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12 results on '"Pala, Giovanni"'

1. Whole-Genome Sequencing of Two Canine Herpesvirus 1 (CaHV-1) Isolates and Clinicopathological Outcomes of Infection in French Bulldog Puppies

Author

Rocchigiani, Angela Maria, primary, Bertoldi, Loris, additional, Coradduzza, Elisabetta, additional, Lostia, Giada, additional, Pintus, Davide, additional, Scivoli, Rosario, additional, Cancedda, Maria Giovanna, additional, Fiori, Mariangela Stefania, additional, Bechere, Roberto, additional, Murtino, Anna Pina, additional, Pala, Giovanni, additional, Cardeti, Giusy, additional, Macioccu, Simona, additional, Dettori, Maria Antonietta, additional, Pintore, Antonio, additional, Ligios, Ciriaco, additional, and Puggioni, Giantonella, additional

Published
2024
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2. Randomized Evidence for Reduction of Perioperative Mortality: An Updated Consensus Process

Author

Landoni, Giovanni, Pisano, Antonio, Lomivorotov, Vladimir, Alvaro, Gabriele, Hajjar, Ludhmila, Paternoster, Gianluca, Nigro Neto, Caetano, Latronico, Nicola, Fominskiy, Evgeny, Pasin, Laura, Finco, Gabriele, Lobreglio, Rosetta, Azzolini, Maria Luisa, Buscaglia, Giuseppe, Castella, Alberto, Comis, Marco, Conte, Adele, Conte, Massimiliano, Corradi, Francesco, Dal Checco, Erika, De Vuono, Giovanni, Ganzaroli, Marco, Garofalo, Eugenio, Gazivoda, Gordana, Lembo, Rosalba, Marianello, Daniele, Baiardo Redaelli, Martina, Monaco, Fabrizio, Tarzia, Valentina, Mucchetti, Marta, Belletti, Alessandro, Mura, Paolo, Musu, Mario, Pala, Giovanni, Paltenghi, Massimiliano, Pasyuga, Vadim, Piras, Desiderio, Riefolo, Claudio, Roasio, Agostino, Ruggeri, Laura, Santini, Francesco, Székely, Andrea, Verniero, Luigi, Vezzani, Antonella, Zangrillo, Alberto, and Bellomo, Rinaldo

Published
2017
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3. Worldwide Opinion on Multicenter Randomized Interventions Showing Mortality Reduction in Critically Ill Patients: A Democracy-Based Medicine Approach

Author

Pisano, Antonio, Landoni, Giovanni, Lomivorotov, Vladimir, Comis, Marco, Gazivoda, Gordana, Conte, Massimiliano, Hajjar, Ludhmila, Finco, Gabriele, Jovic, Miomir, Mucchetti, Marta, Kunstýř, Jan, Paternoster, Gianluca, Likhvantsev, Valery, Ruggeri, Laura, Ma, Jun, Alvaro, Gabriele, Bukamal, Nazar, Borghi, Giovanni, Pasyuga, Vadim, Cabrini, Luca, Greco, Massimiliano, Guarracino, Fabio, Lembo, Rosalba, Lobreglio, Rosetta, Monaco, Fabrizio, Montisci, Andrea, Pala, Giovanni, Pasin, Laura, Pieri, Marina, Santini, Francesco, Silvetti, Simona, Zambon, Massimo, Baiardo Redaelli, Martina, Castella, Alberto, De Vuono, Giovanni, Lucchetta, Luca, Zangrillo, Alberto, and Bellomo, Rinaldo

Published
2016
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4. Reducing Mortality in Acute Kidney Injury Patients: Systematic Review and International Web-Based Survey

Author

Landoni, Giovanni, Bove, Tiziana, Székely, Andrea, Comis, Marco, Rodseth, Reitze N., Pasero, Daniela, Ponschab, Martin, Mucchetti, Marta, Azzolini, Maria L., Caramelli, Fabio, Paternoster, Gianluca, Pala, Giovanni, Cabrini, Luca, Amitrano, Daniele, Borghi, Giovanni, Capasso, Antonella, Cariello, Claudia, Carpanese, Anna, Feltracco, Paolo, Gottin, Leonardo, Lobreglio, Rosetta, Mattioli, Lorenzo, Monaco, Fabrizio, Morgese, Francesco, Musu, Mario, Pasin, Laura, Pisano, Antonio, Roasio, Agostino, Russo, Gianluca, Slaviero, Giorgio, Villari, Nicola, Vittorio, Annalisa, Zucchetti, Mariachiara, Guarracino, Fabio, Morelli, Andrea, De Santis, Vincenzo, Del Sarto, Paolo A., Corcione, Antonio, Ranieri, Marco, Finco, Gabriele, Zangrillo, Alberto, and Bellomo, Rinaldo

Published
2013
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5. Randomized Evidence for Reduction of Perioperative Mortality

Author

Landoni, Giovanni, Rodseth, Reitze N., Santini, Francesco, Ponschab, Martin, Ruggeri, Laura, Székely, Andrea, Pasero, Daniela, Augoustides, John G., Del Sarto, Paolo A., Krzych, Lukasz J., Corcione, Antonio, Slullitel, Alexandre, Cabrini, Luca, Le Manach, Yannick, Almeida, Rui M.S., Bignami, Elena, Biondi-Zoccai, Giuseppe, Bove, Tiziana, Caramelli, Fabio, Cariello, Claudia, Carpanese, Anna, Clarizia, Luciano, Comis, Marco, Conte, Massimiliano, Covello, Remo D., De Santis, Vincenzo, Feltracco, Paolo, Giordano, Gianbeppe, Pittarello, Demetrio, Gottin, Leonardo, Guarracino, Fabio, Morelli, Andrea, Musu, Mario, Pala, Giovanni, Pasin, Laura, Pezzoli, Ivana, Paternoster, Gianluca, Remedi, Rossella, Roasio, Agostino, Zucchetti, Mariachiara, Petrini, Flavia, Finco, Gabriele, Ranieri, Marco, and Zangrillo, Alberto

Published
2012
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7. Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery: A Randomized Clinical Trial

Author

Bove, Tiziana, Zangrillo, Alberto, Guarracino, Fabio, Alvaro, Gabriele, Persi, Bruno, Maglioni, Enivarco, Galdieri, Nicola, Comis, Marco, Caramelli, Fabio, Pasero, Daniela C., Pala, Giovanni, Renzini, Massimo, Conte, Massimiliano, Paternoster, Gianluca, Martinez, Blanca, Pinelli, Fulvio, Frontini, Mario, Zucchetti, Maria C., Pappalardo, Federico, Amantea, Bruno, Camata, Annamaria, Pisano, Antonio, Verdecchia, Claudio, Dal Checco, Erika, Cariello, Claudia, Faita, Luana, Baldassarri, Rubia, Scandroglio, Anna M., Saleh, Omar, Lembo, Rosalba, Calabrò, Maria G., Bellomo, Rinaldo, and Landoni, Giovanni

Published
2014
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8. A randomized controlled trial of levosimendan to reduce mortality in high-risk cardiac surgery patients (CHEETAH): Rationale and design

Author

Zangrillo, Alberto, Alvaro, Gabriele, Pisano, Antonio, Guarracino, Fabio, Lobreglio, Rosetta, Bradić, Nikola, Lembo, Rosalba, Gianni, Stefano, Calabrò, Maria Grazia, Likhvantsev, Valery, Grigoryev, Evgeny, Buscaglia, Giuseppe, Pala, Giovanni, Auci, Elisabetta, Amantea, Bruno, Monaco, Fabrizio, De Vuono, Giovanni, Corcione, Antonio, Galdieri, Nicola, Cariello, Claudia, Bove, Tiziana, Fominskiy, Evgeny, Auriemma, Stefano, Baiocchi, Massimo, Bianchi, Alessandro, Frontini, Mario, Paternoster, Gianluca, Sangalli, Fabio, Wang, Chew-Yin, Zucchetti, Maria Chiara, Biondi-Zoccai, Giuseppe, Gemma, Marco, Lipinski, Michael J., Lomivorotov, Vladimir, and Landoni, Giovanni

Subjects
Levosimendan, High-risk Cardiac Surgery, Myocardial Dysfunction
Abstract

OBJECTIVE: Patients undergoing cardiac surgery are at risk of perioperative low cardiac output syndrome due to postoperative myocardial dysfunction. Myocardial dysfunction in patients undergoing cardiac surgery is a potential indication for the use of levosimendan, a calcium sensitizer with 3 beneficial cardiovascular effects (inotropic, vasodilatory, and anti- inflammatory), which appears effective in improving clinically relevant outcomes. DESIGN: Double-blind, placebo-controlled, multicenter randomized trial. SETTING: Tertiary care hospitals. INTERVENTIONS: Cardiac surgery patients (n = 1, 000) with postoperative myocardial dysfunction (defined as patients with intraaortic balloon pump and/or high-dose standard inotropic support) will be randomized to receive a continuous infusion of either levosimendan (0.05- 0.2 μg/[kg min]) or placebo for 24-48 hours. MEASUREMENTS AND MAIN RESULTS: The primary end point will be 30-day mortality. Secondary end points will be mortality at 1 year, time on mechanical ventilation, acute kidney injury, decision to stop the study drug due to adverse events or to start open-label levosimendan, and length of intensive care unit and hospital stay. We will test the hypothesis that levosimendan reduces 30-day mortality in cardiac surgery patients with postoperative myocardial dysfunction. CONCLUSIONS: This trial is planned to determine whether levosimendan could improve survival in patients with postoperative low cardiac output syndrome. The results of this double-blind, placebo-controlled randomized trial may provide important insights into the management of low cardiac output in cardiac surgery.

Published
2016

9. Impact of different dosage of protamine on heparin reversal during off-pump coronary artery bypass: a clinical study

Author

Suelzu, Salvatore, Cossu, Andrea, Pala, Giovanni, Portoghese, Michele, Columbanu, Valeria, Sales, Gabriele, Solinas, Luigi, and Brazzi, Luca

Subjects
heparin, off-pump coronary artery bypass (OPCAB), protamine, thromboelastography, Research-Article
Abstract

Introduction Currently, a dose of protamine equal to 1 mg for each 100 units of heparin given is used to reverse the residual heparin activity following off-pump coronary artery bypass. We hypothesized that a 1:1 ratio (ratio of protamine to heparin) could be higher than necessary inducing post-operative disturbance of hemostasis. Methods Between January and March 2014 in 9 patients undergoing off-pump coronary artery bypass, we evaluated the effect of a dose of protamine equal to 1 mg per 100 units of heparin (Total Calculated Dose) on hemostasis as evaluated by means of thromboelastomery. Two data analyses were performed: the first after the administration of 2/3 of the Total Calculated Dose of protamine and the second after the administration of the Total Calculated Dose of protamine. Results We found that the administration of 2/3 of Total Calculated Dose of protamine was always able to reverse the anticoagulant effect of heparin and that a significant clotting time elongation was induced by the infusion of the second part of the Total Calculated Dose of protamine. No modification in clot firmness was observed. Conclusions The present study seems to suggest that the commonly applied ratio equal to 1:1 (ratio of protamine to heparin) could be higher than needed with potential and hazardous impacts on the efficacy of the coagulation system.

Published
2015

10. A randomized controlled trial of levosimendan to reduce mortality in high-risk cardiac surgery patients (CHEETAH): Rationale and design

Author

Zangrillo, Alberto, primary, Alvaro, Gabriele, additional, Pisano, Antonio, additional, Guarracino, Fabio, additional, Lobreglio, Rosetta, additional, Bradic, Nikola, additional, Lembo, Rosalba, additional, Gianni, Stefano, additional, Calabrò, Maria Grazia, additional, Likhvantsev, Valery, additional, Grigoryev, Evgeny, additional, Buscaglia, Giuseppe, additional, Pala, Giovanni, additional, Auci, Elisabetta, additional, Amantea, Bruno, additional, Monaco, Fabrizio, additional, De Vuono, Giovanni, additional, Corcione, Antonio, additional, Galdieri, Nicola, additional, Cariello, Claudia, additional, Bove, Tiziana, additional, Fominskiy, Evgeny, additional, Auriemma, Stefano, additional, Baiocchi, Massimo, additional, Bianchi, Alessandro, additional, Frontini, Mario, additional, Paternoster, Gianluca, additional, Sangalli, Fabio, additional, Wang, Chew-Yin, additional, Zucchetti, Maria Chiara, additional, Biondi-Zoccai, Giuseppe, additional, Gemma, Marco, additional, Lipinski, Michael J., additional, Lomivorotov, Vladimir V., additional, and Landoni, Giovanni, additional

Published
2016
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11. Mortality in Multicenter Critical Care Trials

Author

Landoni, Giovanni, primary, Comis, Marco, additional, Conte, Massimiliano, additional, Finco, Gabriele, additional, Mucchetti, Marta, additional, Paternoster, Gianluca, additional, Pisano, Antonio, additional, Ruggeri, Laura, additional, Alvaro, Gabriele, additional, Angelone, Manuela, additional, Bergonzi, Pier C., additional, Bocchino, Speranza, additional, Borghi, Giovanni, additional, Bove, Tiziana, additional, Buscaglia, Giuseppe, additional, Cabrini, Luca, additional, Callegher, Lino, additional, Caramelli, Fabio, additional, Colombo, Sergio, additional, Corno, Laura, additional, Del Sarto, Paolo, additional, Feltracco, Paolo, additional, Forti, Alessandro, additional, Ganzaroli, Marco, additional, Greco, Massimiliano, additional, Guarracino, Fabio, additional, Lembo, Rosalba, additional, Lobreglio, Rosetta, additional, Meroni, Roberta, additional, Monaco, Fabrizio, additional, Musu, Mario, additional, Pala, Giovanni, additional, Pasin, Laura, additional, Pieri, Marina, additional, Pisarra, Stefania, additional, Ponticelli, Giuseppe, additional, Roasio, Agostino, additional, Santini, Francesco, additional, Silvetti, Simona, additional, Székely, Andrea, additional, Zambon, Massimo, additional, Zucchetti, Maria Chiara, additional, Zangrillo, Alberto, additional, and Bellomo, Rinaldo, additional

Published
2015
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12. Impact of different dosage of protamine on heparin reversal during off-pump coronary artery bypass: a clinical study.

Author

Suelzu S, Cossu A, Pala G, Portoghese M, Columbanu V, Sales G, Solinas L, and Brazzi L

Abstract

Introduction: Currently, a dose of protamine equal to 1 mg for each 100 units of heparin given is used to reverse the residual heparin activity following off-pump coronary artery bypass. We hypothesized that a 1:1 ratio (ratio of protamine to heparin) could be higher than necessary inducing post-operative disturbance of hemostasis., Methods: Between January and March 2014 in 9 patients undergoing off-pump coronary artery bypass, we evaluated the effect of a dose of protamine equal to 1 mg per 100 units of heparin (Total Calculated Dose) on hemostasis as evaluated by means of thromboelastomery. Two data analyses were performed: the first after the administration of 2/3 of the Total Calculated Dose of protamine and the second after the administration of the Total Calculated Dose of protamine., Results: We found that the administration of 2/3 of Total Calculated Dose of protamine was always able to reverse the anticoagulant effect of heparin and that a significant clotting time elongation was induced by the infusion of the second part of the Total Calculated Dose of protamine. No modification in clot firmness was observed., Conclusions: The present study seems to suggest that the commonly applied ratio equal to 1:1 (ratio of protamine to heparin) could be higher than needed with potential and hazardous impacts on the efficacy of the coagulation system.

Published
2015

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