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133 results on '"Palan, Prabhudas R."'

5. Alpha-tocopherol and apha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer

Author

Palan, Prabhudas R., Woodall, Angela L., Anderson, Patrick S., and Mikhail, Magdy S.

Subjects
Cervical cancer -- Risk factors, Epithelial cells -- Research, Quinone -- Research, Health
Abstract

A study is conducted to determine the levels of alpha-tocopherol and apha-tocopheryl quinone, the oxidized product of alpha-tocopherol, in plasma and red blood cells that are obtained from control subjects and patients with cervical intraepithelial neoplasia and cervical cancer.

Published
2004

10. Smoking and the antioxidant ascorbic acid: plasma, leukocyte, and cervicovaginal cell concentrations in normal healthy women

Author

Basu, Jayasri, Mikhail, Magdy S., Payraudeau, Patricia H., Palan, Prabhudas R., and Romney, Seymour L.

Subjects
Vitamin C -- Physiological aspects, Cervical cancer -- Physiological aspects, Antioxidants -- Physiological aspects, Smoking and women -- Health aspects, Health
Abstract

Cigarette smoking appears to be a risk factor for cancer of the cervix, independent of sexual habits or socioeconomic status. Whether this is due to components of tobacco smoke that cause or enhance abnormal cell changes, or other causes, is unclear. A mechanism by which smoking may lead to cancerous changes in cervical cells may be alteration in the levels of ascorbic acid (vitamin C) and beta-carotene, two anti-oxidant (protective against cell damage) compounds obtained from the diet. The levels of ascorbic acid in blood, leukocytes (white blood cells), and cervical cells in 16 smokers and 30 non-smokers were evaluated. Vitamin C levels were lower in blood and in cervical cells but higher in leukocytes in smokers. Smokers had significantly more exfoliation, or shedding, of cervical cells. Breakfast habits, oral contraceptive use, and menstrual cycle timing were not related to the observed differences. Ascorbic acid, which may enhance immune function, is apparently preferentially accumulated in leukocytes and cervical cells, tissues that may have a higher exposure to damage by free radical compounds (a type of molecule linked to tissue damage). The study suggests that diminished vitamin C levels in cervical cells of smokers may leave the tissue susceptible to damage. Further research of the relation of this to cancer development is needed. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

12. Risk Factors for Persistent Cervical Intraepithelial Neoplasia Grades 1 and 2

Author

Ho, Gloria Y.F., primary, Einstein, Mark H., additional, Romney, Seymour L., additional, Kadish, Anna S., additional, Abadi, Maria, additional, Mikhail, Magdy, additional, Basu, Jayasri, additional, Thysen, Benjamin, additional, Reimers, Laura, additional, Palan, Prabhudas R., additional, Trim, Shelly, additional, Soroudi, Nafisseh, additional, and Burk, Robert D., additional

Published
2011
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36. Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity.

Author

Palan, Prabhudas R., Strube, Felix, Letko, Juraj, Sadikovic, Azra, and Mikhail, Magdy S.

Subjects
*VAGINAL contraceptives, *UBIQUINONES, *VITAMIN E, *ANTIOXIDANTS, *ETHINYL estradiol, *FREE radicals, *OXIDATIVE stress, *NUCLEIC acids, *T-test (Statistics), *ANALYSIS of variance, SIDE effects of oral contraceptives
Abstract

The use of the transdermal contraceptive patch is associated with greater bioavailability of ethinyl estradiol (EE) compared with contraceptive vaginal ring or oral contraceptives (OC). We compared the influences of three contraceptive methods (OC, vaginal ring, and transdermal patch) on serum levels of coenzyme Q10, α-tocopherol, γ-tocopherol and total antioxidant capacity in premenopausal women. Blood samples from 30 premenopausal women who used hormonal contraception for at least 4 months were collected. Forty subjects who did not use any contraception were studied as control. Serum levels of coenzyme Q10, α- tocopherol and γ-tocopherol were measured by high-pressure liquid chromatography. Serum samples were also assayed for total antioxidant capacity (TAOC). Serum levels of coenzyme Q10 and α-tocopherol were found to be significantly lower (P < .05) in all three contraceptive users compared with controls. Contraceptive patch users had the lowest levels of coenzyme Q10 levels compared with normal subjects. Serum TAOC levels were significantly lower (P < .05) among the contraceptive user groups. Alterations in coenzyme Q10 and α-tocopherol induced by hormonal contraception and the potential effect(s) of exogenous ovarian hormones should be taken into consideration in future antioxidant research. [ABSTRACT FROM AUTHOR]

Published
2010
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38. Plasma Uric Acid Levels in Women WithCervical Intraepithelial Neoplasia.

Author

Basu, Jayasri, Mikhail, Magdy S., Ahn, Chul W., Furguiele, Joseph, Ho, Gloria Y., Burk, Robert D., Palan, Prabhudas R., and Romney, Seymour L.

Subjects
URIC acid, ALLOXAN, HYPERURICEMIA, PURINES, ANTIOXIDANTS, CHEMICAL inhibitors
Abstract

Abstract: The objective of this study was to determine the association of plasma levels of uric acid, an endogenous antioxidant, in women with cervical intraepithelial neoplasia (CIN), while controlling for the confounding effects of human papillomavirus (HPV) infection, age, smoking, and use of oral contraception. Plasma-reduced and oxidized uric acid levels were determined in 650 women by high-performance liquid chromatography, employing electrochemical technique. The findings demonstrated that 1) plasma-reduced uric acid (PRUA) levels in women with CIN (n = 311) were significantly lower (P<0.05) compared with women in a control group (n = 339); 2) according to multiple logistic regression analysis, PRUA levels were negatively (P = 0.0113) and HPV infection were positively associated (P<0.0001) with CIN, after controlling for the confounding effects of the studied factors; 3) according to multiple regression analysis, there was a 31% decrease in CIN risk for each incremental increase of 1mg/dl of PRUA; and 4) according to polychotomous logistic regression analysis, independent of HPV infection, PRUA level was inversely associated with the histopathological graded severity of CIN. We have previously reported decreased plasma levels of exogenous antioxidants, for example, vitamins C and E, in women with CIN independent of HPV infection. The data suggest that plasma deficiencies of several antioxidants in HPV-infected uterine cervical tissue may create an oxidative environment that renders the tissue susceptible to free radical damage. It may be speculated that chronic free radical-induced tissue damage in the context of persistent HPV infection may be involved in the pathogenesis of CIN. [ABSTRACT FROM AUTHOR]

Published
2005
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40. Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzymel Q10,α-Tocopherol and γ-Tocopherol in Preeclampsia and Normal Pregnancy.

Author

Palan, Prabhudas R., Shaban, Danny W., Martino, Teresa, and Mikhail, Magdy S.

Subjects
*ANTIOXIDANTS, *UBIQUINONES, *VITAMIN E, *PREECLAMPSIA, *PREGNANCY
Abstract

It has been hypothesized that in preeclampsia, the antioxidant- deficient state may facilitate increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q10, α-tocopherol and γ-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was observed in serum levels of coenzyme Q10 and α-tocopherol (p < 0.001 for each by the Kruskal-Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. γ-Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed significant association between grades of preeclampsia and both serum coenzyme Q10 and α-tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q10 and α-tocopherol are potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia. [ABSTRACT FROM AUTHOR]

Published
2004
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45. Short Report Computerized measurement of intercapillary distance using image analysis in women with cervical intraepithelial neoplasia: correlation with severity.

Author

Mikhail, Magdy S., Palan, Prabhudas R., Basu, Jayasri, and Romney, Seymour L.

Subjects
DIAGNOSTIC imaging, CERVIX uteri tumors, COLPOSCOPY, VAGINA examination, MEDICAL imaging systems, GYNECOLOGY
Abstract

Describes the computerized measurement of intercapillary distance using image analysis in women with cervical intraepithelial neoplasia (CIN). Use of computerized colposcopy and image analysis; Increased intercapillary distance, mosaic perimeter and mosaic surface area with increasing severity of CIN; Reflection of insufficient vascular adaptation to an accelerated cellular growth rate.

Published
2004
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46. Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia

Author

Ho, Gloria Y.F., Palan, Prabhudas R., Basu, Jayasri, Romney, Seymour L., Kadish, Anna S., Mikhail, Magdy, Wassertheil-Smoller, Sylvia, and Runowicz, Carolyn

Abstract

Genital human papillomavirus (HPV) infection is the major causal factor of cervical intraepithelial neoplasia (CIN). The potential role of nutrition as an additional, independent risk factor for CIN has not been appropriately addressed in the context of HPV. This case-control study evaluated the etiologic role of HPV in terms of viral type and load and examined the association between CIN and plasma levels of micronutrients adjusting for HPV. Cases (n = 378) with histo-pathologically confirmed CIN and controls (n = 366) with no history of abnormal Pap smears were recruited from colposcopy and gynecology clinics, respectively. Risk of CIN was significantly increased among women who were infected with multiple HPV types (odds ratio [OR] = 21.06), a high viral load (OR = 13.08) and HPV 16 (OR = 62.49). After adjusting for HPV positivity and demographic factors, there was an inverse correlation between plasma α-tocopherol and risk of CIN (OR = 0.15). Plasma ascorbic acid was protective at a high level of ≥ 0.803 mg/ dl (OR = 0.46). CIN was not associated with plasma retinol and β-carotene levels. The effect of genital HPV infection on CIN development is highly influenced by oncogenic viral type and high viral load. Vitamins C and E may play an independent protective role in development of CIN that needs to be confirmed in prospective studies. Int. J. Cancer 78:594–599, 1998. © 1998 Wiley-Liss, Inc.

Published
1998
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50. Retinoids and the prevention of cervical dysplasias

Author

Romney, Seymour L., primary, Palan, Prabhudas R., additional, Duttagupta, Chandralekha, additional, Wassertheil-Smoller, Sylvia, additional, Wylie, Judith, additional, Miller, Gail, additional, Slagle, N. Susan, additional, and Lucido, David, additional

Published
1981
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