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10 results on '"Pakhomov VIu"'

1. [The drug "anfen" and the energy status of the liver].

Author

Zhigacheva IV, Kaplan EIa, Pakhomov VIu, Rozantseva TV, Khristianovich DS, Burlakova EB, and Voronkov MG

Subjects
Adenosine Triphosphate metabolism, Animals, Electron Spin Resonance Spectroscopy, Energy Metabolism, Glutamic Acid metabolism, Kinetics, Malates metabolism, Male, Mitochondria, Liver metabolism, NAD metabolism, Oxygen metabolism, Phospholipids metabolism, Rats, Rats, Wistar, Antioxidants pharmacology, Malonates pharmacology, Mitochondria, Liver drug effects
Published
1995

2. [Anphen and energy status of the animal body].

Author

Zhigacheva IV, Vlasova ME, Kaplan EIa, and Pakhomov VIu

Subjects
Animals, Electron Spin Resonance Spectroscopy, Electron Transport, Energy Metabolism, Glycerolphosphate Dehydrogenase metabolism, Lipid Peroxidation, Lymphocytes enzymology, Male, Mitochondria, Liver drug effects, Mitochondria, Liver metabolism, Rats, Succinate Dehydrogenase metabolism, Antioxidants pharmacology, Malonates pharmacology
Abstract

Energy status of rats was altered after administration of anphen [2,4-(hydroxy-3,5-ditretbutyl phenyl)-2-aminomalonic acid] at a dose of 40 mg/kg. Within 30 min after administration, maximal rates of NAD-dependent substrates and succinate oxidation were detected in liver mitochondria, which appears to occur due to activation of the mitochondrogenesis. The rate of electron transport in respiratory chain of mitochondria was decreased 1.3-1.6-fold within 1-1.5 hr, whereas within 3 hrs the patterns of oxidation and energetic coupling in liver mitochondria were reduced to control values. The similar alterations were observed in activities of lymphocyte alpha-glycerophosphate- and succinate dehydrogenases. Shifts in the pool of lipid peroxidation products in biological membranes was apparently responsible for alterations in activity of the energy metabolizing enzymes in lymphocytes and liver mitochondria.

Published
1993

6. [Biological activity of N,N'-bis(3-triethoxysilylpropyl)thiocarbamide].

Author

Safaev RD, Voronkov MG, Fuks SIu, Lycheva TA, Khitrovo IA, Belitskiĭ GA, Pakhomov VIu, Vlasova NN, and Pestunovich AE

Subjects
Animals, Drosophila melanogaster genetics, Mice, Microsomes, Liver enzymology, Mutagenicity Tests, Salmonella typhimurium genetics, Mutagens toxicity, Thiocarbamates toxicity
Published
1992

8. [Interaction with cytochrome P-450 as one of the mechanisms of protective action of 3-hydroxypyridines in the diethylnitrosamine poisoning of animals].

Author

Shuliakovskaia TS, Arshinov VIu, Pakhomov VIu, Rykova VA, and Smirnov LD

Subjects
Animals, Drug Evaluation, Preclinical, Drug Interactions, Male, Microsomes, Liver drug effects, Microsomes, Liver enzymology, Pyridoxine therapeutic use, Rats, Rats, Inbred Strains, Time Factors, Antidotes therapeutic use, Antioxidants therapeutic use, Cytochrome P-450 Enzyme System metabolism, Diethylnitrosamine poisoning, Nitrosamines poisoning, Pyridines therapeutic use, Pyridoxine analogs & derivatives
Published
1984

9. [Modifying effect of antioxidants on the biotransformation of dialkyl-N-nitrosamines in microsomes. A spin trap method].

Author

Pakhomov VIu, Shuliakovskaia TS, Artemova LG, and Saprin AN

Subjects
Animals, Biotransformation, Dealkylation, Diethylamines metabolism, Diethylnitrosamine toxicity, Dimethylamines metabolism, Dimethylnitrosamine toxicity, Electron Spin Resonance Spectroscopy, Free Radicals, Male, Microsomes, Liver enzymology, Rats, Rats, Inbred Strains, Antioxidants pharmacology, Carcinogens metabolism, Diethylnitrosamine metabolism, Dimethylnitrosamine metabolism, Microsomes, Liver metabolism
Published
1986

10. [Modifying effect of antioxidants on the rate of lipid peroxidation in liver microsomes at early stages of diethylnitrosamine biotransformation].

Author

Pakhomov VIu, Artemova LG, and Shuliakovskaia TS

Subjects
Animals, Biotransformation, Cytochrome P-450 Enzyme System metabolism, Diethylnitrosamine toxicity, Drug Interactions, Free Radicals, Lethal Dose 50, Male, Methylcholanthrene pharmacology, Microsomes, Liver enzymology, NADP metabolism, Rats, Rats, Inbred Strains, Time Factors, Antioxidants pharmacology, Diethylnitrosamine pharmacokinetics, Lipid Peroxidation drug effects, Microsomes, Liver metabolism
Abstract

Lipid peroxidation and free radicals' generation were investigated in rats treated with carcinogenic diethylnitrosamine (DENA) after pretreatment with some antioxidants. It was shown that decreased generation of free radicals during DENA metabolism in rat liver microsomes after pretreatment of animals with antioxidants may be the cause of the protective action of these antioxidants against DENA toxicity. Lipid peroxidation was shown to be not a crucial reaction in the toxic effect of DENA.

Published
1988

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