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3. Obsessive-compulsive disorder in the elderly: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

Author

Dell’Osso, B., Benatti, B., Rodriguez, C.I., Arici, C., Palazzo, C., Altamura, A.C., Hollander, E., Fineberg, N., Stein, D.J., Nicolini, H., Lanzagorta, N., Marazziti, D., Pallanti, S., Van Ameringen, M., Lochner, C., Karamustafalioglu, O., Hranov, L., Figee, M., Drummond, L., Grant, J., Denys, D., Cath, D., Menchon, J.M., and Zohar, J.

Published
2017
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4. INDIGO-DataCloud: a Platform to Facilitate Seamless Access to E-Infrastructures

Author

Salomoni, D., Campos, I., Gaido, L., de Lucas, J. Marco, Solagna, P., Gomes, J., Matyska, L., Fuhrman, P., Hardt, M., Donvito, G., Dutka, L., Plociennik, M., Barbera, R., Blanquer, I., Ceccanti, A., Cetinic, E., David, M., Duma, C., López-García, A., Moltó, G., Orviz, P., Sustr, Z., Viljoen, M., Aguilar, F., Alves, L., Antonacci, M., Antonelli, L. A., Bagnasco, S., Bonvin, A. M. J. J., Bruno, R., Chen, Y., Costa, A., Davidovic, D., Ertl, B., Fargetta, M., Fiore, S., Gallozzi, S., Kurkcuoglu, Z., Lloret, L., Martins, J., Nuzzo, A., Nassisi, P., Palazzo, C., Pina, J., Sciacca, E., Spiga, D., Tangaro, M., Urbaniak, M., Vallero, S., Wegh, B., Zaccolo, V., Zambelli, F., and Zok, T.

Published
2018
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7. Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload

Author

Bisicchia, E., Mastrantonio, R., Nobili, A., Palazzo, C., La Barbera, L., Latini, L., Millozzi, F., Sasso, V., Palacios, D., D'Amelio, M., Viscomi, M. T., Palacios, D. (ORCID:0000-0002-2207-2369), Viscomi, M. T. (ORCID:0000-0002-9096-4967), Bisicchia, E., Mastrantonio, R., Nobili, A., Palazzo, C., La Barbera, L., Latini, L., Millozzi, F., Sasso, V., Palacios, D., D'Amelio, M., Viscomi, M. T., Palacios, D. (ORCID:0000-0002-2207-2369), and Viscomi, M. T. (ORCID:0000-0002-9096-4967)

Abstract

The pathogenic mechanisms that underlie the progression of remote degeneration after spinal cord injury (SCI) are not fully understood. In this study, we examined the relationship between endoplasmic reticulum (ER) stress and macroautophagy, hereafter autophagy, and its contribution to the secondary damage and outcomes that are associated with remote degeneration after SCI. Using a rat model of spinal cord hemisection at the cervical level, we measured ER stress and autophagy markers in the axotomized neurons of the red nucleus (RN). In SCI animals, mRNA and protein levels of markers of ER stress, such as GRP78, CHOP, and GADD34, increased 1 day after the injury, peaking on Day 5. Notably, in SCI animals, the increase of ER stress markers correlated with a blockade in autophagic flux, as evidenced by the increase in microtubule-associated protein 2 light chain 3 (LC3-II) and p62/SQSTM1 (p62) and the decline in LAMP1 and LAMP2 levels. After injury, treatment with guanabenz protected neurons from UPR failure and increased lysosomes biogenesis, unblocking autophagic flux. These effects correlated with greater activation of TFEB and improved neuronal survival and functional recovery-effects that persisted after suspension of the treatment. Collectively, our results demonstrate that in remote secondary damage, impairments in autophagic flux are intertwined with ER stress, an association that contributes to the apoptotic cell death and functional damage that are observed after SCI.

Published
2022

8. Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma

Author

Testa, Erika, Palazzo, Claudia, Mastrantonio, Roberta, Viscomi, Maria Teresa, Testa E., Palazzo C., Mastrantonio R. (ORCID:0000-0002-1764-457X), Viscomi M. T. (ORCID:0000-0002-9096-4967), Testa, Erika, Palazzo, Claudia, Mastrantonio, Roberta, Viscomi, Maria Teresa, Testa E., Palazzo C., Mastrantonio R. (ORCID:0000-0002-1764-457X), and Viscomi M. T. (ORCID:0000-0002-9096-4967)

Abstract

GBM is the most aggressive brain tumor among adults. It is characterized by extensive vascularization, and its further growth and recurrence depend on the formation of new blood vessels. In GBM, tumor angiogenesis is a multi-step process involving the proliferation, migration and differentiation of BMECs under the stimulation of specific signals derived from the cancer cells through a wide variety of communication routes. In this review, we discuss the dynamic interaction between BMECs and tumor cells by providing evidence of how tumor cells hijack the BMECs for the formation of new vessels. Tumor cell–BMECs interplay involves multiple routes of communication, including soluble factors, such as chemokines and cytokines, direct cell–cell contact and extracellular vesicles that participate in and fuel this cooperation. We also describe how this interaction is able to modify the BMECs structure, metabolism and physiology in a way that favors tumor growth and invasiveness. Finally, we briefly reviewed the recent advances and the potential future implications of some high-throughput 3D models to better understanding the complexity of BMECs–tumor cell interaction.

Published
2022

12. Eular recommendations for the use of imaging in mechanical low back pain

Author

Hansen, B, Terslev, L, Berenbaum, F, Möller, I, Boesen, M, Laredo, J, Rannou, F, Lohmander, S, Englund, M, Baraliakos, X, Conaghan, P, Genevay, S, Palazzo, C, Wilson, D, Wilkie, R, Prieto-Alhambra, D, Kent, A, Makri, S, Navarro Compán, V, Nguyen, C, Bartels, M, Nordberg, C, D'Agostino, A, Fournier, G, and Force, E

Published
2019

14. Microbiological surveillance of endoscopes and implications for current reprocessing procedures adopted by an Italian teaching hospital.

Author

Cottarelli, A., De Giusti, M., Solimini, A. G., Venuto, G., Palazzo, C., Del Cimmuto, A., Osborn, J., and Marinelli, L.

Subjects
ENDOSCOPES, TEACHING hospitals, QUALITY assurance, PATHOGENIC microorganisms, MULTIDRUG resistance
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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18. INDIGO-DataCloud: a Platform to Facilitate Seamless Access to E-Infrastructures

Author

Sub NMR Spectroscopy, NMR Spectroscopy, Salomoni, D., Campos, I., Gaido, L., de Lucas, J. Marco, Solagna, P., Gomes, J., Matyska, L., Fuhrman, P., Hardt, M., Donvito, G., Dutka, L., Plociennik, M., Barbera, R., Blanquer, I., Ceccanti, A., Cetinic, E., David, M., Duma, C., López-García, A., Moltó, G., Orviz, P., Sustr, Z., Viljoen, M., Aguilar, F., Alves, L., Antonacci, M., Antonelli, L. A., Bagnasco, S., Bonvin, A. M.J.J., Bruno, R., Chen, Y., Costa, A., Davidovic, D., Ertl, B., Fargetta, M., Fiore, S., Gallozzi, S., Kurkcuoglu, Z., Lloret, L., Martins, J., Nuzzo, A., Nassisi, P., Palazzo, C., Pina, J., Sciacca, E., Spiga, D., Tangaro, M., Urbaniak, M., Vallero, S., Wegh, B., Sub NMR Spectroscopy, NMR Spectroscopy, Salomoni, D., Campos, I., Gaido, L., de Lucas, J. Marco, Solagna, P., Gomes, J., Matyska, L., Fuhrman, P., Hardt, M., Donvito, G., Dutka, L., Plociennik, M., Barbera, R., Blanquer, I., Ceccanti, A., Cetinic, E., David, M., Duma, C., López-García, A., Moltó, G., Orviz, P., Sustr, Z., Viljoen, M., Aguilar, F., Alves, L., Antonacci, M., Antonelli, L. A., Bagnasco, S., Bonvin, A. M.J.J., Bruno, R., Chen, Y., Costa, A., Davidovic, D., Ertl, B., Fargetta, M., Fiore, S., Gallozzi, S., Kurkcuoglu, Z., Lloret, L., Martins, J., Nuzzo, A., Nassisi, P., Palazzo, C., Pina, J., Sciacca, E., Spiga, D., Tangaro, M., Urbaniak, M., Vallero, S., and Wegh, B.

Published
2018

19. INDIGO-DataCloud: a platform to facilitate seamless access to e-infrastructures

Author

European Commission, Salomoni, Davide, Campos, Isabel, Gaido, Luciano, Marco, Jesús, Solagna, P., Gomes, Jorge, Matyska, Ludek, Fuhrmann, Patrick, Hardt, Marcus, Donvito, Giacinto, Dutka, L., Plociennik, Marcin, Barbera, R., Blanquer, Ignacio, Ceccanti, Andrea, Cetinic, E., David, Mario, Duma, Doina Cristina, López García, Álvaro, Moltó, Germán, Orviz, Pablo, Šustr, Zdenêk, Viljoen, M., Aguilar, Fernando, Alves, Lincoln M., Antonacci, Marica, Antonelli, L., Bagnasco, Stefano, Bonvin, A. M. J. J., Bruno, R., Chen, Y., Costa, A., Davidovic, D., Ertl, B., Fargetta, M., Fiore, S., Gallozzi, S., Kurkcuoglu, Z., Lloret Iglesias, Lara, Martins Careto, João António, Nuzzo, A., Nassisi, P., Palazzo, C., Pina, Joâo, Sciacca, E., Spiga, Daniele, Tangaro, M., Urbaniak, Michał, Vallero, Sara, Wegh, B., Zaccolo, Valentina, Zambelli, F., Zok, T., European Commission, Salomoni, Davide, Campos, Isabel, Gaido, Luciano, Marco, Jesús, Solagna, P., Gomes, Jorge, Matyska, Ludek, Fuhrmann, Patrick, Hardt, Marcus, Donvito, Giacinto, Dutka, L., Plociennik, Marcin, Barbera, R., Blanquer, Ignacio, Ceccanti, Andrea, Cetinic, E., David, Mario, Duma, Doina Cristina, López García, Álvaro, Moltó, Germán, Orviz, Pablo, Šustr, Zdenêk, Viljoen, M., Aguilar, Fernando, Alves, Lincoln M., Antonacci, Marica, Antonelli, L., Bagnasco, Stefano, Bonvin, A. M. J. J., Bruno, R., Chen, Y., Costa, A., Davidovic, D., Ertl, B., Fargetta, M., Fiore, S., Gallozzi, S., Kurkcuoglu, Z., Lloret Iglesias, Lara, Martins Careto, João António, Nuzzo, A., Nassisi, P., Palazzo, C., Pina, Joâo, Sciacca, E., Spiga, Daniele, Tangaro, M., Urbaniak, Michał, Vallero, Sara, Wegh, B., Zaccolo, Valentina, Zambelli, F., and Zok, T.

Abstract

This paper describes the achievements of the H2020 project INDIGO-DataCloud. The project has provided e-infrastructures with tools, applications and cloud framework enhancements to manage the demanding requirements of scientific communities, either locally or through enhanced interfaces. The middleware developed allows to federate hybrid resources, to easily write, port and run scientific applications to the cloud. In particular, we have extended existing PaaS (Platform as a Service) solutions, allowing public and private e-infrastructures, including those provided by EGI, EUDAT, and Helix Nebula, to integrate their existing services and make them available through AAI services compliant with GEANT interfederation policies, thus guaranteeing transparency and trust in the provisioning of such services. Our middleware facilitates the execution of applications using containers on Cloud and Grid based infrastructures, as well as on HPC clusters. Our developments are freely downloadable as open source components, and are already being integrated into many scientific applications.

Published
2018

20. ASSESSING RISK OF CYBER THREATS USING CISIAPRO SIMULATOR

Author

FOGLIETTA, CHIARA, Palazzo C, SANTINI, RICCARDO, PANZIERI, Stefano, Butts J.,Shenoi S., Springer New York LLC, Foglietta, Chiara, Palazzo, C, Santini, Riccardo, and Panzieri, Stefano

Subjects
Critical Infrastructure, cyber threats
Abstract

Dependencies and, eventually, interdependencies among Critical Infras- tructures are difficult to identify and to model, because their effects appears in few situations with unpredictable consequences. Adding cy- ber attacks in this context makes analysis even more complex. Inte- grating cyber attacks and interdependencies consequences requires the knowledge of both fields with a common abstraction level. CISIApro is a Critical Infrastructure simulator, and it was born for eval- uating consequences of faults and failures on interdependent infrastruc- tures. In this paper, CISIApro implements the effects of cyber attacks on physical equipment and on infrastructure services. The case study highlights the main functionality of the simulator, with a complex scenario where several events may happen: first an ARP spoofing attack, and then a worm infection. The scenario considers three interconnected infrastructures: a medium voltage power grid, controlled by a SCADA control center over a SCADA network, interconnected with a general-purpose telecommunication network. The simulation results display the output of CISIApro in event of cyber attacks. The simulation demonstrates the help of CISIApro output in a decision making process for electric operators: specifically, the choice between different re-configurations.

Published
2015

21. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia

Author

Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Bellomo, A, Biondi, M, Brugnoli, R, Dell'Osso, L, De Ronchi, D, Di Emidio, G, Di Giannantonio, M, Fagiolini, A, Marchesi, C, Monteleone, P, Oldani, L, Pinna, G, S, Pinna, F, Roncone, R, Sacchetti, E, Santonastaso, P, Siracusano, A, Vita, A, Zeppegno, P, Maj, M, Chieffi, M, De Simone, S, De Riso, F, Giugliano, R, Piegari, G, Vignapiano, A, Caforio, G, Mancini, M, Colagiorgio, L, Porcelli, S, Salfi, R, Bianchini, O, Galluzzo, A, Barlati, S, Carpiniello, B, Fatteri, F, Di Santa Sofia, S, Cannavò, D, Minutolo, G, Signorelli, M, Martinotti, G, Di Iorio, G, Acciavatti, T, Pallanti, S, Faravelli, C, Altamura, M, Stella, E, Marasco, D, Calcagno, P, Respino, M, Marozzi, V, Riccardi, I, Collazzoni, A, Stratta, P, Giusti, L, Ussorio, D, Delauretis, I, Serati, M, Caldiroli, A, Palazzo, C, Iasevoli, Fz, Gramaglia, C, Gili, S, Gattoni, E, Tenconi, E, Giannunzio, V, Monaco, F, De Panfilis, C, Camerlengo, A, Ossola, P, Landi, P, Rutigliano, G, Pergentini, I, Mauri, M, Di Fabio, F, Torti, C, Buzzanca, A, Comparelli, A, De Carolis, A, Corigliano, V, DI LORENZO, G, Niolu, C, Troisi, A, Corrivetti, Aa, G, Pinto, Diasco, Aa, F, Goracci, A, Bolognesi, S, Borghini, E, Montemagni, C, Frieri, T, Birindelli, N, Galderisi, S., Rossi, A., Rocca, P., Bertolino, A., Mucci, A., Bucci, P., Rucci, P., Gibertoni, D., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Brugnoli, R., Dell'Osso, L., De Ronchi, D., Di Emidio, G., Di Giannantonio, M., Fagiolini, A., Marchesi, C., Monteleone, P., Oldani, L., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Chieffi, M., De Simone, S., De Riso, F., Giugliano, R., Piegari, G., Vignapiano, A., Caforio, G., Mancini, M., Colagiorgio, L., Porcelli, S., Salfi, R., Bianchini, O., Galluzzo, A., Barlati, S., Carpiniello, B., Fatteri, F., Di Santa Sofia, S. L., Cannavo, D., Minutolo, G., Signorelli, M., Martinotti, G., Di Iorio, G., Acciavatti, T., Pallanti, S., Faravelli, C., Altamura, M., Stella, E., Marasco, D., Calcagno, P., Respino, M., Marozzi, V., Riccardi, I., Collazzoni, A., Stratta, P., Giusti, L., Ussorio, D., Delauretis, I., Serati, M., Caldiroli, A., Palazzo, C., Iasevoli, F., Gramaglia, C., Gili, S., Gattoni, E., Tenconi, E., Giannunzio, V., Monaco, F., De Panfilis, C., Camerlengo, A., Ossola, P., Landi, P., Rutigliano, G., Pergentini, I., Mauri, M., Di Fabio, F., Torti, C., Buzzanca, A., Comparelli, A., De Carolis, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Troisi, A., Corrivetti, G., Pinto, G., Diasco, F., Goracci, A., Bolognesi, S., Borghini, E., Montemagni, C., Frieri, T., Birindelli, N., Galderisi, Silvana, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Bucci, Paola, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Biondi, Massimo, Brugnoli, Roberto, Dell'Osso, Liliana, De Ronchi, Diana, Di Emidio, Gabriella, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pinna, Federica, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Chieffi, Marcello, De Simone, Stefania, De Riso, Francesco, Giugliano, Rosa, Piegari, Giuseppe, Vignapiano, Annarita, Caforio, Grazia, Mancini, Marina, Colagiorgio, Lucia, Porcelli, Stefano, Salfi, Raffaele, Bianchini, Oriana, Galluzzo, Alessandro, Barlati, Stefano, Carpiniello, Bernardo, Fatteri, Francesca, Di Santa Sofia, Silvia Lostia, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria, Martinotti, Giovanni, Di Iorio, Giuseppe, Acciavatti, Tiziano, Pallanti, Stefano, Faravelli, Carlo, Altamura, Mario, Stella, Eleonora, Marasco, Daniele, Calcagno, Pietro, Respino, Matteo, Marozzi, Valentina, Riccardi, Ilaria, Collazzoni, Alberto, Stratta, Paolo, Giusti, Laura, Ussorio, Donatella, Delauretis, Ida, Serati, Marta, Caldiroli, Alice, Palazzo, Carlotta, Iasevoli, Felice, Gramaglia, Carla, Gili, Sabrina, Gattoni, Eleonora, Tenconi, Elena, Giannunzio, Valeria, Monaco, Francesco, De Panfilis, Chiara, Camerlengo, Annalisa, Ossola, Paolo, Landi, Paola, Rutigliano, Grazia, Pergentini, Irene, Mauri, Mauro, Di Fabio, Fabio, Torti, Chiara, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Troisi, Alfonso, Corrivetti, Giulio, Pinto, Gaetano, Diasco, Ferdinando, Goracci, Arianna, Bolognesi, Simone, Borghini, Elisa, Montemagni, Cristiana, Frieri, Tiziana, and Birindelli, Nadia

Subjects
medicine.medical_specialty, media_common.quotation_subject, neurocognition, positive symptoms, Context (language use), avolition, Personal resource, Social cognition, Avolition, Disorganization, Engagement with mental health services, Internalized stigma, Neurocognition, Personal resources, Positive symptoms, Real-life functioning, Resilience, Schizophrenia, Psychiatry and Mental Health, Psychiatric Mental Health, medicine, real-life functioning, personal resources, Psychiatry, resilience, Settore MED/25 - Psichiatria, media_common, business.industry, Schizophrenia, avolition, disorganization, engagement with mental health services, internalized stigma, neurocognition, personal resources, positive symptoms, real-life functioning, resilience, disorganization, internalized stigma, engagement with mental health services, Social environment, Research Reports, medicine.disease, Mental health, Psychiatry and Mental health, Psychological resilience, Pshychiatric Mental Health, medicine.symptom, business, Positive symptom, Independent living, Engagement with mental health service
Abstract

In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia. In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia.

Published
2014

23. Use of benzodiazepines in relation to onset and duration of untreated illness in psychotic and affective disorders

Author

De Carlo, V., primary, Grancini, B., additional, Vismara, M., additional, Benatti, B., additional, Cremaschi, L., additional, Arici, C., additional, Oldani, L., additional, Palazzo, C., additional, De Cagna, F., additional, Degoni, L., additional, Baldassarri, E., additional, Dell’Osso, B., additional, and Altamura, A., additional

Published
2017
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26. LB0001 Intradiscal glucocorticoid injection for patients with chronic low back pain associated with active discopathy: a randomized trial

Author

Nguyen, C, primary, Boutron, I, additional, Baron, G, additional, Sanchez, K, additional, Palazzo, C, additional, Benchimol, R, additional, Paris, G, additional, James-Belin, E, additional, Lefèvre-Colau, M-M, additional, Beaudreuil, J, additional, Laredo, J-D, additional, Béra-Louville, A, additional, Cotten, A, additional, Drapé, J-L, additional, Feydy, A, additional, Ravaud, P, additional, Rannou, F, additional, and Poiraudeau, S, additional

Published
2017
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27. Intradiscal glucocorticoid injection for patients with chronic low back pain associated with active discopathy: a randomized trial

Author

Rannou, F., primary, Nguyen, C., additional, Boutron, I., additional, Baron, G., additional, Sanchez, K., additional, Palazzo, C., additional, Benchimol, R., additional, Paris, G., additional, James - Belin, E., additional, Lefevre Colau, M., additional, Beaudreuil, J., additional, Laredo, J., additional, Bera-Louville, A., additional, Cotten, A., additional, Drape, J., additional, Feydy, A., additional, Ravaud, P., additional, and Poiraudeau, S., additional

Published
2017
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28. Big data analytics for climate change and biodiversity in the EUBrazilCC federated cloud infrastructure

Author

Fiore, S., Mancini, M., Elia, D., Nassisi, P., Vilar Brasileiro, F., Blanquer, I., Rufino, I.A.A., Seijmonsbergen, A.C., de Oliveira Galvao, C., Perez Canhos, V., Mariello, A., Palazzo, C., Nuzzo, A., D'Anca, A., Aloisio, G., and Computational Geo-Ecology (IBED, FNWI)

Subjects
Knowledge extraction, Exploit, Software deployment, business.industry, Analytics, Computer science, Big data, Climate change, Cloud computing, Context (language use), business, Data science
Abstract

The analysis of large volumes of data is key for knowledge discovery in several scientific domains such as climate, astrophysics, life sciences among others. It requires a large set of computational and storage resources, as well as flexible and efficient software solutions able to dynamically exploit the available infrastructure and address issues related to data volume, distribution, velocity and heterogeneity. This paper presents a data-driven and cloud-based use case implemented in the context of the EUBrazilCC project for the analysis of climate change and biodiversity data. The use case architecture and main components, as well as a Platform as a Service (PaaS) framework for big data analytics named PDAS, together with its elastic deployment in the EUBrazilCC federated cloud infrastructure are presented and discussed in detail.

Published
2015
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30. Comparative evaluation of the Vitek-2 Compact and Phoenix systems for rapid identification and antibiotic susceptibility testing directly from blood cultures of Gram-negative and Gram-positive isolates

Author

Gherardi G, Angeletti S, Panitti M, Pompilio A, Di Bonaventura G, Crea F, Avola A, Fico L, Palazzo C, Sapia GF, Dicuonzo G., VISAGGIO, DANIELA, Gherardi, G, Angeletti, S, Panitti, M, Pompilio, A, Di Bonaventura, G, Crea, F, Avola, A, Fico, L, Palazzo, C, Sapia, Gf, Visaggio, Daniela, and Dicuonzo, G.

Subjects
bacterial infections and mycoses
Abstract

We performed a comparative evaluation of the Vitek-2 Compact and Phoenix systems for direct identification and antimicrobial susceptibility testing (AST) from positive blood culture bottles in comparison to the standard methods. Overall, 139 monomicrobial blood cultures, comprising 91 Gram-negative and 48 Gram-positive isolates, were studied. Altogether, 100% and 92.3% of the Gram-negative isolates and 75% and 43.75% of the Gram-positive isolates showed concordant identification between the direct and the standard methods with Vitek and Phoenix, respectively. AST categorical agreements of 98.7% and 99% in Gram-negative and of 96.2% and 99.5% in Gram-positive isolates with Vitek and Phoenix, respectively, were observed. In conclusion, direct inoculation procedures for Gram-negative isolates showed an excellent performance with both automated systems, while for identification of Gram-positive isolates they proved to be less reliable, although Vitek provided acceptable results. This approach contributes to reducing the turnaround time to result of blood cultures, with a positive impact on patient care.

Published
2012

32. Which factors influence onset and latency to treatment in generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder?

Author

Benatti, B, Camuri, G, Dell’Osso, B, Cremaschi, L, Sembira, E, Palazzo, C, Oldani, L, Dobrea, C, Arici, C, Primavera, D, Carpiniello, B, Castellano, F, Carra', G, Clerici, M, Baldwin, D, Altamura, A, Altamura, A., CASTELLANO, FILIPPO, CARRA', GIUSEPPE, CLERICI, MASSIMO, Benatti, B, Camuri, G, Dell’Osso, B, Cremaschi, L, Sembira, E, Palazzo, C, Oldani, L, Dobrea, C, Arici, C, Primavera, D, Carpiniello, B, Castellano, F, Carra', G, Clerici, M, Baldwin, D, Altamura, A, Altamura, A., CASTELLANO, FILIPPO, CARRA', GIUSEPPE, and CLERICI, MASSIMO

Abstract

Anxiety disorders are common, comorbid, and disabling conditions, often underdiagnosed and under-treated, typically with an early onset, chronic course, and prolonged duration of untreated illness. The present study aimed to explore the influence of sociodemographic and clinical factors in relation to onset and latency to treatment in patients with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD). A total of 157 patients with a Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text Revision (DSM-IVTR) diagnosis of PD (n=49), GAD (n=68), and OCD (n=40) were recruited, and epidemiological and clinical variables were collected through a specific questionnaire. Statistical analyses were carried out to compare variables across diagnostic groups. PD, GAD, and OCD patients showed a duration of untreated illness of 53.9 ±81.5, 77.47 ±95.76, and 90.6± 112.1 months, respectively. Significant differences between groups were found with respect to age, age of first diagnosis, age of first treatment, family history of psychiatric illness, onset-related stressful events, benzodiazepine prescription as first treatment, antidepressant prescription as first treatment, and helpseeking (self-initiated vs. initiated by others). Patients with GAD, PD, and OCD showed significant differences in factors influencing onset and latency to treatment, which may, in turn, affect condition-related outcome and overall prognosis. Further studies with larger samples are warranted in the field.

Published
2016

33. Distributed and cloud-based multi-model analytics experiments on large volumes of climate change data in the earth system grid federation eco-system

Author

Fiore, S., primary, Plociennik, M., additional, Doutriaux, C., additional, Palazzo, C., additional, Boutte, J., additional, Zok, T., additional, Elia, D., additional, Owsiak, M., additional, D'Anca, A., additional, Shaheen, Z., additional, Bruno, R., additional, Fargetta, M, additional, Caballer, M., additional, Molto, G., additional, Blanquer, I., additional, Barbera, R., additional, David, M., additional, Donvito, G., additional, Williams, D. N., additional, Anantharaj, V., additional, Salomoni, D., additional, and Aloisio, G., additional

Published
2016
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35. SeaConditions: a web and mobile service for safer professional and recreational activities in the Mediterranean Sea

Author

Coppini, G., primary, Marra, P., additional, Lecci, R., additional, Pinardi, N., additional, Cretì, S., additional, Scalas, M., additional, Tedesco, L., additional, D'Anca, A., additional, Fazioli, L., additional, Olita, A., additional, Turrisi, G., additional, Palazzo, C., additional, Aloisio, G., additional, Fiore, S., additional, Bonaduce, A., additional, Kumkar, Y., additional, Ciliberti, S. A., additional, Federico, I., additional, Mannarini, G., additional, Agostini, P., additional, Bonarelli, R., additional, Martinelli, S., additional, Verri, G., additional, Lusito, L., additional, Rollo, D., additional, Cavallo, A., additional, Tumolo, A., additional, Monacizzo, T., additional, Spagnulo, M., additional, Sorgente, R., additional, Cucco, A., additional, Quattrocchi, G., additional, Tonani, M., additional, Drudi, M., additional, Panzera, L., additional, Navarra, A., additional, and Negro, G., additional

Published
2016
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36. Etude de la contribution respective des maladies chroniques au handicap en France

Author

Palazzo, C, Ravaud, Jean-François, Trinquart, L, Dalichampt, M, Ravaud, P, Poiraudeau, S, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS)

Subjects
ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2014

38. Factors characterizing access and latency to first pharmacological treatment in Italian patients with schizophrenia, mood, and anxiety spectrum disorders

Author

Dell'Osso, B, Cremaschi, L, Palazzo, C, Suardi, N, Spagnolin, G, Camuri, G, Benatti, B, Oldani, L, Dobrea, C, Arici, C, Pace, G, Tiseo, A, Nahum, E, Castellano, F, D'Urso, N, Clerici, M, Primavera, D, Carpiniello, B, Carlo Altamura, A, Carlo Altamura, A., CASTELLANO, FILIPPO, D'URSO, NAZARIO, CLERICI, MASSIMO, Dell'Osso, B, Cremaschi, L, Palazzo, C, Suardi, N, Spagnolin, G, Camuri, G, Benatti, B, Oldani, L, Dobrea, C, Arici, C, Pace, G, Tiseo, A, Nahum, E, Castellano, F, D'Urso, N, Clerici, M, Primavera, D, Carpiniello, B, Carlo Altamura, A, Carlo Altamura, A., CASTELLANO, FILIPPO, D'URSO, NAZARIO, and CLERICI, MASSIMO

Abstract

Latency to first pharmacological treatment [duration of untreated illness (DUI)] in psychiatric disorders can be measured in years, with differences across diagnostic areas and relevant consequences in terms of socio-occupational functioning and outcome. Within the psychopathological onset of a specific disorder, many factors influence access and latency to first pharmacotherapy and the present study aimed to investigate such factors, through an ad-hoc developed questionnaire, in a sample of 538 patients with diagnoses of schizophrenia-spectrum disorder (SZ), mood disorder (MD), and anxiety disorder (AD). Patients with SZs showed earlier ages at onset, first diagnosis and treatment, as well as shorter DUI compared with other patients (43.17 months vs. 58.64 and 80.43 months in MD and AD; F=3.813, P=0.02). Patients with MD and AD reported more frequently onset-related stressful events, benzodiazepines as first treatment, and autonomous help seeking compared with patients with SZs. In terms of first therapist, psychiatrist referral accounted for 43.6% of the cases, progressively decreasing from SZ to MD and AD (57.6, 41.8, and 38.3%, respectively). The opposite phenomenon was observed for nonpsychiatrist clinician referrals, whereas psychologist referrals remained constant. The present findings confirm the presence of a relevant DUI in a large sample of Italian patients with different psychiatric disorders (5 years, on average), pointing out specific differences, in terms of treatment access and latency, between psychotic and affective patients. Such aspects are relevant for detection of at-risk patients and implement early intervention programs.

Published
2015

39. Tumor necrosis factor-alpha blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: Results of a two-year, double-blind, placebo randomized controlled study

Author

Nguyen, C., primary, Palazzo, C., additional, Grabar, S., additional, Feydy, A., additional, Sanchez, K., additional, Zee, N., additional, Quinquis, L., additional, Boutieb, M. Ben, additional, Revel, M., additional, Lefèvre-Colau, M.M., additional, Poiraudeau, S., additional, and Rannou, F., additional

Published
2015
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41. FRI0550 Tumor Necrosis Factor-Alpha Blockade in Recurrent and Disabling Chronic Sciatica Associated with Post-Operative Peridural Lumbar Fibrosis: Results of a Two-Year Double-Blind, Randomized, Controlled Study

Author

Nguyen, C., primary, Sanchez, K., additional, Palazzo, C., additional, Zee, N., additional, Feydy, A., additional, Quinquis, L., additional, Grabar, S., additional, Revel, M., additional, Lefèvre-Colau, M.-M., additional, Poiraudeau, S., additional, and Rannou, F., additional

Published
2015
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44. Pre-participation cardiovascular screening

Author

Corrado, Domenico, Biffi, A, Schiavon, M, Bianchi, G, Chiarella, F, DI PASQUALE, G, Fedele, F, Fernando, F, Fraticelli, A, Migliore, Federico, Palazzo, C, Teoni, P, Volterrani, M, Zito, G, Zorzi, Alessandro, and Thiene, Gaetano

Published
2010

49. C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia

Author

Galimberti, D, Reif, A, Dell'Osso, B, Kittel Schneider, S, Leonhard, C, Herr, A, Palazzo, C, Villa, C, Fenoglio, C, Serpente, M, Cioffi, S, Prunas, C, Paoli, R, Altamura, A, Scarpini, E, Cioffi, SM, Paoli, RA, Altamura, AC, Scarpini, E., VILLA, CHIARA, Galimberti, D, Reif, A, Dell'Osso, B, Kittel Schneider, S, Leonhard, C, Herr, A, Palazzo, C, Villa, C, Fenoglio, C, Serpente, M, Cioffi, S, Prunas, C, Paoli, R, Altamura, A, Scarpini, E, Cioffi, SM, Paoli, RA, Altamura, AC, Scarpini, E., and VILLA, CHIARA

Abstract

A hexanucleotide repeat expansions in the first intron of C9ORF72 has been shown to be responsible for a high number of familial cases of amyotrophic lateral sclerosis and/or frontotemporal lobar degeneration. The same mutation has been described in a patient with bipolar disorder, but up to now, not in patients suffering from schizophrenia. We determined the frequency of the C9ORF72 hexanucleotide repeat expansions in a population of 298 patients with schizophrenia or schizoaffective disorder. The pathogenic repeat expansion was detected in 2 patients (0.67%). Both of them presented with auditory hallucinations and had comorbid alcohol abuse. In addition, a positive family history for psychiatric and/or neurodegenerative diseases was present. The repeat expansion in the C9ORF72 gene is a rare, but possible, cause of schizophrenic spectrum disorders. We cannot rule out however whether the number of repeats influence the phenotype. © 2014 Elsevier Inc.

Published
2014

50. Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder

Author

Galimberti, D, Prunas, C, Paoli, R, Dell'Osso, B, Fenoglio, C, Villa, C, Palazzo, C, Cigliobianco, M, Camuri, G, Serpente, M, Scarpini, E, Altamura, A, Paoli, RA, Altamura, AC, VILLA, CHIARA, Galimberti, D, Prunas, C, Paoli, R, Dell'Osso, B, Fenoglio, C, Villa, C, Palazzo, C, Cigliobianco, M, Camuri, G, Serpente, M, Scarpini, E, Altamura, A, Paoli, RA, Altamura, AC, and VILLA, CHIARA

Abstract

Objective: Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder. Methods: In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels. Results: The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD-I) (odds ratio = 0.55, 95% confidence interval: 0.33-0.93; p = 0.024) but not bipolar II disorder (BD-II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p < 0.001]. Conclusions: Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD-I and BD-II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD.

Published
2014

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