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44 results on '"Palme, Christoph"'

11. Impact of Diquafosol Ophthalmic Solution on Tear Film and Dry Eye Symptom in Type 2 Diabetic Dry Eye: A Pilot Study

Author

Zhang, Qing, primary, Zhang, Hongda, additional, Qin, Guanghao, additional, Wu, Yi, additional, Song, Yilin, additional, Yang, Lanting, additional, Yu, Sile, additional, He, Xingru, additional, Moore, Jonathan E., additional, Moutari, Salissou, additional, Palme, Christoph, additional, Xu, Ling, additional, He, Wei, additional, and Pazo, Emmanuel Eric, additional

Published
2022
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13. Assessment of the correlation of the tear breakup time with quality of vision and dry eye symptoms after SMILE surgery

Author

Palme, Christoph, Mulrine, Fiona, McNeely, Richard N., Steger, Bernhard, Naroo, Shehzad A., and Moore, Jonathan E.

Subjects
genetic structures, eye diseases
Abstract

Purpose: It is well reported that dry eye symptoms can increase after many refractive surgery procedures. This study aims to provide a clinical understanding of the correlation of fluorescein tear film breakup time (FTBUT) with quality of vision (QoV) and dry eye symptoms following small incision lenticule extraction surgery (SMILE). Methods: Patients electing to have SMILE surgery were subdivided into 2 groups: Group 1 included short preoperative FTBUTs of 3 to 6 seconds (s); Group 2 included long FTBUTs of ≥ 8 s. Uncorrected distance visual acuity, corrected distance visual acuity, manifest refraction, FTBUT, QoV and Ocular Surface Disease Index (OSDI) questionnaires were recorded 1 and 6 months postoperatively. Results: Thirty-nine subjects were included in each group. There was no significant difference in visual outcomes between the 2 groups at both the 1- and 6-month postoperative assessments. FTBUT remained significantly lower in group 1. Oxford staining was initially higher for group 1 at 1 month (P = 0.007), but there was no significant difference at 6 months (P = 0.180). There was no significant difference in QoV or OSDI scores between the 2 groups at both postoperative visits. Conclusions: Low preoperative FTBUT (3–6 s) does not appear to negatively affect postoperative visual outcomes or results in a greater likelihood of dry eye symptoms and poor ocular surface compared to eyes with a longer preoperative FTBUT. These results suggest that a low preoperative FTBUT does not necessarily increase the likelihood of poor visual acuity, dry eyes symptoms, or poor ocular surface outcomes following SMILE surgery.

Published
2021

24. En-face analysis of the human limbal lymphatic vasculature

Author

Palme, Christoph, Ahmad, Sajjad, Romano, Vito, Seifarth, Christof, Williams, Bryan, Parekh, Mohit, Kaye, Stephen B., Steger, Bernhard, Palme, Christoph, Ahmad, Sajjad, Romano, Vito, Seifarth, Christof, Williams, Bryan, Parekh, Mohit, Kaye, Stephen B., and Steger, Bernhard

Abstract

Purpose: To describe the location and morphometric characteristics of the human limbal lymphatic vasculature and its relation to the marginal corneal vascular arcades (MCA). Methods: Ex vivo confocal microscopic (CM) imaging and immunofluorescence double staining for CD-31 and D2-40 of histological en-face sections using 12 preserved human cadaveric corneoscleral discs were performed, followed by a semi-automated morphometric analysis of the two-dimensional vascular network architecture. Results: Ex vivo CM confirmed the presence of 2 distinct vascular networks. The haematic limbal vascular complex (HLVC) extended further into the cornea, forming typical MCAs. The lymphatic limbal vascular complex (LLVC) was peripheral from the termination of Bowman's layer and was also found to be peripheral to and deeper than the HLVC. LLVC and HLVC were significantly different with respect to vessel diameter, segment length and wall thickness. Conclusion: The lymphatic vasculature of the human corneoscleral limbal region displays specific morphometric features that allow its differentiation from haematic vessels using CM.

Published
2020

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