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1. Focussed Assessment with Sonography in acute Lassa Fever (FASLa): Development of a point-of-care protocol and description of common ultrasound findings

Author

Erameh, Cyril O., Koch, Till, Edeawe, Osahogie Isaac, Oestereich, Lisa, Omansen, Till, Jochum, Johannes, Adomeh, Donatus I., Ikponmwonsa, Odia, Aire, Chris, Pahlmann, Meike, Asogun, Danny A., Ogbaini-Emovon, Ephraim, Okogbenin, Sylvanus A., Günther, Stephan, Ramharter, Michael, Akideno, Peter E., and Kreuels, Benno

Published
2023
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2. Virus persistence after recovery from acute Lassa fever in Nigeria: a 2-year interim analysis of a prospective longitudinal cohort study

Author

Thielebein, Anke, Ighodalo, Yemisi, Taju, Abubakar, Olokor, Thomas, Omiunu, Racheal, Esumeh, Rita, Ebhodaghe, Paulson, Ekanem, Anieno, Igenegbale, Ganiyu, Giwa, Rosemary, Renevey, Annick, Hinzmann, Julia, Müller, Jonas, Pallasch, Elisa, Pahlmann, Meike, Guedj, Jeremie, Nwatuzor, Joy, Femi Babatunde, Oluwasola, Adomeh, Donatus I, Asogun, Danny, Akpede, Nosa, Okogbenin, Sylvanus, Günther, Stephan, Oestereich, Lisa, Duraffour, Sophie, and Ogbaini-Emovon, Ephraim

Published
2022
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3. Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study

Author

Strampe, Jamie, Asogun, Danny A, Speranza, Emily, Pahlmann, Meike, Soucy, Ali, Bockholt, Sabrina, Pallasch, Elisa, Becker-Ziaja, Beate, Duraffour, Sophie, Bhadelia, Nahid, Ighodalo, Yemisi, Oyakhilome, Jennifer, Omomoh, Emmanuel O, Olokor, Thomas, Adomeh, Donatus I, Ikponwonsa, Odia, Aire, Chris, Tobin, Ekaete, Akpede, Nosa, Okokhere, Peter O, Okogbenin, Sylvanus A, Akpede, George O, Muñoz-Fontela, César, Ogbaini-Emovon, Ephraim, Günther, Stephan, Connor, John H, and Oestereich, Lisa

Published
2021
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4. Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

Author

Keita, Alpha Kabinet, Koundouno, Fara R., Faye, Martin, Düx, Ariane, Hinzmann, Julia, Diallo, Haby, Ayouba, Ahidjo, Le Marcis, Frederic, Soropogui, Barré, Ifono, Kékoura, Diagne, Moussa M., Sow, Mamadou S., Bore, Joseph A., Calvignac-Spencer, Sebastien, Vidal, Nicole, Camara, Jacob, Keita, Mamadou B., Renevey, Annick, Diallo, Amadou, Soumah, Abdoul K., Millimono, Saa L., Mari-Saez, Almudena, Diop, Mamadou, Doré, Ahmadou, Soumah, Fodé Y., Kourouma, Kaka, Vielle, Nathalie J., Loucoubar, Cheikh, Camara, Ibrahima, Kourouma, Karifa, Annibaldis, Giuditta, Bah, Assaïtou, Thielebein, Anke, Pahlmann, Meike, Pullan, Steven T., Carroll, Miles W., Quick, Joshua, Formenty, Pierre, Legand, Anais, Pietro, Karla, Wiley, Michael R., Tordo, Noel, Peyrefitte, Christophe, McCrone, John T., Rambaut, Andrew, Sidibé, Youssouf, Barry, Mamadou D., Kourouma, Madeleine, Saouromou, Cé D., Condé, Mamadou, Baldé, Moussa, Povogui, Moriba, Keita, Sakoba, Diakite, Mandiou, Bah, Mamadou S., Sidibe, Amadou, Diakite, Dembo, Sako, Fodé B., Traore, Fodé A., Ki-Zerbo, Georges A., Lemey, Philippe, Günther, Stephan, Kafetzopoulou, Liana E., Sall, Amadou A., Delaporte, Eric, Duraffour, Sophie, Faye, Ousmane, Leendertz, Fabian H., Peeters, Martine, Toure, Abdoulaye, and Magassouba, N’. Faly

Published
2021
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5. OA-652 Safety and tolerability of favipiravir for the treatment of Lassa fever: a randomized controlled open label phase II clinical trial

Author

Groger, Mirjam, primary, Okwaraeke, Kevin, additional, Akhideno, Peter, additional, Pahlmann, Meike, additional, Kleist, Christine, additional, Mbavu, Cédric, additional, Hinzmann, Julia, additional, Schlicker, Veronika, additional, Babatunde, Femi, additional, Ithete, Ndapewa, additional, Edeawe, Osahogie, additional, Sarpong, Francisca, additional, Fritzell, Camille, additional, Duvignaud, Alexandre, additional, Malvy, Denis, additional, Okogbenin, Sylvanu, additional, Jaspard, Marie, additional, Wicha, Sebastian, additional, Günther, Stephan, additional, Ramharter, Michael, additional, Ayodeji, Oluwafemi, additional, and Erameh, Cyril, additional

Published
2023
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6. PA-424 The INTEGRATE study: an adaptive platform trial for the development of new interventions to combat Lassa Fever in West Africa

Author

Jaspard, Marie, primary, Ramharter, Michael, additional, Duvignaud, Alexandre, additional, Serra, Béatrice, additional, Fritzell, Camille, additional, Juchet, Sylvain, additional, Hubert, Victoire, additional, Kinda, Moumouni, additional, Günther, Stephan, additional, Pahlmann, Meike, additional, Groger, Mirjam, additional, Erameh, Cyril, additional, Malvy, Denis, additional, Ayodeji, Oladele Oluwafemi, additional, and Okogbenin, Sylvanus, additional

Published
2023
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7. Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak

Author

Boisen, Matthew L., Uyigue, Eghosa, Aiyepada, John, Siddle, Katherine J., Oestereich, Lisa, Nelson, Diana K. S., Bush, Duane J., Rowland, Megan M., Heinrich, Megan L., Eromon, Philomena, Kayode, Adeyemi T., Odia, Ikponmwosa, Adomeh, Donatus I., Muoebonam, Ekene B., Akhilomen, Patience, Okonofua, Grace, Osiemi, Blessing, Omoregie, Omigie, Airende, Michael, Agbukor, Jacqueline, Ehikhametalor, Solomon, Aire, Chris Okafi, Duraffour, Sophie, Pahlmann, Meike, Böhm, Wiebke, Barnes, Kayla G., Mehta, Samar, Momoh, Mambu, Sandi, John Demby, Goba, Augustine, Folarin, Onikepe A., Ogbaini-Emovan, Ephraim, Asogun, Danny A., Tobin, Ekaete A., Akpede, George O., Okogbenin, Sylvanus A., Okokhere, Peter O., Grant, Donald S., Schieffelin, John S., Sabeti, Pardis C., Günther, Stephan, Happi, Christian T., Branco, Luis M., and Garry, Robert F.

Published
2020
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8. Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice

Author

Adesina, Adetunji Samuel, primary, Oyeyiola, Akinlabi, additional, Obadare, Adeoba, additional, Igbokwe, Joseph, additional, Abejegah, Chukwuyem, additional, Akhilomen, Patience, additional, Bangura, Umaru, additional, Asogun, Danny, additional, Tobin, Ekaete, additional, Ayodeji, Olufemi, additional, Osoniyi, Omolaja, additional, Davis, Chris, additional, Thomson, Emma C., additional, Pahlmann, Meike, additional, Günther, Stephan, additional, Fichet-Calvet, Elisabeth, additional, and Olayemi, Ayodeji, additional

Published
2023
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9. Lassa Virus in Pygmy Mice, Benin, 2016-2017

Author

Yadouleton, Anges, Agolinou, Achaz, Kourouma, Fode, Saizonou, Raoul, Pahlmann, Meike, Bedie, Sonia Kossou, Bankole, Honore, Becker-Ziaja, Beate, Gbaguidi, Fernand, Thielebein, Anke, Magassouba, N'Faly, Duraffour, Sophie, Baptiste, Jean-Pierre, Gunther, Stephan, and Fichet-Calvet, Elisabeth

Subjects
Health aspects, Lassa fever -- Health aspects, Teachers
Abstract

Lassa fever has recently emerged in Benin and Togo, where it had been unknown until 2014. In November 2014, two persons died of confirmed Lassa virus (LASV) infection at Saint [...]

Published
2019

11. Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria

Author

Groger, Mirjam, primary, Akhideno, Peter, additional, Kleist, Christine J, additional, Babatunde, Femi O, additional, Edeawe, Osahogie, additional, Hinzmann, Julia, additional, Akhigbe, ThankGod, additional, Nwatuzor, Joy, additional, Eifediyi, Gloria, additional, Müller, Jonas, additional, Hinrichs, Mette, additional, Pahlmann, Meike, additional, Sarpong, Francisca Naana, additional, Wagner, Christine, additional, Thielebein, Anke, additional, Aihonwalan, Louis, additional, Koch, Till, additional, Riedner, Maria, additional, Ogbaini-Emovon, Ephraim, additional, Okogbenin, Sylvanus, additional, Günther, Stephan, additional, Wicha, Sebastian G, additional, Ramharter, Michael, additional, Oestereich, Lisa, additional, Duraffour, Sophie, additional, and Erameh, Cyril, additional

Published
2022
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12. Detection of Marburg Virus Disease in Guinea

Author

Koundouno, Fara R., primary, Kafetzopoulou, Liana E., additional, Faye, Martin, additional, Renevey, Annick, additional, Soropogui, Barrè, additional, Ifono, Kékoura, additional, Nelson, Emily V., additional, Kamano, Aly A., additional, Tolno, Charles, additional, Annibaldis, Giuditta, additional, Millimono, Saa L., additional, Camara, Jacob, additional, Kourouma, Karifa, additional, Doré, Ahmadou, additional, Millimouno, Tamba E., additional, Tolno, Fernand M.B., additional, Hinzmann, Julia, additional, Soubrier, Hugo, additional, Hinrichs, Mette, additional, Thielebein, Anke, additional, Herzer, Glaucia, additional, Pahlmann, Meike, additional, Ki-Zerbo, Georges A., additional, Formenty, Pierre, additional, Legand, Anaïs, additional, Wiley, Michael R., additional, Faye, Ousmane, additional, Diagne, Moussa M., additional, Sall, Amadou A., additional, Lemey, Philippe, additional, Bah, Aïssatou, additional, Günther, Stephan, additional, Keita, Sakoba, additional, Duraffour, Sophie, additional, and Magassouba, N’Faly, additional

Published
2022
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13. Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera

Author

Deschermeier, Christina, primary, Ehmen, Christa, additional, von Possel, Ronald, additional, Murawski, Carolin, additional, Rushton, Ben, additional, Amuasi, John, additional, Sarpong, Nimako, additional, Maiga-Ascofaré, Oumou, additional, Rakotozandrindrainy, Raphael, additional, Asogun, Danny, additional, Ighodalo, Yemisi, additional, Oestereich, Lisa, additional, Duraffour, Sophie, additional, Pahlmann, Meike, additional, and Emmerich, Petra, additional

Published
2022
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14. Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.

Author

Groger, Mirjam, Akhideno, Peter, Kleist, Christine J, Babatunde, Femi O, Edeawe, Osahogie, Hinzmann, Julia, Akhigbe, ThankGod, Nwatuzor, Joy, Eifediyi, Gloria, Müller, Jonas, Hinrichs, Mette, Pahlmann, Meike, Sarpong, Francisca Naana, Wagner, Christine, Thielebein, Anke, Aihonwalan, Louis, Koch, Till, Riedner, Maria, Ogbaini-Emovon, Ephraim, and Okogbenin, Sylvanus

Subjects
RNA virus infections, ACADEMIC medical centers, SCIENTIFIC observation, RIBAVIRIN, SEVERITY of illness index, TREATMENT effectiveness, COMPARATIVE studies, RESEARCH funding, DESCRIPTIVE statistics, HEMORRHAGIC fever, POLYMERASE chain reaction, VIROLOGY, LONGITUDINAL method
Abstract

Background Lassa fever is endemic in large parts of West Africa. The recommended antiviral treatment is ribavirin. Two treatment regimens are currently endorsed in Nigeria: the "McCormick regimen" based on a study published in 1986 and the "Irrua regimen" constituting a simplified schedule developed at the Irrua Specialist Teaching Hospital, Nigeria. Evidence for the safety and efficacy of ribavirin in Lassa fever patients is poor and pharmacokinetic data for both regimens are lacking Methods Polymerase chain reaction-confirmed Lassa fever patients with mild to moderate disease severity were invited to participate in this prospective, observational pharmacokinetic study. Pharmacokinetics of ribavirin, clinical, virologic, and clinical laboratory parameters were assessed. Results Using a population pharmacokinetic approach, plasma concentrations of ribavirin were best described by a 3-compartment model. Drug exposure was remarkably consistent between participants. Overall, drug clearance was 28.5% lower in female compared with male participants. Median (5th-95th percentile) time above half maximal inhibitory concentration (IC50) was 37.3% (16.9%–73.1%), 16.7% (8.2%–58.5%), and 9.6% (4.9%–38.4%) on days 1, 7, and 8, respectively. Clinical laboratory parameters indicated reduction of cell damage and development of hemolytic anemia in the course of the treatment period. Conclusions This observational study characterizes the pharmacokinetics of ribavirin in the treatment of Lassa fever indicating consistent exposure across patients. Whereas only a short time interval of concentrations above the IC50 implies rather low antiviral efficacy in vivo, the prominent reduction of cell damage markers might point to indirect—potentially anti-inflammatory—effects of ribavirin. The role of ribavirin in the treatment of Lassa fever requires further scrutiny. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Emergence of Zaire Ebola Virus Disease in Guinea

Author

Baize, Sylvain, Pannetier, Delphine, Oestereich, Lisa, Rieger, Toni, Koivogui, Lamine, Magassouba, NʼFaly, Soropogui, Barrè, Sow, Mamadou Saliou, Keïta, Sakoba, De Clerck, Hilde, Tiffany, Amanda, Dominguez, Gemma, Loua, Mathieu, Traoré, Alexis, Kolié, Moussa, Malano, Emmanuel Roland, Heleze, Emmanuel, Bocquin, Anne, Mély, Stephane, Raoul, Hervé, Caro, Valérie, Cadar, Dániel, Gabriel, Martin, Pahlmann, Meike, Tappe, Dennis, Schmidt-Chanasit, Jonas, Impouma, Benido, Diallo, Abdoul Karim, Formenty, Pierre, Van Herp, Michel, and Günther, Stephan

Published
2014
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16. Limited specificity of commercially available SARS‐CoV‐2 IgG ELISAs in serum samples of African origin

Author

Emmerich, Petra, primary, Murawski, Carolin, additional, Ehmen, Christa, additional, Possel, Ronald, additional, Pekarek, Neele, additional, Oestereich, Lisa, additional, Duraffour, Sophie, additional, Pahlmann, Meike, additional, Struck, Nicole, additional, Eibach, Daniel, additional, Krumkamp, Ralf, additional, Amuasi, John, additional, Maiga‐Ascofaré, Oumou, additional, Rakotozandrindrainy, Raphael, additional, Asogun, Danny, additional, Ighodalo, Yemisi, additional, Kann, Simone, additional, May, Jürgen, additional, Tannich, Egbert, additional, and Deschermeier, Christina, additional

Published
2021
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18. Limited specificity of commercially available SARS-CoV-2 IgG ELISAs in serum samples of African origin

Author

Emmerich, Petra, primary, Murawski, Carolin, additional, Possel, Ronald von, additional, Oestereich, Lisa, additional, Duraffour, Sophie, additional, Pahlmann, Meike, additional, Struck, Nicole, additional, Eibach, Daniel, additional, Krumkamp, Ralf, additional, Amuasi, John, additional, Maiga-Ascofare, Oumou, additional, Rakotozandrindrainy, Raphael, additional, Asogun, Danny, additional, Ighodalo, Yemisi, additional, May, Jürgen, additional, Tannich, Egbert, additional, and Deschermeier, Christina, additional

Published
2020
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19. Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria

Author

Erameh, Cyril, primary, Edeawe, Osahogie, additional, Akhideno, Peter, additional, Eifediyi, Gloria, additional, Omansen, Till F, additional, Wagner, Christine, additional, Sarpong, Francisca, additional, Koch, Till, additional, Wicha, Sebastian, additional, Kurth, Florian, additional, Duraffour, Sophie, additional, Oestereich, Lisa, additional, Pahlmann, Meike, additional, Okogbenin, Sylvanus, additional, Ogbaini-Emovon, Ephraim, additional, Günther, Stephan, additional, Ramharter, Michael, additional, and Groger, Mirjam, additional

Published
2020
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21. Phylogeography of Lassa Virus in Nigeria

Author

Ehichioya, Deborah U., primary, Dellicour, Simon, additional, Pahlmann, Meike, additional, Rieger, Toni, additional, Oestereich, Lisa, additional, Becker-Ziaja, Beate, additional, Cadar, Daniel, additional, Ighodalo, Yemisi, additional, Olokor, Thomas, additional, Omomoh, Emmanuel, additional, Oyakhilome, Jennifer, additional, Omiunu, Racheal, additional, Agbukor, Jacqueline, additional, Ebo, Benevolence, additional, Aiyepada, John, additional, Ebhodaghe, Paulson, additional, Osiemi, Blessing, additional, Ehikhametalor, Solomon, additional, Akhilomen, Patience, additional, Airende, Michael, additional, Esumeh, Rita, additional, Muoebonam, Ekene, additional, Giwa, Rosemary, additional, Ekanem, Anieno, additional, Igenegbale, Ganiyu, additional, Odigie, George, additional, Okonofua, Grace, additional, Enigbe, Racheal, additional, Omonegho Yerumoh, Edna, additional, Pallasch, Elisa, additional, Bockholt, Sabrina, additional, Kafetzopoulou, Liana E., additional, Duraffour, Sophie, additional, Okokhere, Peter O., additional, Akpede, George O., additional, Okogbenin, Sylvanus A., additional, Odia, Ikponmwosa, additional, Aire, Chris, additional, Akpede, Nosa, additional, Tobin, Ekaete, additional, Ogbaini-Emovon, Ephraim, additional, Lemey, Philippe, additional, Adomeh, Donatus I., additional, Asogun, Danny A., additional, and Günther, Stephan, additional

Published
2019
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23. Phylogeography of Lassa Virus in Nigeria

Author

Ehichioya, Deborah, Dellicour, Simon, Pahlmann, Meike, Rieger, Toni, Oestereich, Lisa, Becker-Ziaja, Beate, Cadar, Daniel, Ighodalo, Yemisi, Olokor, Thomas, Omomoh, Emmanuel, Oyakhilome, Jennifer, Omiunu, Racheal, Agbukor, Jacqueline, Ebo, Benevolence, Aiyepada, John, Ebhodaghe, Paulson, Osiemi, Blessing, Ehikhametalor, Solomon, Akhilomen, Patience, Airende, Michael, Esumeh, Rita, Muoebonam, Ekene, Giwa, Rosemary, Ekanem, Anieno, Igenegbale, Ganiyu, Odigie, George, Okonofua, Grace, Enigbe, Racheal, Omonegho Yerumoh, Edna, Pallasch, Elisa, Bockholt, Sabrina, Kafetzopoulou, Liana Eleni, Duraffour, Sophie, Okokhere, Peter, Akpede, George, Okogbenin, Sylvanus, Odia, Ikponmwosa, Aire, Chris, Akpede, Nosa, Tobin, Ekaete Alice, Ogbaini-Emovon, Ephraim, Lemey, Philippe, Adomeh, Donatus I., Asogun, Danny, Günther, Stephan, Ehichioya, Deborah, Dellicour, Simon, Pahlmann, Meike, Rieger, Toni, Oestereich, Lisa, Becker-Ziaja, Beate, Cadar, Daniel, Ighodalo, Yemisi, Olokor, Thomas, Omomoh, Emmanuel, Oyakhilome, Jennifer, Omiunu, Racheal, Agbukor, Jacqueline, Ebo, Benevolence, Aiyepada, John, Ebhodaghe, Paulson, Osiemi, Blessing, Ehikhametalor, Solomon, Akhilomen, Patience, Airende, Michael, Esumeh, Rita, Muoebonam, Ekene, Giwa, Rosemary, Ekanem, Anieno, Igenegbale, Ganiyu, Odigie, George, Okonofua, Grace, Enigbe, Racheal, Omonegho Yerumoh, Edna, Pallasch, Elisa, Bockholt, Sabrina, Kafetzopoulou, Liana Eleni, Duraffour, Sophie, Okokhere, Peter, Akpede, George, Okogbenin, Sylvanus, Odia, Ikponmwosa, Aire, Chris, Akpede, Nosa, Tobin, Ekaete Alice, Ogbaini-Emovon, Ephraim, Lemey, Philippe, Adomeh, Donatus I., Asogun, Danny, and Günther, Stephan

Abstract

Lassa virus is genetically diverse with several lineages circulating in West Africa. This study aimed at describing the sequence variability of Lassa virus across Nigeria and inferring its spatiotemporal evolution. We sequenced and isolated 77 Lassa virus strains from 16 Nigerian states. The final data set, including previous works, comprised metadata and sequences of 219 unique strains sampled between 1969 and 2018 in 22 states. Most of this data originated from Lassa fever patients diagnosed at Irrua Specialist Teaching Hospital, Edo State, Nigeria. The majority of sequences clustered with the main Nigerian lineages II and III, while a few sequences formed a new cluster related to Lassa virus strains from Hylomyscus pamfi .Within lineages II and III, seven and five sublineages, respectively, were distinguishable. Phylogeographic analysis suggests an origin of lineage II in the southeastern part of the country around Ebonyi State and a main vector of dispersal toward the west across the Niger River, through Anambra, Kogi, Delta, and Edo into Ondo State. The frontline of virus dispersal appears to be in Ondo. Minor vectors are directed northeast toward Taraba and Adamawa and south toward Imo and Rivers. Lineage III might have spread from northern Plateau State into Kaduna, Nasarawa, Federal Capital Territory, and Bauchi. One sublineage moved south and crossed the Benue River into Benue State. This study provides a geographic mapping of lineages and phylogenetic clusters in Nigeria at a higher resolution. In addition, we estimated the direction and time frame of virus dispersal in the country. IMPORTANCE Lassa virus is the causative agent of Lassa fever, a viral hemorrhagic fever with a case fatality rate of approximately 30% in Africa. Previous studies disclosed a geographical pattern in the distribution of Lassa virus strains and a westward movement of the virus across West Africa during evolution. Our study provides a deeper understanding of the geography, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

24. Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G

Author

Gabriel, Martin, primary, Adomeh, Donatus I., additional, Ehimuan, Jacqueline, additional, Oyakhilome, Jennifer, additional, Omomoh, Emmanuel O., additional, Ighodalo, Yemisi, additional, Olokor, Thomas, additional, Bonney, Kofi, additional, Pahlmann, Meike, additional, Emmerich, Petra, additional, Lelke, Michaela, additional, Brunotte, Linda, additional, Ölschläger, Stephan, additional, Thomé-Bolduan, Corinna, additional, Becker-Ziaja, Beate, additional, Busch, Carola, additional, Odia, Ikponmwosa, additional, Ogbaini-Emovon, Ephraim, additional, Okokhere, Peter O., additional, Okogbenin, Sylvanus A., additional, Akpede, George O., additional, Schmitz, Herbert, additional, Asogun, Danny A., additional, and Günther, Stephan, additional

Published
2018
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25. Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

Author

Akhuemokhan, Odigie C., primary, Ewah-Odiase, Rosemary O., additional, Akpede, Nosa, additional, Ehimuan, Jacqueline, additional, Adomeh, Donatus I., additional, Odia, Ikpomwonsa, additional, Olomu, Sylvia C., additional, Pahlmann, Meike, additional, Becker-Ziaja, Beate, additional, Happi, Christian T., additional, Asogun, Danny A., additional, Okogbenin, Sylvanus A., additional, Okokhere, Peter O., additional, Dawodu, Osagie S., additional, Omoike, Irekpono U., additional, Sabeti, Pardis C., additional, Günther, Stephan, additional, and Akpede, George O., additional

Published
2017
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27. Hospital-Based Surveillance for Viral Hemorrhagic Fevers and Hepatitides in Ghana

Author

Bonney, Joseph Humphrey Kofi, primary, Osei-Kwasi, Mubarak, additional, Adiku, Theophilus Korku, additional, Barnor, Jacob Samson, additional, Amesiya, Robert, additional, Kubio, Chrysantus, additional, Ahadzie, Lawson, additional, Ölschläger, Stephan, additional, Lelke, Michaela, additional, Becker-Ziaja, Beate, additional, Pahlmann, Meike, additional, and Günther, Stephan, additional

Published
2013
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28. Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

Author

Akhuemokhan, Odigie C., Ewah-Odiase, Rosemary O., Akpede, Nosa, Ehimuan, Jacqueline, Adomeh, Donatus I., Odia, Ikpomwonsa, Olomu, Sylvia C., Pahlmann, Meike, Becker-Ziaja, Beate, Happi, Christian T., Asogun, Danny A., Okogbenin, Sylvanus A., Okokhere, Peter O., Dawodu, Osagie S., Omoike, Irekpono U., Sabeti, Pardis C., Günther, Stephan, and Akpede, George O.

Subjects
Medicine and Health Sciences, Diagnostic Medicine, Signs and Symptoms, Fevers, Pathology and Laboratory Medicine, Convulsions, Parasitic Diseases, Malaria, Tropical Diseases, Biology and Life Sciences, Anatomy, Body Fluids, Cerebrospinal Fluid, Physiology, Nervous System, Infectious Diseases, Bacterial Diseases, Bacterial Meningitis, Infectious Diseases of the Nervous System, Meningitis, Neurology, Inflammatory Diseases, Organisms, Protozoans, Parasitic Protozoans, Malarial Parasites, Biology and life sciences, Viruses, RNA viruses, Arenaviruses, Lassa Virus, Microbiology, Medical Microbiology, Microbial Pathogens, Viral Pathogens, Pathogens
Abstract

Background: Convulsions with fever in children are a common neurologic emergency in the tropics, and determining the contribution of endemic viral infections can be challenging. In particular, there is a dearth of data on the prevalence and clinical differentiation of Lassa virus disease (LVD) in febrile children in endemic areas of Nigeria, which has multiple lineages of the virus. The aim of this study was to determine the prevalence and presentation of LVD in febrile children with and without convulsions. Methodology/Principal findings This was a prospective study of consecutive febrile children aged ≥1 month– 15 years admitted to the Children’s Emergency Room of Irrua Specialist Teaching Hospital over a period of 1 year. Febrile children with convulsions (Cases) were compared with those without convulsions (Controls). LVD was defined by the presence of a positive Lassa virus RT-PCR test. Rates were compared between groups using χ2 or Fisher’s exact tests and p <0.05 taken as significant. 373 (40.9%) of 913 admissions had fever. Of these, 108/373 (29%) presented with convulsions. The overall prevalence of LVD was 13/373 (3.5%; 95% CI = 1.9%, 5.7%) in febrile admissions, 3/108 (2.8%) in Cases and 10/265 (3.8%) in Controls [(Odds Ratio (95% Confidence Interval) (OR (95% CI)) of LVD in Cases versus Controls = 0.73 (0.2, 2.7)]. Only vomiting (OR (95% CI) = 0.09 (0.01, 0.70)) and bleeding (OR (95% CI) = 39.56 (8.52, 183.7)) were significantly associated with an increased prevalence of LVD. Conclusions/Significance: LVD is an important cause of fever, including undifferentiated fever in children in endemic areas, but it is not significantly associated with convulsions associated with fever. Its prevalence, and lack of clinical differentiation on presentation, underscores the importance of a high index of suspicion in diagnosis. Screening of febrile children with undifferentiated fever in endemic areas for LVD could be an important medical and public health control measure.

Published
2017
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29. Virus Load Kinetics in Lassa Fever Patients Treated With Ribavirin: A Retrospective Cohort Study From Southern Nigeria.

Author

Ogbaini-Emovon E, Akpede G, Okogbenin S, Osagiede E, Tobin E, Asogun D, Okokhere P, Okonofua M, Akpede N, Akhideno P, Erameh C, Rafiu M, Azubuike C, Iraoya K, Iruolagbe C, Erohubie C, Ahmed D, Ediawe O, Okoguale J, Eifediyi R, Odia I, Agbukor J, Adomeh D, Odike MAC, Ovienria W, Elkanem A, Muoebenam EB, Ojide KC, Pallasch E, Müller J, Hinzmann J, Günther S, Pahlmann M, Thielebein A, Duraffour S, Oestereich L, and Krumkamp R

Abstract

Background: The standard of care for Lassa fever is the use of ribavirin with supportive therapy. There is little information on the course of viremia and its relationship with clinical outcomes in patients treated with ribavirin., Methods: We conducted a retrospective analysis of virologic and clinical parameters of 152 reverse transcription polymerase chain reaction-confirmed Lassa fever cases admitted and treated with ribavirin therapy. We describe the Lassa virus RNA kinetics in blood in relation to the clinical course of the patients., Results: The overall mortality was 9%. The median duration (interquartile range [IQR]) of illness before admission was 8 (5-12) days. Median (IQR) Ct values on admission ( t 0 ) were lower among patients who died (21 [20-27]) than in those who survived (34 [30-37]; P < .01). The receiver operating characteristics curve of the association between outcome and Ct value at t 0 had a high classification performance, with an AUC of 0.92 (95% CI, 0.86-0.98). The median time to viral clearance (IQR) was 10 (5-15) days. The viral load decreased steadily with the duration of treatment, and all survivors achieved viral clearance within 25 days of hospitalization., Conclusions: Our study demonstrates that the Ct value on admission has prognostic value and Lassa fever patients treated with ribavirin typically clear the virus within 3-4 weeks of hospitalization. This kinetics has implications for the design of clinical case management and future clinical trial protocols., Competing Interests: Potential conflicts of interest. The authors: no reported conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2024
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