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ABSTRACT Objective: Verify the clinical efficacy and safety of a low-cost tDCS device, in a clinical trial for major depressive disorder. Methods: 168 persons were recruited; 32 depressed individuals with moderate or severe depressive symptoms (HDRS17 scores higher than 18) were included and randomized for the trial (16 individuals in each group). The intervention consisted of 10 active anodal tDCS sessions at 2 mA for 30 minutes over the left dorsolateral prefrontal cortex; or sham. The main outcome was HDRS17; secondary outcomes included satisfaction (TSQM II) and quality of life (WHOQOL-BREF). Assessments at baseline, endpoint and at 30 days follow-up. Results: The sample was composed by a total of 11 men and 21 women, mean age of 42.75 years (95% CI: 38.10-47.40). Active treatment was superior than sham: There was a significant interaction between group and time regarding HDRS-17 scores (F = 4.089, df = 2, p = 0.029; partial Eta squared = 0. 239). Post hoc analyses exhibited a statistically significant difference between active and sham group symptoms after a 30 days follow-up (difference = -7.75, p = 0.008, Cohen’s d = 1.069). There were 3 dropouts, all in the active group, due schedule issues. No severe adverse effects reported. Conclusion: The current active tDCS protocol was related with clinical improvement of depressive symptoms. Intervention was well-tolerated. Non-invasive brain stimulation techniques are still not routinely used, although a viable strategy for treatment-resistant patients, partial responders and people unable to use pharmacological treatment. We aim to increase knowledge and use of tDCS for the Brazilian population.

A cardiac lesion detected at ultrasonography might turn out to be a normal structure, a benign tumor or rarely a malignancy, and lesion characterization is very important to appropriately manage the lesion itself. The exact relationship of the mass with coronary arteries and the knowledge of possible concomitant coronary artery disease are necessary preoperative information. Moreover, the increasingly performed coronary CT angiography to evaluate non-invasively coronary artery disease leads to a rising number of incidental findings. Therefore, CT and MRI are frequently performed imaging modalities when echocardiography is deemed insufficient to evaluate a lesion. A brief comprehensive overview about diagnostic radiological imaging and the clinical background of cardiac masses and pseudomasses is reported.

Such as differential correction systems, which are essential for the accuracy of the parallelism of vehicle guidance systems as for the quality of the seeding operation. Therefore, the objective of this work was to evaluate the accuracy of the autopilot - guided passes under RTK differential and geostationary satellite systems involved in pneumatic and mechanical sowing of corn; as well as to analyze the quality of the sowing operation using the plant stand as indicator. Two treatments were analyzed: autopilot RTK (Real Time Kinematic) and geostationary satellites, used in sowing operations. The evaluations were carried out under field. The use of autopilot with RTK differential correction in corn sowing operations offers greater accuracy between passes than that obtained with satellite correction. As to the quality of the sowing operation, the pneumatics show a better regularity in the distribution of corn seeds.

Resumo de dissertação

Aims: Left ventricular global longitudinal strain (GLS) by cardiac magnetic resonance feature tracking (CMR-FT) analysis has shown an incremental prognostic value compared to classical parameters in non-ischemic dilated cardiomyopathy (NICM). However, less is known about the role of right ventricular (RV) GLS. Our objective was to evaluate the prognostic impact of RV-GLS by CMR-FT analysis in a population of NICM patients.Methods: In this multicenter study, we examined NICM patients evaluated with a comprehensive CMR-FT study. Major cardiac events (MACEs) were considered as the study primary outcome measure and were defined as a composite of (a) cardiovascular death, (b) cardiac transplant or destination therapy ventricular assist device, (c) hospitalization for life-threatening ventricular arrhythmias or implantable cardiac defibrillator appropriate intervention. Heart failure (HF) related events, including hospitalizations and life-threatening arrhythmia-related events were considered as secondary end-points. Receiver operating time-dependent analysis were used to calculate the possible additional effect of RV-GLS to standard evaluation.Results: We consecutively enrolled 273 patients. During a median follow-up of 39 months, 41 patients (15%) experienced MACEs. RV-GLS and LV late gadolinium emerged as the strongest prognostic CMR-FT variables: their association provided an estimated 3-year MACEs rate of 29%. The addition of RV-GLS significantly improved the prognostic accuracy in predicting MACEs with respect to the standard evaluation including LGE (areas under the curve from 0.71 [0.66–0.82] to 0.76 [0.66–0.86], p = 0.03). On competing risk analysis, RV-GLS showed a significant ability to reclassify overall both HF-related and life-threatening arrhythmia-related events, regardless of LV and RV ejection fraction.Conclusions: In NICM patients, RV-GLS showed a significant prognostic role in reclassifying the risk of MACEs, incremental with respect to standard evaluation with standard prognostic parameters.

To keep pace with the rapid advancements in molecular genetics and rare diseases research, we have updated the list of ectodermal dysplasias based on the latest classification approach that was adopted in 2017 by an international panel of experts. For this purpose, we searched the databases PubMed and OMIM for the term “ectodermal dysplasia”, referring mainly to changes in the last 5 years. We also tried to obtain information about those diseases on which the last scientific report appeared more than 15 years ago by contacting the authors of the most recent publication. A group of experts, composed of researchers who attended the 8th International Conference on Ectodermal Dysplasias and additional members of the previous classification panel, reviewed the proposed amendments and agreed on a final table listing all 49 currently known ectodermal dysplasias for which the molecular genetic basis has been clarified, including 15 new entities. A newly reported ectodermal dysplasia, linked to the gene LRP6, is described here in more detail. These ectodermal dysplasias, in the strict sense, should be distinguished from syndromes with features of ectodermal dysplasia that are related to genes extraneous to the currently known pathways involved in ectodermal development. The latter group consists of 34 syndromes which had been placed on the previous list of ectodermal dysplasias, but most if not all of them could actually be classified elsewhere. This update should streamline the classification of ectodermal dysplasias, provide guidance to the correct diagnosis of rare disease entities, and facilitate the identification of individuals who could benefit from novel treatment options.

In this work, self-lubricating composites containing MoS2 and graphite dispersed in an iron matrix were produced by powder metallurgy and sintering. Previous studies demonstrate that MoS2 reacts with iron matrixes during sintering, making the production of Fe-MoS2 composites rather difficult. Therefore, this study focused on a potential solution to avoid or reduce this reaction, whilst still providing good tribological properties. Our results show that the addition of graphite retards the reaction of MoS2 with iron and that the combination of MoS2 + graphite results in composites with an optimized coefficient of friction associated with a low wear rate both in nitrogen and air atmospheres. Through adequate control of the lubricant’s particle size, composition, and processing parameters, self-lubricating iron-based composites with a low dry coefficient of friction (0.07) and low wear rate (5 × 10−6 mm3·N−1·m−1) were achieved.

Cardiac lymphomas are rare extranodal lymphomas involving primarily and secondarily the heart and/or pericardium. Here we describe three cases of cardiac involvement from lymphoma with specific peculiarities: two primary cardiac Diffuse Large B-cell Lymphomas and one secondary involvement from Marginal Zone Lymphoma (MZL). The first case highlights the issue of early CNS relapse and the possible role for CNS prophylaxis; the second case demonstrates the difficulties of interpretation and possible mistakes of different radiologic techniques adopted to evaluate cardiac involvement by lymphoma during follow-up; the third is a unique case of MZL with cardiac involvement. Our aim is to share the findings observed in these cases putting them in relation with data from the literature.

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Currently, the use of natural indigo dye has been treated as an alternative to overcome the environmental pollution caused by synthetic indigo. Irrespective of the indigo dye source, it must be reduced to its soluble form by using reducing agents in a suitable alkaline environment. Herein, bio‐sugars such as glucose or fructose were used for this purpose. The results revealed that when fructose was used instead of glucose, colour strength (K/S) values increased. In this work, cotton was cationised with water‐soluble chitosan. Water‐soluble chitosan in a wide pH range extends the use of chitosan in textiles, which otherwise is limited due to its poor water solubility at pH above 6.0. Colour fastness washing test was conducted to evaluate the efficacy of cotton cationisation. The performance of cationised samples was around 30% higher in comparison to non‐cationised samples. Moreover, in this article we have focused on integrating materials and design. We propose a garment, using natural indigo‐dyed cotton and a zero‐waste modelling approach, as a sustainable fashion product. [ABSTRACT FROM AUTHOR]

A cardiac lesion detected at ultrasonography might turn out to be a normal structure, a benign tumor or rarely a malignancy, and lesion characterization is very important to appropriately manage the lesion itself. The exact relationship of the mass with coronary arteries and the knowledge of possible concomitant coronary artery disease are necessary preoperative information. Moreover, the increasingly performed coronary CT angiography to evaluate non-invasively coronary artery disease leads to a rising number of incidental findings. Therefore, CT and MRI are frequently performed imaging modalities when echocardiography is deemed insufficient to evaluate a lesion. A brief comprehensive overview about diagnostic radiological imaging and the clinical background of cardiac masses and pseudomasses is reported. [ABSTRACT FROM AUTHOR]

O processo projetual na atividade do designer envolve etapas, nas quais são requeridas habilidades específicas do profissional. Uma das mais importantes é a tradução da demanda, ou do problema, em forma de soluções de projeto. O processo criativo é um dos principais aliados nessa tarefa, momento em que o designer deve estabelecer conexões entre conteúdos na busca por soluções inovadoras e coerentes com o contexto proposto. Como forma de promover o estabelecimento de conexões, o profissional deve ser munido de uma ampla bagagem de conhecimentos diversos, denominada repertório. Analisou-se, portanto, como a construção de um repertório rico em conteúdos ligados ao design e às experiências de vida influencia na eficiência do processo criativo. Foi construído um cenário de como a criatividade é estimulada ao longo da vida do ser humano, permitindo avaliar como ocorre a construção do repertório a partir das experiências vivenciadas.

Por meio dessa pesquisa, buscou-se apresentar as condições de vida urbana dos moradores do bairro Padre Ulrico, este localizado em uma das áreas periféricas mais pobres da cidade de Francisco Beltrão/PR. Neste sentido, procurou-se pautar este estudo a partir da temática central: a luta pelo Direito à Cidade. Para o desenvolvimento desta pesquisa, foi construído um arcabouço teórico a partir de grandes nomes da Geografia Urbana como Castells (1983); Harvey (2012); Lefebvre (2001) e outros. Além disso, foram realizadas entrevistas com os moradores e líderes populares do bairro, os quais se apresentaram de extrema importância para o resgate da história do bairro. O objetivo principal deste trabalho, permitiu comparar e refletir a luta pelo direito à uma cidade mais justa e menos desigual. Contudo, há um longo caminho a ser construído para alcançar o direito à uma cidade de qualidade para os moradores do bairro, é preciso que haja a junção da comunidade e do poder público municipal, para que de fato o Direito à Cidade seja alcançado.

The present article discourses about digital or electronic literature, as it is called in the United States, understood as such the literature produced specifically for the Web and not to be printed in paper. It is a literature still in search of aesthetic and technical paths, but that has already directed to certain trends, with the mix of languages and resources (image, audio, verbal text). This article aims at reflecting on this production, in order to find elements for its analysis, based on a theoretical reference that discusses concepts such as multimodality and multiliteracy, such as Red (2013), Kress (1998), Van Leeuwen (2011), Hayles (2009), Almeida (2011), Gomes (2011) and Moreira (2013) among others. As a methodology, we will specifically analyze some digital literary pieces of work, such as Dois Palitos (Two matchsticks) and 18:30 by Samir Mesquita, as well as the reference to other digital texts, notably those made available in Artery 8 Digital Magazine, with several authors, including concretist poets such as Augusto dos Campos and Arnaldo Antunes. As characteristic of Web language, that kind of artistic production is characterized by conciseness and discursive fragmentation. Strictly speaking, we are faced with hybrid texts that collaborate to establish new perspectives on the literary universe and even on today's life.

Powder metallurgy is a growing sector in industrial production, as it offers outstanding energy, cost and material savings in comparison with established processing routes such as casting. Hot work toll steels are usually produced by ingot metallurgy, but also by powder metallurgy, namely hot isostatic pressing and powder forging routes. In this paper we investigate the possibility of production of a hot work tool steel (AISI H13) by conventional (die compaction and pressureless sintering) and metal injection molding routes, aiming to reduce cost and production time. The sintering behavior was studied from 1250 °C until 1430 °C and the resulting parts were compared in terms of microstructure, hardness and tensile strength. The results showed that both shaping routes together with pressureless sintering are suitable to produce this alloy. By combining the best shaping approach and a tailored sintering cycle, it was possible to produce samples with 400 HV10 as well as tensile strength of 1 GPa, which are comparable to the ones obtained by powder forging.

ABSTRACT Objective: The objective of this study was to analyze and compare the effectiveness of two types of abduction orthotics used for the feet, the Denis-Browne type (traditional) and the Dobbs type (dynamic), with regard to maintenance of deformity correction and prevention of recurrence . Method: In this comparative retrospective case study, information was collected from the medical records of children with idiopathic congenital clubfoot (CCF). We evaluated a total of 43 feet in 28 patients, which were divided into two groups. Group 1 was comprised of 16 patients with a total of 24 CCFs treated with the traditional orthotic device. Group 2 consisted of 12 patients with a total of 19 CCFs treated with the dynamic orthotic device. The statistical analysis used the ANOVA test to compare the categorical variables between the groups. A significance level of 5% was adopted (p-value≤0.05) . Results: In Group 1, recurrence was observed in 2 feet (8.33%), and in 1 foot in Group 2 (5.26%). No significant difference in effectiveness was seen between the two types of orthotic devices . Conclusion: Both abduction devices were seen to be effective in maintaining correction of congenital clubfoot deformities. There was no statistical significance between type of orthotic device and recurrence. Level of Evidence III, Retrospective Comparative Study.