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2. Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers.

Author

Bhattacharya, Sreyashi, Harris, Hannah, Islam, Ridwan, Bodas, Sanika, Polavaram, Navatha, Mishra, Juhi, Das, Dipanwita, Seshacharyulu, Parthasarathy, Kalluchi, Achyuth, Pal, Anirban, Kohli, Manish, Lele, Subodh, Muders, Michael, Batra, Surinder, Ghosh, Paramita, Datta, Kaustubh, Rowley, M, and Dutta, Samikshan

Subjects
Humans, Male, Docetaxel, Prostatic Neoplasms, Drug Resistance, Neoplasm, Cell Line, Tumor, PAX5 Transcription Factor, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, Carcinoma, Neuroendocrine, Promoter Regions, Genetic, Receptors, Androgen
Abstract

Resistance to the current Androgen Receptor Signaling Inhibitor (ARSI) therapies has led to higher incidences of therapy-induced neuroendocrine-like prostate cancer (t-NEPC). This highly aggressive subtype with predominant small-cell-like characteristics is resistant to taxane chemotherapies and has a dismal overall survival. t-NEPCs are mostly treated with platinum-based drugs with a combination of etoposide or taxane and have less selectivity and high systemic toxicity, which often limit their clinical potential. During t-NEPC transformation, adenocarcinomas lose their luminal features and adopt neuro-basal characteristics. Whether the adaptive neuronal characteristics of t-NEPC are responsible for such taxane resistance remains unknown. Pathway analysis from patient gene-expression databases indicates that t-NEPC upregulates various neuronal pathways associated with enhanced cellular networks. To identify transcription factor(s) (TF) that could be important for promoting the gene expression for neuronal characters in t-NEPC, we performed ATAC-Seq, acetylated-histone ChIP-seq, and RNA-seq in our NE-like cell line models and analyzed the promoters of transcriptionally active and significantly enriched neuroendocrine-like (NE-like) cancer-specific genes. Our results indicate that Pax5 could be an important transcription factor for neuronal gene expression and specific to t-NEPC. Pathway analysis revealed that Pax5 expression is involved in axonal guidance, neurotransmitter regulation, and neuronal adhesion, which are critical for strong cellular communications. Further results suggest that depletion of Pax5 disrupts neurite-mediated cellular communication in NE-like cells and reduces surface growth factor receptor activation, thereby, sensitizing them to docetaxel therapies. Moreover, t-NEPC-specific hydroxymethylation of Pax5 promoter CpG islands favors Pbx1 binding to induce Pax5 expression. Based on our study, we concluded that continuous exposure to ARSI therapies leads to epigenetic modifications and Pax5 activation in t-NEPC, which promotes the expression of genes necessary to adopt taxane-resistant NE-like cancer. Thus, targeting the Pax5 axis can be beneficial for reverting their taxane sensitivity.

Published
2024

3. Effects of a mindfulness-based intervention on pain intensity, disability and quality of life of chronic low back pain patients: A randomised study

Author

Pal, Anirban, Mukhopadhyay, Purnava, Bhattacharyya, Debasish, and Ray, Subrata

Subjects
Medical research, Medicine, Experimental, Disability, Backache, Health
Abstract

Author(s): Anirban Pal (corresponding author) [1]; Purnava Mukhopadhyay [2]; Debasish Bhattacharyya [3]; Subrata Ray [1] INTRODUCTION The lifetime prevalence of low back pain was 66% among Indians (2022).[sup.[1]] Chronic low [...]

Published
2024
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14. An Automated IoT-based Green Corridor Integrated with Smart Traffic Management System for Patients Transfer

Author

Ghosh, Bishal Kumar, Pal, Anirban, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Chaki, Nabendu, editor, Roy, Nilanjana Dutta, editor, Debnath, Papiya, editor, and Saeed, Khalid, editor

Published
2023
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17. Towards the development of phytoextract based healthy ageing cognitive booster formulation, explored through Caenorhabditis elegans model

Author

Pandey, Rakesh, Mani, Dayanandan, Shanker, Karuna, Bawankule, Dnyaneshwar Umrao, Chanda, Debabrata, Lal, Raj Kishori, Pal, Anirban, Khare, Puja, Kumar, Narendra, Tandon, Sudeep, Saikia, Dharmendra, Gupta, Anil Kumar, Srivastava, Ramesh Kumar, Kumar, Sanjay, Suresh, Ram, Singh, Saudan, Kalra, Alok, Maurya, Anil, Singh, Dewasya Pratap, Pandey, Taruna, Trivedi, Shalini, Smita, Shachi Suchi, Pant, Akanksha, Rathor, Laxmi, Asthana, Jyotsna, Trivedi, Mashu, and Trivedi, Prabodh Kumar

Published
2022
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20. Green and proficient process for industrial-scale preparation of Gymnema sylvestre standardized-extract enriched with Gymnemic acids through polymer-matrix-adsorption to reduce hyperglycemia

Author

Kumar, Deepak, Singh, Vipin Kumar, Yadav, Narayan Prasad, Tandon, Sudeep, Shanker, Karuna, Chanotiya, Chandan Singh, Kumar, Narendra, Khare, Puja, Pal, Anirban, Chanda, Debabrata, Saikia, Dharmendra, Hussain, Yusuf, Meena, Abha, Dhawan, Sunita Singh, and Rout, Prasanta Kumar

Published
2022
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23. A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys

Author

Singh, Prateek, Ujjainiya, Rajat, Prakash, Satyartha, Naushin, Salwa, Sardana, Viren, Bhatheja, Nitin, Singh, Ajay Pratap, Barman, Joydeb, Kumar, Kartik, Gayali, Saurabh, Khan, Raju, Rawat, Birendra Singh, Tallapaka, Karthik Bharadwaj, Anumalla, Mahesh, Lahiri, Amit, Kar, Susanta, Bhosale, Vivek, Srivastava, Mrigank, Mugale, Madhav Nilakanth, Pandey, C.P., Khan, Shaziya, Katiyar, Shivani, Raj, Desh, Ishteyaque, Sharmeen, Khanka, Sonu, Rani, Ankita, Promila, Sharma, Jyotsna, Seth, Anuradha, Dutta, Mukul, Saurabh, Nishant, Veerapandian, Murugan, Venkatachalam, Ganesh, Bansal, Deepak, Gupta, Dinesh, Halami, Prakash M., Peddha, Muthukumar Serva, Veeranna, Ravindra P., Pal, Anirban, Singh, Ranvijay Kumar, Anandasadagopan, Suresh Kumar, Karuppanan, Parimala, Rahman, Syed Nasar, Selvakumar, Gopika, Venkatesan, Subramanian, Karmakar, Malay Kumar, Sardana, Harish Kumar, Kothari, Anamika, Parihar, Devendra Singh, Thakur, Anupma, Saifi, Anas, Gupta, Naman, Singh, Yogita, Reddu, Ritu, Gautam, Rizul, Mishra, Anuj, Mishra, Avinash, Gogeri, Iranna, Rayasam, Geethavani, Padwad, Yogendra, Patial, Vikram, Hallan, Vipin, Singh, Damanpreet, Tirpude, Narendra, Chakrabarti, Partha, Maity, Sujay Krishna, Ganguly, Dipyaman, Sistla, Ramakrishna, Balthu, Narender Kumar, A, Kiran Kumar, Ranjith, Siva, Kumar, B. Vijay, Jamwal, Piyush Singh, Wali, Anshu, Ahmed, Sajad, Chouhan, Rekha, Gandhi, Sumit G., Sharma, Nancy, Rai, Garima, Irshad, Faisal, Jamwal, Vijay Lakshmi, Paddar, Masroor Ahmad, Khan, Sameer Ullah, Malik, Fayaz, Ghosh, Debashish, Thakkar, Ghanshyam, Barik, S.K., Tripathi, Prabhanshu, Satija, Yatendra Kumar, Mohanty, Sneha, Khan, Md. Tauseef, Subudhi, Umakanta, Sen, Pradip, Kumar, Rashmi, Bhardwaj, Anshu, Gupta, Pawan, Sharma, Deepak, Tuli, Amit, Ray chaudhuri, Saumya, Krishnamurthi, Srinivasan, Prakash, L., Rao, Ch V., Singh, B.N., Chaurasiya, Arvindkumar, Chaurasiyar, Meera, Bhadange, Mayuri, Likhitkar, Bhagyashree, Mohite, Sharada, Patil, Yogita, Kulkarni, Mahesh, Joshi, Rakesh, Pandya, Vaibhav, Mahajan, Sachin, Patil, Amita, Samson, Rachel, Vare, Tejas, Dharne, Mahesh, Giri, Ashok, Paranjape, Shilpa, Sastry, G. Narahari, Kalita, Jatin, Phukan, Tridip, Manna, Prasenjit, Romi, Wahengbam, Bharali, Pankaj, Ozah, Dibyajyoti, Sahu, Ravi Kumar, Dutta, Prachurjya, Singh, Moirangthem Goutam, Gogoi, Gayatri, Tapadar, Yasmin Begam, Babu, Elapavalooru VSSK., Sukumaran, Rajeev K., Nair, Aishwarya R., Puthiyamadam, Anoop, Valappil, Prajeesh Kooloth, Pillai Prasannakumari, Adrash Velayudhan, Chodankar, Kalpana, Damare, Samir, Agrawal, Ved Varun, Chaudhary, Kumardeep, Agrawal, Anurag, Sengupta, Shantanu, and Dash, Debasis

Published
2022
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28. Optimizing Energy Use Efficiency for Agricultural Sustainability

Author

Pal, Anirban, Nandy, Anirban, Dey, Shiladitya, Singh, Piyush Kumar, Masys, Anthony J., Series Editor, Bichler, Gisela, Advisory Editor, Bourlai, Thirimachos, Advisory Editor, Johnson, Chris, Advisory Editor, Karampelas, Panagiotis, Advisory Editor, Leuprecht, Christian, Advisory Editor, Morse, Edward C., Advisory Editor, Skillicorn, David, Advisory Editor, Yamagata, Yoshiki, Advisory Editor, and Asif, Muhammad, editor

Published
2021
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32. Performance metrics in a hybrid MPI-OpenMP based molecular dynamics simulation with short-range interactions

Author

Pal, Anirban, Agarwala, Abhishek, Raha, Soumyendu, and Bhattacharya, Baidurya

Subjects
Physics - Computational Physics, Condensed Matter - Materials Science, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

We discuss the computational bottlenecks in molecular dynamics (MD) and describe the challenges in parallelizing the computation intensive tasks. We present a hybrid algorithm using MPI (Message Passing Interface) with OpenMP threads for parallelizing a generalized MD computation scheme for systems with short range interatomic interactions. The algorithm is discussed in the context of nanoindentation of Chromium films with carbon indenters using the Embedded Atom Method potential for Cr Cr interaction and the Morse potential for Cr C interactions. We study the performance of our algorithm for a range of MPIthread combinations and find the performance to depend strongly on the computational task and load sharing in the multicore processor. The algorithm scaled poorly with MPI and our hybrid schemes were observed to outperform the pure message passing scheme, despite utilizing the same number of processors or cores in the cluster. Speed-up achieved by our algorithm compared favourably with that achieved by standard MD packages.

Published
2015
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35. Coarse graining with control points: a cubic-Bézier based approach to modeling athermal fibrous materials.

Author

Pal, Anirban

Abstract

Fibrous materials continue to be of central importance to modern life, including traditional materials, such as textiles and paper, modern materials, such as polymeric materials and glass fiber, and emerging materials, such as carbon nanotube yarns. Developing constitutive laws for the mechanical behavior of such materials can be challenging owing to the often non-periodic microstructure, resulting in fairly large and computationally intractable representative volume elements. Therefore, it is imperative to design novel coarse-grained models that can bridge the computational gap and capture accurate physics associated with the mechanical behavior of fibrous materials. In this work, cubic-Béziers are used to represent fiber-segments, allowing for up to C2(curvature)-continuous representation of curved fibers. Equations of motion are derived in terms of the control points, which allow for minimization and time integration strategies with the Lagrangian and Hamiltonian formalism. This coarse-grained model promises faster and more accurate computational performance compared to discrete approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Understanding the role of Pax5 in development of taxane-resistant neuroendocrine like prostate cancers

Author

Dutta, Samikshan, primary, Bhattacharya, Sreyashi, additional, Harris, Hanna, additional, Islam, Ridwan, additional, Bodas, Sanika, additional, Polavaram, Navatha, additional, Mishra, Juhi, additional, Das, Dipanwita, additional, Seshacharyulu, Parthasarathy, additional, Kalluchi, Achyuth, additional, Pal, Anirban, additional, Kohli, Manish, additional, Lele, Subodh, additional, Muders, Michael, additional, Batra, Surinder, additional, Ghosh, Paramita, additional, Datta, Kaustubh, additional, and Rowley, Michael, additional

Published
2023
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48. Anticoagulants and antiplatelet drugs during elective phacoemulsification cataract surgeries under topical anesthesia with corneal incision: A suggestive outline based on present evidence and recommendations in the Indian context

Author

Pal, Anirban

Subjects
Anticoagulants (Medicine), Cataract -- Surgery, Clopidogrel, Anesthesia, Health
Abstract

Byline: Anirban. Pal Dear Editor, In India, with increasing cataract surgeries in patients on anticoagulant/antiplatelet drugs, the decision to continue/discontinue these drugs is becoming crucial. Continuation may increase the risk [...]

Published
2022

49. Fasting guidelines for elective cataract surgeries under regional anesthesia in apparently healthy adults: Practical considerations in the Indian context

Author

Pal, Anirban

Subjects
Cataract -- Surgery, Fasting -- Analysis, Anesthesia -- Analysis, Health
Abstract

Byline: Anirban. Pal Dear Editor, In India, most cataract surgeries are performed using regional anesthesia, which ranges from topical anesthesia to eye blocks.[1] Fasting guidelines are recommendations regarding the period [...]

Published
2022

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