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2. Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial

Author

Paul, Nicolas, Grunow, Julius J., Rosenthal, Max, Spies, Claudia D., Page, Valerie J., Hanison, James, Patel, Brijesh, Rosenberg, Alex, von Haken, Rebecca, Pietsch, Urs, Schrag, Claudia, Waydhas, Christian, Schellongowski, Peter, Lobmeyr, Elisabeth, Sander, Michael, Piper, Sophie K., Conway, Daniel, Totzeck, Andreas, and Weiss, Björn

Published
2024
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3. Advancing specificity in delirium: The delirium subtyping initiative

Author

AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, Cunningham, Emma L, AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, and Cunningham, Emma L

Published
2024

4. Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK

Author

Walsh, Timothy Simon, primary, Aitken, Leanne M, additional, McKenzie, Cathrine A, additional, Boyd, Julia, additional, Macdonald, Alix, additional, Giddings, Annabel, additional, Hope, David, additional, Norrie, John, additional, Weir, Christopher, additional, Parker, Richard Anthony, additional, Lone, Nazir I, additional, Emerson, Lydia, additional, Kydonaki, Kalliopi, additional, Creagh-Brown, Benedict, additional, Morris, Stephen, additional, McAuley, Daniel Francis, additional, Dark, Paul, additional, Wise, Matt P, additional, Gordon, Anthony C, additional, Perkins, Gavin, additional, Reade, Michael, additional, Blackwood, Bronagh, additional, MacLullich, Alasdair, additional, Glen, Robert, additional, and Page, Valerie J, additional

Published
2023
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6. Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial

Author

Paul, Nicolas, primary, Grunow, Julius J., additional, Rosenthal, Max, additional, Spies, Claudia D., additional, Page, Valerie J., additional, Hanison, James, additional, Patel, Brijesh, additional, Rosenberg, Alex, additional, von Haken, Rebecca, additional, Pietsch, Urs, additional, Schrag, Claudia, additional, Waydhas, Christian, additional, Schellongowski, Peter, additional, Lobmeyr, Elisabeth, additional, Sander, Michael, additional, Piper, Sophie K., additional, Conway, Daniel, additional, Totzeck, Andreas, additional, and Weiss, Björn, additional

Published
2023
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7. Advancing specificity in delirium: The delirium subtyping initiative

Author

Bowman, Emily M. L., primary, Brummel, Nathan E., additional, Caplan, Gideon A., additional, Cunningham, Colm, additional, Evered, Lis A., additional, Fiest, Kirsten M., additional, Girard, Timothy D., additional, Jackson, Thomas A., additional, LaHue, Sara C., additional, Lindroth, Heidi L., additional, Maclullich, Alasdair M. J., additional, McAuley, Daniel F., additional, Oh, Esther S., additional, Oldham, Mark A., additional, Page, Valerie J., additional, Pandharipande, Pratik P., additional, Potter, Kelly M., additional, Sinha, Pratik, additional, Slooter, Arjen J. C., additional, Sweeney, Aoife M., additional, Tieges, Zoë, additional, Van Dellen, Edwin, additional, Wilcox, Mary Elizabeth, additional, Zetterberg, Henrik, additional, and Cunningham, Emma L., additional

Published
2023
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11. Advancing specificity in delirium: The delirium subtyping initiative.

Author

Bowman, Emily M. L., Brummel, Nathan E., Caplan, Gideon A., Cunningham, Colm, Evered, Lis A., Fiest, Kirsten M., Girard, Timothy D., Jackson, Thomas A., LaHue, Sara C., Lindroth, Heidi L., Maclullich, Alasdair M. J., McAuley, Daniel F., Oh, Esther S., Oldham, Mark A., Page, Valerie J., Pandharipande, Pratik P., Potter, Kelly M., Sinha, Pratik, Slooter, Arjen J. C., and Sweeney, Aoife M.

Abstract

BACKGROUND: Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long‐term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. METHODS: The Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts. RESULTS: Meeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium‐spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. DISCUSSION: The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. Highlights: Delirium features must be clearly defined, standardized, and operationalized.Large datasets incorporating both clinical and biomarker variables should be analyzed together.Delirium screening should incorporate communication and reasoning. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The intensive care delirium research agenda: a multinational, interprofessional perspective

Author

Pandharipande, Pratik P., Ely, E. Wesley, Arora, Rakesh C., Balas, Michele C., Boustani, Malaz A., La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W., Elefante, Julius, Han, Jin H., MacLullich, Alasdair M., Maldonado, José R., Morandi, Alessandro, Needham, Dale M., Page, Valerie J., Rose, Louise, Salluh, Jorge I. F., Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J. C., and Smith, Heidi A. B.

Published
2017
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19. Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol:a systematic review protocol

Author

McKenzie, Cathrine A, Page, Valerie J, Strain, W David, Blackwood, Bronagh, Ostermann, Marlies, Taylor, David, Spronk, Peter E, and McAuley, Daniel F

Abstract

BACKGROUND: Delirium is an acute confusional state, common in critical illness and associated with cognitive decline. There is no effective pharmacotherapy to prevent or treat delirium, although it is scientifically plausible that thiamine could be effective. Thiamine studies in dementia patients are inconclusive. Aside from small numbers, all used oral administration: bioavailability of thiamine is poor; parenteral thiamine bypasses this. In the UK, parenteral thiamine is administered as a compound vitamin B and C solution (Pabrinex®). The aim of this review is to evaluate the effectiveness of parenteral thiamine (alone or in a compound solution) in preventing or treating delirium in critical illness.METHODS: We will search for studies in electronic databases (MEDLINE (Pro-Quest), EMBASE, CINAHL, LILACS, CNKI, AMED, and Cochrane CENTRAL), clinical trials registries (WHO International Clinical Trials Registry, ClinicalTrials.gov, and Controlled-trials.com), and grey literature (Google Scholar, conference proceedings, and Index to Theses). We will perform complementary searches of reference lists of included studies, relevant reviews, clinical practice guidelines, or other pertinent documents (e.g. official documents and government reports). We will consider quasi-randomised or randomised controlled trials in critically ill adults. We will include studies that evaluate parenteral thiamine versus standard of care, placebo, or any other non-pharmacological or pharmacological interventions. The primary outcomes will be the delirium core outcome set, including incidence and severity of delirium and cognition. Secondary outcomes are adapted from the ventilation core outcome set: duration of mechanical ventilation, length of stay, and adverse events incidence. Screening, data extraction, and risk of bias assessment will be undertaken independently by two reviewers. If data permits, we will conduct meta-analyses using a random effects model and, where appropriate, sensitivity and subgroup analyses to explore sources of heterogeneity.DISCUSSION: This review will provide evidence for the effectiveness of parental thiamine in the prevention or treatment of delirium in critical care. Findings will contribute to establishing the need for a multicentre study of parenteral thiamine in the prevention and treatment of critical care delirium.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019118808.

Published
2020

20. Additional file 2 of Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol

Author

McKenzie, Cathrine A., Page, Valerie J., W. David Strain, Blackwood, Bronagh, Ostermann, Marlies, Taylor, David, Spronk, Peter E., and McAuley, Daniel F.

Subjects
ComputingMethodologies_PATTERNRECOGNITION, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, Data_FILES
Abstract

Additional file 2. MEDLINE search strategy.

Published
2020
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21. Additional file 3 of Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol

Author

McKenzie, Cathrine A., Page, Valerie J., W. David Strain, Blackwood, Bronagh, Ostermann, Marlies, Taylor, David, Spronk, Peter E., and McAuley, Daniel F.

Subjects
health care facilities, manpower, and services, mental disorders, food and beverages, behavioral disciplines and activities, human activities
Abstract

Additional file 3. Data extraction form for delirium and thiamine in the ICU SR (DELTA-ICU).

Published
2020
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26. The intensive care delirium research agenda : a multinational, interprofessional perspective

Author

Pandharipande, Pratik P, Ely, E Wesley, Arora, Rakesh C, Balas, Michele C, Boustani, Malaz A, La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W, Elefante, Julius, Han, Jin H, MacLullich, Alasdair M, Maldonado, José R, Morandi, Alessandro, Needham, Dale M, Page, Valerie J, Rose, Louise, Salluh, Jorge I F, Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J.C., Smith, Heidi A B, Pandharipande, Pratik P, Ely, E Wesley, Arora, Rakesh C, Balas, Michele C, Boustani, Malaz A, La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W, Elefante, Julius, Han, Jin H, MacLullich, Alasdair M, Maldonado, José R, Morandi, Alessandro, Needham, Dale M, Page, Valerie J, Rose, Louise, Salluh, Jorge I F, Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J.C., and Smith, Heidi A B

Published
2017

27. The intensive care delirium research agenda: a multinational, interprofessional perspective

Author

UMC Utrecht, Medische Staf Intensive Care, Brain, Circulatory Health, Pandharipande, Pratik P, Ely, E Wesley, Arora, Rakesh C, Balas, Michele C, Boustani, Malaz A, La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W, Elefante, Julius, Han, Jin H, MacLullich, Alasdair M, Maldonado, José R, Morandi, Alessandro, Needham, Dale M, Page, Valerie J, Rose, Louise, Salluh, Jorge I F, Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J.C., Smith, Heidi A B, UMC Utrecht, Medische Staf Intensive Care, Brain, Circulatory Health, Pandharipande, Pratik P, Ely, E Wesley, Arora, Rakesh C, Balas, Michele C, Boustani, Malaz A, La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W, Elefante, Julius, Han, Jin H, MacLullich, Alasdair M, Maldonado, José R, Morandi, Alessandro, Needham, Dale M, Page, Valerie J, Rose, Louise, Salluh, Jorge I F, Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J.C., and Smith, Heidi A B

Published
2017

30. Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial

Author

Casarin, Annalisa, primary, McAuley, Daniel F, additional, Alce, Timothy M, additional, Zhao, Xiaobei, additional, Ely, E Wesley, additional, Jackson, Jim C, additional, McDowell, Cliona, additional, Agus, Ashley, additional, Murphy, Lynn, additional, and Page, Valerie J, additional

Published
2015
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41. Advancing specificity in delirium: The delirium subtyping initiative.

Author

Bowman EML, Brummel NE, Caplan GA, Cunningham C, Evered LA, Fiest KM, Girard TD, Jackson TA, LaHue SC, Lindroth HL, Maclullich AMJ, McAuley DF, Oh ES, Oldham MA, Page VJ, Pandharipande PP, Potter KM, Sinha P, Slooter AJC, Sweeney AM, Tieges Z, Van Dellen E, Wilcox ME, Zetterberg H, and Cunningham EL

Subjects
Humans, Research Design, Data Collection, Diagnostic and Statistical Manual of Mental Disorders, Delirium diagnosis, Delirium etiology
Abstract

Background: Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology., Methods: The Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts., Results: Meeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations., Discussion: The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes., Highlights: Delirium features must be clearly defined, standardized, and operationalized. Large datasets incorporating both clinical and biomarker variables should be analyzed together. Delirium screening should incorporate communication and reasoning., (© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2024
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43. Delirium on the intensive care unit.

Author

Page VJ and Kurth T

Subjects
Female, Humans, Male, Critical Illness mortality, Delirium mortality, Intensive Care Units statistics & numerical data, Length of Stay statistics & numerical data
Published
2014
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