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9. Poster presentation

Author

Duparc, F., Noyon, M., Ozeel, J., Gerometta, A., Michot, C., Tadjalli, M., Moslemy, H., Safaei, S., Heiman, A., Wish-Baratz, S., Melnikov, T., Smoliar, E., Hakan, A. Y., Yucel, F., Kachlík, D. K., Pešl, M. P., Báča, V. B., Stingl, J. S., Kachlík, K. D., Čech, Č. P., Báča, B. V., Mompeó, B., Marrero-Rodriguez, A., Zeybek, A., Sağlam, B., Çikler, E., Çetinel, Ş., Ercan, F., Şener, G., Kawawa, Y., Kohda, E., Tatsuya, T., Moroi, M., Kunimasa, T., Nagamoto, M., Terada, H., Labuschagne, B. C. J., van der Krieke, T. J., Hoogland, P. V., Muller, C. J. F., Lyners, R., Vorster, W., Matusz, P., Zaboi, D. E., Xu, S. C., Tu, L. L., Wang, Q., Zhang, M., Han, H., Tao, W., Jiao, Y., Pang, G., Aydin, M. E., Kopuz, C., Demir, M. T., Yildirim, M., Kale, A., Ince, Y., Khamanarong, K., Jeeravipoolvarn, P., Chaijaroonkhanarak, W., Gawgleun, W., Fujino, T., Uz, A., Apaydin, N., Bozkurt, M., Elhan, A., Sheibani, M. T., Adibmoradi, M., Jahovic, N., Alican, I., Erkanli, G., Arbak, S., Karakaş, S., Taşer, F., Güneş, H., Yildiz, Y., Yazici, Y., Aland, R. C., Kippers, V., Song, W. C., Park, S. H., Shin, C., Koh, K. S., Russo, G., Pomara, F., Veca, M., Cacciola, F., Martorana, U., Gravante, G., Tobenas-Dujardin, A. C., Laquerrière, A., Muller, J. M., Fréger, P., López-Serna, N., Álvarez-González, E., Torres-Gonzàlez, V., Laredo-López, G., Esparza-González, G. V., Álvarez-Cantú, R., Garza-González, C. E., Guzmán-López, S., Aldur, M. M., Çelik, H. H., Sürücü, S., Denk, C., Yang, H. J., Gil, Y. C., Kim, T. J., Lee, H. Y., Lee, W. J., Lee, H., Hu, K. S., Akita, K., Kim, H. J., Jung, H. S., Gurbuz, H., Balik, S., Wavreille, G., Chantelot, C., Demondion, X., Fontaine, C., Çavdar, S., Yalin, A., Saka, E., Özdoǧmuş, Ö., Çakmak, Ö., Elevli, L., Saǧlam, B., Coquerel-Beghin, D., Milliez, P. Y., Lemierre, G., Oktem, G., Vatansever, S., Ayla, S., Uysal, A., Aktas, S., Karabulut, B., Bilir, A., Uslu, S., Aktug, H., Yurtseven, M. E., Celik, H. H., Tatar, I., Surucu, S., Karaduman, A., Tunali, S., Neuhüttler, S., Kröll, A., Moriggl, B., Brenner, E., Loukas, M., Arora, S., Louis, Jr, R. G., Fogg, Q. A., Wagner, T., Tedman, R. A., Ching, H. Y., Eze, N., Bottrill, I. D., Blyth, P., Faull, R. L. M., Vuletic, J., Elizondo-Omaña, R. E., Rodríguez, M. A. García, López, S. Guzmán, de la Garza, O. Tijerina, Liu, Y. H., Zhang, K. L., Lu, D. H., Kwak, H. H., Park, H. D., Youn, K. H., Kang, H. J., Kang, H. C., Han, S. H., Ikiz, Z. A. Aktan, Ucerler, H., Uygur, M., Kutoglu, T., Dina, C., Iliescu, D., Şapte, E., Bordei, P., Lekšan, I., Marcikić, M., Radić, R., Nikolić, V., Kurbel, S., Selthofer, R., Báča, V., Doubková, A., Kachlík, D., Stingl, J., Džupa, V., Grill, R., Nam, Y. S., Paik, D. J., Shin, C. S., Kim, S. J., Kim, D. G., Jin, C. S., Kim, D. I., Lee, U. Y., Kwak, D. S., Lee, J. H., Han, C. H., Carpino, A., Rago, V., Romeo, F., Carani, C., Andò, S., Arican, R. Y., Coskun, N., Sarikcioglu, L., Sindel, M., Arican, Y. R., Altun, U., Ozsoy, U., Oguz, N., Yildirim, F. B., Nakajima, K., Duygulu, E., Aydin, H., Gurer, E. Inanc, Ozkan, O., Tuzuner, S., Özsoy, U., Çubukçu, S., Demirel, B. M., Akkin, S. M., Marur, T., Weiglein, A. H., Maghiar, T. T., Borza, C., Bumbu, A., Bumbu, G., Polle, G., Auquit-Auckbur, I., Dujardin, F., Biga, N., Olivier, E., Defives, T., Ghazali, S., Anastasi, G., Rizzo, G., Favaloro, A., Miliardi, D., Giacobbe, O., Santoro, G., Trimarchi, F., Cutroneo, G., Govsa, F., Bilge, O., Ozer, M. A., Erdogmus, S., Grizzi, F., Pelillo, F., Mori, M., Franceschini, B., Portinaro, N., Godlewski, G., Viala, M., Rouanet, J. P., Prat, D., Rahmé, Z. S., Prudhomme, M., Eken, E., Kwiatkowska, M., Liegmann, J., Chmielewski, R., Grimmond, J., Kwiatkowski, M., Schintler, M. V., Windisch, G., Wittgruber, G., Prandl, E. C., Prodinger, P., Anderhuber, F., Scharnagl, E., Gerbino, A., Buscemi, M., Leone, A., Mandracchia, R., Peri, G., Lipari, D., Farina-Lipari, E., Valentino, B., D’Arpa, S., Cordova, A., Bucchieri, F., Ribbene, A., David, S., Palma, A., Davies, D. E., Haitchi, H. M., Holgate, S. T., La Rocca, G., Anzalone, R., Campanella, C., Rappa, F., Bartolotta, T., Cappello, F., Bellafiore, M., Sivverini, G., Palumbo, D., Macaluso, F., Farina, F., Di Felice, V., Montalbano, A., Ardizzone, N., Marcianò, V., Zummo, G., Tanyeli, E., Üzel, M., Carini, F., Scardina, G. A., Varia, P., Valenza, V., Messina, P., Meiring, J. H., Schumann, C., Whitmore, I., Greyling, L. M., Hamel, O., Hamel, A., Robert, R., Garçon, M., Lagier, S., Blin, Y., Armstrong, O., Rogez, J. M., Le Borgne, J., Ifrim, C. Feng, Maghiar, A., Botea, M., Ifrim, M., Pop, O., Sandor, M., Behdadipour, Z., Saberi, M., Esfandiary, E., Gentile, C., Marconi, A., Livrea, M. A., Uzan, G., D’Alessio, P., Ridola, C. G., Grassi, N., Pantuso, G., Bottino, A., Cacace, E., Li Petri, S., Di Gaudio, F., Guercio, G., Latteri, M. A., Nobile, D., Cipolla, C., Caruso, G., Salvaggio, G., Lo Cascio, A., Fatta, G., Lagalla, R., Campisi, A., Verderame, F., Martegani, A., Cardinale, A. E., and Luedinghausen, M. V.

Published
2005
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16. Theory of the elastic constants of the rare gas solids

Author

Paik, D. S.

Subjects
530.412
Abstract

Some general results for thermoelastic quantities are derived by considering a solid in different states of strained reference frames. It is shown that simple relationships hold between the nth order and the volume derivatives of (n-1)th order elastic constants. Explicit expressions for these results are obtained for a cubic solid. The contribution to thermoelastic properties of the inert gas solids Ne, A, Kr and Xe for long-range three-body forces of the form given by Axilrod and Teller are calculated. The second order elastic constants C[ij] and the third order elastic constants C[ijk] are calculated at the absolute zero assuming only two-body forces. The approach employed here was not the standard lattice dynamical methods. Instead, an Einstein model modified for anisotropic effects and including correlation as a perturbation was used. This model was found to be more flexible than the standard lattice dynamical approach. Where possible comparision with standard lattice dynamical methods was made. It is shown that although both, the three-body forces and the two-body zero-point effects violate the Cauchy relations they do so in opposite sense. In the case of some of the it is found that contributions due to three-body forces and two-body zero-point effects are often larger than the classical two-body contributions and differing in sign. The calculations of the C[ijk] have further shown that in a certain instance it is possible to distinguish between the contributions of the 3-body forces and the two-body zero-point effect, which is not possible in the case of the C[ij] A method is presented to calculate in a simple manner the contribution of the zero-point energy and the free-energy at finite teperatures to the elastic constants. In the case of the C[ij] where comparision with refined lattice dynamical method are available, good agreement is found. The method also enabled us to assess the many particle correlation effects.

Published
1978

23. Ultrafast vectorial and scalar dynamics of ionic clusters: Azobenzene solvated by oxygen.

Author

Paik, D. Hern, Baskin, J. Spencer, Kim, Nam Joon, and Zewail, Ahmed H.

Subjects
*ANIONS, *OXYGEN, *MOLECULES, *PHOTOELECTRON spectroscopy, *PHOTOELECTRONS, *SCISSION (Chemistry), *ANISOTROPY
Abstract

The ultrafast dynamics of clusters of trans-azobenzene anion (A-) solvated by oxygen molecules was investigated using femtosecond time-resolved photoelectron spectroscopy. The time scale for stripping off all oxygen molecules from A- was determined by monitoring in real time the transient of the A- rise, following an 800 nm excitation of A- (O2)n, where n=1–4. A careful analysis of the time-dependent photoelectron spectra strongly suggests that for n>1 a quasi-O4 core is formed and that the dissociation occurs by a bond cleavage between A- and conglomerated (O2)n rather than a stepwise evaporation of O2. With time and energy resolutions, we were able to capture the photoelectron signatures of transient species which instantaneously rise (<100 fs) then decay. The transient species are assigned as charge-transfer complexes: A·O2- for A-O2 and A·O4-·(O2)n-2 for A-(O2)n, where n=2–4. Subsequent to an ultrafast electron recombination, A- rises with two distinct time scales: a subpicosecond component reflecting a direct bond rupture of the A--(O2)n nuclear coordinate and a slower component (1.6–36 ps, increasing with n) attributed to an indirect channel exhibiting a quasistatistical behavior. The photodetachment transients exhibit a change in the transition dipole direction as a function of time delay. Rotational dephasing occurs on a time scale of 2–3 ps, with a change in the sign of the transient anisotropy between A-O2 and the larger clusters. This behavior is a key indicator of an evolving cluster structure and is successfully modeled by calculations based on the structures and inertial motion of the parent clusters. [ABSTRACT FROM AUTHOR]

Published
2006
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24. Femtosecond dynamics of solvated oxygen anions. II. Nature of dissociation and caging in finite-sized clusters.

Author

Kim, Nam Joon, Paik, D. Hern, and Zewail, Ahmed H.

Subjects
*ANIONS, *OXYGEN, *PHOTOELECTRON spectroscopy, *ION recombination, *KINEMATICS
Abstract

Ultrafast dissociation and recombination dynamics of (O[sub 2])[sub n, sup -], n = 3-10 was studied using femtosecond, time-resolved photoelectron spectroscopy. The observed transients of nascent fragment anions, following 800 nm fs pulse excitation, exhibit a biexponential rise with two distinct time constants. The time constants, which vary with the number of solvent O[sub 2] molecules, clearly show the solvation effect in two different dissociation pathways. Consistent with the bifurcation picture in the preceding paper, the direct subpicosecond dissociation (τ[sub 1] = 110-620 fs, depending on n) is governed by electron recombination and kinematics of the half-collision. The second pathway is indirect (τ[sub 2] = 0.7-8.0 ps, for O[sub 6, sup -] to O[sub 20, sup -]) and controlled by intramolecular vibrational-energy redistribution. In the solvent cage, only O[sub 16, sup -], O[sub 18, sup -], and O[sub 20, sup -] show the reformation of the bond, with the caging time constant decreasing from 4 ps for the first two to 2 ps for the latter. This caging through ion-induced dipole interaction is then followed by vibrational relaxation on the time scale of 12 to 3 ps, for O[sub 16, sup -] to O[sub 20, sup -]. The time scale for the initial direct caging is two to five times slower than that previously observed for diatoms, neutral, or ionic, in van der Waals clusters. We suggest that this initial slower caging is due to the reorientation of O[sub 2, sup -] and O[sub 2] to acquire a proper geometry for O[sub 4, sup -] bond reformation. In these finite-sized homogeneous clusters, we compare theory with experiment. We also found a correlation between the vertical detachment energy and n[sup -1/3], for n in the range of 2-10, which allow for a connection between the mesoscopic structures and a bulk-type dielectric continuum, with an effective dielectric constant. [ABSTRACT FROM AUTHOR]

Published
2003
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25. Femtosecond dynamics of solvated oxygen anions. I. Bifurcated electron transfer dynamics probed by photoelectron spectroscopy.

Author

Paik, D. Hern, Kim, Nam Joon, and Zewail, Ahmed H.

Subjects
*ANIONS, *OXYGEN, *PHOTOELECTRON spectroscopy, *PICOSECOND pulses
Abstract

The ultrafast dissociation dynamics of O[sub 6, sup -]·X (X = O[sub 2], N[sub 2], Xe, or N[sub 2]O) was investigated by femtosecond photoelectron spectroscopy. The transients, monitoring nascent O[sub 2, sup -], exhibit biexponential rises with two distinct time constants—the fast component (τ[sub 1] ∼ 200 fs) corresponds to the joint rate constant for electron recombination and direct dissociation of the O[sub 4, sup -] core perturbed by solvent molecules, whereas the slow component (τ[sub 2] = 2.0-7.7 ps, depending on the solvent) corresponds to the process for the liberation of O[sub 2, sup -], which is governed by vibrational predissociation and intramolecular vibrational-energy redistribution. These observations are consistent with the mechanism proposed in the earlier communication of this work [Paik et al., J. Chem. Phys. 115, 612 (2001)]. The wave packet bifurcates via two separate dissociation pathways: electron transfer followed by electron recombination, and electron transfer followed by vibrational predissociation. Unlike all other solvents, the anomalous behavior observed for O[sub 6, sup -]·N[sub 2]O—a threefold increase in τ[sub 2] value, compared to the other solvents, and a factor of 10 increase for τ[sub 2], compared to that of O[sub 6, sup -]—reflects the more effective energy dissipation via solute-solvent vibration-to-vibration and rotational couplings. Moreover, for all solvents, the ratio of the slow-rise contribution to the total signal can be correlated with the degree of cooling, supporting the concept of bifurcation in the two channels. [ABSTRACT FROM AUTHOR]

Published
2003
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26. Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer

Author

Bolton, KL, Tyrer, J, Song, H, Ramus, SJ, Notaridou, M, Jones, C, Sher, T, Gentry-Maharaj, A, Wozniak, E, Tsai, Y-Y, Weidhaas, J, Paik, D, Van Den Berg, DJ, Stram, DO, Pearce, CL, Wu, AH, Brewster, W, Anton-Culver, H, Ziogas, A, Narod, SA, Levine, DA, Kaye, SB, Brown, R, Paul, J, Flanagan, J, Sieh, W, McGuire, V, Whittemore, AS, Campbell, I, Gore, ME, Lissowska, J, Yang, HP, Medrek, K, Gronwald, J, Lubinski, J, Jakubowska, A, Le, ND, Cook, LS, Kelemen, LE, Brooks-Wilson, A, Massuger, LFAG, Kiemeney, LA, Aben, KKH, van Altena, AM, Houlston, R, Tomlinson, I, Palmieri, RT, Moorman, PG, Schildkraut, J, Iversen, ES, Phelan, C, Vierkant, RA, Cunningham, JM, Goode, EL, Fridley, BL, Kruger-Kjaer, S, Blaeker, J, Hogdall, E, Hogdall, C, Gross, J, Karlan, BY, Ness, RB, Edwards, RP, Odunsi, K, Moyisch, KB, Baker, JA, Modugno, F, Heikkinenen, T, Butzow, R, Nevanlinna, H, Leminen, A, Bogdanova, N, Antonenkova, N, Doerk, T, Hillemanns, P, Dürst, M, Runnebaum, I, Thompson, PJ, Carney, ME, Goodman, MT, Lurie, G, Wang-Gohrke, S, Hein, R, Chang-Claude, J, Rossing, MA, Cushing-Haugen, KL, Doherty, J, Chen, C, Rafnar, T, Besenbacher, S, Sulem, P, Stefansson, K, Birrer, MJ, Terry, KL, Hernandez, D, Cramer, DW, Vergote, I, Amant, F, Lambrechts, D, Despierre, E, Fasching, PA, Beckmann, MW, Thiel, FC, Ekici, AB, Chen, X, Australian Ovarian Cancer Study Group, Johnatty, SE, Webb, PM, Beesley, J, Chanock, S, Garcia-Closas, M, Sellers, T, Easton, DF, Berchuck, A, Chenevix-Trench, G, Pharoah, PDP, and Gayther, SA

Subjects
Australian Ovarian Cancer Study Group
Published
2016
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27. Improvement of surface texture on the hot dip galvanized and galvannealed steel sheets

Author

Hong, M.-H., Tark, H.-J., Park, J.-S., and Paik, D.-J.

Abstract

Customers of hot dip galvanized and/or galvannealed steel sheets for automotive are more and moredemanding on high surface quality, paintability and press-formability. The roll texture for temper-rolling incontinuous galvanizing line should be very precisely treated to give a special roughness, which can betransferred to the Zn-coating surfaces during temper-rolling. Among the various texturing methods, in thepresent study, we adopted a newly developed TCT (TopoCrom Texturing) technology and both roll roughness(high/low Ra) and Cr structures (Open/Closed types) are tested. The products applying TCT had a uniformand dense roughness pattern and surface characteristics is also compared with the conventionally used EDT(electron discharge texturing) treatment. It should be noted that TCT technology on commercial galvannealingcoating surface is firstly used and the best condition was Ra=1.2 ?m with closed type; the roughness valuedecreases about 35% compared to the conventionally used EDT. On the other hand, in hot-dip galvanized steelsheets, the best condition was Ra=3.0 ?m with closed type. The friction coefficient was significantly improvedby the effect of the formation of oil pockets on the hot-dip galvanized steel sheet.

Published
2013

29. Common variants at 19p13 are associated with susceptibility to ovarian cancer

Author

Bolton, KL, Tyrer, J, Song, H, Ramus, SJ, Notaridou, M, Jones, C, Sher, T, Gentry-Maharaj, A, Wozniak, E, Tsai, YY, Weidhaas, J, Paik, D, Van Den Berg, DJ, Stram, DO, Pearce, CL, Wu, AH, Brewster, W, Anton-Culver, H, Ziogas, A, Narod, SA, Levine, DA, Kaye, SB, Brown, R, Paul, J, Flanagan, J, Sieh, W, McGuire, V, Whittemore, AS, Campbell, I, Gore, ME, Lissowska, J, Yang, HP, Medrek, K, Gronwald, J, Lubinski, J, Jakubowska, A, Le, ND, Cook, LS, Kelemen, LE, Brook-Wilson, A, Massuger, LFAG, Kiemeney, LA, Aben, KKH, Van Altena, AM, Houlston, R, Tomlinson, I, Palmieri, RT, Moorman, PG, Schildkraut, J, Iversen, ES, Phelan, C, Vierkant, RA, Cunningham, JM, Goode, EL, Fridley, BL, Kruger-Kjaer, S, Blaeker, J, Hogdall, E, Hogdall, C, Gross, J, Karlan, BY, Ness, RB, Edwards, RP, Odunsi, K, Moyisch, KB, Baker, JA, Modugno, F, Heikkinenen, T, Butzow, R, Nevanlinna, H, Leminen, A, Bogdanova, N, Antonenkova, N, Doerk, T, Hillemanns, P, Dürst, M, Runnebaum, I, Thompson, PJ, Carney, ME, Goodman, MT, Lurie, G, Wang-Gohrke, S, Hein, R, Chang-Claude, J, Rossing, MA, Cushing-Haugen, KL, Doherty, J, Chen, C, Rafnar, T, Besenbacher, S, Sulem, P, Stefansson, K, Birrer, MJ, Terry, KL, Hernandez, D, Cramer, DW, and Vergote, I

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development. © 2010 Nature America, Inc. All rights reserved.

Published
2010
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32. Ultrafast vectorial and scalar dynamics of ionic clusters: Azobenzene solvated by oxygen

Author

Paik, D. Hem, Baskin, J. Spencer, Kim, Nam Joon, and Zewail, Ahmed H.

Subjects
Caltech Library Services
Abstract

The ultrafast dynamics of clusters of trans-azobenzene anion (A–) solvated by oxygen molecules was investigated using femtosecond time-resolved photoelectron spectroscopy. The time scale for stripping off all oxygen molecules from A– was determined by monitoring in real time the transient of the A– rise, following an 800 nm excitation of A– (O2)n, where n=1–4. A careful analysis of the time-dependent photoelectron spectra strongly suggests that for n>1 a quasi-O4 core is formed and that the dissociation occurs by a bond cleavage between A– and conglomerated (O2)n rather than a stepwise evaporation of O2. With time and energy resolutions, we were able to capture the photoelectron signatures of transient species which instantaneously rise (2- for A–O2 and A·O4-·(O2)n–2 for A–(O2)n, where n=2–4. Subsequent to an ultrafast electron recombination, A– rises with two distinct time scales: a subpicosecond component reflecting a direct bond rupture of the A–-(O2)n nuclear coordinate and a slower component (1.6–36 ps, increasing with n) attributed to an indirect channel exhibiting a quasistatistical behavior. The photodetachment transients exhibit a change in the transition dipole direction as a function of time delay. Rotational dephasing occurs on a time scale of 2–3 ps, with a change in the sign of the transient anisotropy between A–O2 and the larger clusters. This behavior is a key indicator of an evolving cluster structure and is successfully modeled by calculations based on the structures and inertial motion of the parent clusters.

Published
2006

35. Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Author

Bolton, K.L., Tyrer, J.P., Song, H., Ramus, S.J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y.Y., Weidhaas, J., Paik, D., Berg, D.P.G. van den, Stram, D.O., Pearce, C.L., Wu, A.H., Brewster, W., Anton-Culver, H., Ziogas, A., Narod, S., Levine, D.A., Kaye, S.B., Brown, R., Paul, J., Flanagan, J., Sieh, W., McGuire, V., Whittemore, A.S., Campbell, I., Gore, M.E., Lissowska, J., Yang, H.P., Medrek, K., Gronwald, J., Lubinski, J., Jakubowska, A., Le, N.D., Cook, L.S., Keleman, L.E., Brook-Wilson, A., Massuger, L.F.A.G., Kiemeney, L.A.L.M., Aben, K.K.H., Altena, A.M. van, Houlston, R.S., Tomlinson, I., Palmieri, R.T., Moorman, P.G., Schildkraut, J., Iversen, E.S., Phelan, C.M., Vierkant, R.A., Cunningham, J.M., Goode, E.L., Fridley, B.L., Kruger-Kjaer, S., Blaeker, J., Hogdall, E., Hogdall, C., Gross, J., Karlan, B.Y., Ness, R.B., Edwards, R.P., Odunsi, K., Moyisch, K.B., Baker, J.A., Modugno, F., Heikkinenen, T., Butzow, R., Nevanlinna, H., Leminen, A., Bogdanova, N., Antonenkova, N., Doerk, T., Hillemanns, P., Durst, M., Runnebaum, I., Thompson, P.J., Carney, M.E., Goodman, M.T., Lurie, G., Wang-Gohrke, S., Hein, R., Chang-Claude, J., Rossing, M.A., Cushing-Haugen, K.L., Doherty, J., Chen, C., Rafnar, T., Besenbacher, S., Sulem, P., Stefansson, K., Birrer, M.J., Bolton, K.L., Tyrer, J.P., Song, H., Ramus, S.J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y.Y., Weidhaas, J., Paik, D., Berg, D.P.G. van den, Stram, D.O., Pearce, C.L., Wu, A.H., Brewster, W., Anton-Culver, H., Ziogas, A., Narod, S., Levine, D.A., Kaye, S.B., Brown, R., Paul, J., Flanagan, J., Sieh, W., McGuire, V., Whittemore, A.S., Campbell, I., Gore, M.E., Lissowska, J., Yang, H.P., Medrek, K., Gronwald, J., Lubinski, J., Jakubowska, A., Le, N.D., Cook, L.S., Keleman, L.E., Brook-Wilson, A., Massuger, L.F.A.G., Kiemeney, L.A.L.M., Aben, K.K.H., Altena, A.M. van, Houlston, R.S., Tomlinson, I., Palmieri, R.T., Moorman, P.G., Schildkraut, J., Iversen, E.S., Phelan, C.M., Vierkant, R.A., Cunningham, J.M., Goode, E.L., Fridley, B.L., Kruger-Kjaer, S., Blaeker, J., Hogdall, E., Hogdall, C., Gross, J., Karlan, B.Y., Ness, R.B., Edwards, R.P., Odunsi, K., Moyisch, K.B., Baker, J.A., Modugno, F., Heikkinenen, T., Butzow, R., Nevanlinna, H., Leminen, A., Bogdanova, N., Antonenkova, N., Doerk, T., Hillemanns, P., Durst, M., Runnebaum, I., Thompson, P.J., Carney, M.E., Goodman, M.T., Lurie, G., Wang-Gohrke, S., Hein, R., Chang-Claude, J., Rossing, M.A., Cushing-Haugen, K.L., Doherty, J., Chen, C., Rafnar, T., Besenbacher, S., Sulem, P., Stefansson, K., and Birrer, M.J.

Abstract

Contains fulltext : 89441.pdf (publisher's version ) (Closed access)

Published
2010

46. Assessment of an Optical Flow Field-Based Polyp Detector for CT Colonography

Author

STANFORD UNIV PALO ALTO CA, Acar, B., Beaulieu, C. F., Paik, D. S., Goekturk, S. B., Tomasi, C., STANFORD UNIV PALO ALTO CA, Acar, B., Beaulieu, C. F., Paik, D. S., Goekturk, S. B., and Tomasi, C.

Abstract

Most current computer-aided detection (CAD) algorithms for the fully automatic detection of colonic polyps from 3D CT data suffer from high false positive rates. We developed and evaluated a post-processing algorithm to decrease the false positive rate of such a method. Our method attempts to model the way a radiologist recognizes a polyp while scrolling a cross-sectional plane through 3D CT data by quantifying the change in location of the edges in 2D plane. It uses a classifier for identification base on the Mahalanobis distance. The new method increase the ROC curve area from 0.89 to 0.98 (an increase from 34.5% to 85.0% in specificity for 100% sensitivity) in a population of 8 patients., Presented at Annual International Conference of the IEEE Engineering in Medicine and Biology Society (23rd) held in Istanbul, Turkey on 25-28 Oct 2001. See also ADM001351 for entire conference on CD-ROM. The original document contains color images.

Published
2001

47. Medial Axis Registration of Supine and Prone CT Colonography Data

Author

STANFORD UNIV PALO ALTO CA, Acar, B., Napel, S., Paik, D. S., Li, P., Yee, J., STANFORD UNIV PALO ALTO CA, Acar, B., Napel, S., Paik, D. S., Li, P., and Yee, J.

Abstract

Computed Tomographic Colonography (CTC) is a minimally invasive method that allows the examination of the colon wall from the source CT sections or in a virtual environment. The primary goal of CTC is the detection of colonic polyps. There are typically two data sets recorded in supine and prone positions. An important step in polyp detection is the anatomical registration of these datasets. We developed and experimentally validated a method to register complementary supine and prone CTC datasets anatomically, using linear stretching/shrinking operations on the medial axis colonic path based on the relative path geometries. To compare improvement in spatial registration of supine and prone datasets, a radiologist determined 5 unique reference points (RP) in the registered and unregistered datasets from each of 5 patients by viewing supine and prone data simultaneously. Initial results suggest that our algorithm is capable of registering supine and prone CTC data anatomically within an approximate range of +/- 13.2mm, which corresponds to 0.8% error with respect to the average colon length., Presented at Annual International Conference of the IEEE Engineering in Medicine and Biology Society (23rd) held in Istanbul, Turkey on 25-28 Oct 2001. See also ADM001351 for entire conference on CD-ROM.

Published
2001

48. A New 3-D Volume Processing Method for PolyP Detection

Author

STANFORD UNIV PALO ALTO CA, Gokturk, S. B., Thomasi, C., Acar, B., Paik, D., Beaulieu, C., STANFORD UNIV PALO ALTO CA, Gokturk, S. B., Thomasi, C., Acar, B., Paik, D., and Beaulieu, C.

Abstract

Early diagnosis and removal of colonic polyps is effective in the elimination of subsequent carcinoma. This paper presents a new approach for computer-aided detection of polyps. The approach mimics the way the radiologists view CT abdomen images and utilizes several geometric attributes obtained from many triples of mutually orthogonal planes. The histogram of the attributes obtained from a sufficiently large number of perpendicular random images serves as a robust signature to represent the shape. We combine the new 3-D pattern recognition with a support vector machine classifier, and show that the number of the false positive detections in the initial polyp detection studies can be substantially reduced. One of the main contributions of this study is the thorough analysis of planar geometrical attributes. When an appropriate combination of planar attributes is used, the false positive rate is reduced by 87 percent beyond that of the initial stage detector, while maintaining a sensitivity level of 95 percent. Using such methods, radiologists should be able to view CTC data much more efficiently and accurately than without CAD., Papers from 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 25-28, 2001, held in Istanbul, Turkey. See also ADM001351 for entire conference on cd-rom., The original document contains color images.

Published
2001

49. Low Reynold's number boundary layers in a disturbed environment

Author

Paik, D. K and Reshotko, E

Subjects
Fluid Mechanics And Heat Transfer
Abstract

Studies of flat plate boundary layer development were made in a low speed wind tunnel at turbulence levels from 2%to 7%. Only transitional and turbulent flows were observed in the range 280 Re sub theta 700. The mean turbulent velocity profiles display law-of-the-wall behavior but have negligible wake component. The u' disturbance profiles compare well with those of other experiments, the peak value of u'/u sub tau being about 2.5. The effect of free-stream turbulence level on turbulent skin friction can be nicely correlated with those of other investigations on a plot of u sub e/u sub tau versus Re sub theta. A discussion on the u' spectra for the transitional boundary-layers is presented.

Published
1986

50. Transition in a disturbed environment

Author

Reshotko, E and Paik, D. K

Subjects
Fluid Mechanics And Heat Transfer
Abstract

The title of this presentation is the title of our research grant. While transition study is the objective of the work, the results to date are principally on the properties of turbulent boundary layers at low Reynolds numbers are discussed. Testing was done in a small return wind tunnel. Mean boundary layer development is given. The skin friction behavior of the turbulent points are considered. No standard laminar flow was observed. Furthermore, the turbulent mean flow data seem reasonable for the elevated disturbance levels of the tests in the sense that there is no discernible wake component to any of the profiles and that the variation of skin friction with R sub theta is consistent with zero wake strength. The no-grid data are in all likelihood transitional.

Published
1985

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