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1. GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

Author

Katzdobler, Sabrina, Nübling, Georg, Klietz, Martin, Fietzek, Urban M., Palleis, Carla, Bernhardt, Alexander M., Wegner, Florian, Huber, Meret, Rogozinski, Sophia, Schneider, Luisa-Sophie, Spruth, Eike Jakob, Beyle, Aline, Vogt, Ina R., Brandt, Moritz, Hansen, Niels, Glanz, Wenzel, Brockmann, Kathrin, Spottke, Annika, Hoffmann, Daniel C., Peters, Oliver, Priller, Josef, Wiltfang, Jens, Düzel, Emrah, Schneider, Anja, Falkenburger, Björn, Klockgether, Thomas, Gasser, Thomas, Nuscher, Brigitte, Haass, Christian, Höglinger, Günter, and Levin, Johannes

Published
2024
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2. Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies

Author

Ferschmann, Christian, Messerschmidt, Konstantin, Gnörich, Johannes, Barthel, Henryk, Marek, Ken, Palleis, Carla, Katzdobler, Sabrina, Stockbauer, Anna, Fietzek, Urban, Finze, Anika, Biechele, Gloria, Rumpf, Jost-Julian, Saur, Dorothee, Schroeter, Matthias L., Rullmann, Michael, Beyer, Leonie, Eckenweber, Florian, Wall, Stephan, Schildan, Andreas, Patt, Marianne, Stephens, Andrew, Classen, Joseph, Bartenstein, Peter, Seibyl, John, Franzmeier, Nicolai, Levin, Johannes, Höglinger, Günter U., Sabri, Osama, Brendel, Matthias, and Scheifele, Maximilian

Published
2024
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3. Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences

Author

Bernhardt, Alexander Maximilian, Oeller, Marc, Friedrich, Isabel, Kocakavuk, Emre, Nachman, Eliana, Peikert, Kevin, Roderigo, Malte, Rossmann, Andreas, Schröter, Tabea, Wilhelm, Lea Olivia, Prell, Tino, van Riesen, Christoph, Nieweler, Johanna, Katzdobler, Sabrina, Weiler, Markus, Jacobi, Heike, Warnecke, Tobias, Claus, Inga, Palleis, Carla, Breimann, Stephan, Falkenburger, Björn, Brandt, Moritz, Hermann, Andreas, Rumpf, Jost-Julian, Claßen, Joseph, Höglinger, Günter, Gandor, Florin, Levin, Johannes, Giese, Armin, Janzen, Annette, and Oertel, Wolfgang Hermann

Published
2024
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4. Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Author

Biechele, Gloria, Rauchmann, Boris-Stephan, Janowitz, Daniel, Buerger, Katharina, Franzmeier, Nicolai, Weidinger, Endy, Guersel, Selim, Schuster, Sebastian, Finze, Anika, Harris, Stefanie, Lindner, Simon, Albert, Nathalie L., Wetzel, Christian, Rupprecht, Rainer, Rominger, Axel, Palleis, Carla, Katzdobler, Sabrina, Burow, Lena, Kurz, Carolin, Zaganjori, Mirlind, Trappmann, Lena-Katharina, Goldhardt, Oliver, Grimmer, Timo, Haeckert, Jan, Keeser, Daniel, Stoecklein, Sophia, Morenas-Rodriguez, Estrella, Bartenstein, Peter, Levin, Johannes, Höglinger, Günter U., Simons, Mikael, Perneczky, Robert, and Brendel, Matthias

Published
2024
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5. Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission

Author

Stockbauer, Anna, Beyer, Leonie, Huber, Maria, Kreuzer, Annika, Palleis, Carla, Katzdobler, Sabrina, Rauchmann, Boris-Stephan, Morbelli, Silvia, Chincarini, Andrea, Bruffaerts, Rose, Vandenberghe, Rik, Kramberger, Milica G., Trost, Maja, Garibotto, Valentina, Nicastro, Nicolas, Lathuilière, Aurélien, Lemstra, Afina W., van Berckel, Bart N. M., Pilotto, Andrea, Padovani, Alessandro, Ochoa-Figueroa, Miguel A., Davidsson, Anette, Camacho, Valle, Peira, Enrico, Bauckneht, Matteo, Pardini, Matteo, Sambuceti, Gianmario, Aarsland, Dag, Nobili, Flavio, Gross, Mattes, Vöglein, Jonathan, Perneczky, Robert, Pogarell, Oliver, Buerger, Katharina, Franzmeier, Nicolai, Danek, Adrian, Levin, Johannes, Höglinger, Günter U., Bartenstein, Peter, Cumming, Paul, Rominger, Axel, and Brendel, Matthias

Published
2024
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6. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Author

Finze, Anika, Biechele, Gloria, Rauchmann, Boris-Stephan, Franzmeier, Nicolai, Palleis, Carla, Katzdobler, Sabrina, Weidinger, Endy, Guersel, Selim, Schuster, Sebastian, Harris, Stefanie, Schmitt, Julia, Beyer, Leonie, Gnörich, Johannes, Lindner, Simon, Albert, Nathalie L., Wetzel, Christian H., Rupprecht, Rainer, Rominger, Axel, Danek, Adrian, Burow, Lena, Kurz, Carolin, Tato, Maia, Utecht, Julia, Papazov, Boris, Zaganjori, Mirlind, Trappmann, Lena-Katharina, Goldhardt, Oliver, Grimmer, Timo, Haeckert, Jan, Janowitz, Daniel, Buerger, Katharina, Keeser, Daniel, Stoecklein, Sophia, Dietrich, Olaf, Morenas-Rodriguez, Estrella, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Simons, Mikael, Haass, Christian, Höglinger, Günter U., Levin, Johannes, Perneczky, Robert, and Brendel, Matthias

Published
2023
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7. Tau deposition patterns are associated with functional connectivity in primary tauopathies

Author

Franzmeier, Nicolai, Brendel, Matthias, Beyer, Leonie, Slemann, Luna, Kovacs, Gabor G, Arzberger, Thomas, Kurz, Carolin, Respondek, Gesine, Lukic, Milica J, Biel, Davina, Rubinski, Anna, Frontzkowski, Lukas, Hummel, Selina, Müller, Andre, Finze, Anika, Palleis, Carla, Joseph, Emanuel, Weidinger, Endy, Katzdobler, Sabrina, Song, Mengmeng, Biechele, Gloria, Kern, Maike, Scheifele, Maximilian, Rauchmann, Boris-Stephan, Perneczky, Robert, Rullman, Michael, Patt, Marianne, Schildan, Andreas, Barthel, Henryk, Sabri, Osama, Rumpf, Jost J, Schroeter, Matthias L, Classen, Joseph, Villemagne, Victor, Seibyl, John, Stephens, Andrew W, Lee, Edward B, Coughlin, David G, Giese, Armin, Grossman, Murray, McMillan, Corey T, Gelpi, Ellen, Molina-Porcel, Laura, Compta, Yaroslau, van Swieten, John C, Laat, Laura Donker, Troakes, Claire, Al-Sarraj, Safa, Robinson, John L, Xie, Sharon X, Irwin, David J, Roeber, Sigrun, Herms, Jochen, Simons, Mikael, Bartenstein, Peter, Lee, Virginia M, Trojanowski, John Q, Levin, Johannes, Höglinger, Günter, and Ewers, Michael

Subjects
Biochemistry and Cell Biology, Biological Sciences, Acquired Cognitive Impairment, Rare Diseases, Brain Disorders, Pick's Disease, Alzheimer's Disease, Dementia, Frontotemporal Dementia (FTD), Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Aging, Alzheimer's Disease Related Dementias (ADRD), Biomedical Imaging, Aetiology, 2.1 Biological and endogenous factors, Neurological, Brain, Humans, Magnetic Resonance Imaging, Supranuclear Palsy, Progressive, Tauopathies, tau Proteins
Abstract

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

Published
2022

8. Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings

Author

Völter, Friederike, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bui, Ngoc, Patt, Marianne, Barthel, Henryk, Katzdobler, Sabrina, Palleis, Carla, Franzmeier, Nicolai, Levin, Johannes, Perneczky, Robert, Rauchmann, Boris-Stephan, Sabri, Osama, Hong, Jimin, Cumming, Paul, Rominger, Axel, Shi, Kuangyu, Bartenstein, Peter, and Brendel, Matthias

Published
2023
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10. Additive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome

Author

Katzdobler, Sabrina, Nitschmann, Alexander, Barthel, Henryk, Bischof, Gerard, Beyer, Leonie, Marek, Ken, Song, Mengmeng, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Nack, Anne, Fietzek, Urban, Kurz, Carolin, Häckert, Jan, Stapf, Theresa, Ferschmann, Christian, Scheifele, Maximilian, Eckenweber, Florian, Biechele, Gloria, Franzmeier, Nicolai, Dewenter, Anna, Schönecker, Sonja, Saur, Dorothee, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael, Schildan, Andreas, Patt, Marianne, Stephens, Andrew W., van Eimeren, Thilo, Neumaier, Bernd, Drzezga, Alexander, Danek, Adrian, Classen, Joseph, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris-Stephan, Stöcklein, Sophia, Perneczky, Robert, Schöberl, Florian, Zwergal, Andreas, Höglinger, Günter U., Bartenstein, Peter, Villemagne, Victor, Seibyl, John, Sabri, Osama, Levin, Johannes, and Brendel, Matthias

Published
2023
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11. Distinct molecular profiles of skull bone marrow in health and neurological disorders

Author

Kolabas, Zeynep Ilgin, Kuemmerle, Louis B., Perneczky, Robert, Förstera, Benjamin, Ulukaya, Selin, Ali, Mayar, Kapoor, Saketh, Bartos, Laura M., Büttner, Maren, Caliskan, Ozum Sehnaz, Rong, Zhouyi, Mai, Hongcheng, Höher, Luciano, Jeridi, Denise, Molbay, Muge, Khalin, Igor, Deligiannis, Ioannis K., Negwer, Moritz, Roberts, Kenny, Simats, Alba, Carofiglio, Olga, Todorov, Mihail I., Horvath, Izabela, Ozturk, Furkan, Hummel, Selina, Biechele, Gloria, Zatcepin, Artem, Unterrainer, Marcus, Gnörich, Johannes, Roodselaar, Jay, Shrouder, Joshua, Khosravani, Pardis, Tast, Benjamin, Richter, Lisa, Díaz-Marugán, Laura, Kaltenecker, Doris, Lux, Laurin, Chen, Ying, Zhao, Shan, Rauchmann, Boris-Stephan, Sterr, Michael, Kunze, Ines, Stanic, Karen, Kan, Vanessa W.Y., Besson-Girard, Simon, Katzdobler, Sabrina, Palleis, Carla, Schädler, Julia, Paetzold, Johannes C., Liebscher, Sabine, Hauser, Anja E., Gokce, Ozgun, Lickert, Heiko, Steinke, Hanno, Benakis, Corinne, Braun, Christian, Martinez-Jimenez, Celia P., Buerger, Katharina, Albert, Nathalie L., Höglinger, Günter, Levin, Johannes, Haass, Christian, Kopczak, Anna, Dichgans, Martin, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Schifferer, Martina, Simons, Mikael, Liesz, Arthur, Krahmer, Natalie, Bayraktar, Omer A., Franzmeier, Nicolai, Plesnila, Nikolaus, Erener, Suheda, Puelles, Victor G., Delbridge, Claire, Bhatia, Harsharan Singh, Hellal, Farida, Elsner, Markus, Bechmann, Ingo, Ondruschka, Benjamin, Brendel, Matthias, Theis, Fabian J., and Erturk, Ali

Published
2023
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12. The Progressive Supranuclear Palsy Clinical Deficits Scale

Author

Piot, Ines, Schweyer, Kerstin, Respondek, Gesine, Stamelou, Maria, Sckopke, Philipp, Schenk, Thomas, Goetz, Christopher G, Stebbins, Glenn T, Höglinger, Günter U, Gasser, Thomas, Hermann, Andreas, Höglinger, Günter, Höllerhage, Matthias, Kimmich, Okka, Klockgether, Thomas, Levin, Johannes, Machetanz, Gerrit, Osterrath, Antje, Palleis, Carla, Prudlo, Johannes, Spottke, Annika, Berg, Daniela, Bürk, Katrin, Claßen, Joseph, Eggers, Carsten, Greuel, Andrea, Grimm, Max‐Joseph, Hermann, Lennard, Iankova, Vassilena, Jahn, Klaus, Jost, Wolfgang, Klietz, Martin, Kühn, Andrea, Marxreiter, Franz, Paschen, Steffen, Poetter‐Nerger, Monika, Preisl, Marie‐Therese, Prilop, Lisa, Tönges, Lars, Trenkwalder, Claudia, Warnecke, Tobias, Wegner, Florian, Winkler, Jürgen, Antonini, Angelo, P, Kailash P, L, Adam L, Colosimo, Carlo, Compta, Yaroslau, Corvol, Jean‐Christophe, I, Lawrence I, E, Anthony E, Litvan, Irene, R, Huw R, Nilsson, Christer, and Pantelyat, Alexander

Subjects
Pediatric, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Neurosciences, Brain Disorders, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Neurological, Disease Progression, Female, Fingers, Humans, Male, Motor Skills, Reproducibility of Results, Supranuclear Palsy, Progressive, progressive supranuclear palsy, clinical rating scales, outcome measures, power calculation, DescribePSP study group, ProPSP study group, MDS-endorsed PSP study group, Clinical Sciences, Human Movement and Sports Sciences, Neurology & Neurosurgery
Abstract

BackgroundThere is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes.ObjectiveTo develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes.MethodsThe Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS-PSP diagnostic criteria in two independent, multicenter, observational studies, both cross-sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12-months' follow-up, both cohorts).ResultsCognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). Mean Progressive Supranuclear Palsy Clinical Deficits Scale completion time was 4 minutes. The Progressive Supranuclear Palsy Clinical Deficits Scale total score correlated with existing scales (e.g., Progressive Supranuclear Palsy Rating Scale: R = 0.88; P

Published
2020

13. Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal

Author

Schönecker, Sonja, Palleis, Carla, Franzmeier, Nicolai, Katzdobler, Sabrina, Ferschmann, Christian, Schuster, Sebastian, Finze, Anika, Scheifele, Maximilian, Prix, Catharina, Fietzek, Urban, Weidinger, Endy, Nübling, Georg, Vöglein, Jonathan, Patt, Marianne, Barthel, Henryk, Sabri, Osama, Danek, Adrian, Höglinger, Günter U., Brendel, Matthias, and Levin, Johannes

Published
2023
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14. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies

Author

Roemer, Sebastian N, primary, Brendel, Matthias, additional, Gnoerich, Johannes, additional, Malpetti, Maura, additional, Zaganjori, Mirlind, additional, Quattrone, Andrea, additional, Gross, Mattes, additional, Steward, Anna, additional, Dewenter, Anna, additional, Wagner, Fabian, additional, Dehsarvi, Amir, additional, Ferschmann, Christian, additional, Wall, Stephan, additional, Palleis, Carla, additional, Rauchmann, Boris S, additional, Katzdobler, Sabrina, additional, Jaeck, Alexander, additional, Stockbauer, Anna, additional, Fietzek, Urban M, additional, Bernhardt, Alexander M, additional, Weidinger, Endy, additional, Zwergal, Andreas, additional, Stoecklein, Sophia, additional, Perneczky, Robert, additional, Barthel, Henryk, additional, Sabri, Osama, additional, Levin, Johannes, additional, Hoeglinger, Guenter U, additional, and Franzmeier, Nicolai, additional

Published
2024
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16. Combining cerebrospinal fluid and PI‐2620 tau‐PET for biomarker‐based stratification of Alzheimer's disease and 4R‐tauopathies.

Author

Dilcher, Roxane, Wall, Stephan, Groß, Mattes, Katzdobler, Sabrina, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Fietzek, Urban, Bernhardt, Alexander, Kurz, Carolin, Ferschmann, Christian, Scheifele, Maximilian, Zaganjori, Mirlind, Gnörich, Johannes, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris‐Stephan, Stöcklein, Sophia, Bartenstein, Peter, and Villemagne, Victor

Abstract

INTRODUCTION: Recent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer's disease (AD), but in vivo biomarker‐based workflows to assess 4R‐tauopathy (4RT) patients are currently missing. We suggest a novel biomarker‐based algorithm to characterize AD and 4RTs. METHODS: We cross‐sectionally assessed combinations of cerebrospinal fluid measures (CSF p‐tau181 and t‐tau) and 18F‐PI‐2620 tau‐positron emission tomography (PET) in patients with AD (n = 64), clinically suspected 4RTs (progressive supranuclear palsy or corticobasal syndrome, n = 82) and healthy controls (n = 19). RESULTS: Elevated CSF p‐tau181 and cortical 18F‐PI‐2620 binding was characteristic for AD while normal CSF p‐tau181 with elevated subcortical 18F‐PI‐2620 binding was characteristic for 4RTs. 18F‐PI‐2620‐assessed posterior cortical hypoperfusion could be used as an additional neuronal injury biomarker in AD. DISCUSSION: The specific combination of CSF markers and 18F‐PI‐2620 tau‐PET in disease‐specific regions facilitates the biomarker‐guided stratification of AD and 4RTs. This has implications for biomarker‐aided diagnostic workflows and the advancement in clinical trials. Highlights: Novel biomarker‐based algorithm for differentiating AD and 4R‐tauopathies.A combination of CSF p‐tau181 and 18F‐PI‐2620 discriminates AD versus 4R tauopathies.Hypoperfusion serves as an additional neuronal injury biomarker in AD. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Neuroinflammation Parallels 18F‐PI‐2620 Positron Emission Tomography Patterns in Primary 4‐Repeat Tauopathies.

Author

Malpetti, Maura, Roemer, Sebastian N., Harris, Stefanie, Gross, Mattes, Gnörich, Johannes, Stephens, Andrew, Dewenter, Anna, Steward, Anna, Biel, Davina, Dehsarvi, Amir, Wagner, Fabian, Müller, Andre, Koglin, Norman, Weidinger, Endy, Palleis, Carla, Katzdobler, Sabrina, Rupprecht, Rainer, Perneczky, Robert, Rauchmann, Boris‐Stephan, and Levin, Johannes

Abstract

Background: Preclinical, postmortem, and positron emission tomography (PET) imaging studies have pointed to neuroinflammation as a key pathophysiological hallmark in primary 4‐repeat (4R) tauopathies and its role in accelerating disease progression. Objective: We tested whether microglial activation (1) progresses in similar spatial patterns as the primary pathology tau spreads across interconnected brain regions, and (2) whether the degree of microglial activation parallels tau pathology spreading. Methods: We examined in vivo associations between tau aggregation and microglial activation in 31 patients with clinically diagnosed 4R tauopathies, using 18F‐PI‐2620 PET and 18F‐GE180 (translocator protein [TSPO]) PET. We determined tau epicenters, defined as subcortical brain regions with highest tau PET signal, and assessed the connectivity of tau epicenters to cortical regions of interest using a 3‐T resting‐state functional magnetic resonance imaging template derived from age‐matched healthy elderly controls. Results: In 4R tauopathy patients, we found that higher regional tau PET covaries with elevated TSPO‐PET across brain regions that are functionally connected to each other (β = 0.414, P < 0.001). Microglial activation follows similar distribution patterns as tau and distributes primarily across brain regions strongly connected to patient‐specific tau epicenters (β = −0.594, P < 0.001). In these regions, microglial activation spatially parallels tau distribution detectable with 18F‐PI‐2620 PET. Conclusions: Our findings indicate that the spatial expansion of microglial activation parallels tau distribution across brain regions that are functionally connected to each other, suggesting that tau and inflammation are closely interrelated in patients with 4R tauopathies. The combination of in vivo tau and inflammatory biomarkers could therefore support the development of immunomodulatory strategies for disease‐modifying treatments in these conditions. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Neuronal and oligodendroglial but not astroglial tau translates to in vivo tau-PET signals in primary tauopathies

Author

Slemann, Luna, primary, Gnorich, Johannes, additional, Hummel, Selina, additional, Bartos, Laura M., additional, Klaus, Carolin, additional, Kling, Agnes, additional, Kusche-Palenga, Julia, additional, Kunte, Sebastian T., additional, Kunze, Lea H., additional, Englert, Amelie L., additional, Li, Yunlei, additional, Vogler, Letizia, additional, Katzdobler, Sabrina, additional, Palleis, Carla, additional, Bernhardt, Alexander, additional, Jäck, Alexander, additional, Zwergal, Andreas, additional, Hopfner, Franziska, additional, Romer, Sebastian, additional, Biechele, Gloria, additional, Stocklein, Sophia, additional, Bischof, Gerard, additional, van Eimeren, Thilo, additional, Drzezga, Alexander, additional, Sabri, Osama, additional, Barthel, Henryk, additional, Respondek, Gesine, additional, Grimmer, Timo, additional, Levin, Johannes, additional, Herms, Jochen, additional, Paeger, Lars, additional, Willroider, Marie, additional, Beyer, Leonie, additional, Hoglinger, Gunter U., additional, Roeber, Sigrun, additional, Franzmeier, Nicolai, additional, and Brendel, Matthias, additional

Published
2024
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20. Biomarker interplay between CSF p‐tau and 18F‐PI‐2620 PET in Alzheimer’s disease and 4R‐tauopathy

Author

Dilcher, Roxane, primary, Wall, Stephan, additional, Franzmeier, Nicolai, additional, Katzdobler, Sabrina, additional, Barthel, Henryk, additional, Wagemann, Olivia, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Fietzek, Urban, additional, Kurz, Carolin Isabella, additional, Ferschmann, Chrsitian, additional, Scheifele, Maximilian, additional, Eckenweber, Florian, additional, Zaganjori, Mirlind, additional, Gnörich, Johannes, additional, Danek, Adrian, additional, Bürger, Katharina, additional, Janowitz, Daniel, additional, Rauchmann, Boris‐Stephan, additional, Stöcklein, Sophia, additional, Perneczky, Robert, additional, Schoeberl, Florian, additional, Zwergal, Andreas, additional, Höglinger, Günter, additional, Bartenstein, Peter, additional, Villemagne, Victor L, additional, Seibyl, John, additional, Sabri, Osama, additional, Levin, Johannes, additional, and Brendel, Matthias, additional

Published
2023
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21. Prognostic value of Neurofilament light chain, [18F]‐PI2620 PET and [18F]GE‐180‐PET in amyloid‐negative Corticobasal Syndrome

Author

Palleis, Carla, primary, Franzmeier, Nicolai, additional, Weidinger, Endy, additional, Bernhardt, Alexander, additional, Katzdobler, Sabrina, additional, Finze, Anika, additional, Nuscher, Brigitte, additional, Rauchmann, Boris‐Stephan, additional, Perneczky, Robert, additional, Haass, Christian, additional, Brendel, Matthias, additional, Levin, Johannes, additional, and Höglinger, Günter, additional

Published
2023
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22. Value of blood‐based biomarkers for differential diagnosis of Alzheimer’s disease: the ActiGliA cohort

Author

Kurz, Carolin Isabella, primary, Carli, Laura, additional, Guersel, Selim Üstün, additional, Schrurs, Isabelle, additional, Jethwa, Alexander, additional, Carboni, Margherita, additional, Bittner, Tobias, additional, Rauchmann, Boris‐Stephan, additional, Brendel, Matthias, additional, Burow, Lena, additional, Haeckert, Jan, additional, Tato, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Pogarell, Oliver Michael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Stöcklein, Sophia, additional, Haass, Christian, additional, Levin, Johannes, additional, Höglinger, Günter, additional, and Perneczky, Robert, additional

Published
2023
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23. Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

Author

Beyer, Leonie, Nitschmann, Alexander, Barthel, Henryk, van Eimeren, Thilo, Unterrainer, Marcus, Sauerbeck, Julia, Marek, Ken, Song, Mengmeng, Palleis, Carla, Respondek, Gesine, Hammes, Jochen, Barbe, Michael T., Onur, Özgür, Jessen, Frank, Saur, Dorothee, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael, Schildan, Andreas, Patt, Marianne, Neumaier, Bernd, Barret, Olivier, Madonia, Jennifer, Russell, David S., Stephens, Andrew W., Roeber, Sigrun, Herms, Jochen, Bötzel, Kai, Levin, Johannes, Classen, Joseph, Höglinger, Günter U., Bartenstein, Peter, Villemagne, Victor, Drzezga, Alexander, Seibyl, John, Sabri, Osama, and Brendel, Matthias

Published
2020
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24. Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission

Author

Stockbauer, Anna, primary, Beyer, Leonie, additional, Huber, Maria, additional, Kreuzer, Annika, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Rauchmann, Boris-Stephan, additional, Morbelli, Silvia, additional, Chincarini, Andrea, additional, Bruffaerts, Rose, additional, Vandenberghe, Rik, additional, Kramberger, Milica G., additional, Trost, Maja, additional, Garibotto, Valentina, additional, Nicastro, Nicolas, additional, Lathuilière, Aurélien, additional, Lemstra, Afina W., additional, van Berckel, Bart N. M., additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Ochoa-Figueroa, Miguel A., additional, Davidsson, Anette, additional, Camacho, Valle, additional, Peira, Enrico, additional, Bauckneht, Matteo, additional, Pardini, Matteo, additional, Sambuceti, Gianmario, additional, Aarsland, Dag, additional, Nobili, Flavio, additional, Gross, Mattes, additional, Vöglein, Jonathan, additional, Perneczky, Robert, additional, Pogarell, Oliver, additional, Buerger, Katharina, additional, Franzmeier, Nicolai, additional, Danek, Adrian, additional, Levin, Johannes, additional, Höglinger, Günter U., additional, Bartenstein, Peter, additional, Cumming, Paul, additional, Rominger, Axel, additional, and Brendel, Matthias, additional

Published
2023
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25. Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Author

Biechele, Gloria, primary, Rauchmann, Boris-Stephan, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Franzmeier, Nicolai, additional, Weidinger, Endy, additional, Guersel, Selim, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Harris, Stefanie, additional, Lindner, Simon, additional, Albert, Nathalie L., additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Burow, Lena, additional, Kurz, Carolin, additional, Zaganjori, Mirlind, additional, Trappmann, Lena-Katharina, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Haeckert, Jan, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Morenas-Rodriguez, Estrella, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Höglinger, Günter U., additional, Simons, Mikael, additional, Perneczky, Robert, additional, and Brendel, Matthias, additional

Published
2023
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26. 17 Biomarker interplay between CSF p-tau and18F-PI-2620 PET in Alzheimer’s disease and 4R-tauopathy

Author

Dilcher, Roxane, primary, Wall, Stephan, additional, Franzmeier, Nicolai, additional, Katzdobler, Sabrina, additional, Barthel, Henryk, additional, Wagemann, Olivia, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Fietzek, Urban, additional, Kurz, Carolin, additional, Ferschmann, Christian, additional, Scheifele, Maximilian, additional, Eckenweber, Florian, additional, Zaganjori, Mirlind, additional, Gnörich, Johannes, additional, Danek, Adrian, additional, Bürger, Katharina, additional, Janowitz, Daniel, additional, Rauchmann, Boris-Stephan, additional, Stöcklein, Sophia, additional, Perneczky, Robert, additional, Schöberl, Florian, additional, Zwergal, Andreas, additional, Höglinger, Günter, additional, Bartenstein, Peter, additional, Villemagne, Victor, additional, Seibyl, John, additional, Sabri, Osama, additional, Levin, Johannes, additional, and Brendel, Matthias, additional

Published
2023
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27. A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases

Author

Bernhardt, Alexander M., primary, Tiedt, Steffen, additional, Teupser, Daniel, additional, Dichgans, Martin, additional, Meyer, Bernhard, additional, Gempt, Jens, additional, Kuhn, Peer-Hendrik, additional, Simons, Mikael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Nübling, Georg, additional, Holdt, Lesca, additional, Hönikl, Lisa, additional, Gasperi, Christiane, additional, Giesbertz, Pieter, additional, Müller, Stephan A., additional, Breimann, Stephan, additional, Lichtenthaler, Stefan F., additional, Kuster, Bernhard, additional, Mann, Matthias, additional, Imhof, Axel, additional, Barth, Teresa, additional, Hauck, Stefanie M., additional, Zetterberg, Henrik, additional, Otto, Markus, additional, Weichert, Wilko, additional, Hemmer, Bernhard, additional, and Levin, Johannes, additional

Published
2023
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28. A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases

Author

Bernhardt, Alexander M., Tiedt, Steffen, Teupser, Daniel, Dichgans, Martin, Meyer, Bernhard, Gempt, Jens, Kuhn, Peer Hendrik, Simons, Mikael, Palleis, Carla, Weidinger, Endy, Nübling, Georg, Holdt, Lesca, Hönikl, Lisa, Gasperi, Christiane, Giesbertz, Pieter, Müller, Stephan A., Breimann, Stephan, Lichtenthaler, Stefan F., Kuster, Bernhard, Mann, Matthias, Imhof, Axel, Barth, Teresa, Hauck, Stefanie M., Zetterberg, Henrik, Otto, Markus, Weichert, Wilko, Hemmer, Bernhard, Levin, Johannes, Bernhardt, Alexander M., Tiedt, Steffen, Teupser, Daniel, Dichgans, Martin, Meyer, Bernhard, Gempt, Jens, Kuhn, Peer Hendrik, Simons, Mikael, Palleis, Carla, Weidinger, Endy, Nübling, Georg, Holdt, Lesca, Hönikl, Lisa, Gasperi, Christiane, Giesbertz, Pieter, Müller, Stephan A., Breimann, Stephan, Lichtenthaler, Stefan F., Kuster, Bernhard, Mann, Matthias, Imhof, Axel, Barth, Teresa, Hauck, Stefanie M., Zetterberg, Henrik, Otto, Markus, Weichert, Wilko, Hemmer, Bernhard, and Levin, Johannes

Abstract

A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi)genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical validity across disease entities and that sufficient evidence for many clinical applications of protein biomarkers is lacking. Our framework may help to identify promising biomarker candidates and classify their applications by clinical context, aiming for routine clinical use of (protein) biomarkers in neurology.

Published
2023

31. Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings

Author

Völter, Friederike, primary, Beyer, Leonie, additional, Eckenweber, Florian, additional, Scheifele, Maximilian, additional, Bui, Ngoc, additional, Patt, Marianne, additional, Barthel, Henryk, additional, Katzdobler, Sabrina, additional, Palleis, Carla, additional, Franzmeier, Nicolai, additional, Levin, Johannes, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Sabri, Osama, additional, Hong, Jimin, additional, Cumming, Paul, additional, Rominger, Axel, additional, Shi, Kuangyu, additional, Bartenstein, Peter, additional, and Brendel, Matthias, additional

Published
2022
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32. Subcortical tau‐accumulation predicts neuronal dysfunction in the cortex based on functional connectivity in 4R‐tauopathies

Author

Roemer, Sebastian Niclas, primary, Franzmeier, Nicolai, additional, Katzdobler, Sabrina, additional, Nitschmann, Alexander, additional, Barthel, Henryk, additional, Bischof, Gerard N, additional, Beyer, Leonie, additional, Marek, Ken, additional, Song, Mengmeng, additional, Wagemann, Olivia, additional, Palleis, Carla, additional, Nack, Anne, additional, Fietzek, Urban, additional, Kurz, Carolin, additional, Haeckert, Jan, additional, Stapf, Theresa, additional, Ferschmann, Chrsitian, additional, Scheifele, Maximilian, additional, Eckenweber, Florian, additional, Biechele, Gloria, additional, Biel, Davina, additional, Dewenter, Anna, additional, Steward, Anna, additional, Schoenecker, Sonja, additional, Saur, Dorothee, additional, Schroeter, Matthias L., additional, Rumpf, Jost‐Julian, additional, Rullmann, Michael, additional, Schildan, Andreas, additional, Patt, Marianne, additional, Stephens, Andrew W, additional, van Eimeren, Thilo, additional, Drzezga, Alexander, additional, Danek, Adrian, additional, Classen, Joseph, additional, Bürger, Katharina, additional, Janowitz, Daniel, additional, Rauchmann, Boris‐Stephan, additional, Stöcklein, Sophia, additional, Perneczky, Robert, additional, Schoeberl, Florian, additional, Zwergal, Andreas, additional, Bartenstein, Peter, additional, Neumaier, Bernd, additional, Villemagne, Victor L, additional, Seibyl, John, additional, Sabri, Osama, additional, Ewers, Michael, additional, Levin, Johannes, additional, Brendel, Matthias, additional, and Höglinger, Günter, additional

Published
2022
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33. First‐in‐human [ 18 F]D2‐Deprenyl‐PET imaging and GFAP evaluation as biomarkers of reactive astrogliosis in neurodegenerative diseases

Author

Katzdobler, Sabrina, primary, Vogler, Letizia, additional, Eckenweber, Florian, additional, Nübling, Georg, additional, Palleis, Carla, additional, Lindner, Simon, additional, Fietzek, Urban, additional, Nuscher, Brigitte, additional, Mueller, Andre, additional, Koglin, Norman, additional, Stephens, Andrew W, additional, Haass, Christian, additional, Brendel, Matthias, additional, and Levin, Johannes, additional

Published
2022
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34. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Author

Finze, Anika, primary, Biechele, Gloria, additional, Rauchmann, Boris-Stephan, additional, Franzmeier, Nicolai, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Weidinger, Endy, additional, Guersel, Selim, additional, Schuster, Sebastian, additional, Harris, Stefanie, additional, Schmitt, Julia, additional, Beyer, Leonie, additional, Gnörich, Johannes, additional, Lindner, Simon, additional, Albert, Nathalie L., additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Danek, Adrian, additional, Burow, Lena, additional, Kurz, Carolin, additional, Tato, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Zaganjori, Mirlind, additional, Trappmann, Lena-Katharina, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Haeckert, Jan, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Morenas-Rodriguez, Estrella, additional, Barthel, Henryk, additional, Sabri, Osama, additional, Bartenstein, Peter, additional, Simons, Mikael, additional, Haass, Christian, additional, Höglinger, Günter U., additional, Levin, Johannes, additional, Perneczky, Robert, additional, and Brendel, Matthias, additional

Published
2022
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35. Neuronal injury assessment with early-phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol β-amyloid-PET recordings

Author

Völter, Friederike, primary, Beyer, Leonie, additional, Eckenweber, Florian, additional, Scheifele, Maximilian, additional, Bui, Ngoc, additional, Patt, Marianne, additional, Barthel, Henryk, additional, Katzdobler, Sabrina, additional, Palleis, Carla, additional, Franzmeier, Nicolai, additional, Levin, Johannes, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Sabri, Osama, additional, Hong, Jimin, additional, Cumming, Paul, additional, Rominger, Axel, additional, Shi, Kuanyu, additional, Bartenstein, Peter, additional, and Brendel, Matthias, additional

Published
2022
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36. Biomarker interplay between CSF p‐tau and 18F‐PI‐2620 PET in Alzheimer's disease and 4R‐tauopathy.

Author

Dilcher, Roxane, Wall, Stephan, Franzmeier, Nicolai, Katzdobler, Sabrina, Barthel, Henryk, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Fietzek, Urban, Kurz, Carolin Isabella, Ferschmann, Chrsitian, Scheifele, Maximilian, Eckenweber, Florian, Zaganjori, Mirlind, Gnörich, Johannes, Danek, Adrian, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris‐Stephan, and Stöcklein, Sophia

Abstract

Background: Reliable biomarkers for detecting different abnormal tau protein isoforms between neurodegenerative diseases are currently missing. Phosphorylated tau (p‐tau) in the cerebrospinal fluid (CSF) is acknowledged as a 3/4R tau biomarker in AD but not in other tauopathies. The positron emission tomography (PET) radiotracer 18F‐PI‐2620 has the potential to detect abnormal 3/4R‐tau in patients with Alzheimer's disease (AD) and 4R‐tau in Progressive Supranuclear Palsy (PSP) or Corticobasal Syndrome (CBS). This study investigates the interplay between tau‐PET and CSF p‐tau in AD and 4R‐tauopathies. Method: In this cross‐sectional analysis, 52 patients with AD, 54 patients with PSP/CBS, and 11 controls underwent lumbar puncture and 0‐60 min dynamic 18F‐PI‐2620 PET scanning. Independent t‐tests assessed group differences in standardized uptake value ratios for the 20‐40min time window (SUVr20‐40) and p‐Tau. Quantitative and voxel‐wise multiple regression analyses tested the association between SUVr20‐40 and p‐tau and group interactions, using R and SPM and controlling for age and sex. ROC analyses were performed to evaluate biomarker performance in differentiating patient groups. Result: Patients with AD showed elevated CSF p‐tau levels (p<0.05; >61 pg/ml) and SUVr20‐40 in temporal, parietal, occipital, frontal, cingulate‐insula, striatum, and amygdala (p<0.05). In patients with AD the two biomarkers correlated positively (p<0.05). Patients with clinically suspected 4R‐tauopathies did not show elevated p‐tau levels but demonstrated high tau‐PET uptake in the lentiform nucleus (p<0.05), compared to controls and AD. ROC analyses showed that temporal SUVr20‐40 (87.3%) and p‐tau levels (80.8%) were able to differentiate AD from 4R‐tauopathies, while the lentiform nucleus tau‐PET showed moderate performance at discriminated patients with 4R‐tau from those with AD (56.7%) and healthy controls (66.3%). Interestingly, the AUC increased to 70%, when excluding patients with CBS. Conclusion: The specific combination of CSF p‐tau levels and 18F‐PI‐2620 PET SUVR in disease‐specific regions facilitates biomarker‐guided stratification of AD and clinically suspected 4R‐tauopathies. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Microglial Activation and Connectivity in Alzheimer Disease and Aging

Author

Rauchmann, Boris‐Stephan, primary, Brendel, Matthias, additional, Franzmeier, Nicolai, additional, Trappmann, Lena, additional, Zaganjori, Mirlind, additional, Ersoezlue, Ersin, additional, Morenas‐Rodriguez, Estrella, additional, Guersel, Selim, additional, Burow, Lena, additional, Kurz, Carolin, additional, Haeckert, Jan, additional, Tatò, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Pogarell, Oliver, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Ewers, Michael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Biechele, Gloria, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Eckenweber, Florian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Höglinger, Günter, additional, and Perneczky, Robert, additional

Published
2022
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38. Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings.

Author

Völter, Friederike, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bui, Ngoc, Patt, Marianne, Barthel, Henryk, Katzdobler, Sabrina, Palleis, Carla, Franzmeier, Nicolai, Levin, Johannes, Perneczky, Robert, Rauchmann, Boris-Stephan, Sabri, Osama, Hong, Jimin, Cumming, Paul, Rominger, Axel, Shi, Kuangyu, Bartenstein, Peter, and Brendel, Matthias

Subjects
POSITRON emission tomography computed tomography, AMYLOID, NEURODEGENERATION, PERFUSION, STATISTICAL correlation
Abstract

Purpose: Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can serve for the A/T/N classification of neurodegenerative diseases. Recent studies showed that the early, perfusion-weighted phases of amyloid- or tau-PET recordings serve to detect cerebrometabolic deficits equally to FDG-PET, therefore providing a surrogate of neuronal injury. As such, two channels of diagnostic information can be obtained in the setting of a single PET scan. However, there has hitherto been no comparison of early-phase amyloid- and tau-PET as surrogates for deficits in perfusion/metabolism. Therefore, we undertook to compare [18F]flutemetamol-amyloid-PET and [18F]PI-2620 tau-PET as "one-stop shop" dual purpose tracers for the detection of neurodegenerative disease. Methods: We obtained early-phase PET recordings with [18F]PI-2620 (0.5–2.5 min p.i.) and [18F]flutemetamol (0–10 min p.i.) in 64 patients with suspected neurodegenerative disease. We contrasted global mean normalized images (SUVr) in the patients with a normal cohort of 15 volunteers without evidence of increased pathology to β-amyloid- and tau-PET examinations. Regional group differences of tracer uptake (z-scores) of 246 Brainnetome volumes of interest were calculated for both tracers, and the correlations of the z-scores were evaluated using Pearson's correlation coefficient. Lobar compartments, regions with significant neuronal injury (z-scores < − 3), and patients with different neurodegenerative disease entities (e.g., Alzheimer's disease or 4R-tauopathies) served for subgroup analysis. Additionally, we used partial regression to correlate regional perfusion alterations with clinical scores in cognition tests. Results: The z-scores of perfusion-weighted images of both tracers showed high correlations across the brain, especially in the frontal and parietal lobes, which were the brain regions with pronounced perfusion deficit in the patient group (R = 0.83 ± 0.08; range, 0.61–0.95). Z-scores of individual patients correlated well by region (R = 0.57 ± 0.15; range, 0.16–0.90), notably when significant perfusion deficits were present (R = 0.66 ± 0.15; range, 0.28–0.90). Conclusion: The early perfusion phases of [18F]PI-2620 tau- and [18F]flutemetamol-amyloid-PET are roughly equivalent indices of perfusion defect indicative of regional and lobar neuronal injury in patients with various neurodegenerative diseases. As such, either tracer may serve for two diagnostic channels by assessment of amyloid/tau status and neuronal activity. [ABSTRACT FROM AUTHOR]

Published
2023
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39. 18F-PI-2620 Tau PET Improves the Imaging Diagnosis of Progressive Supranuclear Palsy

Author

Messerschmidt, Konstantin, primary, Barthel, Henryk, additional, Brendel, Matthias, additional, Scherlach, Cordula, additional, Hoffmann, Karl-Titus, additional, Rauchmann, Boris-Stephan, additional, Rullmann, Michael, additional, Marek, Kenneth, additional, Villemagne, Victor L., additional, Rumpf, Jost-Julian, additional, Saur, Dorothee, additional, Schroeter, Matthias L., additional, Schildan, Andreas, additional, Patt, Marianne, additional, Beyer, Leonie, additional, Song, Mengmeng, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Fietzek, Urban M., additional, Respondek, Gesine, additional, Scheifele, Maximilian, additional, Nitschmann, Alexander, additional, Zach, Christian, additional, Barret, Olivier, additional, Madonia, Jennifer, additional, Russell, David, additional, Stephens, Andrew W, additional, Koglin, Norman, additional, Roeber, Sigrun, additional, Herms, Jochen, additional, Boetzel, Kai, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Seibyl, John P., additional, Höglinger, Günter, additional, Classen, Joseph, additional, and Sabri, Osama, additional

Published
2022
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40. MRI connectivity-based spread of microglial activation in early Alzheimer's disease

Author

Rauchmann, Boris-Stephan, primary, Brendel, Matthias, additional, Franzmeier, Nicolai, additional, Trappmann, Lena, additional, Zaganjori, Mirlind, additional, Morenas-Rodriguez, Estrella, additional, Guersel, Selim, additional, Burow, Lena, additional, Kurz, Carolin, additional, Haeckert, Jan, additional, Tato, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Pogarell, Oliver, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Ewers, Michael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Biechele, Gloria, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Eckenweber, Florian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Hoeglinger, Guenter, additional, and Perneczky, Robert, additional

Published
2022
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41. Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome

Author

Schuster, Sebastian, primary, Beyer, Leonie, additional, Palleis, Carla, additional, Harris, Stefanie, additional, Schmitt, Julia, additional, Weidinger, Endy, additional, Prix, Catharina, additional, Bötzel, Kai, additional, Danek, Adrian, additional, Rauchmann, Boris-Stephan, additional, Stöcklein, Sophia, additional, Lindner, Simon, additional, Unterrainer, Marcus, additional, Albert, Nathalie L., additional, Mittlmeier, Lena M., additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Bartenstein, Peter, additional, Perneczky, Robert, additional, Levin, Johannes, additional, Höglinger, Günter U., additional, Brendel, Matthias, additional, and Dekorsy, Franziska J., additional

Published
2022
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42. Additive value of [18F]PI-2620 perfusion imaging in four-repeat tauopathies

Author

Katzdobler, Sabrina, primary, Nitschmann, Alexander, additional, Barthel, Henryk, additional, Bischof, Gerard, additional, Beyer, Leonie, additional, Marek, Ken, additional, Song, Mengmeng, additional, Wagemann, Olivia, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Nack, Anne, additional, Fietzek, Urban, additional, Kurz, Carolin, additional, Häckert, Jan, additional, Stapf, Theresa, additional, Ferschmann, Christian, additional, Scheifele, Maximilian, additional, Eckenweber, Florian, additional, Biechele, Gloria, additional, Franzmeier, Nicolai, additional, Dewenter, Anna, additional, Schönecker, Sonja, additional, Saur, Dorothee, additional, Schroeter, Matthias L., additional, Rumpf, Jost-Julian, additional, Rullmann, Michael, additional, Schildan, Andreas, additional, Patt, Marianne, additional, Stephens, Andrew W., additional, van, Thilo Eimeren, additional, Neumaier, Bernd, additional, Drzezga, Alexander, additional, Danek, Adrian, additional, Classen, Joseph, additional, Bürger, Katharina, additional, Janowitz, Daniel, additional, Rauchmann, Boris-Stephan, additional, Stöcklein, Sophia, additional, Perneczky, Robert, additional, Schöberl, Florian, additional, Zwergal, Andreas, additional, Höglinger, Günter U., additional, Bartenstein, Peter, additional, Villemagne, Victor, additional, Seibyl, John, additional, Sabri, Osama, additional, Levin, Johannes, additional, and Brendel, Matthias, additional

Published
2022
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44. Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation

Author

Kolabas, Zeynep Ilgin, primary, Kuemmerle, Louis B., additional, Perneczky, Robert, additional, Förstera, Benjamin, additional, Büttner, Maren, additional, Caliskan, Ozum Sehnaz, additional, Ali, Mayar, additional, Rong, Zhouyi, additional, Mai, Hongcheng, additional, Hummel, Selina, additional, Bartos, Laura M., additional, Biechele, Gloria, additional, Zatcepin, Artem, additional, Albert, Natalie L., additional, Unterrainer, Marcus, additional, Gnörich, Johannes, additional, Zhao, Shan, additional, Khalin, Igor, additional, Rauchmann, Boris-Stephan, additional, Molbay, Muge, additional, Sterr, Michael, additional, Kunze, Ines, additional, Stanic, Karen, additional, Besson-Girard, Simon, additional, Kopczak, Anna, additional, Katzdobler, Sabrina, additional, Palleis, Carla, additional, Gokce, Ozgun, additional, Lickert, Heiko, additional, Steinke, Hanno, additional, Bechmann, Ingo, additional, Buerger, Katharina, additional, Levin, Johannes, additional, Haass, Christian, additional, Dichgans, Martin, additional, Havla, Joachim, additional, Kümpfel, Tania, additional, Kerschensteiner, Martin, additional, Simons, Mikael, additional, Plesnila, Nikolaus, additional, Krahmer, Natalie, additional, Bhatia, Harsharan Singh, additional, Erener, Suheda, additional, Hellal, Farida, additional, Brendel, Matthias, additional, Theis, Fabian J., additional, and Erturk, Ali, additional

Published
2021
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45. Associations between sex, body mass index, and the individual microglial response in Alzheimer’s disease

Author

Biechele, Gloria, primary, Rauchmann, Boris‐Stephan, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Franzmeier, Nicolai, additional, Weidinger, Endy, additional, Guersel, Selim, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Harris, Stefanie, additional, Schmitt, Julia, additional, Beyer, Leonie, additional, Lindner, Simon, additional, Unterrainer, Marcus, additional, Eckenweber, Florian, additional, Albert, Nathalie L, additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Danek, Adrian, additional, Burow, Lena, additional, Kurz, Carolin, additional, Zaganjori, Mirlind, additional, Trappmann, Lena‐Katharina, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Haeckert, Jan, additional, Keeser, Daniel, additional, Stöcklein, Sophia, additional, Morenas‐Rodríguez, Estrella, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Höglinger, Günter, additional, Simons, Mikael, additional, Haass, Christian, additional, Perneczky, Robert, additional, and Brendel, Matthias, additional

Published
2021
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46. Tau spreads across connected brain regions in progressive supranuclear palsy and corticobasal syndrome

Author

Franzmeier, Nicolai, primary, Brendel, Matthias, additional, Beyer, Leonie, additional, Arzberger, Thomas, additional, Kovacs, Gabor G., additional, Rubinski, Anna, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Finze, Anika, additional, Song, Mengmeng, additional, Biechele, Gloria, additional, Kern, Maike, additional, Scheifele, Maximilian, additional, Rauchmann, Boris‐Stephan, additional, Perneczky, Robert, additional, Rullmann, Michael, additional, Schildan, Andreas, additional, Barthel, Henryk, additional, Sabri, Osama, additional, Classen, Joseph, additional, Lukic, Milica J., additional, Irwin, David J., additional, Lee, Eddie B., additional, Coughlin, David, additional, Giese, Armin, additional, Grossman, Murray, additional, Kurz, Carolin, additional, McMillan, Corey T., additional, Gelpi, Ellen, additional, Compta, Yaroslau, additional, Swieten, John C., additional, Troakes, Claire, additional, Al‐Sarraj, Safa, additional, Roeber, Sigrun, additional, Xie, Sharon X., additional, Lee, Virginia M‐Y, additional, Herms, Jochen, additional, Bartenstein, Peter, additional, Haass, Christian, additional, Dichgans, Martin, additional, Trojanowski, John Q., additional, Levin, Johannes, additional, Höglinger, Günter, additional, and Ewers, Michael, additional

Published
2021
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47. Feasibility of short imaging protocols for [ 18 F]PI‐2620 tau‐PET in progressive supranuclear palsy

Author

Song, Mengmeng, primary, Scheifele, Maximilian, additional, Barthel, Henryk, additional, van Eimeren, Thilo, additional, Beyer, Leonie, additional, Marek, Ken, additional, Eckenweber, Florian, additional, Palleis, Carla, additional, Finze, Anika, additional, Kaiser, Lena, additional, Kern, Maike, additional, Nitschmann, Alexander, additional, Biechele, Gloria, additional, Katzdobler, Sabrina, additional, Bischof, Gerard N, additional, Hammes, Jochen, additional, Jessen, Frank, additional, Saur, Dorothee, additional, Schroeter, Matthias L., additional, Rumpf, Jost‐Julian, additional, Rullmann, Michael, additional, Schildan, Andreas, additional, Patt, Marianne, additional, Neumaier, Bernd, additional, Stephens, Andrew W, additional, Rauchmann, Boris‐Stephan, additional, Perneczky, Robert, additional, Levin, Johannes, additional, Classen, Joseph, additional, Höglinger, Günter, additional, Bartenstein, Peter, additional, Boening, Guido, additional, Ziegler, Sibylle, additional, Villemagne, Victor L L, additional, Drzezga, Alexander, additional, Seibyl, John P, additional, Sabri, Osama, additional, and Brendel, Matthias, additional

Published
2021
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48. Additive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome.

Author

Katzdobler, Sabrina, Nitschmann, Alexander, Barthel, Henryk, Bischof, Gerard, Beyer, Leonie, Marek, Ken, Song, Mengmeng, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Nack, Anne, Fietzek, Urban, Kurz, Carolin, Häckert, Jan, Stapf, Theresa, Ferschmann, Christian, Scheifele, Maximilian, Eckenweber, Florian, Biechele, Gloria, and Franzmeier, Nicolai

Subjects
PROGRESSIVE supranuclear palsy, PERFUSION imaging, NEURODEGENERATION, BIOMARKERS, TAU proteins
Abstract

Purpose: Early after [18F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [18F]PI-2620 tau-PET is able to discriminate the 4-repeat tauopathies progressive supranuclear palsy and corticobasal syndrome (4RTs) from disease controls and healthy controls. Here, we investigated whether early-phase [18F]PI-2620 PET has an additive value for biomarker based evaluation of 4RTs. Methods: Seventy-eight patients with 4RTs (71 ± 7 years, 39 female), 79 patients with other neurodegenerative diseases (67 ± 12 years, 35 female) and twelve age-matched controls (69 ± 8 years, 8 female) underwent dynamic (0–60 min) [18F]PI-2620 PET imaging. Regional perfusion (0.5–2.5 min p.i.) and tau load (20–40 min p.i.) were measured in 246 predefined brain regions [standardized-uptake-value ratios (SUVr), cerebellar reference]. Regional SUVr were compared between 4RTs and controls by an ANOVA including false-discovery-rate (FDR, p < 0.01) correction. Hypoperfusion in resulting 4RT target regions was evaluated at the patient level in all patients (mean value − 2SD threshold). Additionally, perfusion and tau pattern expression levels were explored regarding their potential discriminatory value of 4RTs against other neurodegenerative disorders, including validation in an independent external dataset (n = 37), and correlated with clinical severity in 4RTs (PSP rating scale, MoCA, activities of daily living). Results: Patients with 4RTs had significant hypoperfusion in 21/246 brain regions, most dominant in thalamus, caudate nucleus, and anterior cingulate cortex, fitting to the topology of the 4RT disease spectrum. However, single region hypoperfusion was not specific regarding the discrimination of patients with 4RTs against patients with other neurodegenerative diseases. In contrast, perfusion pattern expression showed promise for discrimination of patients with 4RTs from other neurodegenerative diseases (AUC: 0.850). Discrimination by the combined perfusion-tau pattern expression (AUC: 0.903) exceeded that of the sole tau pattern expression (AUC: 0.864) and the discriminatory power of the combined perfusion-tau pattern expression was replicated in the external dataset (AUC: 0.917). Perfusion but not tau pattern expression was associated with PSP rating scale (R = 0.402; p = 0.0012) and activities of daily living (R = − 0.431; p = 0.0005). Conclusion: [18F]PI-2620 perfusion imaging mirrors known topology of regional hypoperfusion in 4RTs. Single region hypoperfusion is not specific for 4RTs, but perfusion pattern expression may provide an additive value for the discrimination of 4RTs from other neurodegenerative diseases and correlates closer with clinical severity than tau pattern expression. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

Author

Xiang, Xianyuan, primary, Wind, Karin, additional, Wiedemann, Thomas, additional, Blume, Tanja, additional, Shi, Yuan, additional, Briel, Nils, additional, Beyer, Leonie, additional, Biechele, Gloria, additional, Eckenweber, Florian, additional, Zatcepin, Artem, additional, Lammich, Sven, additional, Ribicic, Sara, additional, Tahirovic, Sabina, additional, Willem, Michael, additional, Deussing, Maximilian, additional, Palleis, Carla, additional, Rauchmann, Boris-Stephan, additional, Gildehaus, Franz-Josef, additional, Lindner, Simon, additional, Spitz, Charlotte, additional, Franzmeier, Nicolai, additional, Baumann, Karlheinz, additional, Rominger, Axel, additional, Bartenstein, Peter, additional, Ziegler, Sibylle, additional, Drzezga, Alexander, additional, Respondek, Gesine, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Levin, Johannes, additional, Höglinger, Günter U., additional, Herms, Jochen, additional, Haass, Christian, additional, and Brendel, Matthias, additional

Published
2021
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50. Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome

Author

Schmitt, Julia, Palleis, Carla, Sauerbeck, Julia, Unterrainer, Marcus, Harris, Stefanie, Prix, Catharina, Weidinger, Endy, Katzdobler, Sabrina, Wagemann, Olivia, Danek, Adrian, Beyer, Leonie, Rauchmann, Boris-Stephan, Rominger, Axel, Simons, Mikael, Bartenstein, Peter, Perneczky, Robert, Haass, Christian, Levin, Johannes, Höglinger, Günter U, and Brendel, Matthias

Subjects
610 Medicine & health
Abstract

Objectives: In recent years several 18F-labeled amyloid PET (Aβ-PET) tracers have been developed and have obtained clinical approval. There is evidence that Aβ-PET perfusion can provide surrogate information about neuronal injury in neurodegenerative diseases when compared to conventional blood flow and glucose metabolism assessment. However, this paradigm has not yet been tested in neurodegenerative disorders with cortical and subcortical affection. Therefore, we investigated the performance of early acquisition 18F-flutemetamol Aβ-PET in comparison to 18F-fluorodeoxyglucose (FDG)-PET in corticobasal syndrome (CBS). Methods: Subjects with clinically possible or probable CBS were recruited within the prospective Activity of Cerebral Networks, Amyloid and Microglia in Aging and Alzheimer's Disease (ActiGliA) observational study and all CBS cases with an available FDG-PET prior to Aβ-PET were selected. Aβ-PET was acquired 0-10 min p.i. (early-phase) and 90-110 min p.i. (late-phase) whereas FDG-PET was recorded statically from 30 to 50 min p.i. Semiquantitative regional values and asymmetry indices (AI) were compared between early-phase Aβ-PET and FDG-PET. Visual assessments of hypoperfusion and hypometabolism were compared between both methods. Late-phase Aβ-PET was evaluated visually for assessment of Aβ-positivity. Results: Among 20 evaluated patients with CBS, 5 were Aβ-positive. Early-phase Aβ-PET and FDG-PET SUVr correlated highly in cortical (mean R = 0.86, range 0.77-0.92) and subcortical brain regions (mean R = 0.84, range 0.79-0.90). Strong asymmetry was observed in FDG-PET for the motor cortex (mean |AI| = 2.9%), the parietal cortex (mean |AI| = 2.9%), and the thalamus (mean |AI| = 5.5%), correlating well with AI of early-phase Aβ-PET (mean R = 0.87, range 0.62-0.98). Visual assessments of hypoperfusion and hypometabolism were highly congruent. Conclusion: Early-phase Aβ-PET facilitates assessment of neuronal injury in CBS for cortical and subcortical areas. Known asymmetries in CBS are captured by this method, enabling assessment of Aβ-status and neuronal injury with a single radiation exposure at a single visit.

Published
2021

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