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155 results on '"Pai, P.-C."'

4. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells

Author

Chan, Tze-Sian, Hsu, Chung-Chi, Pai, Vincent C, Liao, Wen-Ying, Huang, Shenq-Shyang, Tan, Kok-Tong, Yen, Chia-Jui, Hsu, Shu-Ching, Chen, Wei-Yu, Shan, Yan-Shen, Li, Chi-Rong, Lee, Michael T, Jiang, Kuan-Ying, Chu, Jui-Mei, Lien, Gi-Shih, Weaver, Valerie M, and Tsai, Kelvin K

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Prevention, Biotechnology, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Administration, Metronomic, Breast Neoplasms, Female, Fibroblasts, Humans, MCF-7 Cells, NF-kappa B, Receptors, Interleukin-8B, STAT1 Transcription Factor, Stromal Cells, U937 Cells, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Although traditional chemotherapy kills a fraction of tumor cells, it also activates the stroma and can promote the growth and survival of residual cancer cells to foster tumor recurrence and metastasis. Accordingly, overcoming the host response induced by chemotherapy could substantially improve therapeutic outcome and patient survival. In this study, resistance to treatment and metastasis has been attributed to expansion of stem-like tumor-initiating cells (TICs). Molecular analysis of the tumor stroma in neoadjuvant chemotherapy-treated human desmoplastic cancers and orthotopic tumor xenografts revealed that traditional maximum-tolerated dose chemotherapy, regardless of the agents used, induces persistent STAT-1 and NF-κB activity in carcinoma-associated fibroblasts. This induction results in the expression and secretion of ELR motif-positive (ELR+) chemokines, which signal through CXCR-2 on carcinoma cells to trigger their phenotypic conversion into TICs and promote their invasive behaviors, leading to paradoxical tumor aggression after therapy. In contrast, the same overall dose administered as a low-dose metronomic chemotherapy regimen largely prevented therapy-induced stromal ELR+ chemokine paracrine signaling, thus enhancing treatment response and extending survival of mice carrying desmoplastic cancers. These experiments illustrate the importance of stroma in cancer therapy and how its impact on treatment resistance could be tempered by altering the dosing schedule of systemic chemotherapy.

Published
2016

15. Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.

Author

Yoshitsugu Hattori, Pai, Betty C.-J., Takafumi Saito, Pang-Yun Chou, Ting-Chen Lu, Chun-Shin Chang, Yu-Ray Chen, and Lun-Jou Lo

Abstract

Background: Patients with cleft lip and palate have functional and esthetic impairment and typically require multiple interventions in their life. Long-term evaluation following a treatment protocol, especially for patients with complete bilateral cleft lip and palate (BCLP), is important but was rarely reported in the literature. Patients and methods: A retrospective review was conducted on all patients with complete BCLP born between 1995 and 2002 and treated at our center. Inclusion criteria were having adequate medical records and receiving continuous multidisciplinary team care at least until 20 years of age. Exclusion criteria were lack of regular follow-up and congenital syndromic abnormalities. The medical records and photos were reviewed, and facial bone development was evaluated using cephalometric analysis. Results: A total of 122 patients were included, with a mean age of 22.1 years at the final evaluation in this study. Primary one-stage cheiloplasty was performed in 91.0% of the patients, and 9.0% underwent two-stage repair with an initial adhesion cheiloplasty. All patients underwent two-flap palatoplasty at an average of 12.3 months. Surgical intervention for velopharyngeal insufficiency was required in 59.0% of patients. Revisional lip/nose surgery was performed in 31.1% during growing age and in 64.8% after skeletal maturity. Orthognathic surgery was applied in 60.7% of patients with retruded midface, of which 97.3% underwent two-jaw surgery. The average number of operations to complete the treatment was 5.9 per patient. Conclusion: Patients with complete BCLP remain the most challenging group to treat among the cleft. This review revealed certain suboptimal results, and modifications have been made to the treatment protocol. Longitudinal follow-up and periodic assessment help to establish an ideal therapeutic strategy and improve overall cleft care. [ABSTRACT FROM AUTHOR]

Published
2023
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