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ABSTRACT Discovered 160 years ago, the Muge archaeological sites in Portugal yield the most significant documentation of human skeletons from the Mesolithic period in Western Europe (8200–7100 cal B.P.). However, sediment weight has caused significant postmortem alterations that have limited previous studies. Paleoimaging techniques were applied to overcome these limitations and provide previously inaccessible information. Thirteen crania from Moita do Sebastião (one of the Muge shell middens) were CT scanned for virtual reconstruction and morphological analysis. Meticulous examination of 2D and 3D images revealed bone changes not visible to the naked eye and unrelated to postmortem alterations. A comprehensive differential diagnosis was carried out identifying various pathological conditions including epidermoid or dermoid cysts, intraosseous hemangioma, and a possible case of anemia. These “hidden pathologies” offer new insights into the health status of one of Europe's last hunter–gatherer populations. [ABSTRACT FROM AUTHOR]

The skeleton in question derives from the Late Iron Age monument of Nor Armavir and was unearthed from burial No. 19. The deceased was buried in an unusual position. In this article, we characterise the pathological bony changes indicative of tuberculous spondylitis. The skeleton was subject to a detailed macroscopic investigation. Besides age at death estimation and sex determination, a careful palaeopathological evaluation was performed on the bone remains. In addition, volumetric (3D) computed tomography was carried out on four lumbar vertebrae (L2--5) to complement the macromorphology-based diagnosis. [ABSTRACT FROM AUTHOR]

The purpose of this study is to underline the importance of Concha Bullosa (CB), a pathological condition frequently missed in the analysis of human remains in archeological studies. We studied three cases from the Ancient Egyptian necropolis of Dra Abu-el Naga, located on Luxor's (Ancient Thebes) West Bank of the Nile. The sample object of this study belongs to different chronologies, but all were over 2,000 years old. The analysis included both macroscopic and radiological examinations of three skulls, all of adult males, showing different degrees of involvement of the middle turbinate. One presented with extensive bilateral CB without deviation of the nasal septum. The others showed unilaterally without affecting and deviating the nasal septum. The maxillary sinuses were not affected. The embalming technique varied throughout Ancient Egyptian history, with brain extraction first practiced among elites and then spreading across all social classes. This removal of the brain, if carried out through the nose, involved the destruction of the nasal bones. That may be the reason for the paucity of the described cases in the high number of individuals examined, added to the lack of familiarity of the investigators with this entity. These three new cases add to the body of existing evidence on CB and stresses the importance of not missing its identification during paleopathological studies. [ABSTRACT FROM AUTHOR]

The aim of this paper is to present the preliminary results of the recent osteological analysis of the human remains discovered to the north of the funerary temple of King Djedkare at south Saqqara. The excavation began in spring 2018 as a part of Djedkare Project of the exploration and documentation of the pyramid complex of king Djedkare, directed by Mohamed Megahed. This paper will investigate some of the burials discovered in the so-called T.g area which is situated between the funerary temple of the king and the south side of the pyramid of the queen. The burials date back from the late Second Intermediate Period probably to the 1st millennium BCE based on the preliminary analysis of the pottery. The burials were discovered in three levels, the earlier burials in the bottom levels of the debris were in extended north-south or east-west position. Also, the upper-level burials were in extended east-west positions. The Middle level contains burials in ceramic coffins Besides the variety of burial customs and the correlation between age, sex, and grave good, The good preservation of bones surface allowed to record the pathological diseases. Many evidences recorded for activity-related skeletal changes, including degenerative disease in the spines and other joints in the older adult groups. Moreover, trauma (including fractures) was noted in any individuals, affecting the shoulders, femurs, hands and pelvis. It is likely that childhood stress observed in several individuals in the form of iron deficiency anaemia and dental developmental disorders. In some cases, evidence for spondylolysis, which might have been unilateral or bilateral, was observed. More unusual pathological conditions observed included infectious defects in the skull of a young adult female and a possible case of blunt force trauma. Several dental diseases were observed in Djedkare secondary cemetery individuals, including tooth attrition, abscesses, ante-mortem tooth loss and calculus, which related to age changes. This preliminary overview study will contribute to add new non-elite cemetery results and aim to make it accessible for researchers additionally, investigate the biological profile as sex, age, stature. Moreover, sheds light on the distribution of pathologies inside the assemblage. [ABSTRACT FROM AUTHOR]

Imagining life before the advent of modern medical treatments is challenging. Today, congenital dysplasia is typically diagnosed within the first months of a child's life, allowing for timely intervention. In the past, however, this condition often went unrecognized and untreated, as evidenced by archaeological findings that document the presence of congenital dysplasia persisting into adulthood. We present the case of the individual recovered from the hypogeal cemetery of Santa Maria Maggiore in Vercelli, Italy, a funerary context dated from the 18th to the 19th century. Using macroscopic and radiographic analyses, various morphological irregularities were identified, consistent with the characteristics of developmental hip dysplasia. The skeletal remains identified as FU12 SU151 include a right os coxa and femur, belonging to an adult female. The femur features a 90-degree femoral head angle and a shortened neck with nodules. The acetabulum shows significant morphological changes, including a triangular shape and absence of lunate surfaces, deviating from the normal structure for femoral articulation. CT scans revealed a void within the acetabulum, indicating an absence of material. Despite preservation challenges that restrict the identification of definitive signs, our findings offer valuable insights into possible developmental dysplasia in historic skeletal remains. This research provides insights into the impact of untreated congenital conditions on past populations, underscoring the importance of preserving and studying such remains to enhance our understanding of historical health issues. [ABSTRACT FROM AUTHOR]

This article explores the history of bioarchaeology from the beginning of the twentieth century, proxied by representation in publications as reported annually by the editors-in-chief of the American Journal of Physical/Biological Anthropology. Embedded within this history is the career trajectory of Jane E. Buikstra, who coined the term in relationship to the study of archaeologically recovered human remains in 1976. [ABSTRACT FROM AUTHOR]

Late Roman times imprinted with instability, and a consequent decline in large urban centres. In contrast, urbanization seems to have increased in Augusta Emerita (today Mérida), capital of Lusitania, because of the attractive commercial position of this powerful Christian centre. A mixed of beliefs, cultural and social backgrounds was coexisting at the core. These facts could have conditioned diet, perhaps becoming different from the surrounding rural areas, or increasing heterogeneity inside the capital. We reconstructed the diet of the largest Late Roman necropolis of Mérida, the Ampliación del MNAR (3rd -5th centuries AD), whose burial rites have been classified as no-Christian. A total of 70 humans (29 males, 14 females, 23 non-adults) were analysed for δ13Ccol and δ15Ncol to compare their isotopic values in bone with those of 14 animals: 6 sheep/goat, 5 cattle, 2 pigs and 1 horse. Faunal and human isotopic results indicate a trophic chain based on C3 plants. Humans over 12 years old (δ13C=19.2 ± 0.8‰, δ15N = 10.2 ± 1.3‰) seem to have had lower consumption of animal protein and C4 plants than other populations from rural sites, although general diet was rather homogeneous in Hispania. Three outliers, one with important intake of C4 plants, have been identified. Medium animal protein diet reconstructed by stable isotopes and relatively low presence of pathological markers, contrast with high infant mortality, suggesting minor stress in early life. If confirmed, limited diet might be linked to the marginal situation of pagan people in a well christianised Augusta Emerita, but much likely being a consequence of the decline of urban centres during Late Roman times. [ABSTRACT FROM AUTHOR]

This report describes a male skeleton recovered from the Samnite necropolis of Barrea (Abruzzo, 8th–5th century BCE), showing one malformed foot consistent with the diagnosis of unilateral congenital clubfoot associated with tarsal and tarsometatarsal coalitions in the same foot. This finding is particularly noteworthy because tarsal coalitions in congenital equinovarus foot have rarely been reported in medical literature, and to our knowledge, never in the paleopathological record. The recovery of this individual with impaired locomotion from a grave containing a complete array of weapons and armor sheds new light on the occupant's identity and social attitudes toward disabled people in Samnite society. In mortuary archaeology, the correlation between warrior burials and social identity in life of the dead in ancient times is a widely debated issue. Some scholars assert that the weapons in these graves suggest the existence of a warrior class; others propose that the military items of the burial assemblage indicate a high social status or significant power. This study suggests that in Samnite society, physical impairment did not prevent someone from being honored as a warrior or high‐status community member. [ABSTRACT FROM AUTHOR]

Congenital skeletal disorders are a heterogeneous group of anomalies that become evident during gestation. They are expressed in the shape and growth of the bones during development because of a defective genetic background. With the follow‐up of pregnant women and the advances in prenatal ultrasonographic examination and molecular genetic tests, nowadays, congenital skeletal disorders are identified at an early gestational age. If they are considered lethal, the termination of pregnancy is advised. This work unveils an exceptional instance of a rare pathological condition identified in a perinate (birth ± 2 weeks) from the 17th to 19th centuries, recovered during an excavation at the cloister of the São Domingos Convent in Lisbon, Portugal. The skeleton presents with exuberant modifications that include, among others, severe shortening (micromelia) and bowing of the long bones of the upper and lower limbs. The main skeletal findings indicated a presumptive general diagnosis of skeletal dysplasia, while the differential diagnosis includes hypophosphatasia, campomelic dysplasia, achondrogenesis, thanatophoric dysplasia, and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) as the most plausible causes for the observed skeletal changes. Even though an exact diagnosis is unattainable based only on the macroscopic analysis of the bones, the phenotypic features observed in this perinate are more consistent with thanatophoric dysplasia type 1. [ABSTRACT FROM AUTHOR]

Animal domestication led to changes in the interaction between animals and humans, including new ways of exploitation, which could potentially leave lesions on the animals' bones. This study aims to examine changes in the prevalence of pathological manifestation following changes in human‐animal interactions as a result their domestication. For this purpose, we studied 19,565 animal remains recovered from archaeological excavations, dated from the Pre‐Pottery Neolithic period to historical periods and assigned the pathologies into types. Of these, 60 animal remains presented pathological lesions. The suspected pathological cases were validated using a microscope, X‐ray, and/or micro‐CT scan. Lesions were divided into four categories: trauma, aging/musculoskeletal stress marks (MSM), periodontal diseases, and inflammatory processes. Then, our database was combined with previously published data to a total of 26,596 animal remains, out of which 128 demonstrated pathological lesions. We found that the prevalence of lesions in animals was higher in the historical periods compared with prehistoric periods. Moreover, based on a comparison between recent gazelles living in captivity and those living in the wild, we found that captivity resulted in the deterioration of the animals' health. We concluded that pathologies were more frequent in livestock in historic periods, in comparison with wild species and livestock from earlier periods. Such lesions were common not only in working livestock (cattle and donkeys) but also in non‐working domesticates (caprines and chickens) and companion animals (dogs and cats). Variations in the pathological frequencies between these three categories may be attributed to differences in exploitation, including the intensification of farming and herding. Finally, this study provides a unique reference dataset for zooarchaeologists when studying ancient animal assemblages. [ABSTRACT FROM AUTHOR]

This article aims to understand the impact of a condition causing multiple benign neoplasms on a historical individual, and increase understanding of disease processes using a paleopathological case. We present the case of an adult male from the Balizhuang site in Weifang City, Changle County, Shandong Province, China, dated by the burial artifacts to the Qing period (1644–1911 CE). The individual has multiple bony growths found on both long and flat bones, which were also observed radiographically. Imaging revealed that the lesions show continuity with the medullary cavity of the host bone. The individual also exhibited short stature, upper limb length asymmetry, and hip and ankle deformities. Conditions included in a differential diagnosis are myositis ossificans, parosteal osteosarcoma, and osteochondroma, with multiple osteochondromas (MO) being the most likely diagnosis. We also present historical texts suggesting the presence of osteochondromas in China. This may be the first case of adult MO reported in Chinese bioarcheology, helping to expand paleopathological data on benign tumors. [ABSTRACT FROM AUTHOR]

This study aims to shed light on animal management influences on the development of pathological changes observed on animal remains from the medieval site of Crkveno Brdo. Animal remains with abnormalities were discovered during archaeological excavations of the medieval settlement at the site of Crkveno Brdo in 2019. The site is situated near Senta in the northern region of modern‐day Serbia. The part of the settlement dated from the 11th to the 15th centuries was excavated. The percentage represented by various mammalian species documents that the most important economic species were cattle and horses, followed by sheep, goats, and pigs. Fishing and hunting were marginal in the settlement subsistence. The analyzed assemblage of bones with lesions consists of 39 specimens with 40 abnormalities. All of the remains exhibiting abnormalities were subjected to macroscopic and stereomicroscope analysis. The specimens with the most prominent changes also underwent x‐ray imaging and histopathological analysis. Almost all lesions were found in domestic animals. The most prevalent lesions in cattle, sheep, goat, and pig were dental and oral pathology, followed by articular abnormalities. In horses, 77% of pathological changes were articular abnormalities, and 11% dental and oral pathology, followed by traumatic lesions and inherited disorders (5.5% each). Congenital morphological variation is represented by a single specimen of horse lumbar vertebra. Pathological alterations were also noted in dogs, as was a severe healed tibiofibular fracture in a frog. Pathological alterations were related to external factors and specifically to patterns of animal management. Dental pathologies in cattle, sheep/goats, and pigs were primary attributed to malnutrition quality; articular abnormalities in horses, similar to aging and environmental factors, most likely work related. [ABSTRACT FROM AUTHOR]

Derived ornithopods, such as hadrosaurids, show a high occurrence of fossilized lesions and diseases. However, paleopathologies in iguanodontians seem to be less common, considering the rich fossil record of these taxa in Europe, in particular in Belgium, Britain and Spain. Here, we describe an iguanodontian femur discovered in England that exhibits a large overgrowth of its lateral aspect, not previously recognized in any other similar remains. The specimen was scanned with micro‐computed tomography (microCT) and later sectioned in three sites of the overgrowth for histological analysis. The femur belongs to an early adult Iguanodontia indet., based on the presence of a woven parallel fibered complex in the outer cortex and three to four lines of arrested growth. Internal analysis of the dome‐like overgrowth suggests it can be diagnosed as a fracture callus. The injury might have negatively impacted upon the animal's locomotion as the trauma had occurred in the region above the knee, a crucial spot for hindlimb musculature. Finally, a cancellous medullary bone‐like tissue was recognized in the medullary cavity next to the pathological overgrowth. An attempt was made to determine the precise nature of this tissue, as medullary bone is linked with the ovulation period in (avian) dinosaurs, whereas other types of endosteal, medullary bone‐like tissue have previously been recognized in pathological bones. [ABSTRACT FROM AUTHOR]

В статье представлены результаты исследования мужского черепа со следами трепанации. Погребение, где обнаружен краниум, относится к Ходжалы-Кедабекской археологической культуре эпохи поздней бронзы-раннего железа и было выявлено в ходе археологических раскопок Я.И. Гуммеля в Гёйгёльском районе. Трепанационное отверстие, общими размерами 2,4 × 2 см, округлой формы, расположено на венечном шве, на соединении лобной и левой теменной кости. Краниотомия была совершена методом скобления и прорезывания. На черепе присутствуют следы воспалительной реакции и заживления кости. Пациент прожил определённое время после операции. Манипуляция была осуществлена, вероятно, в медицинских целях. На черепе отмечены также дискретные признаки и маркеры физиологического стресса. В настоящее время известно 8 случаев трепанации, датируемых концом II — началом I тыс. до н.э. с территории Азербайджана: из них два (мужчины) совершены прижизненно в медицинских целях методом скобления и прорезывания (один успешно, второй — окончился смертью пациента); шесть в ритуально-символических целях, из них четыре — прижизненно выполнены методом прижигания (мужчина, женщина, два взрослых индивидуума) и два — посмертно (женщина и мужчина), методом прорезывания.

Imagining life before the advent of modern medical treatments is challenging. Today, congenital dysplasia is typically diagnosed within the first months of a child’s life, allowing for timely intervention. In the past, however, this condition often went unrecognized and untreated, as evidenced by archaeological findings that document the presence of congenital dysplasia persisting into adulthood. We present the case of the individual recovered from the hypogeal cemetery of Santa Maria Maggiore in Vercelli, Italy, a funerary context dated from the 18th to the 19th century. Using macroscopic and radiographic analyses, various morphological irregularities were identified, consistent with the characteristics of developmental hip dysplasia. The skeletal remains identified as FU12 SU151 include a right os coxa and femur, belonging to an adult female. The femur features a 90-degree femoral head angle and a shortened neck with nodules. The acetabulum shows significant morphological changes, including a triangular shape and absence of lunate surfaces, deviating from the normal structure for femoral articulation. CT scans revealed a void within the acetabulum, indicating an absence of material. Despite preservation challenges that restrict the identification of definitive signs, our findings offer valuable insights into possible developmental dysplasia in historic skeletal remains. This research provides insights into the impact of untreated congenital conditions on past populations, underscoring the importance of preserving and studying such remains to enhance our understanding of historical health issues.

The paleopathological literature notably lacks the description and analysis of distal humeral fractures and their associated complications. The objectives of this study were (1) to evaluate a distal humerus fracture associated with cubitus valgus observed in the articulated right elbow of an adult male buried in the Santa Caterina Friary site in Barcelona, dating back to the modern period (15th to early 16th century), and (2) to contribute to the valorization of bioarcheological heritage. Employing macroscopic and radiographic studies, the injury was assessed. The results indicated a healed antemortem fracture, probably associated with a fall. In the AO/OTA classification, it corresponds to type 13C1.1 (complete articular fracture, articular simple, metaphyseal simple, above the transcondylar axis), accompanied by a coronoid process fracture due to anterior trochlear dislocation impact (O’Driscoll type 1 classification: transverse fracture of the distal apophysis with involvement of the sublime tubercle). This fracture, resulting in a 28° cubitus valgus and significant elbow changes, infers community support in healing and highlights the socio-economic dynamics of guilds and adaptive strategies to physical adversities. This study is one of the first to describe cubitus valgus in a historical Spanish population, offering a comprehensive view of the complexities, physical adversities, and adaptive strategies employed by individuals following an elbow fracture.

The cemetery of the Church of Santi Simone e Giuda in Borca di Cadore (Belluno province, Veneto region, Italy) was excavated between 2021 and 2023 as part of an archaeological intervention. The excavation area yielded a total of 21 graves dating back to the 18th–19th century; this was intriguing due to the presence of grave goods and taphonomic indicators that allowed these burials to be interpreted as clothed burials. This contribution examines 14 of the 21 graves, representing the available sample considering preservation conditions. Fieldwork was carried out through close synergy between archaeological and anthropological methodologies, involving careful excavation to verify funerary rituals through taphonomic data analysis. Anthropological methods were applied to determine the biological profile of the individuals, while aspects related to their health status were investigated through paleopathological analyses. Data obtained from field and laboratory observations were cross-referenced with historical and anthropological-cultural data from bibliographic and archival research. Reconstructing the social status of the deceased within the burial context is crucial for understanding the social and cultural dynamics of past populations, achievable only through a biocultural approach integrating information from archaeology, cultural anthropology, and bioarchaeology. Modern burial contexts offer privileged realities due to abundant historical and anthropological-cultural documentation, allowing for a more precise contextualization of bioarchaeological findings with significant support from documentary sources. Studies applied to these periods closer to the present enable the continuous refinement of an investigative method attentive to the synergy of different aspects of biocultural research, enhancing the importance of this approach in reconstructing the life histories of populations.

Abstract Background The history of rare diseases is largely unknown. Research on this topic has focused on individual cases of prominent (historical) individuals and artistic (e.g., iconographic) representations. Medical collections include large numbers of specimens that exhibit signs of rare diseases, but most of them date to relatively recent periods. However, cases of rare diseases detected in mummies and skeletal remains derived from archaeological excavations have also been recorded. Nevertheless, this direct evidence from historical and archaeological contexts is mainly absent from academic discourse and generally not consulted in medical research on rare diseases. Results This desideratum is addressed by the Digital Atlas of Ancient Rare Diseases (DAARD: https://daard.dainst.org ), which is an open access/open data database and web-based mapping tool that collects evidence of different rare diseases found in skeletons and mummies globally and throughout all historic and prehistoric time periods. This easily searchable database allows queries by diagnosis, the preservation level of human remains, research methodology, place of curation and publications. In this manuscript, the design and functionality of the DAARD are illustrated using examples of achondroplasia and other types of stunted growth. Conclusions As an open, collaborative repository for collecting, mapping and querying well-structured medical data on individuals from ancient times, the DAARD opens new avenues of research. Over time, the number of rare diseases will increase through the addition of new cases from varied backgrounds such as museum collections and archaeological excavations. Depending on the research question, phenotypic or genetic information can be retrieved, as well as information on the general occurrence of a rare disease in selected space–time intervals. Furthermore, for individuals diagnosed with a rare disease, this approach can help them to build identity and reveal an aspect of their condition they might not have been aware of. Thus, the DAARD contributes to the understanding of rare diseases from a long-term perspective and adds to the latest medical research.

Humans have been constantly exposed to the environment in their daily activities, which may result in some pathological changes. Paleopathology research is rare, particularly on ancient humans who lived in Bali, Indonesia. This research is intended to gain more insight into the history of diseases and the community in the past to assist future health researchers. This study was conducted to understand variation in disease among the ancient populations in Bali, Indonesia. The study examines skeletons from the Gilimanuk, Semawang, and Pacung Sembiran sites in Bali, Indonesia, collected from 1964 to 2008. A total of 336 individuals were identified, including 63 adult males, 75 adult females, and 56 adults whose sex could not be determined. In addition, 142 children were included in the analysis. The examination of the individuals revealed the presence of various dental pathological changes, such as caries and enamel hypoplasia, as well as periodontitis. Furthermore, several bone-related diseases and abnormalities were identified, such as osteophytes, fractures, porotic hyperostosis, and spina bifida occulta. Available evidence suggests a similarity in the types of pathological changes among the ancient populations of Gilimanuk, Semawang, and Pacung Sembiran. While a comprehensive explanation of the paleopathological variations observed in these populations necessitates further investigation, the present findings hold considerable value for medical experts and anthropologists seeking to better understand patterns of disease distribution among ancient Indonesian populations. This study was funded by the Directorate General of Higher Education, Research, and Technology of the Ministry of Education, Culture, Research, and Technology of Indonesia for the fiscal year 2023.

The article presents the complex characteristic of the skeleton from burial № 7 of the Bednodemyanovsk burial ground of the Mordva-Moksha. The archeological site is dated to the Golden Horde period (XIII–XIV centuries) and is located in Upper Moksha river. The skeleton belonged to the man aged 35–55 years. The aim of the study was to make the most complete reconstruction of the morphological specifics of the individual and his life activity. For this purpose, the bones were carefully studied visually and metrically. Cone beam computed tomography was performed on a VATECH PAX 1 3D device with Ez3D-i64 software. The approximate body length of the individual was determined (about 169.0 cm). The longitudinal measurements of the long tubular bones were the base for it. The skeleton showed multiple traces of pathological changes and indicators of mechanical stress. The individual (apparently in infancy) had the foot trauma. The fracture of the right clavicle in the middle third of the body was in adulthood. A specific characteristic of the individual was spastic contraction of the facial muscles of the lower right side of the face, possibly as a result of facial nerve injury. It was habitual for the individual to move with tensely flexed legs. This may have been related to labor activity or may have been the result of pathology. The characteristic structure of the sternum suggests that the individual was engaged in heavy lifting using a strap across the chest. The arms were slightly bent at the forearms to hold the weight. The hands were tensely flexed at the same time. The study of the skeleton from burial № 7 will let know the lot about the life of the medieval Mordvins and the level of medicine of that time.

The paper presents the results of the paleoanthropological materials study of the 5th – 7th centuries originating from under the kurgan mounds and ground burials located in the Volga-Don steppes territory. Eleven skeletal remains of 8 men, 2 women, and 1 child were studied. The data obtained as a result of the paleopathological analysis of the material dating back to the post-Hunnic-early Turkic period have been introduced into scientific circulation for the first time. In the course of the paleoanthropological material analysis, analogies with nomadic cattle breeding groups residing on this territory in the Bronze Age, Early Iron Age, and Late Middle Ages have been established in terms of gender, age, and pathological indicators. The findings were confirmed despite the small number of the analyzed series. In adult individuals, a number of dental conditions were recorded, indicating that viscous foods rich in fats and proteins had dominated the diet of the early Turkic time population. The mobile lifestyle of the Volga-Don steppes population of the 5th – 7th centuries was reflected on the skeletal remains of the studied individuals in the form of stress indicators associated with horse riding and body exposure to low temperatures. The presence on a number of skulls of the studied group of traces of the use of deliberate artificial deformation allows us to make the assumption that they had traditions that were characteristic of the nomads of the Eastern European steppes of the first centuries of our era.

The skeleton in question derives from the Late Iron Age monument of Nor Armavir and was unearthed from burial No. 19. The deceased was buried in an unusual position. In this article, we characterize the pathological bony changes indicative of tuberculous spondylitis. The skeleton was subject to a detailed macroscopic investigation. Besides age at death estimation and sex determination, a careful palaeopathological evaluation was performed on the bone remains. In addition, volumetric (3D) computed tomography was carried out on four lumbar vertebrae (L2–5) to complement the macromorphology-based diagnosis.

The paleopathological literature notably lacks the description and analysis of distal humeral fractures and their associated complications. The objectives of this study were (1) to evaluate a distal humerus fracture associated with cubitus valgus observed in the articulated right elbow of an adult male buried in the Santa Caterina Friary site in Barcelona, dating back to the modern period (15th to early 16th century), and (2) to contribute to the valorization of bioarcheological heritage. Employing macroscopic and radiographic studies, the injury was assessed. The results indicated a healed antemortem fracture, probably associated with a fall. In the AO/OTA classification, it corresponds to type 13C1.1 (complete articular fracture, articular simple, metaphyseal simple, above the transcondylar axis), accompanied by a coronoid process fracture due to anterior trochlear dislocation impact (O'Driscoll type 1 classification: transverse fracture of the distal apophysis with involvement of the sublime tubercle). This fracture, resulting in a 28° cubitus valgus and significant elbow changes, infers community support in healing and highlights the socio-economic dynamics of guilds and adaptive strategies to physical adversities. This study is one of the first to describe cubitus valgus in a historical Spanish population, offering a comprehensive view of the complexities, physical adversities, and adaptive strategies employed by individuals following an elbow fracture. [ABSTRACT FROM AUTHOR]

The cemetery of the Church of Santi Simone e Giuda in Borca di Cadore (Belluno province, Veneto region, Italy) was excavated between 2021 and 2023 as part of an archaeological intervention. The excavation area yielded a total of 21 graves dating back to the 18th–19th century; this was intriguing due to the presence of grave goods and taphonomic indicators that allowed these burials to be interpreted as clothed burials. This contribution examines 14 of the 21 graves, representing the available sample considering preservation conditions. Fieldwork was carried out through close synergy between archaeological and anthropological methodologies, involving careful excavation to verify funerary rituals through taphonomic data analysis. Anthropological methods were applied to determine the biological profile of the individuals, while aspects related to their health status were investigated through paleopathological analyses. Data obtained from field and laboratory observations were cross-referenced with historical and anthropological-cultural data from bibliographic and archival research. Reconstructing the social status of the deceased within the burial context is crucial for understanding the social and cultural dynamics of past populations, achievable only through a biocultural approach integrating information from archaeology, cultural anthropology, and bioarchaeology. Modern burial contexts offer privileged realities due to abundant historical and anthropological-cultural documentation, allowing for a more precise contextualization of bioarchaeological findings with significant support from documentary sources. Studies applied to these periods closer to the present enable the continuous refinement of an investigative method attentive to the synergy of different aspects of biocultural research, enhancing the importance of this approach in reconstructing the life histories of populations. [ABSTRACT FROM AUTHOR]

Palaeopathology is the science that seeks to understand the pathological processes in fossils and mummies. Such understanding ranges from identifying diseases and how they work to raising hypotheses on how these illnesses have affected the individual's life and even that of an entire community. In this sense, there has been about Brazilian palaeopathology since 1990; however, only in the last decade has the theme gained prominence and been explored. Thus, this review of palaeopathologies in Brazilian terrestrial vertebrates presents an overview of more than 20 diseases that affected approximately seven groups of those animals, distributed from the Palaeozoic (Eopermian) to the Cenozoic (Quaternary). The development of each disease and the possible impacts caused on the lives of the affected wildlife were analysed for each illness, as well as the techniques used by each researcher and the notes they made. Some of the identified pathologies extend geographically and chronologically several diseases previously restricted to only a few groups of vertebrates and/or regions of the globe. Besides these Palaeopathological studies help in understanding how the pathology altered the biomechanics of a given animal, in establishing ecological relationships, and many other arrangements. [ABSTRACT FROM AUTHOR]

Paleopathology, the study of diseases and injuries from the fossil record, allows for a unique view into the life of prehistoric animals. Pathologies have nowadays been described in nearly all groups of fossil vertebrates, especially dinosaurs. Despite the large number of skeletons, pathologies had never been reported in the sauropodomorph Plateosaurus trossingensis. Here we describe the first pathologies of Plateosaurus using two individuals with pathologies in the chevrons of the tail, from the Upper Triassic of Trossingen, SW Germany. The two specimens each contain three consecutive pathological chevrons. Our results show that the pathologies were caused by external trauma in one individual and potentially tendinous trauma in the other. Healing of the lesions allowed survival of both animals. Using additional pathological specimens found in other collections and from multiple localities, we observe that 14.8% of all individuals of Plateosaurus contain pathologies within their chevrons, suggesting it was a vulnerable bone. [ABSTRACT FROM AUTHOR]

Background: The history of rare diseases is largely unknown. Research on this topic has focused on individual cases of prominent (historical) individuals and artistic (e.g., iconographic) representations. Medical collections include large numbers of specimens that exhibit signs of rare diseases, but most of them date to relatively recent periods. However, cases of rare diseases detected in mummies and skeletal remains derived from archaeological excavations have also been recorded. Nevertheless, this direct evidence from historical and archaeological contexts is mainly absent from academic discourse and generally not consulted in medical research on rare diseases. Results: This desideratum is addressed by the Digital Atlas of Ancient Rare Diseases (DAARD: https://daard.dainst.org), which is an open access/open data database and web-based mapping tool that collects evidence of different rare diseases found in skeletons and mummies globally and throughout all historic and prehistoric time periods. This easily searchable database allows queries by diagnosis, the preservation level of human remains, research methodology, place of curation and publications. In this manuscript, the design and functionality of the DAARD are illustrated using examples of achondroplasia and other types of stunted growth. Conclusions: As an open, collaborative repository for collecting, mapping and querying well-structured medical data on individuals from ancient times, the DAARD opens new avenues of research. Over time, the number of rare diseases will increase through the addition of new cases from varied backgrounds such as museum collections and archaeological excavations. Depending on the research question, phenotypic or genetic information can be retrieved, as well as information on the general occurrence of a rare disease in selected space–time intervals. Furthermore, for individuals diagnosed with a rare disease, this approach can help them to build identity and reveal an aspect of their condition they might not have been aware of. Thus, the DAARD contributes to the understanding of rare diseases from a long-term perspective and adds to the latest medical research. [ABSTRACT FROM AUTHOR]

Objectives: This research aimed to replicate the Swinson, D., Snaith, J., Buckberry, J., & Brickley, M. (2010). High performance liquid chromatography (HPLC) in the investigation of gout in paleopathology. International Journal of Osteoarchaeology, 20, 135–143. https://doi.org/10.1002/oa.1009 method for detecting uric acid in archeological human remains to investigate gout in past populations and to improve the original High Performance Liquid Chromatography‐ultraviolet (HPLC‐UV) method by using HPLC‐mass spectrometry (HPLC‐MS), a more sensitive, compound‐specific detection method. Materials and Methods: We used reference samples of uric acid to create a dilution series to assess the limits of quantification and detection. Samples from individuals with and without gout lesions were taken from foot bones and ribs from the English cemeteries of Tanyard, Hickleton, Gloucester, and Lincoln. Results: We could not replicate the results of Swinson and colleagues using HPLC‐UV. Tests using a dilution series of uric acid showed HPLC‐MS was approximately 100× more sensitive than HPLC‐UV, with the additional benefit of being compound specific. A newly developed hydrophilic interaction chromatography (HILIC) method improved retention characteristics. Fourteen samples from eight individuals, five with skeletal lesions consistent with gout, were analyzed with the final method. None showed evidence of uric acid despite the newly developed method's improved sensitivity and specificity. Discussion: The lack of detectable uric acid extracted from these samples suggests that (1) urate crystals were not present in any of the bone samples, regardless of gout status; (2) urate crystals did not survive these specific archeological conditions; or (3) the concentration of uric acid in our bone extracts was low, and thus larger samples would be required. [ABSTRACT FROM AUTHOR]

The analysis of traumatic injuries in human skeletal remains from archaeological contexts offers important challenges for the reconstruction of past populations’ behaviors. In this study, a sample of 303 buried skeletons retrieved from the Etruscan necropolis of Spina (Ferrara, Italy) and dated back to the 5th to the 3rd century BC, were macroscopically analyzed for traumatic injuries. The sample consisted of 38% males, 22% females, and 40% undetermined individuals. Subadults represented 25% of the entire sample. The aim of this study was to collect and describe new data on antemortem and perimortem injuries in the Spina Etruscans, bringing a new perspective to the understanding of social behaviors in this population. In the sample of Etruscans examined 16 individuals showed evidence of one injury and two individuals of two injuries. The analysis revealed 18 cases of antemortem trauma and 2 cases of perimortem trauma. No traumatic injuries were detected among subadults, while men and women presented different types of traumas: women were more prone to stress fractures involving the spine, whereas men were affected by antemortem and perimortem inflicted traumas, suggesting a division of labor and a major exposition of the latter to interpersonal violence. The reduced presence of sharp force traumas found exclusively in males (3 cases, 1.3% of the adult sample) is basically consistent with archaeological and historical data that described this site as a free port without an explicit history of violence. [ABSTRACT FROM AUTHOR]

This article, published in the European Heart Journal, presents the findings of the HORUS study, which aimed to investigate the presence of atherosclerosis in ancient mummified humans. The study analyzed whole body CT scans of mummies from seven different cultures, including Egyptian, Peruvian, Bolivian, Unangan/Aleutian Islander, Greenlandic Inuit, ancestral Puebloan, and Middle-Ages Gobi Desert pastoralists. The results showed that atherosclerosis was present in all cultures except for one Indigenous Australian mummy. The study suggests that atherosclerosis has been a part of human populations for thousands of years and supports the existence of an innate human predisposition to the disease. [Extracted from the article]

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Simple Summary: This paper presents, to the best of our knowledge, the first documented instance of a specific pathological lesion found in a Late Iron Age (La Tène period) horse. This discovery was made in the CX 143 pit in Alba Iulia, Romania, during archaeological rescue excavations conducted in 2022. In addition to the standard morphological features of the horse, comprehensive investigations revealed an unusual lesion on the left scapular neck. This lesion was evaluated both macroscopically and radiologically and has been interpreted as periarticular and supraarticular hyperostosis. A series of hypotheses were proposed regarding the cause of this specific type of injury, including the possibility of it being traumatic in nature, and potentially influenced by particular conformational aspects of the identified horse. The reconstruction of past life based on archaeozoology is a challenging domain that offers a range of valuable details concerning former human and animal populations. Additionally, the ancient era is a source of information for human and veterinary medicine, as well as for other biological sciences. This report highlights a pathological lesion identified during the investigation of a horse skeleton from a pit dated La Tène in Alba County (Romania). The left scapula with lesions was collected from the skeleton of a buried 7–8-year-old male horse. The aforementioned bone underwent gross, radiological, and computerized tomography evaluation. Macroscopically, a collar of supraarticular cancellous hyperostosis was detected, most likely as a consequence of an invasive chronic phlegmonous periarthritis and/or bursitis of the infraspinate muscle following probably a penetrating cutaneous wound in the shoulder region. A suppurative periarthritis\bursitis of the infraspinate muscle situated nearby caused, apparently, supraglenoidian periosteitis responsible for osteophytes and exostoses formation in the neck region of the scapula. [ABSTRACT FROM AUTHOR]

SUMMARY: Over the past decade, the history of tobacco's introduction to Europe and its societal impact has been extensively studied, resulting in prevailing narratives about its adoption and consumption. In the Netherlands, historical records generally concur that: (I) tobacco rose in popularity among all socioeconomic classes between 1590 and 1630 CE; and (II) it spread throughout the Country as a male habit. However, the presence and consumption of tobacco have exhibited profound variations across diverse societies throughout history, manifesting dissimilar patterns of employment and significance over varying temporal and spatial dimensions. By analysing a sample of 351 human skeletons dating from 1300 to 1829 CE, the present study challenges the limited historical narratives presented above and emphasizes the diverse contextual factors that influenced tobacco's prevalence in two different Dutch centres. Our results suggest that in certain areas of the Netherlands tobacco was likely present and widely consumed well before 1630 CE, while also highlighting overall substantial female participation in the practice. Furthermore, our analysis hints at the possibility of divergent methods of tobacco consumption between sexes, suggesting that the historical narrative of tobacco as solely a male habit may warrant reconsideration. Overall, our study contributes to a deeper understanding of the complex history of tobacco in the Netherlands, shedding light on historical trends and cultural practices. [ABSTRACT FROM AUTHOR]

This study investigates a series of antemortem injuries in the skeletal remains of a 36-45-year-old male from the medieval site of Rižinice. It presents the injuries comprising a fractured sternum, spinal hyperflexion, multiple rib fractures, and a non-union fracture to the olecranon process of the left ulna and a patella cubiti, a rare anomaly, which until now has not been reported in a paleopathological context. The research aims to uncover the causes, timing, and effects of these traumata, providing insight into the challenges of life in the mid-9th to mid-10th century.

Introduction. This paper presents results of an anthropological and paleopathological studies of newly excavated materials from the Karanayevsky cemetery located in the Southwestern Bashkortostan and attributed to Srubnaya culture. The goal of this study was to introduce new data from kurgan 2, as well as to compare this sample with the samples from other Karanayevsky kurgans, and with synchronous population characteristics of the region. Discussion involves skeletal material from 12 individual burials (nine children and three adults). Methods. Sex, age and the state of preservation/completeness of the remains were assessed. We performed a morphometric study, an analysis of dental morphology, description of pathologies and individual characteristics, taking into consideration the recommendations in the specific literature. The Spearman’s rank correlation coefficient was used to test for the relationship between skeletal preservation, sex, age, and grave construction. A single cranium from the kurgan was compared with the pooled samples from the region using Heincke’s method. The Fisher’s exact test was used to assess the possible statistical differences in frequencies of dental non-metric traits between the Karanayevsky kurgan 2 sample and the pooled Srubnaya samples of the Pre-Urals. Analysis. The skeleton preservation appears to be related to the age of the buried, but to a greater extent varies depending on the depth of the grave. The female skull from kurgan 2 shows characteristics of European ancestry and has mesomorphic morphology with a medium or slightly weakened horizontal and vertical profiling. It shows similarity to the pooled Srubnaya craniological series from the forest-steppe subareas. The dental morphology observed in the sample corresponds to the archaic gracile variant of European ancestry. Osteometric data characterize adult individuals as representatives of the mesomorphic, moderately massive group with reduced or medium limb length. Like in other groups of the region, the sample is defined by the predominance of dental calculus and dental chips, some markers of physiological and mechanical stress and the absence of indicators of specific infections. Results. In general, the Karanayevsky kurgan 2 skeletal sample corresponds to the characteristics of other Karanaevsky cemetery samples, and is consistent with the results on the synchronous sites of the Pre-Urals and Trans-Urals.

Objectives: To test a hypothesis on interpersonal violence events during the transition between Chalcolithic and Bronze Age in the Eastern Pyrenees, to contextualize it in Western Europe during that period, and to assess if these marks can be differentiated from secondary funerary treatment. Materials and Methods: Metric and non‐metric methods were used to estimate the age‐at‐death and sex of the skeletal remains. Perimortem injuries were observed and analyzed with stereomicroscopy and confocal microscopy. Results: Among the minimum of 51 individuals documented, at least six people showed evidence of perimortem trauma. All age groups and both sexes are represented in the skeletal sample, but those with violent injuries are predominantly males. Twenty‐six bones had 49 injuries, 48 of which involved sharp force trauma on postcranial elements, and one example of blunt force trauma on a cranium. The wounds were mostly located on the upper extremities and ribs, anterior and posterior. Several antemortem lesions were also documented in the assemblage. Discussion: The perimortem lesions, together with direct dating, suggest that more than one episode of interpersonal violence took place between the Late Chalcolithic and the Early Bronze Age in northeastern Spain. The features of the sharp force trauma indicate that different weapons were used, including sharp metal objects and lithic projectiles. The Roc de les Orenetes assemblage represents a scenario of recurrent lethal confrontation in a high mountain geographic context, representing the evidence of inferred interpersonal violence located at the highest altitude settings in the Pyrenees, at 1836 meters above sea level. [ABSTRACT FROM AUTHOR]

Climate change can adversely affect population health by limiting resource availability. Climate shocks may cause resource shortfalls directly via declining economic productivity, but favorable climate conditions may also create food shortages indirectly by promoting demographic growth that then pressures a resource base. Current population health and capacities for resilience reflect long-term human-environment interactions, highlighting the need for studies on the relationship between climate and population health through time. In this article, we combine theory from population ecology and life history with structural equation models to evaluate archaeological evidence of changing population health in response to climate change in the Nasca highlands of Peru from the terminal Middle Horizon to Late Intermediate period (1250 - 500 cal BP). Specifically, we examine potential causal chains between local precipitation, population growth, agricultural intensification, and two skeletal indicators of childhood physiological stress—cribra orbitalia (CO) and porotic hyperostosis (PH)—in 149 radiocarbon dated individuals. We find that higher precipitation has a positive indirect impact on PH frequency that is entirely mediated by local population pressure and maize agricultural intensification. Precipitation has a negative direct effect on CO, which is most common during intervals of extreme drought, low dietary maize inputs, and in periods of higher fertility. Additionally, we find that PH and CO negatively co-vary over time. These findings add to a growing body of evidence that, though PH and CO have historically been considered manifestations of the same pathological process, these two skeletal lesions likely result from distinct sources of physiological stress in the Prehispanic central Andes. [ABSTRACT FROM AUTHOR]

In their article, Finch and Burstein explore the hypothesis that Alzheimer's disease and related dementias (ADRD) may predominantly be phenomena of the modern era. Through a review of classical Greek and Latin literature, they found minimal reference to conditions akin to ADRD, suggesting a historical rarity of severe cognitive decline. Instead, ancient texts focused on physical aspects of aging, with cognitive changes, when noted, not resembling modern-day dementia. Finch and Burstein further extend their analysis by drawing parallels with the Tsimane people of Bolivia, known for their low prevalence of dementia and cardiovascular diseases, attributed to lifestyle factors such as diet and physical activity. By comparing historical sleep patterns transitioning from segmented to monophasic sleep with those of the Tsimane community, we enriched Finch and Burstein's research, highlighting the need to take into account a range of diverse factors, including sleep, in understanding the etiopathogenesis of ADRD in today's society. [ABSTRACT FROM AUTHOR]

Malaria is a disease of global significance. Ongoing changes to the earth's climate, antimalarial resistance, insecticide resistance, and socioeconomic decline test the resilience of malaria prevention programs. Museum insect specimens present an untapped resource for studying vector-borne pathogens, spurring the question: Do historical mosquito collections contain Plasmodium DNA, and, if so, can museum specimens be used to reconstruct the historical epidemiology of malaria? In this Perspective, we explore molecular techniques practical to pathogen prospecting, which, more broadly, we define as the science of screening entomological museum specimens for human, animal, or plant pathogens. Historical DNA and pathogen prospecting provide a means of describing the coevolution of human, vector, and parasite, informing the development of insecticides, diagnostics, therapeutics, and vaccines. [ABSTRACT FROM AUTHOR]

Humans have been constantly exposed to the environment in their daily activities, which may result in some pathological changes. Paleopathology research is rare, particularly on ancient humans who lived in Bali, Indonesia. This research is intended to gain more insight into the history of diseases and the community in the past to assist future health researchers. This study was conducted to understand variation in disease among the ancient populations in Bali, Indonesia. The study examines skeletons from the Gilimanuk, Semawang, and Pacung Sembiran sites in Bali, Indonesia, collected from 1964 to 2008. A total of 336 individuals were identified, including 63 adult males, 75 adult females, and 56 adults whose sex could not be determined. In addition, 142 children were included in the analysis. The examination of the individuals revealed the presence of various dental pathological changes, such as caries and enamel hypoplasia, as well as periodontitis. Furthermore, several bone-related diseases and abnormalities were identified, such as osteophytes, fractures, porotic hyperostosis, and spina bifida occulta. Available evidence suggests a similarity in the types of pathological changes among the ancient populations of Gilimanuk, Semawang, and Pacung Sembiran. While a comprehensive explanation of the paleopathological variations observed in these populations necessitates further investigation, the present findings hold considerable value for medical experts and anthropologists seeking to better understand patterns of disease distribution among ancient Indonesian populations. [ABSTRACT FROM AUTHOR]

The accurate comparison of prevalence rates of disease between different groups/populations is vital if we seek to contextualize our understanding of the impact of risk factors on health in the past. The majority of bioarchaeological studies of maxillary sinusitis employ the methods and "diagnostic criteria" outlined by Boocock and colleagues in 1995. However, until now, few attempts have been made to assess the inter‐rater reliability of these methods. This study presents the results of the analysis of interobserver variability in the recording of bone changes related to maxillary sinusitis among three observers within three human osteoarchaeological populations. The results of Cohen's kappa coefficient tests indicated variability in agreement between different observers. The agreement on the presence/absence of maxillary sinusitis in different osteoarchaeological populations ranged from κ = 0.433 ("moderate" agreement) to κ = 0.629 ("substantial" agreement). The agreement on the type of bone change present within affected sinuses was often poor, with almost no to negative agreement for pitting (Observers 1 and 2) and remodeled spicules (Observers 1 and 3). Methodological problems that can impact consistency of results between researchers include variability in sinus preservation, duration of observer experience, the use of different endoscopic equipment, lack of clarity in the original method descriptions, and a deficit in clinical corroborations for bone changes. The results of this study highlight the need to improve standards for the recording of bone changes related to sinusitis to allow for meaningful comparisons of past maxillary sinusitis frequency rates. Further investigations of interobserver variability, incorporating a greater range of variables, are also required. [ABSTRACT FROM AUTHOR]

A pathological metatarsal of the early-branching megaraptoran Phuwiangvenator yaemniyomi from the Lower Cretaceous of Thailand is here studied. It was CT-scanned and compared with pathology in other dinosaurs and living animals. The result shows that the palaeopathology in Phuwiangvenator was a traumatic fracture, specifically a greenstick fracture, based on the incomplete breakage of the bone, which occurred only on one side and twisted or distorted in the opposite direction to the force that caused the pathology. The cause of the fracture was possibly by accidentally hitting or kicking hard material, fighting, or falling to the ground. Phuwiangvenator was probably an adolescent when it was injured and survived the incident. This is the second report of a greenstick fracture in Theropoda after Akansaurus fridayii; the first detailed analysis of palaeopathology in Megaraptora; and the first record and detailed description of palaeopathology in non-avian theropods in Southeast Asia. [ABSTRACT FROM AUTHOR]

The article presents the results of a study of the materials from the necropolis of the Chersonesus fortified settlement, dated V–IV centuries BC. 70 individuals were examined, the main attention was paid to determining the key demographic and paleopathological features of the group. The distribution of mortality rates is consistent with the standard for paleopopulations, both within the entire group and for its male and female subsets. The group is characterized by early age at death, moderately high infant (under 15) mortality, and a low proportion of elderly population. A high occurrence of routine non-lethal injuries cases as well as the cribra orbitalia prevalence might be defined as a notable feature of the group based on the results of the paleopathological analysis. All identified characteristics may reflect the group's adaptation to the new living conditions during the initial stages of the colony growth.

Abstract Studies on pathological fossil bones have allowed improving the knowledge of physiology and ecology, and consequently the life history of extinct organisms. Among extinct vertebrates, non-avian dinosaurs have drawn attention in terms of pathological evidence, since a wide array of fossilized lesions and diseases were noticed in these ancient organisms. Here, we evaluate the pathological conditions observed in individuals of different brachyrostran (Theropoda, Abelisauridae) taxa, including Aucasaurus garridoi, Elemgasem nubilus, and Quilmesaurus curriei. For this, we use multiple methodological approaches such as histology and computed tomography, in addition to the macroscopic evaluation. The holotype of Aucasaurus shows several pathognomonic traits of a failure of the vertebral segmentation during development, causing the presence of two fused caudal vertebrae. The occurrence of this condition in Aucasaurus is the first case to be documented so far in non-tetanuran theropods. Regarding the holotype of Elemgasem, the histology of two fused vertebrae shows an intervertebral space between the centra, thus the fusion is limited to the distal rim of the articular surfaces. This pathology is here considered as spondyloarthropathy, the first evidence for a non-tetanuran theropod. The microstructural arrangement of the right tibia of Quilmesaurus shows a marked variation in a portion of the outer cortex, probably due to the presence of the radial fibrolamellar bone tissue. Although similar bone tissue is present in other extinct vertebrates and the cause of its formation is still debated, it could be a response to some kind of pathology. Among non-avian theropods, traumatic injuries are better represented than other maladies (e.g., infection, congenital or metabolic diseases, etc.). These pathologies are recovered mainly among large-sized theropods such as Abelisauridae, Allosauridae, Carcharodontosauridae, and Tyrannosauridae, and distributed principally among axial elements. Statistical tests on the distribution of injuries in these theropod clades show a strong association between taxa-pathologies, body regions-pathologies, and taxa-body regions, suggesting different life styles and behaviours may underlie the frequency of different injuries among theropod taxa.

Introduction. The publication finalizes the series of paleodemographic studies into materials from Catacomb burials discovered by archaeologists in grave mounds across the three territorial zones of Kalmykia — Sarpa Lowland, Yergeni Upland, and Caspian Depression. The current paper focuses on anthropological material from burials investigated in the Caspian Depression. Goals. The study shall introduce new anthropological material from the Middle Bronze Age once discovered in the territory of Kalmykia. Materials and methods. The work examines human bone remains from grave fields of the Caspian Depression stored at the Osteological Materials Repository of Kalmyk Scientific Center (RAS). Age and sex determination procedures have been conducted following a comprehensive anthropological program. Results. The diverse research efforts have yielded paleodemographic characteristics of the population that once inhabited the Caspian Depression, a comparative intra-group principal component analysis involving synchronous anthropological series in the territory of Kalmykia (multivariate statistics), and a discussion of summarized results of our insights into the demographic situation across Middle Bronze Age Kalmykia. The paper notes some similarities (and differences) between the identified paleodemographic indicators and those of neighboring regions (Republic of Dagestan and Rostov Oblast) on average age of death, high mortality of children, and predominance of male individuals, the two latter being typical for societies of that era. The Kalmykia-based materials are characterized by almost equal mean ages of death in the male and female groups, and a larger number of individuals aged fifty and more, with a small but evident predominance of female ones among the latter.

For the first time, a contextual consideration of some paleopathological manifestations on the adult skulls from the excavations of the Altyn-Asar 4 (n=363) burial grounds is proposed, which makes it possible to indirectly assess social stratification degree of the population of the Eastern Aral Sea region and the chronological dynamics of some indicators reflecting the quality of life of the population of the era of migrations. Comparison of the total samples selected according to chronology (2nd century BC – 2nd century AD, 2nd – 4th centuries, 4th – 6th centuries) revealed consistently high frequencies of enamel hypoplasia, intercalary bones on the cranial vault and metopic suture. In the sample of 2nd – 4th centuries, a downward trend in the frequencies of caries and abscesses was traced. When correlated with the type of burial structures (crypts of 2 types, soil pits of 4 types), a better state of health of the dental system was revealed in individuals in crypts of the first type, and, in general, in those buried in crypts compared to those buried in the soil pits. The most diverse picture is obtained from the analysis of the materials from the detached cemeteries. The frequencies of discretely varying features confirm the previous conclusions about the heterogeneity of the anthropological composition in the Jetyasar population, in particular, of the migrant origin of those buried in the Altyn-Asar 4m burial ground. Variations in the frequency of dental pathologies, anemia, and enamel hypoplasia may reflect differences in the lifestyle and quality of life of those buried in different necropolises, for example, different levels of dietary stress. A high number of skull injuries, including fatal wounds caused by military weapons, indicate the aggressive nature of the social environment. The greatest number of such damages is observed in the 2nd – 4th centuries‘ series.

The Paper presents publication and analysis of the burial materials from excavations of a detached kurgan Kalinovsky II located in the central part of the Volga-Don interfluve near the eastern outskirts of the Kalinovsky farm of the Frolovsky district of the Volgograd region. The kurgan under consideration is located on the southern Archeda steppe riverside terrace of the left confluent of the Medveditsa River belonging to the Don River basin. The excavations were carried out in 2022 by the expedition of the Volgograd State University. In the course of the excavations, it was found that the archeological site was a kurgan-cemetery which had functioned for a long time. It contained 20 burials of an extended chronological period from the Bronze Age to the Early Iron Age. This study examines burial complexes of the Bronze Age from archaeological and anthropological perspectives and is based on the materials from 12 burials. The main burial No. 14 can be attributed to the late stage of the Early Bronze Age within the boundaries of the first half of the 3rd millennium BC. The Middle Bronze Age is represented by 9 inlet burials belonging to the Middle Don Catacomb culture. Two burials No. 2 and 19, located in the lateral part of the kurgan mound, were made in the Late Bronze Age in 19th-18th centuries BC. The paleoanthropological study data have shown that this kurgan is to be considered as a family cemetery for a group of individuals (mainly children) belonging to the Middle Don Catacomb culture. The signs of deliberate artificial deformation in most of the children may indicate selectivity and belonging of this complex to a particular group with a special social status. In all probability, most of the children buried in the kurgan died as a result of stress caused by a long period of hunger, possibly in winter or early spring seasons. For adults, regardless of cultural affiliation, the typical diet was based on viscous food rich in proteins, as indicated by a specific pathological complex (absence of caries and abscesses, presence of tartar, periodontal disease and interproximal grooves). Exostosis of the external auditory canal was identified in a Pokrovsk time individual from burial 19 which might have been caused by his professional activity associated with a long stay in a cold wind or water environment.