Search

Your search keyword '"Pahus, Laurie"' showing total 33 results
Start Over Author "Pahus, Laurie"
33 results on '"Pahus, Laurie"'

2. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Author

Adriaens, Nora, Ahmed, Hassan, Aliprantis, Antonios, Alving, Kjell, Badorek, Philipp, Balgoma, David, Barber, Clair, Bautmans, An, Behndig, Annelie F., Bel, Elisabeth, Beleta, Jorge, Berglind, Ann, Berton, Alix, Bigler, Jeanette, Bisgaard, Hans, Bochenek, Grazyna, Boedigheimer, Michael J., Bøonnelykke, Klaus, Brandsma, Joost, Braun, Armin, Brinkman, Paul, Burg, Dominic, Campagna, Davide, Carayannopoulos, Leon, Carvalho da Purfição Rocha, João P., Chaiboonchoe, Amphun, Chaleckis, Romanas, Coleman, Courtney, Compton, Chris, D'Amico, Arnaldo, Dahlén, Barbro, De Alba, Jorge, de Boer, Pim, De Lepeleire, Inge, Dekker, Tamara, Delin, Ingrid, Dennison, Patrick, Dijkhuis, Annemiek, Draper, Aleksandra, Edwards, Jessica, Emma, Rosalia, Ericsson, Magnus, Erpenbeck, Veit, Erzen, Damijan, Faulenbach, Cornelia, Fichtner, Klaus, Fitch, Neil, Flood, Breda, Frey, Urs, Gahlemann, Martina, Galffy, Gabriella, Gallart, Hector, Garret, Trevor, Geiser, Thomas, Gent, Jilaiha, Gerhardsson de Verdier, Maria, Gibeon, David, Gomez, Cristina, Gove, Kerry, Gozzard, Neil, Guo, Yi-Ke, Hashimoto, Simone, Haughney, John, Hedlin, Gunilla, Hekking, Pieter-Paul, Henriksson, Elisabeth, Hewitt, Lorraine, Higgenbottam, Tim, Hoda, Uruj, Hohlfeld, Jans, Holweg, Cecile, Howarth, Peter, Hu, Richard, Hu, Sile, Hu, Xugang, Hudson, Val, James, Anna J., Kamphuis, Juliette, Kennington, Erika J., Kerry, Dyson, Klüglich, Matthias, Knobel, Hugo, Knowles, Richard, Knox, Alan, Kolmert, Johan, Konradsen, Jon, Kots, Maxim, Krueger, Linn, Kuo, Scott, Kupczyk, Maciej, Lambrecht, Bart, Lantz, Ann-Sofie, Larsson, Lars, Lazarinis, Nikos, Lone-Satif, Saeeda, Marouzet, Lisa, Martin, Jane, Masefield, Sarah, Mathon, Caroline, Matthews, John G., Mazein, Alexander, Meah, Sally, Maiser, Andrea, Menzies-Gow, Andrew, Metcalf, Leanne, Middelveld, Roelinde, Mikus, Maria, Miralpeix, Montse, Monk, Philips, Mores, Nadia, Murray, Clare S., Musial, Jacek, Myles, David, Naz, Shama, Nething, Katja, Nicholas, Ben, Nihlen, Ulf, Nilsson, Peter, Nordlund, Björn, Östling, Jörgen, Pacino, Antonio, Pahus, Laurie, Palkonnen, Susanna, Pavlidis, Stelios, Pennazza, Giorgio, Petrén, Anne, Pink, Sandy, Postle, Anthony, Powel, Pippa, Rahman-Amin, Malayka, Rao, Navin, Ravanetti, Lara, Ray, Emma, Reinke, Stacey, Reynolds, Leanne, Riemann, Kathrin, Riley, John, Robberechts, Martine, Roberts, Amanda, Rossios, Christos, Russell, Kirsty, Rutgers, Michael, Santini, Giuseppe, Sentoninco, Marco, Schoelch, Corinna, Schofield, James P.R., Seibold, Wolfgang, Sigmund, Ralf, Sjödin, Marcus, Skipp, Paul J., Smids, Barbara, Smith, Caroline, Smith, Jessica, Smith, Katherine M., Söderman, Päivi, Sogbesan, Adesimbo, Staykova, Doroteya, Strandberg, Karin, Sun, Kai, Supple, David, Szentkereszty, Marton, Tamasi, Lilla, Tariq, Kamran, Thörngren, John-Olof, Thornton, Bob, Thorsen, Jonathan, Valente, Salvatore, van Aalderenm, Wim, van de Pol, Marianne, van Drunen, Kees, van Geest, Marleen, Versnel, Jenny, Vestbo, Jorgen, Vink, Anton, Vissing, Nadja, von Garnier, Christophe, Wagerner, Arianne, Wagers, Scott, Wald, Frans, Walker, Samantha, Ward, Jonathan, Weiszhart, Zsoka, Wetzel, Kristiane, Wheelock, Craig E., Wiegman, Coen, Williams, Siân, Wilson, Susan J., Woosdcock, Ashley, Yang, Xian, Yeyashingham, Elizabeth, Yu, Wen, Zetterquist, Wilhelm, Zwinderman, Koos, Lefaudeux, Diane, De Meulder, Bertrand, Loza, Matthew J., Peffer, Nancy, Rowe, Anthony, Baribaud, Frédéric, Bansal, Aruna T., Lutter, Rene, Sousa, Ana R., Corfield, Julie, Pandis, Ioannis, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fleming, Louise J., Fowler, Stephen J., Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandstrom, Thomas, Shaw, Dominic E., Singer, Florian, Sterk, Peter J., Roberts, Graham, Adcock, Ian M., Djukanovic, Ratko, Auffray, Charles, and Chung, Kian Fan

Published
2017
Full Text
View/download PDF

11. Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Author

Lipp, Theresa, primary, Acar Şahin, Aydan, additional, Aggelidis, Xenophon, additional, Arasi, Stefania, additional, Barbalace, Andrea, additional, Bourgoin, Anne, additional, Bregu, Blerina, additional, Brighetti, Maria Antonia, additional, Caeiro, Elsa, additional, Caglayan Sozmen, Sule, additional, Caminiti, Lucia, additional, Charpin, Denis, additional, Couto, Mariana, additional, Delgado, Luís, additional, Di Rienzo Businco, Andrea, additional, Dimier, Claire, additional, Dimou, Maria V., additional, Fonseca, João A., additional, Goksel, Ozlem, additional, Guvensen, Aykut, additional, Hernandez, Dolores, additional, Hoffmann, Tara Maria, additional, Jang, Dah Tay, additional, Kalpaklioglu, Fusun, additional, Lame, Blerta, additional, Llusar, Ruth, additional, Makris, Michael P., additional, Mazon, Angel, additional, Mesonjesi, Eris, additional, Nieto, Antonio, additional, Öztürk, Ayse, additional, Pahus, Laurie, additional, Pajno, Giovanni Battista, additional, Panasiti, Ilenia, additional, Papadopoulos, Nikolaos G., additional, Pellegrini, Elisabetta, additional, Pelosi, Simone, additional, Pereira, Ana M., additional, Pereira, Mariana, additional, Pinar, Munevver, additional, Potapova, Ekaterina, additional, Priftanji, Alfred, additional, Psarros, Fotis, additional, Sackesen, Cansin, additional, Sfika, Ifigenia, additional, Suarez, Javier, additional, Thibaudon, Michel, additional, Travaglini, Alessandro, additional, Tripodi, Salvatore, additional, Verdier, Valentine, additional, Villella, Valeria, additional, Xepapadaki, Paraskevi, additional, Yazici, Duygu, additional, Matricardi, Paolo M., additional, and Dramburg, Stephanie, additional

Published
2021
Full Text
View/download PDF

12. Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study

Author

Mattei, Laura, primary, Suehs, Carey M., additional, Alagha, Khuder, additional, Bourdin, Arnaud, additional, Brousse, Christophe, additional, Charriot, Jeremy, additional, Devouassoux, Gilles, additional, Fry, Stephanie, additional, Guilleminault, Laurent, additional, Gouitaa, Marion, additional, Taille, Camille, additional, Chanez, Pascal, additional, and Pahus, Laurie, additional

Published
2021
Full Text
View/download PDF

13. Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Author

Bourdin, Arnaud, primary, Charriot, Jérémy, additional, Boissin, Clément, additional, Ahmed, Engi, additional, Suehs, Carey, additional, De Sevin, Arthur, additional, Volpato, Mathilde, additional, Pahus, Laurie, additional, Gras, Delphine, additional, Vachier, Isabelle, additional, Halimi, Laurence, additional, Hamerlijnck, Dominic, additional, and Chanez, Pascal, additional

Published
2020
Full Text
View/download PDF

14. Letter from France

Author

Charriot, Jérémy, primary, Pahus, Laurie, additional, Chanez, Pascal, additional, Nagot, Nicolas, additional, and Bourdin, Arnaud, additional

Published
2020
Full Text
View/download PDF

15. “Whole” vs. “fragmented” approach to EAACI pollen season definitions: A multicenter study in six Southern European cities

Author

Hoffmann, Tara Maria, primary, Acar Şahin, Aydan, additional, Aggelidis, Xenophon, additional, Arasi, Stefania, additional, Barbalace, Andrea, additional, Bourgoin, Anne, additional, Bregu, Blerina, additional, Brighetti, Maria Antonia, additional, Caeiro, Elsa, additional, Caglayan Sozmen, Sule, additional, Caminiti, Lucia, additional, Charpin, Denis, additional, Couto, Mariana, additional, Delgado, Luís, additional, Di Rienzo Businco, Andrea, additional, Dimier, Claire, additional, Dimou, Maria V., additional, Fonseca, João A., additional, Goksel, Ozlem, additional, Guvensen, Aykut, additional, Hernandez, Dolores, additional, Jang, Dah Tay, additional, Kalpaklioglu, Fusun, additional, Lame, Blerta, additional, Llusar, Ruth, additional, Makris, Michael P., additional, Mazon, Angel, additional, Mesonjesi, Eris, additional, Nieto, Antonio, additional, Öztürk, Ayse, additional, Pahus, Laurie, additional, Pajno, Giovanni Battista, additional, Panasiti, Ilenia, additional, Panetta, Valentina, additional, Papadopoulos, Nikolaos G., additional, Pellegrini, Elisabetta, additional, Pelosi, Simone, additional, Pereira, Ana Margarida, additional, Pereira, Mariana, additional, Pinar, Munevver, additional, Pfaar, Oliver, additional, Potapova, Ekaterina, additional, Priftanji, Alfred, additional, Psarros, Fotis, additional, Sackesen, Cansin, additional, Sfika, Ifigenia, additional, Suarez, Javier, additional, Thibaudon, Michel, additional, Travaglini, Alessandro, additional, Tripodi, Salvatore, additional, Verdier, Valentine, additional, Villella, Valeria, additional, Xepapadaki, Paraskevi, additional, Yazici, Duygu, additional, Matricardi, Paolo M., additional, and Dramburg, Stephanie, additional

Published
2020
Full Text
View/download PDF

16. 'Whole' vs 'fragmented' approach to EAACI pollen season definitions: a multicenter study in six Southern European cities

Author

Öztürk, Ayşe Bilge (ORCID 0000-0003-0166-424X & YÖK ID 147629); Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537); Yazıcı, Duygu, Hoffmann, Tara Maria; Şahin, Aydan Acar; Aggelidis, Xenophon; Arasi, Stefania; Barbalace, Andrea; Bourgoin, Anne; Bregu, Blerina; Brighetti, Maria Antonia; Caeiro, Elsa; Sozmen, Sule Caglayan; Caminiti, Lucia; Charpin, Denis; Couto, Mariana; Delgado, Luis; Businco, Andrea Di Rienzo; Dimier, Claire; Dimou, Maria, V; Fonseca, Joao A.; Göksel, Özlem; Güvensen, Aykut; Hernandez, Dolores; Jang, Dah Tay; Kalpaklıoğlu, Füsun; Lame, Blerta; Llusar, Ruth; Makris, Michael P.; Mazon, Angel; Mesonjesi, Eris; Nieto, Antonio; Pahus, Laurie; Pajno, Giovanni Battista; Panasiti, Ilenia; Panetta, Valentina; Papadopoulos, Nikolaos G.; Pellegrini, Elisabetta; Pelosi, Simone; Pereira, Ana Margarida; Pereira, Mariana; Pinar, Munevver; Pfaar, Oliver; Potapova, Ekaterina; Priftanji, Alfred; Psarros, Fotis; Sfika, Ifigenia; Suarez, Javier; Thibaudon, Michel; Travaglini, Alessandro; Tripodi, Salvatore; Verdier, Valentine; Villella, Valeria; Xepapadaki, Paraskevi; Matricardi, Paolo M.; Dramburg, Stephanie, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), Koç University Hospital, School of Medicine; Graduate School of Health Sciences, Öztürk, Ayşe Bilge (ORCID 0000-0003-0166-424X & YÖK ID 147629); Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537); Yazıcı, Duygu, Hoffmann, Tara Maria; Şahin, Aydan Acar; Aggelidis, Xenophon; Arasi, Stefania; Barbalace, Andrea; Bourgoin, Anne; Bregu, Blerina; Brighetti, Maria Antonia; Caeiro, Elsa; Sozmen, Sule Caglayan; Caminiti, Lucia; Charpin, Denis; Couto, Mariana; Delgado, Luis; Businco, Andrea Di Rienzo; Dimier, Claire; Dimou, Maria, V; Fonseca, Joao A.; Göksel, Özlem; Güvensen, Aykut; Hernandez, Dolores; Jang, Dah Tay; Kalpaklıoğlu, Füsun; Lame, Blerta; Llusar, Ruth; Makris, Michael P.; Mazon, Angel; Mesonjesi, Eris; Nieto, Antonio; Pahus, Laurie; Pajno, Giovanni Battista; Panasiti, Ilenia; Panetta, Valentina; Papadopoulos, Nikolaos G.; Pellegrini, Elisabetta; Pelosi, Simone; Pereira, Ana Margarida; Pereira, Mariana; Pinar, Munevver; Pfaar, Oliver; Potapova, Ekaterina; Priftanji, Alfred; Psarros, Fotis; Sfika, Ifigenia; Suarez, Javier; Thibaudon, Michel; Travaglini, Alessandro; Tripodi, Salvatore; Verdier, Valentine; Villella, Valeria; Xepapadaki, Paraskevi; Matricardi, Paolo M.; Dramburg, Stephanie, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), Koç University Hospital, and School of Medicine; Graduate School of Health Sciences

Abstract

Background: the adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy of Allergy and Clinical Immunology (EAACI) proposed season definitions for Northern and Middle Europe. Objective To test the pollen season definitions proposed by EAACI in six Mediterranean cities for seven pollen taxa. Methods: as part of the @IT.2020 multi-center study, pollen counts for Poaceae, Oleaceae, Fagales, Cupressaceae, Urticaceae (Parietaria spp.), and Compositae (Ambrosia spp., Artemisia spp.) were collected from January 1 to December 31, 2018. Based on these data, pollen seasons were identified according to EAACI criteria. A unified monitoring period for patients in AIT trials was created and assessed for feasibility. Results: the analysis revealed a great heterogeneity between the different locations in terms of pattern and length of the examined pollen seasons. Further, we found a fragmentation of pollen seasons in several segments (max. 8) separated by periods of low pollen counts (intercurrent periods). Potential monitoring periods included often many recording days with low pollen exposure (max. 341 days). Conclusion: the Mediterranean climate leads to challenging pollen exposure times. Monitoring periods for AIT trials based on existing definitions may include many intermittent days with low pollen concentrations. Therefore, it is necessary to find an adapted pollen season definition as individual solution for each pollen and geographical area., Euroimmun

Published
2020

17. Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Author

Bourdin, Arnaud, Charriot, Jérémy, Boissin, Clément, Ahmed, Engi, Suehs, Carey, De Sevin, Arthur, Volpato, Mathilde, Pahus, Laurie, Gras, Delphine, Vachier, Isabelle, Halimi, Laurence, Hamerlijnck, Dominic, and Chanez, Pascal

Subjects
ASTHMA, ADULTS, RESPIRATORY obstructions, PATIENTS' attitudes, TREATMENT failure, WHEEZE
Abstract

Purpose: Asthma exacerbations are inflammatory events that rarely result in full hospitalization following an ER visit. Unfortunately, certain patients require prolonged support, including occasional external lung support through ECMO or ECCOR (with subsequent further exposure to other life‐threatening issues), and some die. In parallel, biologics are revolutionizing severe asthma management, mostly in T2 high patients. Methods: We extensively reviewed the current unmet needs surrounding ICU‐admitted asthma exacerbations, with a focus on currently available drugs and the underlying biological processes involved. We explored whether currently available T2‐targeting drugs can reasonably be seen as potential players not only for relapse prevention but also as candidate drugs for a faster resolution of such episodes. The patient's perspective was also sought. Results: About 30% of asthma exacerbations admitted to the ICU do not resolve within five days. Persistent severe airway obstruction despite massive doses of corticosteroids and maximal pharmacologically induced bronchodilation is the main cause of treatment failure. Previous ICU admission is the main risk factor for such episodes and may eventually be considered as a T2 surrogate marker. Fatal asthma cases are hallmarked by poorly steroid‐sensitive T2‐inflammation associated with severe mucus plugging. New, fast‐acting T2‐targeting biologics (already used for preventing asthma exacerbations) have the potential to circumvent steroid sensitivity pathways and decrease mucus plugging. This unmet need was confirmed by patients who reported highly negative, traumatizing experiences. Conclusions: There is room for improvement in the management of ICU‐admitted severe asthma episodes. Clinical trials assessing how biologics might improve ICU outcomes are direly needed. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

18. PROTOACCEPT Questionnaire

Author

Pahus, Laurie, primary, Suehs, Carey Meredith, additional, Halimi, Laurence, additional, Bourdin, Arnaud, additional, Chanez, Pascal, additional, Jaffuel, Dany, additional, Marciano, Julie, additional, Gamez, Anne-Sophie, additional, Vachier, Isabelle, additional, and Molinari, Nicolas, additional

Published
2020
Full Text
View/download PDF

26. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Author

Lefaudeux, Diane, primary, De Meulder, Bertrand, additional, Loza, Matthew J., additional, Peffer, Nancy, additional, Rowe, Anthony, additional, Baribaud, Frédéric, additional, Bansal, Aruna T., additional, Lutter, Rene, additional, Sousa, Ana R., additional, Corfield, Julie, additional, Pandis, Ioannis, additional, Bakke, Per S., additional, Caruso, Massimo, additional, Chanez, Pascal, additional, Dahlén, Sven-Erik, additional, Fleming, Louise J., additional, Fowler, Stephen J., additional, Horvath, Ildiko, additional, Krug, Norbert, additional, Montuschi, Paolo, additional, Sanak, Marek, additional, Sandstrom, Thomas, additional, Shaw, Dominic E., additional, Singer, Florian, additional, Sterk, Peter J., additional, Roberts, Graham, additional, Adcock, Ian M., additional, Djukanovic, Ratko, additional, Auffray, Charles, additional, Chung, Kian Fan, additional, Adriaens, Nora, additional, Ahmed, Hassan, additional, Aliprantis, Antonios, additional, Alving, Kjell, additional, Badorek, Philipp, additional, Balgoma, David, additional, Barber, Clair, additional, Bautmans, An, additional, Behndig, Annelie F., additional, Bel, Elisabeth, additional, Beleta, Jorge, additional, Berglind, Ann, additional, Berton, Alix, additional, Bigler, Jeanette, additional, Bisgaard, Hans, additional, Bochenek, Grazyna, additional, Boedigheimer, Michael J., additional, Bøonnelykke, Klaus, additional, Brandsma, Joost, additional, Braun, Armin, additional, Brinkman, Paul, additional, Burg, Dominic, additional, Campagna, Davide, additional, Carayannopoulos, Leon, additional, Carvalho da Purfição Rocha, João P., additional, Chaiboonchoe, Amphun, additional, Chaleckis, Romanas, additional, Coleman, Courtney, additional, Compton, Chris, additional, D'Amico, Arnaldo, additional, Dahlén, Barbro, additional, De Alba, Jorge, additional, de Boer, Pim, additional, De Lepeleire, Inge, additional, Dekker, Tamara, additional, Delin, Ingrid, additional, Dennison, Patrick, additional, Dijkhuis, Annemiek, additional, Draper, Aleksandra, additional, Edwards, Jessica, additional, Emma, Rosalia, additional, Ericsson, Magnus, additional, Erpenbeck, Veit, additional, Erzen, Damijan, additional, Faulenbach, Cornelia, additional, Fichtner, Klaus, additional, Fitch, Neil, additional, Flood, Breda, additional, Frey, Urs, additional, Gahlemann, Martina, additional, Galffy, Gabriella, additional, Gallart, Hector, additional, Garret, Trevor, additional, Geiser, Thomas, additional, Gent, Jilaiha, additional, Gerhardsson de Verdier, Maria, additional, Gibeon, David, additional, Gomez, Cristina, additional, Gove, Kerry, additional, Gozzard, Neil, additional, Guo, Yi-Ke, additional, Hashimoto, Simone, additional, Haughney, John, additional, Hedlin, Gunilla, additional, Hekking, Pieter-Paul, additional, Henriksson, Elisabeth, additional, Hewitt, Lorraine, additional, Higgenbottam, Tim, additional, Hoda, Uruj, additional, Hohlfeld, Jans, additional, Holweg, Cecile, additional, Howarth, Peter, additional, Hu, Richard, additional, Hu, Sile, additional, Hu, Xugang, additional, Hudson, Val, additional, James, Anna J., additional, Kamphuis, Juliette, additional, Kennington, Erika J., additional, Kerry, Dyson, additional, Klüglich, Matthias, additional, Knobel, Hugo, additional, Knowles, Richard, additional, Knox, Alan, additional, Kolmert, Johan, additional, Konradsen, Jon, additional, Kots, Maxim, additional, Krueger, Linn, additional, Kuo, Scott, additional, Kupczyk, Maciej, additional, Lambrecht, Bart, additional, Lantz, Ann-Sofie, additional, Larsson, Lars, additional, Lazarinis, Nikos, additional, Lone-Satif, Saeeda, additional, Marouzet, Lisa, additional, Martin, Jane, additional, Masefield, Sarah, additional, Mathon, Caroline, additional, Matthews, John G., additional, Mazein, Alexander, additional, Meah, Sally, additional, Maiser, Andrea, additional, Menzies-Gow, Andrew, additional, Metcalf, Leanne, additional, Middelveld, Roelinde, additional, Mikus, Maria, additional, Miralpeix, Montse, additional, Monk, Philips, additional, Mores, Nadia, additional, Murray, Clare S., additional, Musial, Jacek, additional, Myles, David, additional, Naz, Shama, additional, Nething, Katja, additional, Nicholas, Ben, additional, Nihlen, Ulf, additional, Nilsson, Peter, additional, Nordlund, Björn, additional, Östling, Jörgen, additional, Pacino, Antonio, additional, Pahus, Laurie, additional, Palkonnen, Susanna, additional, Pavlidis, Stelios, additional, Pennazza, Giorgio, additional, Petrén, Anne, additional, Pink, Sandy, additional, Postle, Anthony, additional, Powel, Pippa, additional, Rahman-Amin, Malayka, additional, Rao, Navin, additional, Ravanetti, Lara, additional, Ray, Emma, additional, Reinke, Stacey, additional, Reynolds, Leanne, additional, Riemann, Kathrin, additional, Riley, John, additional, Robberechts, Martine, additional, Roberts, Amanda, additional, Rossios, Christos, additional, Russell, Kirsty, additional, Rutgers, Michael, additional, Santini, Giuseppe, additional, Sentoninco, Marco, additional, Schoelch, Corinna, additional, Schofield, James P.R., additional, Seibold, Wolfgang, additional, Sigmund, Ralf, additional, Sjödin, Marcus, additional, Skipp, Paul J., additional, Smids, Barbara, additional, Smith, Caroline, additional, Smith, Jessica, additional, Smith, Katherine M., additional, Söderman, Päivi, additional, Sogbesan, Adesimbo, additional, Staykova, Doroteya, additional, Strandberg, Karin, additional, Sun, Kai, additional, Supple, David, additional, Szentkereszty, Marton, additional, Tamasi, Lilla, additional, Tariq, Kamran, additional, Thörngren, John-Olof, additional, Thornton, Bob, additional, Thorsen, Jonathan, additional, Valente, Salvatore, additional, van Aalderenm, Wim, additional, van de Pol, Marianne, additional, van Drunen, Kees, additional, van Geest, Marleen, additional, Versnel, Jenny, additional, Vestbo, Jorgen, additional, Vink, Anton, additional, Vissing, Nadja, additional, von Garnier, Christophe, additional, Wagerner, Arianne, additional, Wagers, Scott, additional, Wald, Frans, additional, Walker, Samantha, additional, Ward, Jonathan, additional, Weiszhart, Zsoka, additional, Wetzel, Kristiane, additional, Wheelock, Craig E., additional, Wiegman, Coen, additional, Williams, Siân, additional, Wilson, Susan J., additional, Woosdcock, Ashley, additional, Yang, Xian, additional, Yeyashingham, Elizabeth, additional, Yu, Wen, additional, Zetterquist, Wilhelm, additional, and Zwinderman, Koos, additional

Published
2017
Full Text
View/download PDF

27. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Author

Shaw, Dominick E., Sousa, Ana R., Fowler, Stephen J., Fleming, Louise J., Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T., Bel, Elisabeth H., Auffray, Charles, Compton, Chris H., Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlen, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W., Higenbottam, Tim, Knox, Alan J., Krug, Norbert, Erpenbeck, Veit J., Larsson, Lars X., Lazarinis, Nikos, Matthews, John G., Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M., Wagers, Scott, Rowe, Anthony, Howarth, Peter, Wagener, Ariane H., Djukanovic, Ratko, Sterk, Peter J., and Chung, Kian Fan

Subjects
Pulmonary and Respiratory Medicine, respiratory tract diseases
Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12?months; p

Published
2015

28. Severe asthma patients on oral corticosteroid therapy as a distinct phenotype: The european U-BIOPRED cohort

Author

Chung, Kian F., Gibeon, David, Sousa, Ana R., Corfield, Julie, Shaw, Dominick E., Fowler, Stephen J., Fleming, Louise J., Riley, John, Jeyasingham, Elisabeth, Rowe, Anthony, Fichtner, Klaus, Roberts, Graham, Bakke, Per, Garnier, Christophe von, Horvath, Ildiko, Riccardo, Polosa, Krug, Norbert, Dahlen, Barbaro, Musial, Jacek, Pahus, Laurie, Myles, David, Compton, Chris, Higenbottam, Tim W., Montuschi, Paolo, Larsson, Lars, Sandstrom, Thomas, Wagers, Scott S., Howarth, Peter H., Bel, Elisabeth, Bansal, Aruna T., Djukanovic, Ratko, Sterk, Peter J., and Publica

Abstract

Rationale: A relatively important proportion of patients with severe asthma end up using a daily dose of oral corticosteroids (OCS) in addition to their high dose of inhaled corticosteroids (ICS). We have determined whether oral CS-dependent severe asthma is a distinct phenotype from those only on ICS. Methods: Participants were recruited from adult pulmonary clinics across Europe and severe asthma diagnosed according to IMI-criteria (Bel et al. Thorax 2011). They had either uncontrolled asthma as defined by the GINA guidelines AND/OR two or more severe exacerbations in the past 12 months. Asthma diagnosis was confirmed by a history of typical symptoms and either reversibility in FEV1 of >=12% and 200ml after 400 T-test, Mann Whitney U test and Chi-square test were used. Results: In the 374 severe asthma participants, 167 (44%) were on oral prednisolone. The oral prednisolone group was older but had similar FEV1 (% predicted) and BMI. There was a lower rate of cigarette smoking with lower proportion of current smokers and never-smokers, but a higher percentage with nasal polyps. There was no difference in atopy as measured by skin prick tests or RAST IgE. A higher proportion of patients had 2 or more exacerbations per year (68.3% vs 56.4%; p=0.02). A greater proportion of patients were using MDI and nebulised short-acting b-agonists and theophylline. Exhaled NO was raised (31 ppb vs 22 ppb; p=3% and neutrophils>=65%, there was a greater proportion of eosinophilic (38% vs 30%) and of mixed granulocytic (23% vs 5%), at the expense of lower paucigranulocytic (14% vs 41%)(Chi-square: p

Published
2014

29. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Author

Shaw, Dominick E, Sousa, Ana R, Fowler, Stephen J, Fleming, Louise J, Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T, Bel, Elisabeth H, Auffray, Charles, Compton, Chris H, Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlén, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-Ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W, Higenbottam, Tim, Horváth, Ildikó, Knox, Alan J, Krug, Norbert, Erpenbeck, Veit J, Larsson, Lars X, Lazarinis, Nikos, Matthews, John G, Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Sandström, Thomas, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M, Wagers, Scott, Rowe, Anthony, Shaw, Dominick E, Sousa, Ana R, Fowler, Stephen J, Fleming, Louise J, Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T, Bel, Elisabeth H, Auffray, Charles, Compton, Chris H, Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlén, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-Ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W, Higenbottam, Tim, Horváth, Ildikó, Knox, Alan J, Krug, Norbert, Erpenbeck, Veit J, Larsson, Lars X, Lazarinis, Nikos, Matthews, John G, Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Sandström, Thomas, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M, Wagers, Scott, and Rowe, Anthony

Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.

Published
2015

32. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Author

Krug, Norbert, Fleming, Louise J, Hekking, Pieter-Paul W, Shaw, Dominick E, Larsson, Lars X, Gerhardsson De Verdier, Maria, Roberts, Graham, Hashimoto, Simone, Auffray, Charles, Compton, Chris H, Myles, David, Wagers, Scott, Pandis, Ioannis, Hedlin, Gunilla, Horváth, Ildikó, Guo, Yi-Ke, Djukanovic, Ratko, Dahlen, Sven-Erik, Dyson, Kerry, Strandberg, Karin, Bel, Elisabeth H, Sterk, Peter J, Seibold, Wolfgang, Gibeon, David, Sousa, Ana R, U-BIOPRED Study Group, Bucchioni, Enrica, Erpenbeck, Veit J, Higenbottam, Tim, Vissing, Nadja, Dahlén, Barbro, Geiser, Thomas, Adcock, Ian M, Wagener, Ariane H, Caruso, Massimo, Rowe, Anthony, Bansal, Aruna T, Frey, Urs Peter, Corfield, Julie, Lazarinis, Nikos, Howarth, Peter, Pahus, Laurie, Matthews, John G, Chanez, Pascal, Sandström, Thomas, Chung, Kian Fan, Montuschi, Paolo, Vestbo, Jorgen, Bisgaard, Hans, Jeyasingham, Elizabeth, Fowler, Stephen J, Singer, Florian, Middelveld, Roelinde, Knox, Alan J, Musial, Jacek, and Von Garnier, Christophe

Subjects
610 Medicine & health, respiratory tract diseases, 3. Good health
Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p

33. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Author

Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, Chanez P, Dahlén B, Dahlen SE, Dyson K, Frey U, Geiser T, Gerhardsson de Verdier M, Gibeon D, Guo YK, Hashimoto S, Hedlin G, Jeyasingham E, Hekking PP, Higenbottam T, Horváth I, Knox AJ, Krug N, Erpenbeck VJ, Larsson LX, Lazarinis N, Matthews JG, Middelveld R, Montuschi P, Musial J, Myles D, Pahus L, Sandström T, Seibold W, Singer F, Strandberg K, Vestbo J, Vissing N, von Garnier C, Adcock IM, Wagers S, Rowe A, Howarth P, Wagener AH, Djukanovic R, Sterk PJ, and Chung KF

Subjects
Adult, Anxiety epidemiology, Asthma drug therapy, Asthma epidemiology, Case-Control Studies, Comorbidity, Cross-Sectional Studies, Depression epidemiology, Europe, Female, Gastroesophageal Reflux epidemiology, Humans, Male, Middle Aged, Nitric Oxide analysis, Prospective Studies, Quality of Life, Severity of Illness Index, Smoking epidemiology, Spirometry, Surveys and Questionnaires, Systems Biology, Adrenal Cortex Hormones administration & dosage, Anti-Asthmatic Agents administration & dosage, Asthma complications, Smoking adverse effects
Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach., (Copyright ©ERS 2015.)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results