Author: "Pagès, G" - Searchworks@Jio Institute Digital Library Search Results

441 results on '"Pagès, G"'

1. Computation of VaR and CVaR using stochastic approximations and unconstrained importance sampling

Author: Bardou, Olivier Aj, Frikha, Noufel, and Pagès, G.
Subjects: Quantitative Finance - Computational Finance, Mathematics - Probability, Quantitative Finance - Risk Management
Abstract: Value-at-Risk (VaR) and Conditional Value-at-Risk (CVaR) are two risk measures which are widely used in the practice of risk management. This paper deals with the problem of computing both VaR and CVaR using stochastic approximation (with decreasing steps): we propose a first Robbins-Monro procedure based on Rockaffelar-Uryasev's identity for the CVaR. The convergence rate of this algorithm to its target satisfies a Gaussian Central Limit Theorem. As a second step, in order to speed up the initial procedure, we propose a recursive importance sampling (I.S.) procedure which induces a significant variance reduction of both VaR and CVaR procedures. This idea, which goes back to the seminal paper of B. Arouna, follows a new approach introduced by V. Lemaire and G. Pag\`es. Finally, we consider a deterministic moving risk level to speed up the initialization phase of the algorithm. We prove that the convergence rate of the resulting procedure is ruled by a Central Limit Theorem with minimal variance and its efficiency is illustrated by considering several typical energy portfolios.
Published: 2008

2. The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma

Author: Benhamou, Y., Picco, V., and Pagès, G.
Published: 2016
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3. GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α

Author: Chiche, J, Pommier, S, Beneteau, M, Mondragón, L, Meynet, O, Zunino, B, Mouchotte, A, Verhoeyen, E, Guyot, M, Pagès, G, Mounier, N, Imbert, V, Colosetti, P, Goncalvès, D, Marchetti, S, Brière, J, Carles, M, Thieblemont, C, and Ricci, J-E
Published: 2015
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4. AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy

Author: Thwaite, R, Pagès, G, Chillón, M, and Bosch, A
Published: 2015
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5. A study of the Roman iron bars of Saintes-Maries-de-la-Mer (Bouches-du-Rhône, France). A proposal for a comprehensive metallographic approach

Author: Pagès, G., Dillmann, P., Fluzin, P., and Long, L.
Published: 2011
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6. A measured service to customers

Author: Pages, G. L. and Symonds, J. D., editor
Published: 1994
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7. MAP Kinase Cascade and the Control of Cell Proliferation

Author: Pagès, G., Brunet, A., Chambard, J-C., L’Allemain, G., Lenormand, P., Pouysségur, J., Azzi, A., editor, Packer, L., editor, Cittadini, A., editor, Baserga, R., editor, Pinedo, H. M., editor, Galeotti, T., editor, and Corda, D., editor
Published: 1993
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8. Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1)

Author: Wakabayashi, S., Sardet, C., Fafournoux, P., Counillon, L., Meloche, S., Pagés, G., Pouysségur, J., Blaustein, M. P., editor, Creutzfeldt, O., editor, Grunicke, H., editor, Habermann, E., editor, Numa, S., editor, Pette, D., editor, Reuter, H., editor, Sakmann, B., editor, Schweiger, M., editor, and Wright, E. M., editor
Published: 1992
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9. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Author: Klionsky, D, Abdel-Aziz, A, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, M, Abudu, Y, Acevedo-Arozena, A, Adamopoulos, I, Adeli, K, Adolph, T, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, B, Agnello, M, Agostinis, P, Agrewala, J, Agrotis, A, Aguilar, P, Ahmad, S, Ahmed, Z, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, H, Al-Abd, A, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, M, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, M, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, G, Altan-Bonnet, N, Altieri, D, Álvarez, É, Alves, S, Alves da Costa, C, Alzaharna, M, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, A, Ammanathan, V, An, Z, Andersen, S, Andrabi, S, Andrade-Silva, M, Andres, A, Angelini, S, Ann, D, Anozie, U, Ansari, M, Antas, P, Antebi, A, Antón, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araújo, W, Araya, J, Arden, C, Arévalo, M, Arguelles, S, Arias, E, Arikkath, J, Arimoto, H, Ariosa, A, Armstrong-James, D, Arnauné-Pelloquin, L, Aroca, A, Arroyo, D, Arsov, I, Artero, R, Asaro, D, Aschner, M, Ashrafizadeh, M, Ashur-Fabian, O, Atanasov, A, Au, A, Auberger, P, Auner, H, Aurelian, L, Autelli, R, Avagliano, L, Ávalos, Y, Aveic, S, Aveleira, C, Avin-Wittenberg, T, Aydin, Y, Ayton, S, Ayyadevara, S, Azzopardi, M, Baba, M, Backer, J, Backues, S, Bae, D, Bae, O, Bae, S, Baehrecke, E, Baek, A, Baek, S, Bagetta, G, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, X, Bai, Y, Bairagi, N, Baksi, S, Balbi, T, Baldari, C, Balduini, W, Ballabio, A, Ballester, M, Balazadeh, S, Balzan, R, Bandopadhyay, R, Banerjee, S, Bánréti, Á, Bao, Y, Baptista, M, Baracca, A, Barbati, C, Bargiela, A, Barilà, D, Barlow, P, Barmada, S, Barreiro, E, Barreto, G, Bartek, J, Bartel, B, Bartolome, A, Barve, G, Basagoudanavar, S, Bassham, D, Bast, R, Basu, A, Batoko, H, Batten, I, Baulieu, E, Baumgarner, B, Bayry, J, Beale, R, Beau, I, Beaumatin, F, Bechara, L, Beck, G, Beers, M, Begun, J, Behrends, C, Behrens, G, Bei, R, Bejarano, E, Bel, S, Behl, C, Belaid, A, Belgareh-Touzé, N, Bellarosa, C, Belleudi, F, Belló Pérez, M, Bello-Morales, R, Beltran, J, Beltran, S, Benbrook, D, Bendorius, M, Benitez, B, Benito-Cuesta, I, Bensalem, J, Berchtold, M, Berezowska, S, Bergamaschi, D, Bergami, M, Bergmann, A, Berliocchi, L, Berlioz-Torrent, C, Bernard, A, Berthoux, L, Besirli, C, Besteiro, S, Betin, V, Beyaert, R, Bezbradica, J, Bhaskar, K, Bhatia-Kissova, I, Bhattacharya, R, Bhattacharya, S, Bhattacharyya, S, Bhuiyan, M, Bhutia, S, Bi, L, Bi, X, Biden, T, Bijian, K, Billes, V, Binart, N, Bincoletto, C, Birgisdottir, A, Bjorkoy, G, Blanco, G, Blas-Garcia, A, Blasiak, J, Blomgran, R, Blomgren, K, Blum, J, Boada-Romero, E, Boban, M, Boesze-Battaglia, K, Boeuf, P, Boland, B, Bomont, P, Bonaldo, P, Bonam, S, Bonfili, L, Bonifacino, J, Boone, B, Bootman, M, Bordi, M, Borner, C, Bornhauser, B, Borthakur, G, Bosch, J, Bose, S, Botana, L, Botas, J, Boulanger, C, Boulton, M, Bourdenx, M, Bourgeois, B, Bourke, N, Bousquet, G, Boya, P, Bozhkov, P, Bozi, L, Bozkurt, T, Brackney, D, Brandts, C, Braun, R, Braus, G, Bravo-Sagua, R, Bravo-San Pedro, J, Brest, P, Bringer, M, Briones-Herrera, A, Broaddus, V, Brodersen, P, Brodsky, J, Brody, S, Bronson, P, Bronstein, J, Brown, C, Brown, R, Brum, P, Brumell, J, Brunetti-Pierri, N, Bruno, D, Bryson-Richardson, R, Bucci, C, Buchrieser, C, Bueno, M, Buitrago-Molina, L, Buraschi, S, Buch, S, Buchan, J, Buckingham, E, Budak, H, Budini, M, Bultynck, G, Burada, F, Burgoyne, J, Burón, M, Bustos, V, Büttner, S, Butturini, E, Byrd, A, Cabas, I, Cabrera-Benitez, S, Cadwell, K, Cai, J, Cai, L, Cai, Q, Cairó, M, Calbet, J, Caldwell, G, Caldwell, K, Call, J, Calvani, R, Calvo, A, Calvo-Rubio Barrera, M, Camara, N, Camonis, J, Camougrand, N, Campanella, M, Campbell, E, Campbell-Valois, F, Campello, S, Campesi, I, Campos, J, Camuzard, O, Cancino, J, Candido de Almeida, D, Canesi, L, Caniggia, I, Canonico, B, Cantí, C, Cao, B, Caraglia, M, Caramés, B, Carchman, E, Cardenal-Muñoz, E, Cardenas, C, Cardenas, L, Cardoso, S, Carew, J, Carle, G, Carleton, G, Carloni, S, Carmona-Gutierrez, D, Carneiro, L, Carnevali, O, Carosi, J, Carra, S, Carrier, A, Carrier, L, Carroll, B, Carter, A, Carvalho, A, Casanova, M, Casas, C, Casas, J, Cassioli, C, Castillo, E, Castillo, K, Castillo-Lluva, S, Castoldi, F, Castori, M, Castro, A, Castro-Caldas, M, Castro-Hernandez, J, Castro-Obregon, S, Catz, S, Cavadas, C, Cavaliere, F, Cavallini, G, Cavinato, M, Cayuela, M, Cebollada Rica, P, Cecarini, V, Cecconi, F, Cechowska-Pasko, M, Cenci, S, Ceperuelo-Mallafré, V, Cerqueira, J, Cerutti, J, Cervia, D, Cetintas, V, Cetrullo, S, Chae, H, Chagin, A, Chai, C, Chakrabarti, G, Chakrabarti, O, Chakraborty, T, Chami, M, Chamilos, G, Chan, D, Chan, E, Chan, H, Chan, M, Chan, Y, Chandra, P, Chang, C, Chang, H, Chang, K, Chao, J, Chapman, T, Charlet-Berguerand, N, Chatterjee, S, Chaube, S, 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N, Cortese, K, Costa, M, Costantino, S, Costelli, P, Coto-Montes, A, Crack, P, Crespo, J, Criollo, A, Crippa, V, Cristofani, R, Csizmadia, T, Cuadrado, A, Cui, B, Cui, J, Cui, Y, Culetto, E, Cumino, A, Cybulsky, A, Czaja, M, Czuczwar, S, D'Adamo, S, D'Amelio, M, D'Arcangelo, D, D'Lugos, A, D'Orazi, G, da Silva, J, Dafsari, H, Dagda, R, Dagdas, Y, Daglia, M, Dai, X, Dai, Y, Dal Col, J, Dalhaimer, P, Dalla Valle, L, Dallenga, T, Dalmasso, G, Damme, M, Dando, I, Dantuma, N, Darling, A, Das, H, Dasarathy, S, Dasari, S, Dash, S, Daumke, O, Dauphinee, A, Davies, J, Dávila, V, Davis, R, Davis, T, Dayalan Naidu, S, De Amicis, F, De Bosscher, K, De Felice, F, De Franceschi, L, De Leonibus, C, de Mattos Barbosa, M, De Meyer, G, De Milito, A, De Nunzio, C, De Palma, C, De Santi, M, De Virgilio, C, De Zio, D, Debnath, J, Debosch, B, Decuypere, J, Deehan, M, Deflorian, G, Degregori, J, Dehay, B, Del Rio, G, Delaney, J, Delbridge, L, Delorme-Axford, E, Delpino, M, Demarchi, F, Dembitz, V, Demers, 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Eftekharpour, E, Eichinger, L, Eid, N, Eisenberg, T, Eissa, N, Eissa, S, Ejarque, M, El Andaloussi, A, El-Hage, N, El-Naggar, S, Eleuteri, A, El-Shafey, E, Elgendy, M, Eliopoulos, A, Elizalde, M, Elks, P, Elsasser, H, Elsherbiny, E, Emerling, B, Emre, N, Eng, C, Engedal, N, Engelbrecht, A, Engelsen, A, Enserink, J, Escalante, R, Esclatine, A, Escobar-Henriques, M, Eskelinen, E, Espert, L, Eusebio, M, Fabrias, G, Fabrizi, C, Facchiano, A, Facchiano, F, Fadeel, B, Fader, C, Faesen, A, Fairlie, W, Falcó, A, Falkenburger, B, Fan, D, Fan, J, Fan, Y, Fang, E, Fang, Y, Fanto, M, Farfel-Becker, T, Faure, M, Fazeli, G, Fedele, A, Feldman, A, Feng, D, Feng, J, Feng, L, Feng, Y, Feng, W, Fenz Araujo, T, Ferguson, T, Fernández, Á, Fernandez-Checa, J, Fernández-Veledo, S, Fernie, A, Ferrante, A, Ferraresi, A, Ferrari, M, Ferreira, J, Ferro-Novick, S, Figueras, A, Filadi, R, Filigheddu, N, Filippi-Chiela, E, Filomeni, G, Fimia, G, Fineschi, V, Finetti, F, Finkbeiner, S, Fisher, E, Fisher, P, Flamigni, F, Fliesler, S, Flo, T, Florance, I, Florey, O, Florio, T, Fodor, E, Follo, C, Fon, E, Forlino, A, Fornai, F, Fortini, P, Fracassi, A, Fraldi, A, Franco, B, Franco, R, Franconi, F, Frankel, L, Friedman, S, Fröhlich, L, Frühbeck, G, Fuentes, J, Fujiki, Y, Fujita, N, Fujiwara, Y, Fukuda, M, Fulda, S, Furic, L, Furuya, N, Fusco, C, Gack, M, Gaffke, L, Galadari, S, Galasso, A, Galindo, M, Gallolu Kankanamalage, S, Galluzzi, L, Galy, V, Gammoh, N, Gan, B, Ganley, I, Gao, F, Gao, H, Gao, M, Gao, P, Gao, S, Gao, W, Gao, X, Garcera, A, Garcia, M, Garcia, V, García-Del Portillo, F, Garcia-Escudero, V, Garcia-Garcia, A, Garcia-Macia, M, García-Moreno, D, Garcia-Ruiz, C, García-Sanz, P, Garg, A, Gargini, R, Garofalo, T, Garry, R, Gassen, N, Gatica, D, Ge, L, Ge, W, Geiss-Friedlander, R, Gelfi, C, Genschik, P, Gentle, I, Gerbino, V, Gerhardt, C, Germain, K, Germain, M, Gewirtz, D, Ghasemipour Afshar, E, Ghavami, S, Ghigo, A, Ghosh, M, Giamas, G, Giampietri, C, Giatromanolaki, A, Gibson, G, Gibson, S, Ginet, V, Giniger, E, Giorgi, C, Girao, H, Girardin, S, Giridharan, M, Giuliano, S, Giulivi, C, Giuriato, S, Giustiniani, J, Gluschko, A, Goder, V, Goginashvili, A, Golab, J, Goldstone, D, Golebiewska, A, Gomes, L, Gomez, R, Gómez-Sánchez, R, Gomez-Puerto, M, Gomez-Sintes, R, Gong, Q, Goni, F, González-Gallego, J, Gonzalez-Hernandez, T, Gonzalez-Polo, R, Gonzalez-Reyes, J, González-Rodríguez, P, Goping, I, Gorbatyuk, M, Gorbunov, N, Görgülü, K, Gorojod, R, Gorski, S, Goruppi, S, Gotor, C, Gottlieb, R, Gozes, I, Gozuacik, D, Graef, M, Gräler, M, Granatiero, V, Grasso, D, Gray, J, Green, D, Greenhough, A, Gregory, S, Griffin, E, Grinstaff, M, Gros, F, Grose, C, Gross, A, Gruber, F, Grumati, P, Grune, T, Gu, X, Guan, J, Guardia, C, Guda, K, Guerra, F, Guerri, C, Guha, P, Guillén, C, Gujar, S, Gukovskaya, A, Gukovsky, I, Gunst, J, Günther, A, Guntur, A, Guo, C, Guo, H, Guo, L, Guo, M, Gupta, P, Gupta, S, Gupta, V, Gustafsson, A, Gutterman, D, H B, R, Haapasalo, A, Haber, J, Hać, A, Hadano, S, Hafrén, A, Haidar, M, Hall, B, Halldén, G, Hamacher-Brady, A, Hamann, A, Hamasaki, M, Han, W, Hansen, M, Hanson, P, Hao, Z, Harada, M, Harhaji-Trajkovic, L, Hariharan, N, Haroon, N, Harris, J, Hasegawa, T, Hasima Nagoor, N, Haspel, J, Haucke, V, Hawkins, W, Hay, B, Haynes, C, Hayrabedyan, S, Hays, T, He, C, He, Q, He, R, He, Y, Heakal, Y, Heberle, A, Hejtmancik, J, Helgason, G, Henkel, V, Herb, M, Hergovich, A, Herman-Antosiewicz, A, Hernández, A, Hernandez, C, Hernandez-Diaz, S, Hernandez-Gea, V, Herpin, A, Herreros, J, Hervás, J, Hesselson, D, Hetz, C, Heussler, V, Higuchi, Y, Hilfiker, S, Hill, J, Hlavacek, W, Ho, E, Ho, I, Ho, P, Ho, S, Ho, W, Hobbs, G, Hochstrasser, M, Hoet, P, Hofius, D, Hofman, P, Höhn, A, Holmberg, C, Hombrebueno, J, Yi-Ren Hong, C, Hooper, L, Hoppe, T, Horos, R, Hoshida, Y, Hsin, I, Hsu, H, Hu, B, Hu, D, Hu, L, Hu, M, Hu, R, Hu, W, Hu, Y, Hu, Z, Hua, F, Hua, J, Hua, Y, Huan, C, Huang, C, Huang, H, Huang, K, 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Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

10. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

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(ORCID:0000-0001-9567-6983), and Viscomi MT (ORCID:0000-0002-9096-4967)
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

11. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

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Proud CG, Puertollano R, Puglielli L, Pulinilkunnil T, Puri D, Puri R, Puyal J, Qi X, Qi Y, Qian W, Qiang L, Qiu Y, Quadrilatero J, Quarleri J, Raben N, Rabinowich H, Ragona D, Ragusa MJ, Rahimi N, Rahmati M, Raia V, Raimundo N, Rajasekaran NS, Ramachandra Rao S, Rami A, Ramírez-Pardo I, Ramsden DB, Randow F, Rangarajan PN, Ranieri D, Rao H, Rao L, Rao R, Rathore S, Ratnayaka JA, Ratovitski EA, Ravanan P, Ravegnini G, Ray SK, Razani B, Rebecca V, Reggiori F, Régnier-Vigouroux A, Reichert AS, Reigada D, Reiling JH, Rein T, Reipert S, Rekha RS, Ren H, Ren J, Ren W, Renault T, Renga G, Reue K, Rewitz K, Ribeiro de Andrade Ramos B, Riazuddin SA, Ribeiro-Rodrigues TM, Ricci JE, Ricci R, Riccio V, Richardson DR, Rikihisa Y, Risbud MV, Risueño RM, Ritis K, Rizza S, Rizzuto R, Roberts HC, Roberts LD, Robinson KJ, Roccheri MC, Rocchi S, Rodney GG, Rodrigues T, Rodrigues Silva VR, Rodriguez A, Rodriguez-Barrueco R, Rodriguez-Henche N, Rodriguez-Rocha H, Roelofs J, Rogers RS, Rogov VV, Rojo AI, Rolka K, Romanello V, Romani L, Romano A, Romano PS, Romeo-Guitart D, Romero LC, Romero M, Roney JC, Rongo C, Roperto S, Rosenfeldt MT, Rosenstiel P, Rosenwald AG, Roth KA, Roth L, Roth S, Rouschop KMA, Roussel BD, Roux S, Rovere-Querini P, Roy A, Rozieres A, Ruano D, Rubinsztein DC, Rubtsova MP, Ruckdeschel K, Ruckenstuhl C, Rudolf E, Rudolf R, Ruggieri A, Ruparelia AA, Rusmini P, Russell RR, Russo GL, Russo M, Russo R, Ryabaya OO, Ryan KM, Ryu KY, Sabater-Arcis M, Sachdev U, Sacher M, Sachse C, Sadhu A, Sadoshima J, Safren N, Saftig P, Sagona AP, Sahay G, Sahebkar A, Sahin M, Sahin O, Sahni S, Saito N, Saito S, Saito T, Sakai R, Sakai Y, Sakamaki JI, Saksela K, Salazar G, Salazar-Degracia A, Salekdeh GH, Saluja AK, Sampaio-Marques B, Sanchez MC, Sanchez-Alcazar JA, Sanchez-Vera V, Sancho-Shimizu V, Sanderson JT, Sandri M, Santaguida S, Santambrogio L, Santana MM, Santoni G, Sanz A, Sanz P, Saran S, Sardiello M, Sargeant TJ, Sarin A, Sarkar C, Sarkar S, Sarrias MR, Sarmah DT, Sarparanta J, Sathyanarayan A, Sathyanarayanan R, Scaglione KM, Scatozza F, Schaefer L, Schafer ZT, Schaible UE, Schapira AHV, Scharl M, Schatzl HM, Schein CH, Scheper W, Scheuring D, Schiaffino MV, Schiappacassi M, Schindl R, Schlattner U, Schmidt O, Schmitt R, Schmidt SD, Schmitz I, Schmukler E, Schneider A, Schneider BE, Schober R, Schoijet AC, Schott MB, Schramm M, Schröder B, Schuh K, Schüller C, Schulze RJ, Schürmanns L, Schwamborn JC, Schwarten M, Scialo F, Sciarretta S, Scott MJ, Scotto KW, Scovassi AI, Scrima A, Scrivo A, Sebastian D, Sebti S, Sedej S, Segatori L, Segev N, Seglen PO, Seiliez I, Seki E, Selleck SB, Sellke FW, Selsby JT, Sendtner M, Senturk S, Seranova E, Sergi C, Serra-Moreno R, Sesaki H, Settembre C, Setty SRG, Sgarbi G, Sha O, Shacka JJ, Shah JA, Shang D, Shao C, Shao F, Sharbati S, Sharkey LM, Sharma D, Sharma G, Sharma K, Sharma P, Sharma S, Shen HM, Shen H, Shen J, Shen M, Shen W, Shen Z, Sheng R, Sheng Z, Sheng ZH, Shi J, Shi X, Shi YH, Shiba-Fukushima K, Shieh JJ, Shimada Y, Shimizu S, Shimozawa M, Shintani T, Shoemaker CJ, Shojaei S, Shoji I, Shravage BV, Shridhar V, Shu CW, Shu HB, Shui K, Shukla AK, Shutt TE, Sica V, Siddiqui A, Sierra A, Sierra-Torre V, Signorelli S, Sil P, Silva BJA, Silva JD, Silva-Pavez E, Silvente-Poirot S, Simmonds RE, Simon AK, Simon HU, Simons M, Singh A, Singh LP, Singh R, Singh SV, Singh SK, Singh SB, Singh S, Singh SP, Sinha D, Sinha RA, Sinha S, Sirko A, Sirohi K, Sivridis EL, Skendros P, Skirycz A, Slaninová I, Smaili SS, Smertenko A, Smith MD, Soenen SJ, Sohn EJ, Sok SPM, Solaini G, Soldati T, Soleimanpour SA, Soler RM, Solovchenko A, Somarelli JA, Sonawane A, Song F, Song HK, Song JX, Song K, Song Z, Soria LR, Sorice M, Soukas AA, Soukup SF, Sousa D, Sousa N, Spagnuolo PA, Spector SA, Srinivas Bharath MM, St Clair D, Stagni V, Staiano L, Stalnecker CA, Stankov MV, Stathopulos PB, Stefan K, Stefan SM, Stefanis L, Steffan JS, Steinkasserer A, Stenmark H, Sterneckert J, Stevens C, Stoka V, Storch S, Stork B, Strappazzon F, Strohecker AM, Stupack DG, Su H, Su LY, Su L, Suarez-Fontes AM, Subauste CS, Subbian S, Subirada PV, Sudhandiran G, Sue CM, Sui X, Summers C, Sun G, Sun J, Sun K, Sun MX, Sun Q, Sun Y, Sun Z, Sunahara KKS, Sundberg E, Susztak K, Sutovsky P, Suzuki H, Sweeney G, Symons JD, Sze SCW, Szewczyk NJ, Tabecka-Lonczynska A, Tabolacci C, Tacke F, Taegtmeyer H, Tafani M, Tagaya M, Tai H, Tait SWG, Takahashi Y, Takats S, Talwar P, Tam C, Tam SY, Tampellini D, Tamura A, Tan CT, Tan EK, Tan YQ, Tanaka M, Tang D, Tang J, Tang TS, Tanida I, Tao Z, Taouis M, Tatenhorst L, Tavernarakis N, Taylor A, Taylor GA, Taylor JM, Tchetina E, Tee AR, Tegeder I, Teis D, Teixeira N, Teixeira-Clerc F, Tekirdag KA, Tencomnao T, Tenreiro S, Tepikin AV, Testillano PS, Tettamanti G, Tharaux PL, Thedieck K, Thekkinghat AA, Thellung S, Thinwa JW, Thirumalaikumar VP, Thomas SM, Thomes PG, Thorburn A, Thukral L, Thum T, Thumm M, Tian L, Tichy A, Till A, Timmerman V, Titorenko VI, Todi SV, Todorova K, Toivonen JM, Tomaipitinca L, Tomar D, Tomas-Zapico C, Tomic S, Tong BC, Tong C, Tong X, Tooze SA, Torgersen ML, Torii S, Torres-López L, Torriglia A, Towers CG, Towns R, Toyokuni S, Trajkovic V, Tramontano D, Tran QG, Travassos LH, Trelford CB, Tremel S, Trougakos IP, Tsao BP, Tschan MP, Tse HF, Tse TF, Tsugawa H, Tsvetkov AS, Tumbarello DA, Tumtas Y, Tuñón MJ, Turcotte S, Turk B, Turk V, Turner BJ, Tuxworth RI, Tyler JK, Tyutereva EV, Uchiyama Y, Ugun-Klusek A, Uhlig HH, Ulamek-Koziol M, Ulasov IV, Umekawa M, Ungermann C, Unno R, Urbe S, Uribe-Carretero E, Üstün S, Uversky VN, Vaccari T, Vaccaro MI, Vahsen BF, Vakifahmetoglu-Norberg H, Valdor R, Valente MJ, Valko A, Vallee RB, Valverde AM, Van den Berghe G, van der Veen S, Van Kaer L, van Loosdregt J, van Wijk SJL, Vandenberghe W, Vanhorebeek I, Vannier-Santos MA, Vannini N, Vanrell MC, Vantaggiato C, Varano G, Varela-Nieto I, Varga M, Vasconcelos MH, Vats S, Vavvas DG, Vega-Naredo I, Vega-Rubin-de-Celis S, Velasco G, Velázquez AP, Vellai T, Vellenga E, Velotti F, Verdier M, Verginis P, Vergne I, Verkade P, Verma M, Verstreken P, Vervliet T, Vervoorts J, Vessoni AT, Victor VM, Vidal M, Vidoni C, Vieira OV, Vierstra RD, Viganó S, Vihinen H, Vijayan V, Vila M, Vilar M, Villalba JM, Villalobo A, Villarejo-Zori B, Villarroya F, Villarroya J, Vincent O, Vindis C, Viret C, Viscomi MT, Visnjic D, Vitale I, Vocadlo DJ, Voitsekhovskaja OV, Volonté C, Volta M, Vomero M, Von Haefen C, Vooijs MA, Voos W, Vucicevic L, Wade-Martins R, Waguri S, Waite KA, Wakatsuki S, Walker DW, Walker MJ, Walker SA, Walter J, Wandosell FG, Wang B, Wang CY, Wang C, Wang D, Wang F, Wang G, Wang H, Wang HG, Wang J, Wang K, Wang L, Wang MH, Wang M, Wang N, Wang P, Wang QJ, Wang Q, Wang QK, Wang QA, Wang WT, Wang W, Wang X, Wang Y, Wang YY, Wang Z, Warnes G, Warnsmann V, Watada H, Watanabe E, Watchon M, Wawrzynska A, Weaver TE, Wegrzyn G, Wehman AM, Wei H, Wei L, Wei T, Wei Y, Weiergräber OH, Weihl CC, Weindl G, Weiskirchen R, Wells A, Wen RH, Wen X, Werner A, Weykopf B, Wheatley SP, Whitton JL, Whitworth AJ, Wiktorska K, Wildenberg ME, Wileman T, Wilkinson S, Willbold D, Williams B, Williams RSB, Williams RL, Williamson PR, Wilson RA, Winner B, Winsor NJ, Witkin SS, Wodrich H, Woehlbier U, Wollert T, Wong E, Wong JH, Wong RW, Wong VKW, Wong WW, Wu AG, Wu C, Wu J, Wu KK, Wu M, Wu SY, Wu S, Wu WKK, Wu X, Wu YW, Wu Y, Xavier RJ, Xia H, Xia L, Xia Z, Xiang G, Xiang J, Xiang M, Xiang W, Xiao B, Xiao G, Xiao H, Xiao HT, Xiao J, Xiao L, Xiao S, Xiao Y, Xie B, Xie CM, Xie M, Xie Y, Xie Z, Xilouri M, Xu C, Xu E, Xu H, Xu J, Xu L, Xu WW, Xu X, Xue Y, Yakhine-Diop SMS, Yamaguchi M, Yamaguchi O, Yamamoto A, Yamashina S, Yan S, Yan SJ, Yan Z, Yanagi Y, Yang C, Yang DS, Yang H, Yang HT, Yang JM, Yang J, Yang L, Yang M, Yang PM, Yang Q, Yang S, Yang SF, Yang W, Yang WY, Yang X, Yang Y, Yao H, Yao S, Yao X, Yao YG, Yao YM, Yasui T, Yazdankhah M, Yen PM, Yi C, Yin XM, Yin Y, Yin Z, Ying M, Ying Z, Yip CK, Yiu SPT, Yoo YH, Yoshida K, Yoshii SR, Yoshimori T, Yousefi B, Yu B, Yu H, Yu J, Yu L, Yu ML, Yu SW, Yu VC, Yu WH, Yu Z, Yuan J, Yuan LQ, Yuan S, Yuan SF, Yuan Y, Yuan Z, Yue J, Yue Z, Yun J, Yung RL, Zacks DN, Zaffagnini G, Zambelli VO, Zanella I, Zang QS, Zanivan S, Zappavigna S, Zaragoza P, Zarbalis KS, Zarebkohan A, Zarrouk A, Zeitlin SO, Zeng J, Zeng JD, Žerovnik E, Zhan L, Zhang B, Zhang DD, Zhang H, Zhang HL, Zhang J, Zhang JP, Zhang KYB, Zhang LW, Zhang L, Zhang M, Zhang P, Zhang S, Zhang W, Zhang X, Zhang XW, Zhang XD, Zhang Y, Zhang YD, Zhang YY, Zhang Z, Zhao H, Zhao L, Zhao S, Zhao T, Zhao XF, Zhao Y, Zheng G, Zheng K, Zheng L, Zheng S, Zheng XL, Zheng Y, Zheng ZG, Zhivotovsky B, Zhong Q, Zhou A, Zhou B, Zhou C, Zhou G, Zhou H, Zhou J, Zhou K, Zhou R, Zhou XJ, Zhou Y, Zhou ZY, Zhou Z, Zhu B, Zhu C, Zhu GQ, Zhu H, Zhu WG, Zhu Y, Zhuang H, Zhuang X, Zientara-Rytter K, Zimmermann CM, Ziviani E, Zoladek T, Zong WX, Zorov DB, Zorzano A, Zou W, Zou Z, Zuryn S, Zwerschke W, Brand-Saberi B, Dong XC, Kenchappa CS, Lin Y, Oshima S, Rong Y, Sluimer JC, Stallings CL, and Tong CK
Subjects: flux, macroautophagy, phagophore, stress, vacuole, Autophagosome, LC3, lysosome, neurodegeneration, cancer
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

12. Conditional Monte Carlo Learning for Diffusions I: main methodology and application to backward stochastic differential equations

Author: Abbas-Turki, Lokman, Pagès, G., Diallo, Babacar, Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR]
Abstract: We present a new algorithm based on a One-layered Nested Monte Carlo (1NMC) to simulate functionals U of a Markov process X. The main originality of the proposed methodology comes from the fact that it provides a recipe to simulate U_{t≥s} conditionally on X_s. Because of the nested structure that allows a Taylor-like expansion, it is possible to use a very reduced basis for the regression. Although this methodology can be adapted for a large number of situations, we only apply it here for the simulation of Backward Stochastic Differential Equations (BSDEs). The generality and the stability of this algorithm, even in high dimension, make its strength. It is heavier than a straight Monte Carlo (MC) but it is far more accurate to simulate quantities that are almost impossible to simulate with MC. The parallel suitability of 1NMC makes it feasible in a reasonable computing time. This paper explains the main version of this algorithm and provides first results of error estimates. We also give various numerical examples with a dimension equal to 100 that are executed from few seconds to few minutes on one Graphics Processing Unit (GPU).
Published: 2020

13. Conditional Monte Carlo Learning for Diffusions II: extended methodology and application to risk measures and early stopping problems

Author: Abbas-Turki, Lokman, Pagès, G., Diallo, Babacar, Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR]
Abstract: In Conditional Monte Carlo Learning for Diffusions part I (CMCLDI) [2], we presented a One-layered Nested Monte Carlo (1NMC) to simulate functionals U of a Markov process X. Based on a judicious combination between regression and 1NMC used for localization purpose, this methodology allows to simulate U_{t≥s} conditionally on X{s}. The parallel suitability and scalability of 1NMC makes this algorithm very competitive to simulate quantities that are almost impossible to simulate with other methods. In this paper, using the double layer of trajectories, we explain further the mathematical background of the control on the bias propagation. With this double layer structure, we also detail how to adjust the variance to get a better approximation of the second moment from the regression. In normal and log-normal models, this variance adjustment allows a better description of tail events. Since we applied this algorithm on Backward Stochastic Differential Equations in CMCLDI, we show here its strength for the simulation of risk measures and optimal stopping problems. Two highly dimensional numerical examples are executed in few minutes on one Graphics Processing Unit (GPU).
Published: 2020

14. Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration

Author: Homs, J, Ariza, L, Pagès, G, Udina, E, Navarro, X, Chillón, M, and Bosch, A
Published: 2011
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15. Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity

Author: Jager, J., Corcelle, V., Grémeaux, T., Laurent, K., Waget, A., Pagès, G., Binétruy, B., Le Marchand-Brustel, Y., Burcelin, R., Bost, F., and Tanti, J. F.
Published: 2011
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16. Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway

Author: Bermudez, O, Marchetti, S, Pagès, G, and Gimond, C
Published: 2008
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17. Overexpression of Sp1 transcription factor induces apoptosis

Author: Deniaud, E, Baguet, J, Mathieu, A-L, Pagès, G, Marvel, J, and Leverrier, Y
Published: 2006
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18. Dilatometry as a tool to study a new synthesis for calcium hexaluminate

Author: Tulliani, J. M., Pagès, G., Fantozzi, G., and Montanaro, L.
Published: 2003
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19. UDCA slows down intestinal cell proliferation by inducing high and sustained ERK phosphorylation

Author: Krishna-Subramanian, S., Hanski, M. L., Loddenkemper, C., Choudhary, B., Pagès, G., Zeitz, M., and Hanski, C.
Published: 2012
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20. Non-asymptotic Gaussian estimates for the recursive approximation of the invariant distribution of a diffusion

Author: Honoré, I., primary, Menozzi, S., additional, and Pagès, G., additional
Published: 2020
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21. Angiogenic/lymphangiogenic factors and adaptation to extreme altitudes during an expedition to Mount Everest

Author: Patitucci, M., Lugrin, D., and Pagès, G.
Published: 2009
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22. Profiling the temperature-dependent frequency of an open-magnet for outdoor applications

Author: Traore, A., Rondeau-Mouro, Corinne, Alouissi, R., Benmoussa, A., Bonny, J.-M., Pagès, G., Institut National de la Recherche Agronomique (INRA), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and Irstea Publications, Migration
Subjects: [SDE] Environmental Sciences, [SDE]Environmental Sciences
Abstract: International audience; Low-field NMR relaxometers are powerful instruments as they can be moved outside the laboratory to be closer to the sample (in fields or next to a production line), for on-line quality control for example. Openmagnets present the advantages of (i) being slice selective and (ii) able to record 1D NMR profile if the magnet is mounted on a high-precision lift. The NMR-MOUSE is an example of a device combining both features. This magnet can measure the NMR signal at various depths (NMR profile) with a resolution as low as few tens of micrometers. However, the magnet frequency distribution of such instrument is dependent on the magnet temperature, which is currently nor regulated nor controlled. Hence, its performance might be questioned in case of temperature fluctuations (e.g. outdoor applications), inducing unintended variations in the position of the slice. In this work, we aim at characterizing the NMR profile shift as a function of the magnet temperature. For this, we measured the profile of a doped water sample while the surrounding temperature of the magnet was varied. We clearly observed a linear variation of the water profile position for temperatures between 10 and 35
Published: 2019

23. Interest of in vivo CEST MRI to study chondrosarcoma tumour microenvironment

Author: Autissier, R, Maubert, E, Schmitt, S, Auzeloux, P, Peyrode, C, Degoul, F, Traoré, A, Bonny, J, Miot-Noirault, E, Mazuel, L, Pagès, G, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)
Subjects: [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

24. Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity

Author: Beauclair, S., Formento, P., Fischel, J. L., Lescaut, W., Largillier, R., Chamorey, E., Hofman, P., Ferrero, J. M., Pagès, G., and Milano, G.
Published: 2007

25. Intrathecal AAVrh10 corrects biochemical and histological hallmarks of mucopolysaccharidosis VII mice and improves behavior and survival

Author: Pagès, G, primary, Giménez-Llort, L, additional, García-Lareu, B, additional, Ariza, L, additional, Navarro, M, additional, Casas, C, additional, Chillón, M, additional, and Bosch, A, additional
Published: 2019
Full Text: View/download PDF

26. Effects of proton versus photon irradiation on (lymph) angiogenic, inflammatory, proliferative and anti-tumor immune responses in head and neck squamous cell carcinoma

Author: Lupu-Plesu, M, Claren, A, Martial, S., N’Diaye, P-D, Lebrigand, K., Pons, N, Ambrosetti, D, Peyrottes, I, Feuillade, J, Herault, J., Dufies, M, Doyen, J., Pagès, G., Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), and UNICANCER-Université Côte d'Azur (UCA)
Subjects: [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract: International audience; The proximity of organs at risk makes the treatment of head and neck squamous cell carcinoma (HNSCC) challenging by standard radiotherapy. The higher precision in tumor targeting of proton (P) therapy could promote it as the treatment of choice for HNSCC. Besides the physical advantage in dose deposition, few is known about the biological impact of P versus photons (X) in this setting. To investigate the comparative biological effects of P versus X radiation in HNSCC cells, we assessed the relative biological effectiveness (RBE), viability, proliferation and mRNA levels for genes involved in (lymph)angiogenesis, inflammation, proliferation and anti-tumor immunity. These parameters, particularly VEGF-C protein levels and regulations, were documented in freshly irradiated and/or long-term surviving cells receiving low/high-dose, single (SI)/multiple (MI) irradiations with P/X. The RBE was found to be 1.1 Key (lymph)angiogenesis and inflammation genes were downregulated (except for vegf-c) after P and upregulated after X irradiation in MI surviving cells, demonstrating a more favorable profile after P irradiation. Both irradiation types stimulated vegf-c promoter activity in a NF-κB-dependent transcriptional regulation manner, but at a lesser extent after P, as compared to X irradiation, which correlated with mRNA and protein levels. The cells surviving to MI by P or X generated tumors with higher volume, anarchic architecture and increased density of blood vessels. Increased lymphangiogenesis and a transcriptomic analysis in favor of a more aggressive phenotype were observed in tumors generated with X-irradiated cells. Increased detection of lymphatic vessels in relapsed tumors from patients receiving X radiotherapy was consistent with these findings. This study provides new data about the biological advantage of P, as compared to X irradiation. In addition to its physical advantage in dose deposition, P irradiation may help to improve treatment approaches for HNSCC.
Published: 2017