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Abstract: Geophysical methods are adequate for imaging the CO2 plume in order to follow its migration within the reservoir and possible leakages through the caprock formation. In particular, changes in density, seismic velocity or electrical resistivity are associated with changes in the gas saturation and make methods such as gravity, 4D seismic and electrical resistivity tomography (ERT) or CSEM powerful tools to follow up the fate of injected CO2. Respect to the minimum amount of CO2 stored that can be quantified for verification purpose, there is an order of magnitude between 4D seismic (few 100s of Kt) and the other two methods (few Mt). Respect to the detection of leakage at the reservoir level, only 4D seismic could be considered as useful. Using downhole measurements, such as crosshole electric or downhole gravity will increase the resolution of these methods and therefore its ability to detect leakage. In case of CO2 leakage upwards and accumulation within a secondary reservoir located at a few hundreds of meters depth, the resolution of the three methods is increased by several order of magnitude and small amounts of CO2 could be detected, depending whether it is in gaseous phase or dissolved. It is expected that controlled experiments of leaking CO2 at shallow depth will help to define more precisely the conditions of use of the three methods. [Copyright &y& Elsevier]

Background/objectives: Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain in younger adults., Subjects/methods: At baseline, 126 adult participants under the age of 35 were weighed and underwent measurement of gastrointestinal phenotypes including gastric emptying (GE), gastric volume, satiation, satiety, and gastrointestinal hormones. Patients were reappraised after median 4.4 years unless, during the period of follow-up, they participated in a formal weight loss program, received obesity-weight loss interventions, or developed a health condition likely to affect weight. Participants were dichotomized into two groups for each phenotype at the median of each phenotype., Results: In total, 60 participants met criteria for inclusion and were evaluated after a median of 4.4 years [IQR: 3.5-5], 36 participants were excluded due to conditions that would abnormally affect weight during study period including pregnancy and weight loss treatment, and 30 participants were lost to prospective follow-up. Faster GE was significantly associated with weight gain. Those with faster GE at baseline (n = 30) gained a median of 9.6 kg [3.1-14.9] compared with those with slower GE at baseline (n = 30) who gained a median of 2.8 kg [-4.6 to 9.2] (p = 0.03), over the follow-up period. There was no association between the other phenotypes and weight gain., Conclusions: In adults ≤35 years old, faster gastric emptying is associated with significantly increased weight gain over the medium term. This provides supportive evidence for the role of gastric emptying in weight gain and development of obesity.

Purpose of review Endoscopic bariatric therapy (EBT) is a rapidly developing area that has now seen FDA approval of six endoscopic bariatric devices and procedures and there are a number of other novel EBTs progressing through various stages of development with newly published findings. This paper aims to assist readers in either selecting an appropriate therapy for their patient or deciding to incorporate these therapies into their practice. This paper provides an updated review of the available data on EBTs, both FDA approved and not, with a particular focus on effectiveness and safety, as well as guidance for discussing with your patient the decision to use endoscopic therapies. Findings The authors of a large meta-analysis of Orbera concluded its ideal balloon volume to be 600-650 mL. AspireAssist has had favorable effectiveness and safety data published in a large RCT. A large study of endoscopic sleeve gastroplasty has published findings at up to 24 months showing promising durability. Elipse, a swallowed intragastric balloon not requiring endoscopy for either insertion or removal, has had early favorable results published. A magnet-based system for creation of a gastrojejunostomy has published favorable findings from its pilot study. Summary EBTs are safe and effective therapies for weight loss when used in conjunction with lifestyle changes and fill an important gap in the management of obesity. There are now six FDA-approved EBTs available and several more in ongoing trials with favorable early findings. More study is needed to understand the role of EBTs used in combination or in sequence with medications and bariatric surgery.