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Background: The Mamanet Cachibol League (MCL), a community-based model developed in Israel, promotes physical activity and amateur team sports among women. Women in the Arab society have traditionally played few sports, especially team sports. Aims: The study aimed to assess the differences in health indicators and well-being, including psychosomatic symptoms, self-reported health, healthy eating habits, and social support, by comparing Arab women MCL participants and nonparticipants and examines benefits and motivations of community-based team sports for participants. Methods: An explanatory sequential mixed-methods approach included a cross-sectional study with intervention and control groups of Israeli Arab women aged 25–59 years. Two-way analyses of covariance and multiple regression models evaluated demographics, well-being, healthy eating, and social support. Quality in-depth interviews with 30 MCL participants further explained the quantitative findings. Results: MCL participants reported higher self-assessed health (P <.001) and decreased psychosomatic symptoms (P <.001) than nonparticipants. Healthier eating and well-being were also linked to MCL participation. The women sense of belonging improved social interactions, personal and professional happiness, and group dedication. MCL attendees felt empowered because the group advocated equality and valued women. Women said their involvement helped their families. Conclusions: Findings on the MCL community-based model suggest that team sports may serve as an effective tool for promoting health and well-being of Arab women and foster positive community relationships. The sense of belonging and personal empowerment derived from being part of a sports team may also contribute to positive mental health outcomes. [ABSTRACT FROM AUTHOR]

The current study examines associations between mindful parenting, family support, and youth information management practices (disclosure, lying, and secrecy) in a diverse sample of college-attending emerging adults (n = 304). Participants were recruited through college classes, and students completed surveys in classrooms or in nearby campus spaces. Data were analyzed to assess for the potential interactive implications of parental mindfulness and support. Results indicate that both parenting variables are important to consider when conceptualizing emerging adults’ information management. Youth who reported the highest levels of parental mindfulness and support also disclosed the most to their parents about their daily activities. In contrast, youth who reported the lowest levels of mindfulness and support lied the most to their parents. Low support was also associated with increased secrecy. Results suggest that parent-youth relationships continue to be important through the emerging adult developmental period, especially in terms of promoting communication practices that can help youth adjust to their increasingly complex worlds.

Abstract Many of the world's most important crops are polyploid. The presence of more than two sets of chromosomes within their nuclei and frequently aberrant reproductive biology in polyploids present obstacles to conventional breeding. The presence of a larger number of homoeologous copies of each gene makes random mutation breeding a daunting task for polyploids. Genome editing has revolutionized improvement of polyploid crops as multiple gene copies and/or alleles can be edited simultaneously while preserving the key attributes of elite cultivars. Most genome‐editing platforms employ sequence‐specific nucleases (SSNs) to generate DNA double‐stranded breaks at their target gene. Such DNA breaks are typically repaired via the error‐prone nonhomologous end‐joining process, which often leads to frame shift mutations, causing loss of gene function. Genome editing has enhanced the disease resistance, yield components, and end‐use quality of polyploid crops. However, identification of candidate targets, genotyping, and requirement of high mutagenesis efficiency remain bottlenecks for targeted mutagenesis in polyploids. In this review, we will survey the tremendous progress of SSN‐mediated targeted mutagenesis in polyploid crop improvement, discuss its challenges, and identify optimizations needed to sustain further progress.

DIY's coastal area is one of DIY's development priorities by establishing the site as an economic corridor that impacts physical development, such as settlements in the coastal area of DIY. This study aims to analyze the distribution and density of settlements. The method used in research is a quantitative descriptive and Geography Information System approach. The analysis used in this study is Nearest Neighbour Analysis (NNA) and Kernel Density Analysis with an analysis tool in ArcGIS 10.5. The results of the NNA show that the three districts located on the coast of DIY have the same distribution pattern characteristics, namely, the clustered pattern, which means the NNA index value is

ZnO-Au nanocomposite thin films have been previously reported as hybrid metamaterials with unique optical properties such as plasmonic resonance properties and hyperbolic behaviors. In this study, Au composition in the ZnO-Au nanocomposites has been effectively tuned by target composition variation and thus resulted in microstructure and optical property tuning. Specifically, all the ZnO-Au nanocomposite thin films grown through the pulsed laser deposition (PLD) method show obvious vertically aligned nanocomposite (VAN) structure with the Au nanopillars embedded in the ZnO matrix. Moreover, the average diameter of Au nanopillars increases as Au concentration increases, which also leads to the redshifts in the surface plasmon resonance (SPR) wavelength and changes in the hyperbolic behaviors of the films. As a whole, this work discusses how strain-driven tuning of optical properties and microstructure resulted through a novel Au concentration variation approach which has not been previously attempted in the ZnO-Au thin film system. These highly ordered films present great promise in the areas of sensing, waveguides, and nanophotonics to name a few.

Cell lineage tracking is a long-standing and unresolved problem in biology. Microfluidic technologies have the potential to address this problem, by virtue of their ability to manipulate and process single-cells in a rapid, controllable and efficient manner. Indeed, when coupled with traditional imaging approaches, microfluidic systems allow the experimentalist to follow single-cell divisions over time. Herein, we present a valve-based microfluidic system able to probe the decision-making processes of single-cells, by tracking their lineage over multiple generations. The system operates by trapping single-cells within growth chambers, allowing the trapped cells to grow and divide, isolating sister cells after a user-defined number of divisions and finally extracting them for downstream transcriptome analysis. The platform incorporates multiple cell manipulation operations, image processing-based automation for cell loading and growth monitoring, reagent addition and device washing. To demonstrate the efficacy of the microfluidic workflow, 6C2 (chicken erythroleukemia) and T2EC (primary chicken erythrocytic progenitors) cells are tracked inside the microfluidic device over two generations, with a cell viability rate in excess of 90%. Sister cells are successfully isolated after division and extracted within a 500 nL volume, which was demonstrated to be compatible with downstream single-cell RNA sequencing analysis.

When human cord blood-derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. In particular, the cells pass through a transitory phase known as "multilineage-primed" state. These cells are characterized by a mixed gene expression profile, different in each cell, with the coexpression of many genes characteristic for concurrent cell lineages. The aim of our study is to understand the mechanisms of the establishment and the exit from this transitory state. We investigated this issue using single-cell RNA sequencing and ATAC-seq. Two phases were detected. The first phase is a rapid and global chromatin decompaction that makes most of the gene promoters in the genome accessible for transcription. It results 24 h later in enhanced and pervasive transcription of the genome leading to the concomitant increase in the cell-to-cell variability of transcriptional profiles. The second phase is the exit from the multilineage-primed phase marked by a slow chromatin closure and a subsequent overall down-regulation of gene transcription. This process is selective and results in the emergence of coherent expression profiles corresponding to distinct cell subpopulations. The typical time scale of these events spans 48 to 72 h. These observations suggest that the nonspecificity of genome decompaction is the condition for the generation of a highly variable multilineage expression profile. The nonspecific phase is followed by specific regulatory actions that stabilize and maintain the activity of key genes, while the rest of the genome becomes repressed again by the chromatin recompaction. Thus, the initiation of differentiation is reminiscent of a constrained optimization process that associates the spontaneous generation of gene expression diversity to subsequent regulatory actions that maintain the activity of some genes, while the rest of the genome sinks back to the repressive closed chromatin state.

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R. A. Fisher, genome-wide association studies (GWAS) extract information using averages and variances from genotype-phenotype datasets. Averages and variances are legitimated upon creating distribution density functions obtained through the grouping of data into categories. However, as data from within a given category cannot be differentiated, the investigative power of such methodologies is limited. Genomic informational field theory (GIFT) is a method specifically designed to circumvent this issue. The way GIFT proceeds is opposite to that of GWAS. Although GWAS determines the extent to which genes are involved in phenotype formation (bottom-up approach), GIFT determines the degree to which the phenotype can select microstates (genes) for its subsistence (top-down approach). Doing so requires dealing with new genetic concepts, a.k.a. genetic paths, upon which significance levels for genotype-phenotype associations can be determined. By using different datasets obtained in Ovis aries related to bone growth (dataset 1) and to a series of linked metabolic and epigenetic pathways (dataset 2), we demonstrate that removing the informational barrier linked to categories enhances the investigative and discriminative powers of GIFT, namely that GIFT extracts more information than GWAS. We conclude by suggesting that GIFT is an adequate tool to study how phenotypic plasticity and genetic assimilation are linked. NEW & NOTEWORTHY: The genetic basis of complex traits remains challenging to investigate using classic genome-wide association studies (GWASs). Given the success of gene editing technologies, this point needs to be addressed urgently since there can only be useful editing technologies whether precise genotype-phenotype mapping information is available initially. Genomic informational field theory (GIFT) is a new mapping method designed to increase the investigative power of biological/medical datasets suggesting, in turn, the need to rethink the conceptual bases of quantitative genetics. [ABSTRACT FROM AUTHOR]

An increasing number of scholars suggest the need to enhance the incorporation of diversity and social justice across all areas of family science. Part of this work has seen family science more strongly and explicitly incorporate intersectional theorizing to problematize individual biases and power positions, generally, and of researchers and participants, more specifically. More work is needed to connect theory, method, and methodology to advance the call of scholars. Here, we attend to this call by providing methodological considerations for conducting intersectional phenomenological research in family science. We begin with an overview of phenomenology, including its philosophical and methodological foundations and variations. We then introduce the history of intersectionality, followed by critical methodological considerations for intersectional phenomenological research in family science. This integration of intersectionality and phenomenological research centers the lived experiences of individuals and families with historically marginalized identities while attending to power dynamics often part of scholarship. [ABSTRACT FROM AUTHOR]

Background Since 2010, Israel has expanded the adoption of procedure-related group (PRG) based payments for hospitals. While there is a rich quantitative literature that assesses the effects of payment reforms on efficiency or quality of care, very few qualitative studies have focused on the impacts of diagnosis-related group (DRG)-like payments on hospitals from the perspective of hospital workers as change agents. Methods We used a qualitative, thematic analysis based on 33 semi-structured in-depth interviews with chief executive officers (CEOs), chief financial officers (CFOs), ward directors and physicians conducted in five public hospitals in Israel, sampled by maximum variation according to hospital characteristics. Results Interviewees reported that the payment reform led to organizational changes such as increased transparency and enhanced supervision. Interviewees also reported several actions in response to the economic incentives of PRGbased payment. These included (1) shifting activities to afterhours and using operating rooms (ORs) more efficiently to enable increased surgical volumes; (2) reducing costs by shortening lengths of stay and increasing cost-consciousness in procurement; and (3) increasing revenues by improving coding and selecting procedures. Moderating factors reduced the effects of the reform. For example, organizational factors such as the public nature of hospitals or the (un)availability of healthcare resources did not always allow hospitals to increase the number of cases treated. Also, conflicting incentives such as multiple payment mechanisms or underpricing of procedures blurred the incentives of the reform. Finally, managers and physicians have many other considerations that outweigh the economic ones. Conclusion PRG payments affected the organizational dynamics of hospitals and changed decision-making about admission and treatment policies. However, such effects were moderated by many other factors that should be considered when shaping and analyzing hospital payment reforms.

Author(s): Flora Paldi [sup.1] , Bonnie Alver [sup.1] , Daniel Robertson [sup.1] , Stephanie A. Schalbetter [sup.2] , Alastair Kerr [sup.1] , David A. Kelly [sup.1] , Jonathan Baxter [sup.2] [...], The three-dimensional architecture of the genome governs its maintenance, expression and transmission. The cohesin protein complex organizes the genome by topologically linking distant loci, and is highly enriched in specialized chromosomal domains surrounding centromeres, called pericentromeres.sup.1-6. Here we report the three-dimensional structure of pericentromeres in budding yeast (Saccharomyces cerevisiae) and establish the relationship between genome organization and function. We find that convergent genes mark pericentromere borders and, together with core centromeres, define their structure and function by positioning cohesin. Centromeres load cohesin, and convergent genes at pericentromere borders trap it. Each side of the pericentromere is organized into a looped conformation, with border convergent genes at the base. Microtubule attachment extends a single pericentromere loop, size-limited by convergent genes at its borders. Reorienting genes at borders into a tandem configuration repositions cohesin, enlarges the pericentromere and impairs chromosome biorientation during mitosis. Thus, the linear arrangement of transcriptional units together with targeted cohesin loading shapes pericentromeres into a structure that is competent for chromosome segregation. Our results reveal the architecture of the chromosomal region within which kinetochores are embedded, as well as the restructuring caused by microtubule attachment. Furthermore, we establish a direct, causal relationship between the three-dimensional genome organization of a specific chromosomal domain and cellular function. The three-dimensional structure of pericentromeres in budding yeast is defined by convergent genes, which mark pericentromere borders and trap cohesin complexes loaded at centromeres, generating an architecture that allows correct chromosome segregation.

Penelitian ini bertujuan untuk mendeskripsikan keterlaksanaan standar proses pada pembelajaran matematika menurut Kurikulum 2013 pada kelas XII SMA Negeri. Penelitian ini merupakan penelitian mixed method dengan desain sequential explanatory strategy. Partisipan pada penelitian ini adalah guru matematika kelas XII SMA Negeri di Kota Pekanbaru yang menerapkan Kurikulum 2013. Keterlaksanaan standar proses dinilai berdasarkan aspek perencanaan, pelaksanaan, dan penilaian pembelajaran. Analisis data deskriptif menggunakan kecenderungan keterlaksanaan dalam lima kriteria, yaitu sangat baik, baik, cukup, kurang, dan sangat kurang. Hasil penelitian menunjukkan bahwa keterlaksanaan standar proses menurut Kurikulum 2013 pada kelas XII SMA Negeri di Kota Pekanbaru ditinjau dari aspek perencanaan, pelaksanaan, dan penilaian pembelajaran adalah masuk pada kategori baik. Hasil penelitian juga menunjukkan bahwa pada aspek perencanaan guru masih mengalami kendala dalam penyusunan lembar kegiatan siswa, rencana pelaksanaan pembelajaran, serta perencanaan alokasi waktu. Pada aspek pelaksanaan pembelajaran, masih terdapat kendala yaitu pada kemauan guru untuk menerapkan pendekatan saintifik, terutama pada tahap menanya dan menalar. Adapun pada aspek penilaian, guru masih mengalami kendala terkait penilaian sikap dan keterampilan. The implementation of process standard in mathematics learning according to the Curriculum 2013 in 12th-grade of public senior high school Abstract This study aimed to describe the implementation of process standard in mathematics learning according to the Curriculum 2013 in 12th-grade of public senior high school. This research was mixed-method research with a sequential explanatory strategy design. Participants in this study were mathematics teachers of 12th-grade of public senior high school in Pekanbaru City, Indonesia who applied the Curriculum 2013. The process standard was assessed based on aspects of planning, implementing, and assessment of learning. Descriptive data analysis used the tendency of implementation in five criteria, namely very good, good, enough, less, and very less. The results showed that the implementation of process standard according to the Curriculum 2013 in class 12th-grade of public senior high school in Pekanbaru City in terms of planning, implementation, and assessment of learning were included in the good category. The results of the study also showed that in the aspect of planning, the teacher was still experiencing problems in the preparation of students’ worksheet, lesson plan, and time allocation planning. In the aspect of implementing learning, there were still obstacles, namely the teacher's willingness to apply a scientific approach, especially at the questioning and reasoning stages. As for the aspects of assessment, teachers still experience obstacles related to the assessment of attitudes and skills.

Nanocomposite thin film materials present great opportunities in coupling materials and functionalities in unique nanostructures including nanoparticles-in-matrix, vertically aligned nanocomposites (VANs), and nanolayers. Interestingly the nanocomposites processed through a non-equilibrium processing method, e.g., pulsed laser deposition (PLD), often possess unique metastable phases and microstructures that could not achieve using equilibrium techniques, and thus lead to novel physical properties. In this work, a unique three-phase system composed of BaTiO3 (BTO), with two immiscible metals, Au and Fe, is demonstrated. By adjusting the deposition laser frequency from 2 Hz to 10 Hz, the phase and morphology of Au and Fe nanoparticles in BTO matrix vary from separated Au and Fe nanoparticles to well-mixed Au-Fe alloy pillars. This is attributed to the non-equilibrium process of PLD and the limited diffusion under high laser frequency (e.g., 10 Hz). The magnetic and optical properties are effectively tuned based on the morphology variation. This work demonstrates the stabilization of non-equilibrium alloy structures in the VAN form and allows for the exploration of new non-equilibrium materials systems and their properties that could not be easily achieved through traditional equilibrium methods.

Epitaxial lithium niobate (LNO) thin films are an attractive material for devices across a broad range of fields, including optics, acoustics, and electronics. These applications demand high‐quality thin films without in‐plane growth domains to reduce the optical/acoustical losses and optimize efficiency. Twin‐free single‐domain‐like growth has been achieved previously, but it requires specific growth conditions that might be hard to replicate. In this work, a versatile nanocomposite‐seeded approach is demonstrated as an effective approach to grow single‐domain epitaxial lithium niobate thin films. Films are grown through a pulsed laser deposition method and growth conditions are optimized to achieve high‐quality epitaxial film. A comprehensive microstructure characterization is performed and optical properties are measured. A piezoelectric acoustic resonator device is developed to demonstrate the future potential of the nanocomposite‐seeded approach for high‐quality LNO growth for radio frequency (RF) applications.

Hyperbolic metamaterials are a class of materials exhibiting anisotropic dielectric function owing to the morphology of the nanostructures. In these structures, one direction behaves as a metal, and the orthogonal direction behaves as a dielectric material. Applications include subdiffraction imaging and hyperlenses. However, key limiting factors include energy losses of noble metals and challenging fabrication methods. In this work, self-assembled plasmonic metamaterials consisting of anisotropic nanoalloy pillars embedded into the ZnO matrix are developed using a seed-layer approach. Alloys of AuxAl1−x or AuxCu1−x are explored due to their lower losses and higher stability. Optical and microstructural properties were explored. The ZnO-AuxCu1−x system demonstrated excellent epitaxial quality and optical properties compared with the ZnO-AuxAl1−x system. Both nanocomposite systems demonstrate plasmonic resonance, hyperbolic dispersion, low losses, and epsilon-near-zero permittivity, making them promising candidates towards direct photonic integration.

It is time for the Islamic finance industry to create a unique and independent dispute resolution mechanism equipped with standardized legal contracts in order to modernize and harmonize dispute resolution across the Islamic finance industry. This brief article explores what went wrong with the Dana Gas Sukuk and then leads into why we need a Sukuk Bankruptcy Tribunal (SBT). The article sets out a proposal for such a tribunal including a framework for operation. [ABSTRACT FROM AUTHOR]

Oxytocin (OT) and vasopressin (AVP) are neuropeptides that govern the social-emotional functioning of humans. We contend that to fully understand their function, research should consider how they are flexibly fitted to maximize survival and reproduction given the variety of human experience. In a series of two studies, we show that early life stress is associated with change in the core function of OT and AVP in evolutionary predictable ways: Under high early life stress, AVP promotes threat-detection capabilities, whereas OT motivates non-selective proximity seeking to others. Conversely, under low early life stress these neuropeptides have an opposite, yet adaptive response: AVP promotes low vigilance and preservation of energy, whereas OT increases detection of interpersonal flaws. Our results demonstrate the plasticity of neuropeptide functioning that mirrors the variance in human social-emotional functioning.

This paper highlights the key features of the Christian and Islamic Economic systems and encourages Christians and Muslims to work together to develop not only a system of Christian Economics, but also a pan-Abrahamic system of economics called Holy Book Finance. The paper outlines various methods of inter-faith collaboration to make this vision a reality. [ABSTRACT FROM AUTHOR]