Search

The transition to higher education at University is a critical moment for young adults to acquire unhealthy habits regarding physical activity (PA) and adherence to a healthy diet. Negative behaviors might be maintained in the years to come with a major risk of suffering from a Non-Communicable Disease. This study aims to determine the relationship between diet and PA in the student community of University of Milano-Bicocca. Students between 18 and 30 years old completed an online survey (6949 students). Two analyses of covariance (ANCOVA), chi-square tests of independence, and a binomial logistic regression were performed to examine the relationship between adequacy of food consumption and PA, in association also with sociodemographic characteristics. Data show a strong correlation between behaviors analyzed, with a proportional positive association between PA and healthy diet. Nevertheless, a third of the sample students incur in incorrect habits for both diet and PA. Further, students performing intensive PA have the healthiest food consumption in general but the worst red meat and pork intake. Accordingly, men practice more PA but have a less adequate diet, exactly contrary to women. In conclusion, policies promoting consciousness of well-being would transform Universities into healthy hubs for virtuous habits.

The overlap between the geographic distribution of COVID-19 outbreaks and pollution levels confirmed a correlation between exposure to atmospheric particulate matter (PM) and the SARS-CoV-2 pandemic. The RAS system is essential in the pathogenesis of inflammatory diseases caused by pollution: the ACE/AngII/AT1 axis activates a pro-inflammatory pathway, which is counteracted by the ACE2/Ang(1-7)/MAS axis, which activates an anti-inflammatory and protective pathway. However, ACE2 is also known to act as a receptor through which SARS-CoV-2 enters host cells to replicate. Furthermore, in vivo systems have demonstrated that exposure to PM increases ACE2 expression. In this study, the effects of acute and sub-acute exposure to ultrafine particles (UFP), originating from different anthropogenic sources (DEP and BB), on the levels of ACE2, ACE, COX-2, HO-1, and iNOS in the lungs and other organs implicated in the pathogenesis of COVID-19 were analyzed in the in vivo BALB/c male mice model. Exposure to UFP alters the levels of ACE2 and/or ACE in all examined organs, and exposure to sub-acute DEP also results in the release of s-ACE2. Furthermore, as evidenced in this and our previous works, COX-2, HO-1, and iNOS levels also demonstrated organ-specific alterations. These proteins play a pivotal role in the UFP-induced inflammatory and oxidative stress responses, and their dysregulation is linked to the development of severe symptoms in individuals infected with SARS-CoV-2, suggesting a heightened vulnerability or a more severe clinical course of the disease. UFP and SARS-CoV-2 share common pathways; therefore, in a “risk stratification” concept, daily exposure to air pollution may significantly increase the likelihood of developing a severe form of COVID-19, explaining, at least in part, the greater lethality of the virus observed in highly polluted areas.

Background and objectives: Promoting healthy behaviors throughout life is an essential prevention tool against chronic disease onset and progression in adulthood. This study aims to explore the lifestyles of an Italian academic community to plan targeted initiatives to promote and improve healthy lifestyles in students and employees with consequent impact on their entourage. Methods: A sample of 8715 adults (mean age = 26 years; range = 18-76; 30% male) participated in an online survey designed to evaluate the associations among lifestyle profiles (including diet, physical activity, cigarette smoking, and alcohol consumption), sociodemographic factors (age, gender, and academic role), and Body Mass Index (BMI). Lifestyle profiles were identified through cluster analysis, and a multinomial logistic regression was then performed to relate clusters obtained to sociodemographic variables and BMI. Results: Data show that older age was associated with the probability of belonging to the clusters with the worst behavior in smoking and alcohol consumption, but with the healthiest diet. The younger the age, the greater the probability of belonging to the more physically active cluster. Men were more likely than women to belong to the lifestyle profile with the highest alcohol consumption and the highest physical activity. Lower BMI was associated with the highest amount of physical activity profile. Conclusion: This study shed light on factors associated with different co-occurring health-related behaviors that should be considered in planning effective communication strategies promoting adherence to health claims.

The contributing role of environmental factors to the development of neurodegenerative diseases has become increasingly evident. Here, we report that exposure of C6 glioma cells to diesel exhaust particles (DEPs), a major constituent of urban air pollution, causes intracellular reactive oxygen species (ROS) production. In this scenario, we suggest employing the possible protective role that coffee phenolic metabolites may have. Coffee is a commonly consumed hot beverage and a major contributor to the dietary intake of (poly) phenols. Taking into account physiological concentrations, we analysed the effects of two different coffee phenolic metabolites mixes consisting of compounds derived from bacterial metabolization reactions or phase II conjugations, as well as caffeic acid. The results showed that these mixes were able to counteract DEP-induced oxidative stress. The cellular components mediating the downregulation of ROS included extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and uncoupling protein 2 (UCP2). Contrary to coffee phenolic metabolites, the treatment with N-acetylcysteine (NAC), a known antioxidant, was found to be ineffective in preventing the DEP exposure oxidant effect. These results revealed that coffee phenolic metabolites could be promising candidates to protect against some adverse health effects of daily exposure to air pollution.

The strong spread of COVID-19 and the significant number of deaths associated with it could be related to improper lifestyles, which lead to a low-grade inflammation (LGI) that not only increases the risk of chronic diseases, but also the risk of facing complications relating to infections and a greater susceptibility to infections themselves. Recently, scientific research has widely demonstrated that the microbiota plays a fundamental role in modulating metabolic responses in the immune system. There is, in fact, a two-way interaction between lifestyle, infection, and immunity. The immune response is compromised if nutrition is unbalanced or insufficient, because diet affects the intestinal flora predisposing people to infections and, at the same time, the nutritional state can be aggravated by the immune response itself to the infection. We evaluate the link between balanced diet, the efficiency of the immune system, and microbiota with the aim of providing some practical advice for individuals, with special attention to the elderly. A correct lifestyle that follows the Mediterranean model, which is especially rich in plant-based foods along with the use of extra-virgin olive oil, are the basis of preventing LGI and other chronic pathologies, directly influencing the intestinal microbiota and consequently the immune response.

Despite Mediterranean dietary pattern has become a healthy eating standard, even Mediterranean countries such as Italy, show a progressive disaffection from this diet in parallel to the increasing trend in prevalence of body overweight and obesity and correlate pathologies. The causes that led to the explosion of the body overweight and obesity phenomenon and the differences in the prevalence of this condition among various social groups, are cultural and economic as well as biological and epidemiological. In developed countries out-of-home eating, defined as the consumption of foods and beverages out of home, has received increasing attention among cultural and behavioral factors linked to obesity. Indeed, with the rapid development of economy, diet habits have undergone great changes. An increasingly number of people, especially in urban settings, is eating out of home not only for working people during their lunch break, but also at dinnertime. Studies showed that a very high dietary energy content of both full service and fast-food restaurant meals is a widespread phenomenon and that there is a positive relationship between the consumption of food away from home and weight gain. This has garnered considerable attention from public health experts in formulating national policies and programs designed to curb the growing trends in obesity. USA, Canada and Australia, proposed calorie-labeling policy that required chain restaurants to post the calorie content of items on menus. In Europe, there is not such a policy yet. Unfortunately, many studies show that menu restaurant calories and nutritionallabeling mandatory policies did not have achieved the set goals in guiding consumers throughout restaurant menu to choose healthier dishes in terms of less calories and nutrients composition. Probably, educational and information campaigns are factors to put beside calorie and nutrient labeling.

Since it was founded in 1998, the University of Milano-Bicocca has worked to make its structures environmentally, socially, and economically sustainable, not only to reduce the costs and environmental impact of its management processes, but also to promote sustainable behaviour on the part of its employees, lecturers and students. This report focuses on the measures implemented by the university in order to make food consumption and lifestyles healthier and more sustainable. Inspired by nudge theory (according to which in order to achieve a change in behaviour it is necessary to act on indirect encouragement and enablement rather than on direct instruction, enforcement and punishment), these measures aimed to promote healthier and more appropriate styles of food consumption, in particular at university canteens. The interventions were oriented both towards offering healthier products and towards modifying the environment in order to encourage more balanced food choices. The programme of interventions was divided into three phases: firstly an investigation of eating behaviours and lifestyles; secondly planning the interventions; and finally evaluating the project and disseminating good practices