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Maria Mariana Barros Melo da Silveira,1,2 Leiliandry de Araújo Melo,1,2 Filipe Maia Ferreira Gomes,1 Leonardo José de Cupertino Barreto da Rocha Andrade,1 Isabela Paulino Serur,1 Isabelle Cecília de Vasconcellos Piscoya,1 Raposo Marina Gueiros,1 Kleyton Palmeira do Ó,1 Raul Emídio de Lima,3 Victor Arthur Eulálio Brasileiro,1,2 Luydson Richardson Silva Vasconcelos,1,3 Dário Celestino Sobral Filho21Faculdade de Ciências Médicas, Universidade de Pernambuco - FCM/UPE, Recife, Brazil; 2Pronto Socorro Cardiológico Professor Luiz Tavares - PROCAPE/UPE, Recife, Brazil; 3Instituto Aggeu Magalhães - FIOCRUZ-PE, Recife, BrazilIntroduction: Warfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the CYP2C9 and VKORC1 genes.Methods: This study examined the association between polymorphisms of the CYP2C9 and VKORC1 genes and control of oral anticoagulation, through TTR, in patients with AF. A cross-sectional study was conducted within a cohort follow-up. The study comprised of 317 patients with AF, using warfarin, who were followed up for one year. The genotyping of genes CYP2C9 (rs1057910), (rs1799853) and VKORC1 (rs923231) was performed by PCR in real time, using TaqMan probes.Results: Patients who had variant genotypes for the CYP2C9*3 gene (rs1057910) presented higher TTR (TTR 81–100%) when compared to when compared to the

Individuals with intellectual disability (ID) tend to have a sedentary lifestyle, with low physical fitness and an increased risk of chronic diseases. One reason for the prevalence of a sedentary lifestyle is the existence of barriers to participation in physical activity (PA). The purpose of this systematic review is to update knowledge about the perceived barriers of PA participation in individuals with ID. Electronic searches were carried out in the PubMed, Scopus, SPORTDiscus and Web of Science databases, from September 2020 to May 2021, and included articles published between January 2016 and May 2021. The terms used were: "mental retardation", "intellectual disability", "intellectual disabilities", "physical activity", "motor activity", "barriers", "obstacles", "embarrassment" and "constraint", in combination with the Boolean operators "AND" or "OR". After the methodological process, five studies were included for analysis. These studies revealed the existence of several perceived barriers to regular PA participation, which were grouped into five main groups: personal (6 topics), family (4 topics), social (13 topics), financial (1 topic) and environmental (1 topic). The knowledge and identification of participation barriers can be of extreme importance both to institutions and professionals aiming to enhance the participation of individuals with ID in regular PA programs.

Pyridine- and quinoline-stabilized silyl cations have been prepared, and their structure in condensed phases unambiguously assigned using 1 H, 13 C, 15 N, 29 Si, and 1 H DOSY NMR as well as X-ray diffraction studies. Solid state structures thus show in both cases a stabilization of the cationic silicon center through an N-Si interaction and formation of a highly strained four-membered ring system. Chiral memory at the silicon atom in these heterocycle-stabilized silyl cations was also established, leading to various levels of selectivity depending on the nature of the heterocycle. Lowest energy conformations of the starting silanes obtained through DFT calculations, along with the isolation and characterization of the Si-centered chiral silyl cation intermediates, finally allowed to propose a plausible hypothesis as to the configurational stability of these silyl cations.

Objective: : To compare gait spatiotemporal parameters of healthy and ACL reconstructed subjects in order to classify the status of gait normality., Methods: : Fourteen healthy subjects and eight patients submitted to ACL reconstruction walked along a walkway while the lower limbs movement was captured by an infrared camera system. The frames where the initial contact and toe-off took place were determined and the following dependent variables, which were compared between groups through the Mann-Whitney test (a=0.05) were calculated: percentage of time in initial double stance, percentage of time in single stance, percentage of time in terminal double stance, stride length and gait velocity. Initially, all variables were compared between groups using a Mann-Whitney test. A logistic regression was applied, including all dependent variables, to create a model that could differentiate healthy and ACL reconstructed subjects., Results: : ACL reconstructed group showed no differences in any spatiotemporal parameter of gait (p > 0.05) in relation to the control group, although the angular kinematic differences of the knee remained altered, as evidenced in a study with a similar sample., Conclusion: : The regression classified all subjects as healthy, including the ACL reconstructed group, suggesting the spatiotemporal variables should not be used as the sole criterion of return to sports activities at the same level as prior to injury. Level of Evidence III, Case Control Study.

1. This study attempts to elucidate unique heart and blood pressure responses seen in sloths in response to tilting by blocking autonomics with atropine, propranolol, or a combination of these. 2. Atropine produces less heart rate increase in sloths than in other mammals but blocks reflex bradycardia as expected. 3. Propranolol reduces heart rate to about the same degree as in man and completely blocks all cardiac responses to tilting, both direct and reflex. 4. Atropine slightly diminishes blood pressure responses to tilting whereas propranolol tends to augment the already marked increases.