V. M., Nsubuga, Rebecca N., Olafsson, Isleifur, Ong, Ken K., Palotie, Aarno, Papamarkou, Theodore, Pomilla, Cristina, Pouta, Anneli, Rader, Daniel J., Reilly, Muredach P., Ridker, Paul M., Rivadeneira, Fernando, Rudan, Igor, Ruokonen, Aimo, Samani, Nilesh, Scharnagl, Hubert, Seeley, Janet, Silander, Kaisa, Stancakova, Alena, Stirrups, Kathleen, Swift, Amy J., Tiret, Laurence, Uitterlinden, Andre G., van Pelt, L. Joost, Vedantam, Sailaja, Wainwright, Nicholas, Wijmenga, Cisca, Wild, Sarah H., Willemsen, Gonneke, Wilsgaard, Tom, Wilson, James F., Young, Elizabeth H., Zhao, Jing Hua, Adair, Linda S., Arveiler, Dominique, Assimes, Themistocles L., Bandinelli, Stefania, Bennett, Franklyn, Bochud, Murielle, Boehm, Bernhard O., Boomsma, Dorret I., Borecki, Ingrid B., Bornstein, Stefan R., Bovet, Pascal, Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C., Chen, Yii-Der Ida, Collins, Francis S., Cooper, Richard S., Danesh, John, Dedoussis, George, de Faire, Ulf, Feranil, Alan B., Ferrieres, Jean, Ferrucci, Luigi, Freimer, Nelson B., Gieger, Christian, Groop, Leif C., Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hingorani, Aroon, Hirschhorn, Joel N., Hofman, Albert, Hovingh, G. Kees, Hsiung, Chao Agnes, Humphries, Steve E., Hunt, Steven C., Hveem, Kristian, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Jula, Antti, Kahonen, Mika, Kaprio, Jaakko, Kesaniemi, Antero, Kivimaki, Mika, Kooner, Jaspal S., Koudstaal, Peter J., Krauss, Ronald M., Kuh, Diana, Kuusisto, Johanna, Kyvik, Kirsten O., Laakso, Markku, Lakka, Timo A., Lind, Lars, Lindgren, Cecilia M., Martin, Nicholas G., Maerz, Winfried, McCarthy, Mark I., McKenzie, Colin A., Meneton, Pierre, Metspalu, Andres, Moilanen, Leena, Morris, Andrew D., Munroe, Patricia B., Njolstad, Inger, Pedersen, Nancy L., Power, Chris, Pramstaller, Peter P., Price, Jackie F., Psaty, Bruce M., Quertermous, Thomas, Rauramaa, Rainer, Saleheen, Danish, Salomaa, Veikko, Sanghera, Dharambir K., Saramies, Jouko, Schwarz, Peter E. H., Sheu, Wayne H-H, Shuldiner, Alan R., Siegbahn, Agneta, Spector, Tim D., Stefansson, Kari, Strachan, David P., Tayo, Bamidele O., Tremoli, Elena, Tuomilehto, Jaakko, Uusitupa, Matti, van Duijn, Cornelia M., Vollenweider, Peter, Wallentin, Lars, Wareham, Nicholas J., Whitfield, John B., Wolffenbuttel, Bruce H. R., Ordovas, Jose M., Boerwinkle, Eric, Palmer, Colin N. A., Thorsteinsdottir, Unnur, Chasman, Daniel I., Rotter, Jerome I., Franks, Paul W., Ripatti, Samuli, Cupples, L. Adrienne, Sandhu, Manjinder S., Rich, Stephen S., Boehnke, Michael, Deloukas, Panos, Kathiresan, Sekar, Mohlke, Karen L., Ingelsson, Erik, and Abecasis, Goncalo R. more...

Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research., De sex sista författarna delar sistaförfattarskapet. more...

Published
2013
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37. Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Author

Ramasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli, Robertson, Colin F., Viikari, Jorma, Widen, Elisabeth, Wjst, Matthias, Jarvis, Deborah L., Montgomery, Grant W., Thompson, Philip J., Wareham, Nick, Eriksson, Johan, Jousilahti, Pekka, Laitinen, Tarja, Pekkanen, Juha, Raitakari, Olli T., O'Connor, George T., Salomaa, Veikko, Jarvelin, Marjo-Riitta, Hirschhorn, Joel N., Ramasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli, Robertson, Colin F., Viikari, Jorma, Widen, Elisabeth, Wjst, Matthias, Jarvis, Deborah L., Montgomery, Grant W., Thompson, Philip J., Wareham, Nick, Eriksson, Johan, Jousilahti, Pekka, Laitinen, Tarja, Pekkanen, Juha, Raitakari, Olli T., O'Connor, George T., Salomaa, Veikko, Jarvelin, Marjo-Riitta, and Hirschhorn, Joel N. more...

Abstract

Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies. Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations. Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P < 5x10(-8)) and three variants reported as suggestive (P < 5 x 10(-7)). We also searched for novel associations in APCAT (Stage 1) and followed-up the most promising variants in 4,035 asthmatics and 11,251 healthy controls (Stage 2). Finally, we conducted the first genome-wide screen for interactions with smoking or hay fever. Main Results: We observed association in the same direction for all thirteen previously reported variants and nominally replicated ten of them. One variant that was previously suggestive, rs11071559 in RORA, now reaches genome-wide significance when combined with our data (P = 2.4x10(-9)). We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (PStage1+Stage2 = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (PStage1+Stage2 = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. Finally, we found no strong evidence for gene-environment interactions with smoking or hay fever status. Conclusions: Population-based cohorts with simple asthma phenotypes represent a valuable and largely untapped resource for genetic studies of asthma. more...

Published
2012
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38. Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Author

University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health (-2009), Ramasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli, Robertson, Colin F., Viikari, Jorma, Widen, Elisabeth, Wjst, Matthias, Jarvis, Deborah L., Montgomery, Grant W., Thompson, Philip J., Wareham, Nick, Eriksson, Johan, Jousilahti, Pekka, Laitinen, Tarja, Pekkanen, Juha, Raitakari, Olli T., O'Connor, George T., Salomaa, Veikko, Jarvelin, Marjo-Riitta, Hirschhorn, Joel N., Australian Asthma Genetics, University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health (-2009), Ramasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli, Robertson, Colin F., Viikari, Jorma, Widen, Elisabeth, Wjst, Matthias, Jarvis, Deborah L., Montgomery, Grant W., Thompson, Philip J., Wareham, Nick, Eriksson, Johan, Jousilahti, Pekka, Laitinen, Tarja, Pekkanen, Juha, Raitakari, Olli T., O'Connor, George T., Salomaa, Veikko, Jarvelin, Marjo-Riitta, Hirschhorn, Joel N., and Australian Asthma Genetics more...

Published
2012

39. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

Author

Voight, Benjamin F, Kang, Hyun Min, Ding, Jun, Palmer, Cameron D, Sidore, Carlo, Chines, Peter S, Burtt, Noël P, Fuchsberger, Christian, Li, Yanming, Erdmann, Jeanette, Frayling, Timothy M, Heid, Iris M, Jackson, Anne U, Johnson, Toby, Oskari Kilpeläinen, Tuomas, Lindgren, Cecilia M, Morris, Andrew P, Prokopenko, Inga, Randall, Joshua C, Saxena, Richa, Soranzo, Nicole, Speliotes, Elizabeth K, Teslovich, Tanya M, Wheeler, Eleanor, Maguire, Jared, Parkin, Melissa, Potter, Simon, Rayner, N William, Robertson, Neil, Stirrups, Kathleen, Winckler, Wendy, Sanna, Serena, Mulas, Antonella, Nagaraja, Ramaiah, Cucca, Francesco, Barroso, Inês, Deloukas, Panos, Loos, Ruth J F, Kathiresan, Sekar, Munroe, Patricia B, Newton-Cheh, Christopher, Pfeufer, Arne, Samani, Nilesh J, Schunkert, Heribert, Hirschhorn, Joel N, Altshuler, David, McCarthy, Mark I, Abecasis, Gonçalo R, Boehnke, Michael, Voight, Benjamin F, Kang, Hyun Min, Ding, Jun, Palmer, Cameron D, Sidore, Carlo, Chines, Peter S, Burtt, Noël P, Fuchsberger, Christian, Li, Yanming, Erdmann, Jeanette, Frayling, Timothy M, Heid, Iris M, Jackson, Anne U, Johnson, Toby, Oskari Kilpeläinen, Tuomas, Lindgren, Cecilia M, Morris, Andrew P, Prokopenko, Inga, Randall, Joshua C, Saxena, Richa, Soranzo, Nicole, Speliotes, Elizabeth K, Teslovich, Tanya M, Wheeler, Eleanor, Maguire, Jared, Parkin, Melissa, Potter, Simon, Rayner, N William, Robertson, Neil, Stirrups, Kathleen, Winckler, Wendy, Sanna, Serena, Mulas, Antonella, Nagaraja, Ramaiah, Cucca, Francesco, Barroso, Inês, Deloukas, Panos, Loos, Ruth J F, Kathiresan, Sekar, Munroe, Patricia B, Newton-Cheh, Christopher, Pfeufer, Arne, Samani, Nilesh J, Schunkert, Heribert, Hirschhorn, Joel N, Altshuler, David, McCarthy, Mark I, Abecasis, Gonçalo R, and Boehnke, Michael more...

Abstract

Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, lipid levels, and blood pressure. These studies also have pointed to thousands of loci with promising but not yet compelling association evidence. To establish association at additional loci and to characterize the genome-wide significant loci by fine-mapping, we designed the "Metabochip," a custom genotyping array that assays nearly 200,000 SNP markers. Here, we describe the Metabochip and its component SNP sets, evaluate its performance in capturing variation across the allele-frequency spectrum, describe solutions to methodological challenges commonly encountered in its analysis, and evaluate its performance as a platform for genotype imputation. The metabochip achieves dramatic cost efficiencies compared to designing single-trait follow-up reagents, and provides the opportunity to compare results across a range of related traits. The metabochip and similar custom genotyping arrays offer a powerful and cost-effective approach to follow-up large-scale genotyping and sequencing studies and advance our understanding of the genetic basis of complex human diseases and traits. more...

Published
2012

40. Correction: The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

Author

Voight, Benjamin F., primary, Kang, Hyun Min, additional, Ding, Jun, additional, Palmer, Cameron D., additional, Sidore, Carlo, additional, Chines, Peter S., additional, Burtt, Noël P., additional, Fuchsberger, Christian, additional, Li, Yanming, additional, Erdmann, Jeanette, additional, Frayling, Timothy M., additional, Heid, Iris M., additional, Jackson, Anne U., additional, Johnson, Toby, additional, Kilpeläinen, Tuomas O., additional, Lindgren, Cecilia M., additional, Morris, Andrew P., additional, Prokopenko, Inga, additional, Randall, Joshua C., additional, Saxena, Richa, additional, Soranzo, Nicole, additional, Speliotes, Elizabeth K., additional, Teslovich, Tanya M., additional, Wheeler, Eleanor, additional, Maguire, Jared, additional, Parkin, Melissa, additional, Potter, Simon, additional, Rayner, N. William, additional, Robertson, Neil, additional, Stirrups, Kathleen, additional, Winckler, Wendy, additional, Sanna, Serena, additional, Mulas, Antonella, additional, Nagaraja, Ramaiah, additional, Cucca, Francesco, additional, Barroso, Inês, additional, Deloukas, Panos, additional, Loos, Ruth J. F., additional, Kathiresan, Sekar, additional, Munroe, Patricia B., additional, Newton-Cheh, Christopher, additional, Pfeufer, Arne, additional, Samani, Nilesh J., additional, Schunkert, Heribert, additional, Hirschhorn, Joel N., additional, Altshuler, David, additional, McCarthy, Mark I., additional, Abecasis, Gonçalo R., additional, and Boehnke, Michael, additional more...

Published
2013
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41. Correction: Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Author

Ramasamy, Adaikalavan, primary, Kuokkanen, Mikko, additional, Vedantam, Sailaja, additional, Gajdos, Zofia K., additional, Couto Alves, Alexessander, additional, Lyon, Helen N., additional, Ferreira, Manuel A. R., additional, Strachan, David P., additional, Zhao, Jing Hua, additional, Abramson, Michael J., additional, Brown, Matthew A., additional, Coin, Lachlan, additional, Dharmage, Shyamali C., additional, Duffy, David L., additional, Haahtela, Tari, additional, Heath, Andrew C., additional, Janson, Christer, additional, Kähönen, Mika, additional, Khaw, Kay-Tee, additional, Laitinen, Jaana, additional, Le Souef, Peter, additional, Lehtimäki, Terho, additional, Madden, Pamela A. F., additional, Marks, Guy B., additional, Martin, Nicholas G., additional, Matheson, Melanie C., additional, Palmer, Cameron D., additional, Palotie, Aarno, additional, Pouta, Anneli, additional, Robertson, Colin F., additional, Viikari, Jorma, additional, Widen, Elisabeth, additional, Wjst, Matthias, additional, Jarvis, Deborah L., additional, Montgomery, Grant W., additional, Thompson, Philip J., additional, Wareham, Nick, additional, Eriksson, Johan, additional, Jousilahti, Pekka, additional, Laitinen, Tarja, additional, Pekkanen, Juha, additional, Raitakari, Olli T., additional, O'Connor, George T., additional, Salomaa, Veikko, additional, Jarvelin, Marjo-Riitta, additional, and Hirschhorn, Joel N., additional more...

Published
2013
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42. Novel Loci Associated With PR Interval in a Genome-Wide Association Study of 10 African American Cohorts

Author

Butler, Anne M., primary, Yin, Xiaoyan, additional, Evans, Daniel S., additional, Nalls, Michael A., additional, Smith, Erin N., additional, Tanaka, Toshiko, additional, Li, Guo, additional, Buxbaum, Sarah G., additional, Whitsel, Eric A., additional, Alonso, Alvaro, additional, Arking, Dan E., additional, Benjamin, Emelia J., additional, Berenson, Gerald S., additional, Bis, Josh C., additional, Chen, Wei, additional, Deo, Rajat, additional, Ellinor, Patrick T., additional, Heckbert, Susan R., additional, Heiss, Gerardo, additional, Hsueh, Wen-Chi, additional, Keating, Brendan J., additional, Kerr, Kathleen F., additional, Li, Yun, additional, Limacher, Marian C., additional, Liu, Yongmei, additional, Lubitz, Steven A., additional, Marciante, Kristin D., additional, Mehra, Reena, additional, Meng, Yan A., additional, Newman, Anne B., additional, Newton-Cheh, Christopher, additional, North, Kari E., additional, Palmer, Cameron D., additional, Psaty, Bruce M., additional, Quibrera, P. Miguel, additional, Redline, Susan, additional, Reiner, Alex P., additional, Rotter, Jerome I., additional, Schnabel, Renate B., additional, Schork, Nicholas J., additional, Singleton, Andrew B., additional, Smith, J. Gustav, additional, Soliman, Elsayed Z., additional, Srinivasan, Sathanur R., additional, Zhang, Zhu-ming, additional, Zonderman, Alan B., additional, Ferrucci, Luigi, additional, Murray, Sarah S., additional, Evans, Michele K., additional, Sotoodehnia, Nona, additional, Magnani, Jared W., additional, and Avery, Christy L., additional more...

Published
2012
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43. The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

Author

Voight, Benjamin F., primary, Kang, Hyun Min, additional, Ding, Jun, additional, Palmer, Cameron D., additional, Sidore, Carlo, additional, Chines, Peter S., additional, Burtt, Noël P., additional, Fuchsberger, Christian, additional, Li, Yanming, additional, Erdmann, Jeanette, additional, Frayling, Timothy M., additional, Heid, Iris M., additional, Jackson, Anne U., additional, Johnson, Toby, additional, Kilpeläinen, Tuomas O., additional, Lindgren, Cecilia M., additional, Morris, Andrew P., additional, Prokopenko, Inga, additional, Randall, Joshua C., additional, Saxena, Richa, additional, Soranzo, Nicole, additional, Speliotes, Elizabeth K., additional, Teslovich, Tanya M., additional, Wheeler, Eleanor, additional, Maguire, Jared, additional, Parkin, Melissa, additional, Potter, Simon, additional, Rayner, N. William, additional, Robertson, Neil, additional, Stirrups, Kathleen, additional, Winckler, Wendy, additional, Sanna, Serena, additional, Mulas, Antonella, additional, Nagaraja, Ramaiah, additional, Cucca, Francesco, additional, Barroso, Inês, additional, Deloukas, Panos, additional, Loos, Ruth J. F., additional, Kathiresan, Sekar, additional, Munroe, Patricia B., additional, Newton-Cheh, Christopher, additional, Pfeufer, Arne, additional, Samani, Nilesh J., additional, Schunkert, Heribert, additional, Hirschhorn, Joel N., additional, Altshuler, David, additional, McCarthy, Mark I., additional, Abecasis, Gonçalo R., additional, and Boehnke, Michael, additional more...

Published
2012
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44. Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

Author

N'Diaye, Amidou, primary, Chen, Gary K., additional, Palmer, Cameron D., additional, Ge, Bing, additional, Tayo, Bamidele, additional, Mathias, Rasika A., additional, Ding, Jingzhong, additional, Nalls, Michael A., additional, Adeyemo, Adebowale, additional, Adoue, Véronique, additional, Ambrosone, Christine B., additional, Atwood, Larry, additional, Bandera, Elisa V., additional, Becker, Lewis C., additional, Berndt, Sonja I., additional, Bernstein, Leslie, additional, Blot, William J., additional, Boerwinkle, Eric, additional, Britton, Angela, additional, Casey, Graham, additional, Chanock, Stephen J., additional, Demerath, Ellen, additional, Deming, Sandra L., additional, Diver, W. Ryan, additional, Fox, Caroline, additional, Harris, Tamara B., additional, Hernandez, Dena G., additional, Hu, Jennifer J., additional, Ingles, Sue A., additional, John, Esther M., additional, Johnson, Craig, additional, Keating, Brendan, additional, Kittles, Rick A., additional, Kolonel, Laurence N., additional, Kritchevsky, Stephen B., additional, Le Marchand, Loic, additional, Lohman, Kurt, additional, Liu, Jiankang, additional, Millikan, Robert C., additional, Murphy, Adam, additional, Musani, Solomon, additional, Neslund-Dudas, Christine, additional, North, Kari E., additional, Nyante, Sarah, additional, Ogunniyi, Adesola, additional, Ostrander, Elaine A., additional, Papanicolaou, George, additional, Patel, Sanjay, additional, Pettaway, Curtis A., additional, Press, Michael F., additional, Redline, Susan, additional, Rodriguez-Gil, Jorge L., additional, Rotimi, Charles, additional, Rybicki, Benjamin A., additional, Salako, Babatunde, additional, Schreiner, Pamela J., additional, Signorello, Lisa B., additional, Singleton, Andrew B., additional, Stanford, Janet L., additional, Stram, Alex H., additional, Stram, Daniel O., additional, Strom, Sara S., additional, Suktitipat, Bhoom, additional, Thun, Michael J., additional, Witte, John S., additional, Yanek, Lisa R., additional, Ziegler, Regina G., additional, Zheng, Wei, additional, Zhu, Xiaofeng, additional, Zmuda, Joseph M., additional, Zonderman, Alan B., additional, Evans, Michele K., additional, Liu, Yongmei, additional, Becker, Diane M., additional, Cooper, Richard S., additional, Pastinen, Tomi, additional, Henderson, Brian E., additional, Hirschhorn, Joel N., additional, Lettre, Guillaume, additional, and Haiman, Christopher A., additional more...

Published
2011
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45. Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

Author

N'Diaye, Amidou, primary, Chen, Gary K., additional, Palmer, Cameron D., additional, Ge, Bing, additional, Tayo, Bamidele, additional, Mathias, Rasika A., additional, Ding, Jingzhong, additional, Nalls, Michael A., additional, Adeyemo, Adebowale, additional, Adoue, Véronique, additional, Ambrosone, Christine B., additional, Atwood, Larry, additional, Bandera, Elisa V., additional, Becker, Lewis C., additional, Berndt, Sonja I., additional, Bernstein, Leslie, additional, Blot, William J., additional, Boerwinkle, Eric, additional, Britton, Angela, additional, Casey, Graham, additional, Chanock, Stephen J., additional, Demerath, Ellen, additional, Deming, Sandra L., additional, Diver, W. Ryan, additional, Fox, Caroline, additional, Harris, Tamara B., additional, Hernandez, Dena G., additional, Hu, Jennifer J., additional, Ingles, Sue A., additional, John, Esther M., additional, Johnson, Craig, additional, Keating, Brendan, additional, Kittles, Rick A., additional, Kolonel, Laurence N., additional, Kritchevsky, Stephen B., additional, Le Marchand, Loic, additional, Lohman, Kurt, additional, Liu, Jiankang, additional, Millikan, Robert C., additional, Murphy, Adam, additional, Musani, Solomon, additional, Neslund-Dudas, Christine, additional, North, Kari E., additional, Nyante, Sarah, additional, Ogunniyi, Adesola, additional, Ostrander, Elaine A., additional, Papanicolaou, George, additional, Patel, Sanjay, additional, Pettaway, Curtis A., additional, Press, Michael F., additional, Redline, Susan, additional, Rodriguez-Gil, Jorge L., additional, Rotimi, Charles, additional, Rybicki, Benjamin A., additional, Salako, Babatunde, additional, Schreiner, Pamela J., additional, Signorello, Lisa B., additional, Singleton, Andrew B., additional, Stanford, Janet L., additional, Stram, Alex H., additional, Stram, Daniel O., additional, Strom, Sara S., additional, Suktitipat, Bhoom, additional, Thun, Michael J., additional, Witte, John S., additional, Yanek, Lisa R., additional, Ziegler, Regina G., additional, Zheng, Wei, additional, Zhu, Xiaofeng, additional, Zmuda, Joseph M., additional, Zonderman, Alan B., additional, Evans, Michele K., additional, Liu, Yongmei, additional, Becker, Diane M., additional, Cooper, Richard S., additional, Pastinen, Tomi, additional, Henderson, Brian E., additional, Hirschhorn, Joel N., additional, Lettre, Guillaume, additional, and Haiman, Christopher A., additional more...

Published
2011
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46. Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

Author

Lettre, Guillaume, primary, Palmer, Cameron D., additional, Young, Taylor, additional, Ejebe, Kenechi G., additional, Allayee, Hooman, additional, Benjamin, Emelia J., additional, Bennett, Franklyn, additional, Bowden, Donald W., additional, Chakravarti, Aravinda, additional, Dreisbach, Al, additional, Farlow, Deborah N., additional, Folsom, Aaron R., additional, Fornage, Myriam, additional, Forrester, Terrence, additional, Fox, Ervin, additional, Haiman, Christopher A., additional, Hartiala, Jaana, additional, Harris, Tamara B., additional, Hazen, Stanley L., additional, Heckbert, Susan R., additional, Henderson, Brian E., additional, Hirschhorn, Joel N., additional, Keating, Brendan J., additional, Kritchevsky, Stephen B., additional, Larkin, Emma, additional, Li, Mingyao, additional, Rudock, Megan E., additional, McKenzie, Colin A., additional, Meigs, James B., additional, Meng, Yang A., additional, Mosley, Tom H., additional, Newman, Anne B., additional, Newton-Cheh, Christopher H., additional, Paltoo, Dina N., additional, Papanicolaou, George J., additional, Patterson, Nick, additional, Post, Wendy S., additional, Psaty, Bruce M., additional, Qasim, Atif N., additional, Qu, Liming, additional, Rader, Daniel J., additional, Redline, Susan, additional, Reilly, Muredach P., additional, Reiner, Alexander P., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Liu, Yongmei, additional, Shrader, Peter, additional, Siscovick, David S., additional, Tang, W. H. Wilson, additional, Taylor, Herman A., additional, Tracy, Russell P., additional, Vasan, Ramachandran S., additional, Waters, Kevin M., additional, Wilks, Rainford, additional, Wilson, James G., additional, Fabsitz, Richard R., additional, Gabriel, Stacey B., additional, Kathiresan, Sekar, additional, and Boerwinkle, Eric, additional more...

Published
2011
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48. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Author

Ehret, Georg B, Ferreira, Teresa, Chasman, Daniel I, Jackson, Anne U, Schmidt, Ellen M, Johnson, Toby, Thorleifsson, Gudmar, Luan, Jian'an, Donnelly, Louise A, Kanoni, Stavroula, Petersen, Ann-Kristin, Pihur, Vasyl, Strawbridge, Rona J, Shungin, Dmitry, Hughes, Maria F, Meirelles, Osorio, Kaakinen, Marika, Bouatia-Naji, Nabila, Kristiansson, Kati, Shah, Sonia, Kleber, Marcus E, Guo, Xiuqing, Lyytikäinen, Leo-Pekka, Fava, Cristiano, Eriksson, Niclas, Nolte, Ilja M, Magnusson, Patrik K, Salfati, Elias L, Rallidis, Loukianos S, Theusch, Elizabeth, Smith, Andrew J P, Folkersen, Lasse, Witkowska, Kate, Pers, Tune H, Joehanes, Roby, Kim, Stuart K, Lataniotis, Lazaros, Jansen, Rick, Johnson, Andrew D, Warren, Helen, Kim, Young Jin, Zhao, Wei, Wu, Ying, Tayo, Bamidele O, Bochud, Murielle, Absher, Devin, Adair, Linda S, Amin, Najaf, Arking, Dan E, Axelsson, Tomas, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Barnes, Michael R, Barroso, Inês, Bevan, Stephen, Bis, Joshua C, Bjornsdottir, Gyda, Boehnke, Michael, Boerwinkle, Eric, Bonnycastle, Lori L, Boomsma, Dorret I, Bornstein, Stefan R, Brown, Morris J, Burnier, Michel, Cabrera, Claudia P, Chambers, John C, Chang, I-Shou, Cheng, Ching-Yu, Chines, Peter S, Chung, Ren-Hua, Collins, Francis S, Connell, John M, Döring, Angela, Dallongeville, Jean, Danesh, John, de Faire, Ulf, Delgado, Graciela, Dominiczak, Anna F, Doney, Alex S F, Drenos, Fotios, Edkins, Sarah, Eicher, John D, Elosua, Roberto, Enroth, Stefan, Erdmann, Jeanette, Eriksson, Per, Esko, Tonu, Evangelou, Evangelos, Evans, Alun, Fall, Tove, Farrall, Martin, Felix, Janine F, Ferrières, Jean, Ferrucci, Luigi, Fornage, Myriam, Forrester, Terrence, Franceschini, Nora, Franco, Oscar H, Franco-Cereceda, Anders, Fraser, Ross M, Ganesh, Santhi K, Gao, He, Gertow, Karl, Gianfagna, Francesco, Gigante, Bruna, Giulianini, Franco, Goel, Anuj, Goodall, Alison H, Goodarzi, Mark O, Gorski, Mathias, Gräßler, Jürgen, Groves, Christopher J, Gudnason, Vilmundur, Gyllensten, Ulf, Hallmans, Göran, Hartikainen, Anna-Liisa, Hassinen, Maija, Havulinna, Aki S, Hayward, Caroline, Hercberg, Serge, Herzig, Karl-Heinz, Hicks, Andrew A, Hingorani, Aroon D, Hirschhorn, Joel N, Hofman, Albert, Holmen, Jostein, Holmen, Oddgeir Lingaas, Hottenga, Jouke-Jan, Howard, Phil, Hsiung, Chao A, Hunt, Steven C, Ikram, M Arfan, Illig, Thomas, Iribarren, Carlos, Jensen, Richard A, Kähönen, Mika, Kang, Hyun Min, Kathiresan, Sekar, Keating, Brendan J, Khaw, Kay-Tee, Kim, Yun Kyoung, Kim, Eric, Kivimaki, Mika, Klopp, Norman, Kolovou, Genovefa, Komulainen, Pirjo, Kooner, Jaspal S, Kosova, Gulum, Krauss, Ronald M, Kuh, Diana, Kutalik, Zoltan, Kuusisto, Johanna, Kvaløy, Kirsti, Lakka, Timo A, Lee, Nanette R, Lee, I-Te, Lee, Wen-Jane, Levy, Daniel, Li, Xiaohui, Liang, Kae-Woei, Lin, Honghuang, Lin, Li, Lindström, Jaana, Lobbens, Stéphane, Männistö, Satu, Müller, Gabriele, Müller-Nurasyid, Martina, Mach, François, Markus, Hugh S, Marouli, Eirini, McCarthy, Mark I, McKenzie, Colin A, Meneton, Pierre, Menni, Cristina, Metspalu, Andres, Mijatovic, Vladan, Moilanen, Leena, Montasser, May E, Morris, Andrew D, Morrison, Alanna C, Mulas, Antonella, Nagaraja, Ramaiah, Narisu, Narisu, Nikus, Kjell, O'Donnell, Christopher J, O'Reilly, Paul F, Ong, Ken K, Paccaud, Fred, Palmer, Cameron D, Parsa, Afshin, Pedersen, Nancy L, Penninx, Brenda W, Perola, Markus, Peters, Annette, Poulter, Neil, Pramstaller, Peter P, Psaty, Bruce M, Quertermous, Thomas, Rao, Dabeeru C, Rasheed, Asif, Rayner, N William, Renström, Frida, Rettig, Rainer, Rice, Kenneth M, Roberts, Robert, Rose, Lynda M, Rossouw, Jacques, Samani, Nilesh J, Sanna, Serena, Saramies, Jouko, Schunkert, Heribert, Sebert, Sylvain, Sheu, Wayne H-H, Shin, Young-Ah, Sim, Xueling, Smit, Johannes H, Smith, Albert V, Sosa, Maria X, Spector, Tim D, Stančáková, Alena, Stanton, Alice V, Stirrups, Kathleen E, Stringham, Heather M, Sundstrom, Johan, Swift, Amy J, Syvänen, Ann-Christine, Tai, E-Shyong, Tanaka, Toshiko, Tarasov, Kirill V, Teumer, Alexander, Thorsteinsdottir, Unnur, Tobin, Martin D, Tremoli, Elena, Uitterlinden, Andre G, Uusitupa, Matti, Vaez, Ahmad, Vaidya, Dhananjay, van Duijn, Cornelia M, van Iperen, Erik P A, Vasan, Ramachandran S, Verwoert, Germaine C, Virtamo, Jarmo, Vitart, Veronique, Voight, Benjamin F, Vollenweider, Peter, Wagner, Aline, Wain, Louise V, Wareham, Nicholas J, Watkins, Hugh, Weder, Alan B, Westra, Harm-Jan, Wilks, Rainford, Wilsgaard, Tom, Wilson, James F, Wong, Tien Y, Yang, Tsun-Po, Yao, Jie, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zhu, Xiaofeng, Bovet, Pascal, Cooper, Richard S, Mohlke, Karen L, Saleheen, Danish, Lee, Jong-Young, Elliott, Paul, Gierman, Hinco J, Willer, Cristen J, Franke, Lude, Hovingh, G Kees, Taylor, Kent D, Dedoussis, George, Sever, Peter, Wong, Andrew, Lind, Lars, Assimes, Themistocles L, Njølstad, Inger, Schwarz, Peter E H, Langenberg, Claudia, Snieder, Harold, Caulfield, Mark J, Melander, Olle, Laakso, Markku, Saltevo, Juha, Rauramaa, Rainer, Tuomilehto, Jaakko, Ingelsson, Erik, Lehtimäki, Terho, Hveem, Kristian, Palmas, Walter, März, Winfried, Kumari, Meena, Salomaa, Veikko, Chen, Yii-Der I, Rotter, Jerome I, Froguel, Philippe, Jarvelin, Marjo-Riitta, Lakatta, Edward G, Kuulasmaa, Kari, Franks, Paul W, Hamsten, Anders, Wichmann, H-Erich, Palmer, Colin N A, Stefansson, Kari, Ridker, Paul M, Loos, Ruth J F, Chakravarti, Aravinda, Deloukas, Panos, Morris, Andrew P, Newton-Cheh, Christopher, and Munroe, Patricia B more...

Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure–associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure–related pathways and highlight tissues beyond the classical renal system in blood pressure regulation. more...

Published
2016
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50. Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Author

Yang, Jialiang, Huang, Tao, Petralia, Francesca, Long, Quan, Zhang, Bin, Argmann, Carmen, Zhao, Yong, Mobbs, Charles V., Schadt, Eric E., Zhu, Jun, Tu, Zhidong, Ardlie, Kristin G., Deluca, David S., Segrè, Ayellet V., Sullivan, Timothy J., Young, Taylor R., Gelfand, Ellen T., Trowbridge, Casandra A., Maller, Julian B., Tukiainen, Taru, Lek, Monkol, Ward, Lucas D., Kheradpour, Pouya, Iriarte, Benjamin, Meng, Yan, Palmer, Cameron D., Winckler, Wendy, Hirschhorn, Joel, Kellis, Manolis, MacArthur, Daniel G., Getz, Gad, Shablin, Andrey A., Li, Gen, Zhou, Yi-Hui, Nobel, Andrew B., Rusyn, Ivan, Wright, Fred A., Lappalainen, Tuuli, Ferreira, Pedro G., Ongen, Halit, Rivas, Manuel A., Battle, Alexis, Mostafavi, Sara, Monlong, Jean, Sammeth, Michael, Mele, Marta, Reverter, Ferran, Goldman, Jakob, Koller, Daphne, Guigo, Roderic, McCarthy, Mark I., Dermitzakis, Emmanouil T., Gamazon, Eric R., Konkashbaev, Anuar, Nicolae, Dan L., Cox, Nancy J., Flutre, Timothée, Wen, Xiaoquan, Stephens, Matthew, Pritchard, Jonathan K., Lin, Luan, Liu, Jun, Brown, Amanda, Mestichelli, Bernadette, Tidwell, Denee, Lo, Edmund, Salvatore, Mike, Shad, Saboor, Thomas, Jeffrey A., Lonsdale, John T., Choi, Christopher, Karasik, Ellen, Ramsey, Kimberly, Moser, Michael T., Foster, Barbara A., Gillard, Bryan M., Syron, John, Fleming, Johnelle, Magazine, Harold, Hasz, Rick, Walters, Gary D., Bridge, Jason P., Miklos, Mark, Sullivan, Susan, Barker, Laura K., Traino, Heather, Mosavel, Magboeba, Siminoff, Laura A., Valley, Dana R., Rohrer, Daniel C., Jewel, Scott, Branton, Philip, Sobin, Leslie H., Qi, Liqun, Hariharan, Pushpa, Wu, Shenpei, Tabor, David, Shive, Charles, Smith, Anna M., Buia, Stephen A., Undale, Anita H., Robinson, Karna L., Roche, Nancy, Valentino, Kimberly M., Britton, Angela, Burges, Robin, Bradbury, Debra, Hambright, Kenneth W., Seleski, John, Korzeniewski, Greg E., Erickson, Kenyon, Marcus, Yvonne, Tejada, Jorge, Taherian, Mehran, Lu, Chunrong, Robles, Barnaby E., Basile, Margaret, Mash, Deborah C., Volpi, Simona, Struewing, Jeff, Temple, Gary F., Boyer, Joy, Colantuoni, Deborah, Little, Roger, Koester, Susan, Carithers, NCI Latarsha J., Moore, Helen M., Guan, Ping, Compton, Carolyn, Sawyer, Sherilyn J., Demchok, Joanne P., Vaught, Jimmie B., Rabiner, Chana A., and Lockhart, Nicole C. more...

Abstract

Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger “co-aging” than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases. more...

Published
2015
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