1. Clinician preferences for prescription of corticosteroids in patients with septic shock: an international survey
- Author
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Sarah Grattan, Yaseen M. Arabi, Tony Yeh, Anders Perner, Gavin M. Joynt, Flávia Ribeiro Machado, Vernon van Heerden, Balasubramanian Venkatesh, Andrew Rhodes, Naomi E Hammond, Gian Luca Di Tanna, Bharath Kumar Tirupakuzhi Vijayaraghavan, Ashwani Kumar, Royal Brisbane, Jeremy Cohen, Pain Intensive Care Anesthesiology, and Rigshospitalet, Copenhagen, Denmark
- Subjects
medicine.medical_specialty ,Septic shock ,business.industry ,Emergency medicine ,International survey ,medicine ,In patient ,Medical prescription ,medicine.disease ,business - Abstract
In 2010, following the publication of two large trials of corticosteroids in septic shock, an international survey of corticosteroid use in the management of septic shock reported marked variability in practice. Two large randomised controlled trials of corticosteroids in septic shock (ie, the ADRENAL trial comparing hydrocortisone v placebo 4 and the APROCCHSS trial comparing hydrocortisone plus fludrocortisone v placebo) published in 2018 reported divergent effects of steroids on mortality at day 90, although important secondary outcomes such as duration of shock and mechanical ventilation were improved in both trials.
- Published
- 2021