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19. Manganese Benefits Heat-Stressed Corals at the Cellular Level

Author

Montalbetti, E, Biscere, T, Ferrier-Pages, C, Houlbreque, F, Orlandi, I, Forcella, M, Galli, P, Vai, M, Seveso, D, Montalbetti E., Biscere T., Ferrier-Pages C., Houlbreque F., Orlandi I., Forcella M., Galli P., Vai M., Seveso D., Montalbetti, E, Biscere, T, Ferrier-Pages, C, Houlbreque, F, Orlandi, I, Forcella, M, Galli, P, Vai, M, Seveso, D, Montalbetti E., Biscere T., Ferrier-Pages C., Houlbreque F., Orlandi I., Forcella M., Galli P., Vai M., and Seveso D.

Abstract

The intensity and frequency of coral bleaching events have increased worldwide especially due to thermal stress and seawater pollution. Although it has been observed that metal concentration in seawater can affect the coral’s ability to adopt cellular defensive mechanisms to counteract bleaching, more investigations are needed to better understand the role of metals in coral physiology. In this study, we analyzed the individual and combined effects of prolonged heat stress and manganese (Mn) and iron (Fe) enrichments at the cellular level on the coral Stylophora pistillata. Thermal stress caused an up-regulation in the expression of the host Heat shock proteins (Hsps) 60 and 70, which showed a parallel pattern of modulation in all treatments, as well as an increase of lipid peroxidation (LPO) in the holobiont. Fe enrichment did not induce any change in Hsp expression or in the oxidative status of the corals both at the ambient temperature of 26°C or at increased temperature, suggesting that Fe didn’t seem to play a role in mitigating the cellular damages and the coral bleaching. Mn or MnFe enrichment at 26°C seemed to increase the oxidative stress in zooxanthellae, since high LPO and glutathione reductase (GR) levels were recorded, but it did not cause any effect on polyp Hsp expression, probably due to the antioxidant action of GR. With the temperature increase, Mn enrichments prevented any increase in Hsp levels and caused a significant decrease of LPO and GR activity, strengthening a previous hypothesis suggesting that Mn could mitigate the negative cellular effects produced by the thermal stress.

Published
2021

20. P1588: A SINGLE CENTER COMPARATIVE CLINICAL ANALYSIS OF THE SARS-COV-2 INFECTION BEFORE AND AFTER VACCINATION IN PATIENTS DIAGNOSED WITH HEMATOLOGIC MALIGNANCIES

Author

Jiménez, M., primary, Novoa, S., additional, Fernandez-Naval, C., additional, Navarro, V., additional, Andrés, C., additional, Martínez-Gallo, M., additional, Antón, A., additional, Fox, L., additional, Roldán, E., additional, Cabirta, A., additional, Gironella, M., additional, Orti, G., additional, Barba, P., additional, Medina, D., additional, Peralta, S., additional, Pujadas, G., additional, Hernández, C., additional, Pages, C., additional, Pumarola, T., additional, Valentin, M., additional, Marín-Niebla, A., additional, Valcárcel, D., additional, Hernández, M., additional, Ruiz-Camps, I., additional, Crespo, M., additional, Esperalba, J., additional, Bosch, F., additional, and Abrisqueta, P., additional

Published
2022
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28. PSDR4 Brie’Eau - Vers une nouvelle construction de paysage agricole et écologique sur le territoire de la Brie : associer qualité de l’eau et biodiversité. Innovations Agronomiques 86, 137-149

Author

Seguin, L., Bouarfa, S., Chaumont, C., Lebrun, J., Bontoux, C., Berthomé, B., Letournel, G., Barataud, F., Arrighi, A., Guichard, L., Bonifazzi, M., Birmant, F., Roger, L., Royer, L., Hureau, D., Farinetti, A., Pages, C., Rougier, J.E., and Tournebize, J.

Published
2022
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36. Avélumab en traitement de 1re ligne des patients atteints d’un carcinome à cellules de Merkel métastatique : analyse des données en vie réelle en France à partir de bases de données de cancers rares et du Système National de Données de Santé (SNDS)

Author

Blom, A., Mortier, L., van Hille, B., Pagès, C., Samimi, M., Luciani, L., Cahuzac, C., Robert, C., Quéreux, G., Maubec, E., Maillard, C., Miotti, H., Aubin, F., Arnault, J.P., Dompmartin, A., Mansard, S., Dereure, O., Montaudié, H., Amini-Adle, M., Viguier, M., Kramkimel, N., Granel-Brocard, F., Gaudy-Marqueste, C., Zehou, O., Jeudy, G., Bernard, P., De Quatrebarbes, J., Leccia, M.T., Le Corre, Y., Beneton, N., Wierzbicka-Hainaut, E., Brunet Possenti, F., Lenormand, C., Solbes, M.N., Duval-Modeste, A.B., Kachaner, I., Lebbé, C., Dutriaux, C., and Saiag, P.

Published
2023
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37. Méthodes d’administration du nivolumab dans le mélanome avancé : comparaison des effets indésirables chez des patients traités avec une dose fixe ou une dose ajustée au poids, l’étude FLATIMEL

Author

Campo Le Brun, I., Dalle, S., Mortier, L., Dereure, O., Dalac-Rat, S., Dutriaux, C., Leccia, M.T., Legoupil, D., Montaudié, H., De Quatrebarbes, J., Gaudy-Marqueste, C., Maubec, E., Saiag, P., Pagès, C., Brunet-Possenti, F., Granel-Brocard, F., Arnault, J.P., Stoebner, P.E., Aubin, F., Lesimple, T., Dupuy, A., Porcher, R., Lefevre, W., Lebbé, C., and Kempf, E.

Published
2023
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43. A comparative analysis of fine-scale genetic structure in three closely related syntopic species of the grasshopper genus Calliptamus

Author

Blanchet, E., Lecoq, M., Sword, G.A., Berthier, K., Pages, C., Billot, C., Rivallan, R., Foucart, A., Vassal, J.-M., Risterucci, A.M., and Chapuis, M.-P.

Subjects
Animal genetics -- Comparative analysis, Zoology and wildlife conservation
Abstract

Landscape analysis and genetics can allow a better understanding of grasshoppers for which ecology is not very well known. We analysed landscape changes between 1990 and 2006 at two areas from southern France where three grasshopper species (Calliptamus italicus (L., 1758), Calliptamus wattenwylianus Pantel, 1896, and Calliptamus barbarus (Costa, 1836)) occur. We then applied microsatellite markers to the study of 1200 georeferenced samples collected over both areas. We used a recent Bayesian clustering method with correlated allele frequencies to detect weak population genetic structure. We found evidence of breaks in gene flow only in C. wattenwylianus, thought to be sedentary relative to its congenerics. By using different allele frequency models and prior information to different levels of genetic differentiation for our six real data sets, our study also informs on the ability of the newly available Bayesian clustering methods model to detect weak genetic structure in natural field populations. L'analyse du paysage et la genetique peuvent apporter une meilleure connaissance sur des criquets dont l'ecologie n'est pas bien connue. Nous etudions les changements de paysage survenus dans deux regions du sud de la France dans lesquelles cohabitent trois especes de criquets (Calliptamus italicus (L., 1758), Calliptamus wattenwylianus Pantel, 1896 et Calliptamus barbarus (Costa, 1836)). Nous avons genotype 1200 echantillons georeferences provenant des deux regions, a l' aide de marqueurs microsatellites. Nous avons utilise une methode bayesienne de regroupement recente, avec un modele de frequences alleliques correlees afin de detecter des structures genetiques faibles. Nous avons mis en evidence une barriere au flux de gene seulement chez C. wattenwylianus qu'on croit etre sedentaire par comparaison a ses congeneres. En utilisant des modeles de frequences correlees, parametres avec des informations differant selon les niveaux de differenciation genetique attendus dans nos six bases de donnees reelles, notre etude renseigne egalement sur la capacite des recents modeles bayesiens de regroupement a discerner de faibles structures genetiques dans les populations naturelles. [Traduit par la Redaction], Introduction Ecological and conservation theory predicts impacts of habitat characteristics and their changes, most notably owing to human activities, on the genetic structure of natural populations. To our knowledge, studies [...]

Published
2012
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44. 1160P Methods of nivolumab administration in advanced melanoma: A comparison of patients’ clinical outcomes treated with flat dose or weight-adjusted dose, FLATIMEL study

Author

Campo le Brun, I., Dalle, S., Mortier, L., Dereure, O., Dalac Rat, S., Dutriaux, C., Leccia, M-T., Legoupil, D., Montaudie, H., De Quatrebarbes, J., Gaudy Marqueste, C., Maubec, E., Saiag, P., Pages, C., Brunet Possenti, F., Granel Brocard, F., Porcher, R., Lefevre, W., Lebbe, C., and Kempf, E.

Published
2023
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45. Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC)

Author

Lebbe C, Garbe C, Stratigos AJ, Harwood C, Peris K, Marmol VD, Malvehy J, Zalaudek I, Hoeller C, Dummer R, Forsea AM, Kandolf-Sekulovic L, Olah J, Arenberger P, Bylaite-Bucinskiene M, Vieira R, Middleton M, Levy A, Eggermont AM, Battistella M, Spano JP, Grob JJ, Pages C, European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation for Research and Treatment of Cancer (EORTC)., Lebbe, C, Garbe, C, Stratigos, Aj, Harwood, C, Peris, K, Marmol, Vd, Malvehy, J, Zalaudek, I, Hoeller, C, Dummer, R, Forsea, Am, Kandolf-Sekulovic, L, Olah, J, Arenberger, P, Bylaite-Bucinskiene, M, Vieira, R, Middleton, M, Levy, A, Eggermont, Am, Battistella, M, Spano, Jp, Grob, Jj, Pages, C, European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation for Research and Treatment of Cancer (EORTC)., University of Zurich, and Lebbe, Celeste

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Electrochemotherapy, Consensus, EADO, medicine.medical_treatment, 610 Medicine & health, Disease, Kaposi, Guideline, 03 medical and health sciences, 0302 clinical medicine, Immune reconstitution inflammatory syndrome, Risk Factors, Internal medicine, medicine, Humans, 1306 Cancer Research, Kaposi's sarcoma, Sarcoma, Kaposi, business.industry, EDF, EORTC, Sarcoma, 10177 Dermatology Clinic, medicine.disease, Radiation therapy, Europe, 030104 developmental biology, Lymphatic system, 030220 oncology & carcinogenesis, 2730 Oncology, Female, business, Settore MED/35 - MALATTIE CUTANEE E VENEREE
Abstract

Kaposi's sarcoma (KS) is a multifocal neoplasm of lymphatic endothelium-derived cells infected with human herpesvirus 8. Four clinical subtypes are distinguished: the classic, the endemic, the epidemic subtype in HIV positive patients and the iatrogenic subtype. The diagnosis is primarily based on clinical features and confirmation by histology with immunohistochemistry. Cutaneous distribution and severity, mucosal, nodal and visceral involvement depend on the type of KS with in general indolent behaviour and chronic evolution in the classic subtype and the more severe forms in iatrogenic or epidemic subtypes. Management should aim at achieving disease control. For localised lesions, several local therapies have been developed without randomised trial comparisons. Radiotherapy, intralesional chemotherapies and electrochemotherapy have high response rates. Topical treatments-imiquimod or topical 9-cis-retinoid acid-can also be used. Systemic treatments are reserved for locally aggressive extensive and disseminated KS: the recommended first-line agents are pegylated liposomal doxorubicin (PLD) and paclitaxel. In CKS, PLD or low-dose interferon-alfa are the recommended first-line agents in younger patients. In AIDS-related KS, combination antiretroviral therapy is the first treatment option; specific systemic treatment is needed only in case of extensive disease and in the prevention and treatment of immune reconstitution inflammatory syndrome. In post-transplant KS, tapering down immunosuppressive therapy and switching to mammalian target of rapamycin (m-TOR) inhibitors are used. Follow-up schedules for patients with KS disease depend on aggressiveness of the disease.

Published
2019

47. Résultats à long terme des patients avec dermatofibrosarcome de Darier-Ferrand localement avancé (DFSP-LA) traités par inhibiteurs de tyrosine kinase suivis d’une exérèse chirurgicale complète

Author

Beaziz, J., primary, Battistella, M., additional, Delyon, J., additional, Farges, C., additional, Marco, O., additional, Pages, C., additional, Le Maignan, C., additional, Basset-Seguin, N., additional, Walter-Petrich, A., additional, Kérob, D., additional, Lebbé, C., additional, and Baroudjian, B., additional

Published
2020
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