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127 results on '"Paleologo, G."'

21. Dissociation between carotid artery lesions and lipid parameters in recipients of successful kidney graft

Author

Giannarelli, R., Coppelli, A., Aragona, M., Boggi, U., Napoli, V., Donadio, F., Paleologo, G., Tregnaghi, C., Rizzo, G., Mosca, F., Del Prato, F., and Piero Marchetti

Subjects
Adult, Carotid Artery Diseases, Male, Arteriosclerosis, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Kidney Transplantation, Lipids, Body Mass Index, Carotid Arteries, Cholesterol, Cyclosporine, Humans, Female, Immunosuppressive Agents, Triglycerides, Ultrasonography
Abstract

The relationships between lipid levels and atherosclerotic lesions of carotid arteries in kidney graft recipients are still unclear.We evaluated carotid morphology in 53 recipients of functioning renal transplantation, and studied the relationship of carotid artery wall lesions with relevant clinical and laboratory risk factors for cardiovascular disease. The patients were on stable, cyclosporine-based immunosuppressive therapy.The main clinical characteristics of patients were: age, 46.5 +/- 10.1 years; males/females, 40/13; body mass index, 25.8 +/- 4.4 kg/m2; duration of transplantation, 43 +/- 52 months. Ultrasonographic scanning of carotid arteries showed the presence of lesions (intimal-media thickness and/or plaque) in 28 patients (52.8%). These recipients differed from patients without carotid lesions in terms of age (50.4 +/- 9.0 vs 42.2 +/- 9.7 years, p0.01) and duration of pre-transplant dialysis (4.6 +/- 3.4 vs 2.3 +/- 1.9 years, p0.01), whereas no statistically significant difference was observed as for total cholesterol (230 +/- 44 vs 235 +/- 35 mg/dl), LDL-cholesterol (142 +/- 32 vs 143 +/- 30 mg/dl), HDL-cholesterol (52 +/- 12 vs 58 +/- 20 mg/dl) and triglycerides (178 +/- 94 vs 167 +/- 89 mg/dl). The percentage of post-transplant diabetes was 3-fold higher in patients with carotid lesions (25 vs 8%). No difference was observed as for the following parameters: body mass index, duration of transplantation, fibrinogen levels, DDimer concentrations, reactive C-protein values, prevalence of hypertension, percentage of smokers vs non-smokers.The present study supports the view that carotid artery lesions in kidney graft recipients on stable, cyclosporine-based immunosuppressive therapy may not be related to circulating lipid values.

Published
2004

47. Low-antigen-content diet in the treatment of patients with IgA nephropathy.

Author

Ferri, C., Puccini, R., Longombardo, G., Paleologo, G., Migliorini, P., Moriconi, L., Pasero, G., and Cioni, L.

Abstract

Since dietary macromolecular antigens can be involved in the pathogenesis of IgA nephropathy (IgAN), the effect of a low-antigen-content diet was evaluated in 21 patients (10 women, 11 men, mean age 27.7±10 years) with immunohistochemical findings of active IgAN. The diet was followed for a 14–24-week period (mean 18.8±6); in all cases the effects of the treatment were evaluated by clinical and serological parameters, and in 11 patients also by repeat renal biopsy. After dietetic therapy a significant reduction of urinary proteins was recorded (< 0.001); in particular, heavy proteinuria (>1 g/day), present in 12 cases during the 6 months preceding the treatment, was markedly reduced or disappeared in 11. At posttreatment control biopsy mesangial and parietal deposits of immunoglobulins, complement C, fraction and fibrinogen were significantly reduced. The improvement of the objective parameters such as heavy proteinuria, a strong predictor of a poor prognosis, and of immunohistochemical alterations indicate that a low-antigen diet can positively affect patients with IgAN. These results could be ascribed to a reduction of nephritogenic food antigen input and to a putative functional restoration of the mononuclear phagocytic system. [ABSTRACT FROM PUBLISHER]

Published
1993

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