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2. Long-term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real-world experience in Italy

Author

Gentile, Luca, Mazzeo, Anna, Briani, Chiara, Casagrande, Silvia, De Luca, Marcella, Fabrizi, Gian Maria, Gagliardi, Christian, Gemelli, Chiara, Forcina, Francesca, Grandis, Marina, Guglielmino, Valeria, Iabichella, Giacomo, Leonardi, Luca, Lozza, Alessandro, Manganelli, Fiore, Mussinelli, Roberta, My, Filomena, Occhipinti, Giuseppe, Fenu, Silvia, Russo, Massimo, Romano, Angela, Salvalaggio, Alessandro, Tagliapietra, Matteo, Tozza, Stefano, Palladini, Giovanni, Obici, Laura, and Luigetti, Marco

Published
2024
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3. Correction to: Long-term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real-world experience in Italy

Author

Gentile, Luca, Mazzeo, Anna, Briani, Chiara, Casagrande, Silvia, De Luca, Marcella, Fabrizi, Gian Maria, Gagliardi, Christian, Gemelli, Chiara, Forcina, Francesca, Grandis, Marina, Guglielmino, Valeria, Iabichella, Giacomo, Leonardi, Luca, Lozza, Alessandro, Manganelli, Fiore, Mussinelli, Roberta, My, Filomena, Occhipinti, Giuseppe, Fenu, Silvia, Russo, Massimo, Romano, Angela, Salvalaggio, Alessandro, Tagliapietra, Matteo, Tozza, Stefano, Palladini, Giovanni, Obici, Laura, and Luigetti, Marco

Published
2024
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4. Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

Author

Schulte, Tim, Chaves-Sanjuan, Antonio, Speranzini, Valentina, Sicking, Kevin, Milazzo, Melissa, Mazzini, Giulia, Rognoni, Paola, Caminito, Serena, Milani, Paolo, Marabelli, Chiara, Corbelli, Alessandro, Diomede, Luisa, Fiordaliso, Fabio, Anastasia, Luigi, Pappone, Carlo, Merlini, Giampaolo, Bolognesi, Martino, Nuvolone, Mario, Fernández-Busnadiego, Rubén, Palladini, Giovanni, and Ricagno, Stefano

Published
2024
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5. Healthcare Resource Utilization and Cost-of-Illness in Systemic Light Chain (AL) Amyloidosis in Europe: Results From the Real-World, Retrospective EMN23 Study

Author

Jaccard, Arnaud, Bridoux, Frank, Roeloffzen, Wilfried, Minnema, Monique C., Bergantim, Rui, Hájek, Roman, João, Cristina, Cibeira, M. Teresa, Palladini, Giovanni, Schönland, Stefan, Merlini, Giampaolo, Milani, Paolo, Dimopoulos, Meletios A., Ravichandran, Sriram, Hegenbart, Ute, Agis, Hermine, Gros, Blanca, Asra, Aisha, Magarotto, Valeria, Cheliotis, Giorgos, Psarros, Giorgos, Sonneveld, Pieter, Wechalekar, Ashutosh, and Kastritis, Efstathios

Published
2024
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6. The management of light chain (AL) amyloidosis in Europe: clinical characteristics, treatment patterns, and efficacy outcomes between 2004 and 2018

Author

Palladini, Giovanni, Schönland, Stefan, Merlini, Giampaolo, Milani, Paolo, Jaccard, Arnaud, Bridoux, Frank, Dimopoulos, Meletios A., Ravichandran, Sriram, Hegenbart, Ute, Roeloffzen, Wilfried, Cibeira, M. Teresa, Agis, Hermine, Minnema, Monique C., Bergantim, Rui, Hájek, Roman, João, Cristina, Leonidakis, Alexandros, Cheliotis, Giorgos, Sonneveld, Pieter, Kastritis, Efstathios, and Wechalekar, Ashutosh

Published
2023
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7. Prognostic impact of cytogenetic abnormalities detected by FISH in AL amyloidosis with daratumumab-based frontline therapy

Author

Chakraborty, Rajshekhar, Zanwar, Saurabh, Hegenbart, Ute, Bhutani, Divaya, Gertz, Morie A., Dispenzieri, Angela, Kumar, Shaji, D’Souza, Anita, Patwari, Anannya, Cowan, Andrew, Chen, GuiZhen, Milani, Paolo, Palladini, Giovanni, Sanchorawala, Vaishali, Bodanapu, Geethika, Schönland, Stefan O., Lentzsch, Suzanne, and Muchtar, Eli

Published
2024
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11. Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial

Author

Gertz, Morie A., Cohen, Adam D., Comenzo, Raymond L., Kastritis, Efstathios, Landau, Heather J., Libby, Edward N., Liedtke, Michaela, Sanchorawala, Vaishali, Schönland, Stefan, Wechalekar, Ashutosh, Zonder, Jeffrey A., Palladini, Giovanni, Walling, Jackie, Guthrie, Spencer, Nie, Christie, Karp, Carol, Jin, Yuying, Kinney, Gene G., and Merlini, Giampaolo

Published
2023
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12. Muscle quantitative MRI as a novel biomarker in hereditary transthyretin amyloidosis with polyneuropathy: a cross-sectional study

Author

Vegezzi, Elisa, Cortese, Andrea, Bergsland, Niels, Mussinelli, Roberta, Paoletti, Matteo, Solazzo, Francesca, Currò, Riccardo, Ascagni, Lucia, Callegari, Ilaria, Quartesan, Ilaria, Lozza, Alessandro, Deligianni, Xeni, Santini, Francesco, Marchioni, Enrico, Cosentino, Giuseppe, Alfonsi, Enrico, Tassorelli, Cristina, Bastianello, Stefano, Merlini, Giampaolo, Palladini, Giovanni, Obici, Laura, and Pichiecchio, Anna

Published
2023
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13. An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis

Author

Nevone, Alice, Girelli, Maria, Mangiacavalli, Silvia, Paiva, Bruno, Milani, Paolo, Cascino, Pasquale, Piscitelli, Maggie, Speranzini, Valentina, Cartia, Claudio Salvatore, Benvenuti, Pietro, Goicoechea, Ibai, Fazio, Francesca, Basset, Marco, Foli, Andrea, Nanci, Martina, Mazzini, Giulia, Caminito, Serena, Sesta, Melania Antonietta, Casarini, Simona, Rognoni, Paola, Lavatelli, Francesca, Petrucci, Maria Teresa, Olimpieri, Pier Paolo, Ricagno, Stefano, Arcaini, Luca, Merlini, Giampaolo, Palladini, Giovanni, and Nuvolone, Mario

Published
2022
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14. Renal alterations in cats (Felis catus) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features

Author

Ferri, Filippo, primary, Ferro, Silvia, additional, Lucia Benali, Silvia, additional, Aresu, Luca, additional, Muscardin, Lorenza, additional, Porporato, Federico, additional, Rossi, Francesco, additional, Guglielmetti, Chiara, additional, Gallo, Enrico, additional, Palizzotto, Carlo, additional, Callegari, Carolina, additional, Ricagno, Stefano, additional, Mazza, Maria, additional, Michele Coppola, Luigi, additional, Gerardi, Gabriele, additional, Lavatelli, Francesca, additional, Caminito, Serena, additional, Mazzini, Giulia, additional, Palladini, Giovanni, additional, Merlini, Giampaolo, additional, and Zini, Eric, additional

Published
2024
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16. Inclusion criteria of clinical trials select patients with AL amyloidosis with favorable outcome and exclude almost one half of the real-life population.

Author

Bellofiore, Claudia, primary, Basset, Marco, primary, Nanci, Martina, primary, Nuvolone, Mario, primary, Ciardo, Martina, primary, Damiano, Giuseppe, primary, Benigna, Francesca, primary, Mussinelli, Roberta, primary, Foli, Andrea, primary, Merlini, Giampaolo, primary, Palladini, Giovanni, primary, and Milani, Paolo, primary

Published
2024
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17. Prognostic impact of cytogenetic abnormalities by FISH in systemic AL amyloidosis in the era of daratumumab and bortezomib-based frontline combination regimens

Author

Chakraborty, Rajshekhar, primary, Zanwar, Saurabh, primary, Bhutani, Divaya, primary, Gertz, Morie, primary, Dispenzieri, Angela, primary, Kumar, Shaji, primary, D’Souza, Anita, primary, Patwari, Anannya, primary, Cowan, Andrew, primary, Chen, GuiZhen, primary, Hegenbart, Ute, primary, Schönland, Stefan, primary, Milani, Paolo, primary, Palladini, Giovanni, primary, Sanchorawala, Vaishali, primary, Bodanapu, Geethika, primary, Lentzsch, Suzanne, primary, and Muchtar, Eli, primary

Published
2024
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18. Proposed hematologic progression criterion in patients with AL amyloidosis.

Author

Palladini, Giovanni, primary, Hegenbart, Ute, primary, Milani, Paolo, primary, Bellofiore, Claudia, primary, Basset, Marco, primary, Benvenuti, Pietro, primary, Nanci, Martina, primary, Nuvolone, Mario, primary, Ciardo, Martina, primary, Damiano, Giuseppe, primary, Benigna, Francesca, primary, Mussinelli, Roberta, primary, Foli, Andrea, primary, Merlini, Giampaolo, primary, and Schönland, Stefan, primary

Published
2024
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19. Bone marrow-free sequencing of M protein genes: a liquid biopsy approach in monoclonal gammopathies

Author

Nevone, Alice, primary, Mazzini, Giulia, primary, SADEGHI, ARIAN, primary, Milani, Paolo, primary, Mangiacavalli, Silvia, primary, Melati, Anna, primary, Caminito, Serena, primary, Russo, Monica, primary, Lattarulo, Francesca, primary, Basset, Marco, primary, Salvatore, Claudio, primary, Benvenuti, Pietro, primary, Nanci, Martina, primary, Bellofiore, Claudia, primary, Foli, Andrea, primary, Merlini, Giampaolo, primary, Arcaini, Luca, primary, Palladini, Giovanni, primary, and Nuvolone, Mario, primary

Published
2024
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20. A phase II study of daratumumab and pomalidomide in previously treated patients with AL amyloidosis

Author

Milani, Paolo, primary, Annibali, Ombretta, primary, Basset, Marco, primary, Ciardo, Martina, primary, Nanci, Martina, primary, Nuvolone, Mario, primary, Mussinelli, Roberta, primary, Bellofiore, Claudia, primary, Tomarchio, Valeria, primary, Benvenuti, Pietro, primary, Damiano, Giuseppe, primary, Foli, Andrea, primary, Merlini, Giampaolo, primary, and Palladini, Giovanni, primary

Published
2024
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22. New reference ranges of free light chain ratio: impact on clinical practice in AL and ATTRwt amyloidosis

Author

Milani, Paolo, primary, Ciardo, Martina, primary, Basset, Marco, primary, Bellofiore, Claudia, primary, Nanci, Martina, primary, Mussinelli, Roberta, primary, Vetro, Martina, primary, Nuvolone, Mario, primary, Damiano, Giuseppe, primary, Benigna, Francesca, primary, Albertini, Riccardo, primary, Bosoni, Tiziana, primary, Foli, Andrea, primary, Merlini, Giampaolo, primary, and Palladini, Giovanni, primary

Published
2024
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23. Diagnostic performance of [18F]-Florbetaben PET for the detection of cardiac involvement in AL amyloidosis: first results of the MoRBiDA trial

Author

Milani, Paolo, primary, Pepe, Giovanna, primary, Valentini, Adele, primary, Matassa, Giovanni, primary, Guida, Gianluigi, primary, Mussinelli, Roberta, primary, Basset, Marco, primary, Benvenuti, Pietro, primary, Damiano, Giuseppe, primary, Turco, Annalisa, primary, Perlini, Stefano, primary, Greco, Alessandra, primary, Schirinzi, Sandra, primary, Nuvolone, Mario, primary, Bassi, Emilio, primary, Zacchino, Michela, primary, Foli, Andrea, primary, Preda, Lorenzo, primary, Merlini, Giampaolo, primary, and Palladini, Giovanni, primary

Published
2024
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24. Long term outcome of a sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis

Author

Basset, Marco, primary, Milani, Paolo, primary, Benvenuti, Pietro, primary, Damiano, Giuseppe, primary, Bellofiore, Claudia, primary, Nanci, Martina, primary, Benigna, Francesca, primary, Ciardo, Martina, primary, Foli, Andrea, primary, Nuvolone, Mario, primary, Merlini, Giampaolo, primary, and Palladini, Giovanni, primary

Published
2024
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25. N-glycosylation of clonal immunoglobulin light chains as a risk factor for AL amyloidosis: Benchmarking N-glycosylation prediction tools

Author

Nevone, Alice, primary, Russo, Monica, primary, Girelli, Maria, primary, Lattarulo, Francesca, primary, CORPINA, CHIARA, primary, Novello, Elisa, primary, Mazzini, Giulia, primary, Milani, Paolo, primary, Caminito, Serena, primary, Mangiacavalli, Silvia, primary, Basset, Marco, primary, Salvatore, Claudio, primary, Benvenuti, Pietro, primary, Nanci, Martina, primary, Bellofiore, Claudia, primary, Foli, Andrea, primary, Arcaini, Luca, primary, Merlini, Giampaolo, primary, Palladini, Giovanni, primary, and Nuvolone, Mario, primary

Published
2024
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26. The Pavia Amyloidosis Research and Treatment Center’s 25-year experience in molecular diagnostics for hereditary amyloidoses

Author

Nuvolone, Mario, primary, Casarini, Simona, primary, Antonietta, Melania, primary, Mussinelli, Roberta, primary, Nevone, Alice, primary, Chiarella, Giulia, primary, Foli, Andrea, primary, Milani, Paolo, primary, Basset, Marco, primary, Benigna, Francesca, primary, Donadei, Simona, primary, Sirchia, Fabio, primary, Albertini, Riccardo, primary, Perlini, Stefano, primary, Merlini, Giampaolo, primary, Palladini, Giovanni, primary, and Obici, Laura, primary

Published
2024
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27. Biomarker-based renal response and progression criteria in AA amyloidosis: results from the testing cohort of the Pavia-Heidelberg study

Author

Basset, Marco, primary, Hegenbart, Ute, primary, Obici, Laura, primary, Riva, Eloisa, primary, Milani, Paolo, primary, Pasquinucci, Ettore, primary, Foli, Andrea, primary, Nanci, Martina, primary, Ciardo, Martina, primary, Corpina, Chiara, primary, Bellofiore, Claudia, primary, Benigna, Francesca, primary, Benvenuti, Pietro, primary, Damiano, Giuseppe, primary, Mussinelli, Roberta, primary, Nuvolone, Mario, primary, Albertini, Riccardo, primary, Merlini, Giampaolo, primary, Schönland, Stefan, primary, Blank, Norbert, primary, and Palladini, Giovanni, primary

Published
2024
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28. Nanobodies as novel tools to target cardiac light chain amyloidosis

Author

BROGGINI, LUCA, primary, Monica, Maria, primary, Speranzini, Valentina, primary, Schulte, Tim, primary, Sonzini, Federica, primary, Romeo, Margherita, primary, Milani, Paolo, primary, Caminito, Serena, primary, Mazzini, Giulia, primary, Merlini, Giampaolo, primary, Pappone, Carlo, primary, Anastasia, Luigi, primary, Nuvolone, Mario, primary, Palladini, Giovanni, primary, Diomede, Luisa, primary, and ricagno, stefano, primary

Published
2024
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29. Evolution over time of echocardiographic features in patients with wild-type transthyretin cardiac amyloidosis

Author

Damiano, Giuseppe, primary, Milani, Paolo, primary, Perlini, Stefano, primary, Fogliani, Alessandro, primary, Guida, Gianluigi, primary, Attanasio, Andrea, primary, Foli, Andrea, primary, Basset, Marco, primary, Benvenuti, Pietro, primary, Nanci, Martina, primary, Carnevale, Anna, primary, Mussinelli, Roberta, primary, Obici, Laura, primary, Nuvolone, Mario, primary, Casu, Gavino, primary, Merlini, Giampaolo, primary, and Palladini, Giovanni, primary

Published
2024
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30. Prevalence and evolution over time of 12-lead ECG and Holter monitoring features in patients with wild-type transthyretin cardiac amyloidosis

Author

Damiano, Giuseppe, primary, Perlini, Stefano, primary, Fogliani, Alessandro, primary, Guida, Gianluigi, primary, Attanasio, Andrea, primary, Foli, Andrea, primary, Basset, Marco, primary, Benvenuti, Pietro, primary, Nanci, Martina, primary, Carnevale, Anna, primary, Mussinelli, Roberta, primary, Obici, Laura, primary, Nuvolone, Mario, primary, Casu, Gavino, primary, Merlini, Giampaolo, primary, Palladini, Giovanni, primary, and Milani, Paolo, primary

Published
2024
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33. Determinants of amyloidogenic behavior in AL amyloidosis patient-derived AL55 light chain: Insights from structural and biophysical studies

Author

Sarita, Sarita, primary, Gadda, Angela, primary, Polsinelli, Ivan, primary, Visentin, Cristina, primary, BROGGINI, LUCA, primary, Monica, Maria, primary, Romeo, Margherita, primary, Toto, Angelo, primary, K., Manoj, primary, Hsu, Karen, primary, Wang, Yong-Sheng, primary, Gianni, Stefano, primary, Danny, Shang-Te, primary, Nuvolone, Mario, primary, Palladini, Giovanni, primary, Diomede, Luisa, primary, and ricagno, stefano, primary

Published
2024
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34. The Cryo-EM structure of renal amyloid fibrils suggests structurally homogeneous multiorgan aggregation in AL amyloidosis

Author

Sarita, Sarita, primary, Schulte, Tim, primary, Chaves-Sanjuan, Antonio, primary, Mazzini, Giulia, primary, Caminito, Serena, primary, Pappone, Carlo, primary, Anastasia, Luigi, primary, Milani, Paolo, primary, Merlini, Giampaolo, primary, Bolognesi, Martino, primary, Nuvolone, Mario, primary, Palladini, Giovanni, primary, and ricagno, stefano, primary

Published
2024
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36. Prognosis of Transthyretin Cardiac Amyloidosis Without Heart Failure Symptoms

Author

Gonzalez-Lopez, Esther, Escobar-Lopez, Luis, Obici, Laura, Saturi, Giulia, Bezard, Mélanie, Saith, Sunil E., AbouEzzeddine, Omar F., Mussinelli, Roberta, Gagliardi, Christian, Kharoubi, Mounira, Griffin, Jan M., Dispenzieri, Angela, Vilches, Silvia, Perlini, Stefano, Longhi, Simone, Oghina, Silvia, Rivas, Adrian, Grogan, Martha, Maurer, Mathew S., Damy, Thibaud, Palladini, Giovanni, Rapezzi, Claudio, and Garcia-Pavia, Pablo

Published
2022
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40. Graded Organ Response and Progression Criteria for Kidney Immunoglobulin Light Chain Amyloidosis.

Author

Muchtar, Eli, Wisniowski, Brendan, Geyer, Susan, Palladini, Giovanni, Milani, Paolo, Merlini, Giampaolo, Schönland, Stefan, Veelken, Kaya, Hegenbart, Ute, Leung, Nelson, Dispenzieri, Angela, Kumar, Shaji K., Kastritis, Efstathios, Dimopoulos, Meletios A., Liedtke, Michaela, Ulloa, Patricia, Sanchorawala, Vaishali, Szalat, Raphael, Dooley, Katharine, and Landau, Heather

Published
2024
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41. International prevalence of transthyretin amyloid cardiomyopathy in high-risk patients with heart failure and preserved or mildly reduced ejection fraction.

Author

Yun, Sergi, Palladini, Giovanni, Anderson, Lisa J., Cariou, Eve, Wang, Ronnie, Angeli, Franca S., Ebede, Ben, and Garcia-Pavia, Pablo

Subjects
*CARPAL tunnel syndrome, *VENTRICULAR septum, *VENTRICULAR ejection fraction, *CORONARY disease, *PEPTIDES, *HEART failure, *CARDIAC amyloidosis
Abstract

AbstractBackgroundMethodsResultsConclusionsTransthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed cause of heart failure (HF).This epidemiology study assessed the international prevalence of ATTR-CM among patients aged ≥60 years with a history of HF, left ventricular ejection fraction (LVEF) >40%, an end-diastolic interventricular septum thickness (IVST) ≥12 mm, but without diagnosed amyloidosis, history of LVEF ≤40%, cardiomyopathy of known cause, severe valvular, or coronary heart disease. ATTR-CM was determined using cardiac scintigraphy alongside exclusionary testing for light chain amyloidosis. The study was terminated early due to slow recruitment, without safety concerns.Overall, 56/315 (18%; 95% CI: 13.7–22.5) patients with evaluable scintigraphy had ATTR-CM, with a numerically higher prevalence in: Europe (24%) vs. other regions (9% Asia; 5% North America); at specialist vs non-specialist centres (26% vs. 11%); in males vs. females (24% vs. 10%); and in older vs. younger patients (e.g. >40% among those ≥85 years). Other risk markers (p<.05) included a history of carpal tunnel syndrome, higher N-terminal pro B-type natriuretic peptide concentration, and higher end-diastolic IVST.ATTR-CM was diagnosed in 18% (95% CI: 13.7–22.5) of evaluable patients with HF, LVEF >40%, and risk markers for ATTR-CM, but no previous diagnosis of amyloidosis. Recruitment bias may have contributed to regional variability. NCT04424914 [ABSTRACT FROM AUTHOR]

Published
2024
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42. Delayed identification of monoclonal protein is associated with early death in isolated cardiac AL amyloidosis.

Author

Milani, Paolo, Fabris, Francesca, Mussinelli, Roberta, Sanna, Giuseppe Damiano, Basset, Marco, Benvenuti, Pietro, Bellofiore, Claudia, Nanci, Martina, Nuvolone, Mario, Attanasio, Andrea, Guida, Gianluigi, Perlini, Stefano, Foli, Andrea, Merlini, Giampaolo, and Palladini, Giovanni

Subjects
IMMUNOGLOBULIN light chains, MULTIPLE myeloma, PROTEOMICS, SURVIVAL rate, OVERALL survival, MONOCLONAL gammopathies, CARDIAC amyloidosis
Abstract

Background: Early identification of immunoglobulin light-chain amyloidosis (AL) is crucial due to its rapid progression. Monoclonal light-chain (M-LC) testing is the first step in the diagnostic workup for patients with suspected cardiac amyloidosis (CA). We aimed to determine whether the time interval between the first CA suspicion and M-LC testing can be related to AL amyloidosis survival outcomes. Methods: All patients (n = 94) with isolated cardiac AL amyloidosis diagnosed at our center between 2016 and 2020 were included. Those with pre-existing known monoclonal protein (monoclonal gammopathy of undetermined significance or smoldering multiple myeloma) were excluded. Time intervals to diagnostic tests and diagnosis were calculated and assessed for their survival prediction ability. Results: The time interval between first CA suspicion (on echocardiography) and M-LC testing correlated with early mortality, and the best cutoff predicting survival, was 6 weeks. The 26 patients (∼28% of entire cohort) who underwent M-LC-studies >6 weeks after first suspicion more frequently presented Mayo stage IIIb (65% vs. 35%, p =.008), showing poorer overall survival than those (n = 68, 72%) referred for early M-LC studies (median 3 vs. 14 months, p =.039). Conclusions: Monoclonal protein testing should be the first-step in the diagnostic workup for patients with echocardiographic/other instrumental red flags raising CA suspicion. [ABSTRACT FROM AUTHOR]

Published
2024
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43. The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis.

Author

Palladini, Giovanni, Liedtke, Michaela, Zago, Wagner, Dolan, Phil, Kinney, Gene G., and Gertz, Morie A.

Subjects
*CARDIAC amyloidosis, *AMYLOID, *PLASMA cell diseases, *AMYLOIDOSIS, *CLINICAL trials, *PLASMA cells
Abstract

Amyloid light chain (AL) amyloidosis is a progressive plasma cell disorder caused by amyloid deposition resulting in organ damage and failure. Current standard-of-care treatments target clonal plasma cells, the source of misfolded light chains (amyloid precursors), yet only half of patients with advanced disease survive ≥6 months. The amyloid depleter birtamimab is an investigational humanized monoclonal antibody that binds misfolded κ and λ light chains with high specificity and was designed to neutralize soluble toxic light chain aggregates and promote phagocytic clearance of deposited amyloid. Post hoc analyses from the Phase 3 VITAL trial suggested birtamimab plus standard of care confers a survival benefit in patients with advanced (Mayo Stage IV) AL amyloidosis. AFFIRM-AL (NCT04973137), a Phase 3 confirmatory trial of birtamimab plus standard of care in patients with Mayo Stage IV AL amyloidosis, is ongoing. This review summarizes birtamimab's mechanism of action, attributes, and potential clinical utility. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Outcomes of renal transplantation in patients with AL amyloidosis: an international collaboration through The International Kidney and Monoclonal Gammopathy Research Group

Author

Havasi, Andrea, Heybeli, Cihan, Leung, Nelson, Angel-Korman, Avital, Sanchorawala, Vaishali, Cohen, Oliver, Wechalekar, Ashutosh, Bridoux, Frank, Jaffer, Insara, Gutgarts, Victoria, Hassoun, Hani, Levinson, Maya, Rosenbaum, Cara, Milani, Paolo, Palladini, Giovanni, Merlini, Giampaolo, Hegenbart, Ute, Schönland, Stefan, Veelken, Kaya, Pogrebinsky, Alexander, Doros, Gheorghe, and Landau, Heather

Published
2022
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45. Efficacy and Safety of Daratumumab Monotherapy in Newly Diagnosed Patients with Stage 3B Light-Chain Amyloidosis: A Phase 2 Study by the European Myeloma Network

Author

Kastritis, Efstathios, primary, C., Monique, primary, Athanasios, Meletios, primary, Merlini, Giampaolo, primary, Theodorakakou, Foteini, primary, Fotiou, Despina, primary, Huart, Antoine, primary, Belhadj, Karim, primary, Ninos, Ioannis, primary, Psarros, Giorgos, primary, Sonneveld, Pieter, primary, and Palladini, Giovanni, primary

Published
2024
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46. Efficacy and Safety of Belantamab Mafodotin Monotherapy in Patients with Relapsed or Refractory Light Chain Amyloidosis: A Phase 2 Study by the European Myeloma Network

Author

Kastritis, Efstathios, primary, Palladini, Giovanni, primary, Athanasios, Meletios, primary, Jaccard, Arnaud, primary, Merlini, Giampaolo, primary, Theodorakakou, Foteini, primary, Fotiou, Despina, primary, C., Monique, primary, Wechalekar, Ashutosh, primary, Ninos, Ioannis, primary, Psarros, Giorgos, primary, Sonneveld, Pieter, primary, and Schönland, Stefan, primary

Published
2024
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49. Search for AL amyloidosis risk factors using Mendelian randomization

Author

Saunders, Charlie N., Chattopadhyay, Subhayan, Huhn, Stefanie, Weinhold, Niels, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Schmidt, Börge, Landi, Stefano, Goldschmidt, Hartmut, Milani, Paolo, Merlini, Giampaolo, Rowcieno, Dorota, Hawkins, Philip, Hegenbart, Ute, Palladini, Giovanni, Wechalekar, Ashutosh, Schönland, Stefan O., Försti, Asta, Houlston, Richard, and Hemminki, Kari

Published
2021
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