35 results on '"Pai, Lee-Yuh"'
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2. Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947
3. Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores
4. The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics
5. Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold
6. Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation
7. Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one
8. Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension
9. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure
10. Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
11. Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
12. Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
13. A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors
14. Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors
15. Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors
16. Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis
17. The correlation of pharmacodynamic activity of mineralocorticoid receptor antagonism with its blood pressure lowering effect in rat with the remnant kidney
18. Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement
19. Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα
20. Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms
21. Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain
22. Estrogen receptor-β regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe
23. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus
24. Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs
25. Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans
26. Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers
27. Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains
28. Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains
29. Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains
30. Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins
31. Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators
32. The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
33. Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
34. Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe.
35. Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
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