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Your search keyword '"Pafundi, Paolo"' showing total 3 results
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3 results on '"Pafundi, Paolo"'

2. Transanal endoscopic microsurgery after neoadjuvant radiochemotherapy for locally advanced extraperitoneal rectal cancer: short-term morbidity and functional outcome.

Author

Coco, Claudio, Rizzo, Gianluca, Mattana, Claudio, Gambacorta, Maria Antonietta, Verbo, Alessandro, Barbaro, Brunella, Vecchio, Fabio Maria, Pafundi, Paolo, Mastromarino, Maria Giovanna, Valentini, Vincenzo, Coco, Claudio (ORCID:0000-0002-4713-7093), Mattana, Claudio (ORCID:0000-0002-8605-4952), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Verbo, Alessandro (ORCID:0000-0003-4993-6638), Barbaro, Brunella (ORCID:0000-0002-9638-543X), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Coco, Claudio, Rizzo, Gianluca, Mattana, Claudio, Gambacorta, Maria Antonietta, Verbo, Alessandro, Barbaro, Brunella, Vecchio, Fabio Maria, Pafundi, Paolo, Mastromarino, Maria Giovanna, Valentini, Vincenzo, Coco, Claudio (ORCID:0000-0002-4713-7093), Mattana, Claudio (ORCID:0000-0002-8605-4952), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Verbo, Alessandro (ORCID:0000-0003-4993-6638), Barbaro, Brunella (ORCID:0000-0002-9638-543X), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), and Valentini, Vincenzo (ORCID:0000-0003-4637-6487)

Abstract

BACKGROUND: Transanal endoscopic microsurgery (TEM) after radiochemotherapy (RCT) has been reported in selected cases of locally advanced rectal cancer as an alternative to traditional radical resection with total mesorectal excision with a curative intent or as diagnostic tool to confirm a pathological complete response of the primary tumor. No study has evaluated functional outcome after TEM in preoperatively irradiated patients. METHODS: This study was designed to evaluate short-term morbidity (according to Clavien's classifications) and establish (by a questionnaire) continence and evacuative function after RCT and TEM, at 1 year from surgery, analyzing the impact of RCT on postoperative outcomes. Patients with locally advanced rectal cancer treated by RCT and TEM (group 1) or with early T1 or adenomas treated only by TEM (group 2) entered this cohort comparative study. RESULTS: Twenty-two patients entered the study as group 1 and 25 as group 2. No postoperative mortality occurred. The morbidity rate was 36.4 % in group 1 vs. 16 % in group 2 (p = 0.114). The rate of suture dehiscence was 22.7 % in group 1 vs. 4 % in group 2 (p = 0.068). No grade III complications, reoperation, or hospital readmission within 30 days was recorded in either group. One year after surgery, continence and evacuative scores in group 1 were 1.05 ± 1.25 and 24.72 ± 2.79, respectively, which were similar to group 2 (p = 0.081 and 0.288, respectively). CONCLUSIONS: TEM after RCT in selected rectal cancer patients has an acceptable morbidity and functional results at 1 year from surgery. Preoperative irradiation could increase postoperative short-term morbidity, but it does not seem to influence evacuative or sphincter function after 1 year from surgery.

Published
2013

3. Polyvinylidene Fluoride Mesh (PVDF, DynaMesh®-IPOM) in The Laparoscopic Treatment of Incisional Hernia: A Prospective Comparative Trial versus Gore® ePTFE DUALMESH® Plus.

Author

Verbo A, Pafundi P, Manno A, Baccaro R, Veneziani A, Colli R, and Coco C

Subjects
Adult, Aged, Aged, 80 and over, Equipment Failure Analysis, Female, Herniorrhaphy methods, Humans, Incidence, Italy epidemiology, Laparoscopy methods, Laparoscopy statistics & numerical data, Length of Stay statistics & numerical data, Male, Middle Aged, Operative Time, Polytetrafluoroethylene, Polyvinyls, Postoperative Complications prevention & control, Prosthesis Design, Risk Factors, Treatment Outcome, Herniorrhaphy instrumentation, Incisional Hernia epidemiology, Incisional Hernia surgery, Laparoscopy instrumentation, Postoperative Complications epidemiology, Surgical Mesh statistics & numerical data
Abstract

Background: Laparoscopic approach is now generally accepted for the treatment of incisional hernia. The ideal mesh is still to be found. The aim of this study is to compare the well-known Gore® DUALMESH® Plus (WL Gore & Associates, Flagstaff, AZ) to a new prosthesis, the DynaMesh®-IPOM (FEG Textiltechnik GmbH, Aachen, Germany), to clinically verify its potential benefits in the laparoscopic treatment of incisional hernia., Materials and Methods: Comparing the results of the laparoscopic treatment of two groups of patients affected by incisional hernia using Gore® DUALMESH® Plus and DynaMesh®-IPOM., Results: There were 45 females and 31 males, with age variable from 21 to 84 years of age. The two groups were well matched for age (median age 60 years for group A and 57.6 years for group B-p=0.44) and sex (28F and 17M group A and 13 F and 18 M group B-p=0.008), while median BMI resulted slightly higher in group B (26.12 group A and 29.74 group B-p=0.001). The median size of the defect was similar in the two groups (87.5 mm group A and 83.4 mm for group B-p=0.83), while the median operating time was slightly longer in group A (77 min group A and 67 min group B-p=0.44). No difference in the length of hospital stay was evidenced between the two groups (3.19 days for group A and 3 days for group B-p=0.74). Time to return to physical activity was similar between the two groups (13.46 days for group A and 12.7 days for group B-p=0.32). Minor complications occurred in 15 cases (19.7%): seromas (7 cases), prolonged ileus (6 cases), and hemoperitoneum (2 cases), without significant difference in the incidence of such complications in the two groups. Five recurrences (6.5% of cases) occurred. No differences in the recurrence rate was noted between the two groups (3 cases/7% for group A and 2 cases/6% for group B-p=00.7)., Conclusions: DynaMesh®-IPOM proved to be a safe and effective mesh for the laparoscopic repair of incisional hernia even when compared to DUALMESH® Plus.

Published
2016

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