Search

Your search keyword '"Padua, Rose Ann"' showing total 283 results
Start Over Author "Padua, Rose Ann"
283 results on '"Padua, Rose Ann"'

1. Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Author

Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N., Sweeney, Shannon R., Ryan, Jeremy A., Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E., Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R., Ma, Helen, Weng, Connie C., Ramage, Cassandra L., Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L., Mi, Yingchang, Wang, Jing, DiNardo, Courtney D., Andreeff, Michael, Tyner, Jeffery W., Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E., Tiziani, Stefano, Leverson, Joel, Popovic, Relja, and Konopleva, Marina

Published
2022
Full Text
View/download PDF

2. Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Author

Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N., Sweeney, Shannon R., Ryan, Jeremy A., Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E., Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R., Ma, Helen, Weng, Connie C., Ramage, Cassandra L., Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L., Mi, Yingchang, Wang, Jing, DiNardo, Courtney D., Andreeff, Michael, Tyner, Jeffery W., Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E., Tiziani, Stefano, Leverson, Joel, Popovic, Relja, and Konopleva, Marina

Published
2022
Full Text
View/download PDF

3. p53 activation during ribosome biogenesis regulates normal erythroid differentiation

Author

Le Goff, Salomé, Boussaid, Ismael, Floquet, Celia, Raimbault, Anna, Hatin, Isabelle, Andrieu-Soler, Charlotte, Salma, Mohammad, Leduc, Marjorie, Gautier, Emilie-Fleur, Guyot, Boris, d'Allard, Diane, Montel-Lehry, Nathalie, Ducamp, Sarah, Houvert, Amandine, Guillonneau, François, Giraudier, Stéphane, Cramer-Bordé, Elisabeth, Morlé, François, Diaz, Jean-Jacques, Hermine, Olivier, Taylor, Naomi, Kinet, Sandrina, Verdier, Frédérique, Padua, Rose-Ann, Mohandas, Narla, Gleizes, Pierre-Emmanuel, Soler, Eric, Mayeux, Patrick, and Fontenay, Michaela

Published
2021
Full Text
View/download PDF

4. The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Author

Narayanan, Ashwin, Gagliardi, Filippo, Gallotti, Alberto L., Mazzoleni, Stefania, Cominelli, Manuela, Fagnocchi, Luca, Pala, Mauro, Piras, Ignazio S., Zordan, Paola, Moretta, Nicole, Tratta, Elisa, Brugnara, Gianluca, Altabella, Luisa, Bozzuto, Giuseppina, Gorombei, Petra, Molinari, Agnese, Padua, Rose-Ann, Bulfone, Alessandro, Politi, Letterio S., Falini, Andrea, Castellano, Antonella, Mortini, Pietro, Zippo, Alessio, Poliani, Pietro L., and Galli, Rossella

Published
2019
Full Text
View/download PDF

9. Data from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

10. Data from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Author

Omidvar, Nader, primary, Kogan, Scott, primary, Beurlet, Stephanie, primary, le Pogam, Carole, primary, Janin, Anne, primary, West, Robert, primary, Noguera, Maria-Elena, primary, Reboul, Murielle, primary, Soulie, Annie, primary, Leboeuf, Christophe, primary, Setterblad, Niclas, primary, Felsher, Dean, primary, Lagasse, Eric, primary, Mohamedali, Azim, primary, Thomas, N. Shaun B., primary, Fenaux, Pierre, primary, Fontenay, Michaela, primary, Pla, Marika, primary, Mufti, Ghulam J., primary, Weissman, Irving, primary, Chomienne, Christine, primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Procedures, Figures 1-4 from BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

Author

Omidvar, Nader, primary, Kogan, Scott, primary, Beurlet, Stephanie, primary, le Pogam, Carole, primary, Janin, Anne, primary, West, Robert, primary, Noguera, Maria-Elena, primary, Reboul, Murielle, primary, Soulie, Annie, primary, Leboeuf, Christophe, primary, Setterblad, Niclas, primary, Felsher, Dean, primary, Lagasse, Eric, primary, Mohamedali, Azim, primary, Thomas, N. Shaun B., primary, Fenaux, Pierre, primary, Fontenay, Michaela, primary, Pla, Marika, primary, Mufti, Ghulam J., primary, Weissman, Irving, primary, Chomienne, Christine, primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Table 1 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure 1 Legend from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure 1 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

15. Supplementary Table 2 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Table 5 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

17. Supplementary Table 3 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Table 4 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?

Author

Rassool, Feyruz V., primary, Gaymes, Terry J., primary, Omidvar, Nader, primary, Brady, Nicola, primary, Beurlet, Stephanie, primary, Pla, Marika, primary, Reboul, Murielle, primary, Lea, Nicholas, primary, Chomienne, Christine, primary, Thomas, Nicholas S.B., primary, Mufti, Ghulam J., primary, and Padua, Rose Ann, primary

Published
2023
Full Text
View/download PDF

19. JAK Inhibition Mediates Clonal Selection of RAS Pathway Mutations in Myeloproliferative Neoplasms

Author

Maslah, Nabih, primary, Roux, Blandine, additional, Kaci, Nina, additional, Verger, Emmanuelle, additional, Daltro De Oliveira, Rafael, additional, Pasquer, Hélène, additional, Gauthier, Nicolas, additional, Soret, Juliette, additional, Ganesan, Saravanan, additional, Gou, Panhong, additional, Ling, Frank, additional, Parquet, Nathalie, additional, Vainchenker, William, additional, Raffoux, Emmanuel, additional, Padua, Rose Ann, additional, Giraudier, Stephane, additional, Puissant, Alexandre, additional, Lobry, Camille, additional, Kiladjian, Jean-Jacques, additional, Cassinat, Bruno, additional, and Benajiba, Lina, additional

Published
2022
Full Text
View/download PDF

20. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Author

Beurlet, Stephanie, Omidvar, Nader, Gorombei, Petra, Krief, Patricia, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Leboeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Hervatin, Florence, Sarda-Mantel, Laure, Konopleva, Marina, Andreeff, Michael, Tu, Andrea W., Fan, Alice C., Felsher, Dean W., Whetton, Anthony, Pla, Marika, West, Robert, Fenaux, Pierre, Chomienne, Christine, and Padua, Rose Ann

Published
2013
Full Text
View/download PDF

21. Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes

Author

Le Pogam, Carole, Krief, Patricia, Beurlet, Stephanie, Soulié, Annie, Balitrand, Nicole, Cassinat, Bruno, Cavé, Helene, Kosmider, Olivier, Setterblad, Niclas, Leboeuf, Christophe, Sarda-Mantel, Laure, Hervatin, Florence, Merlet, Pascal, Noguera, Maria-Elena, Janin, Anne, Pla, Marika, Fontenay, Michaela, Adès, Lionel, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann, and Omidvar, Nader

Published
2013
Full Text
View/download PDF

25. BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

Author

Gorombei, Petra, primary, Guidez, Fabien, additional, Ganesan, Saravanan, additional, Chiquet, Mathieu, additional, Pellagatti, Andrea, additional, Goursaud, Laure, additional, Tekin, Nilgun, additional, Beurlet, Stephanie, additional, Patel, Satyananda, additional, Guerenne, Laura, additional, Le Pogam, Carole, additional, Setterblad, Niclas, additional, de la Grange, Pierre, additional, LeBoeuf, Christophe, additional, Janin, Anne, additional, Noguera, Maria-Elena, additional, Sarda-Mantel, Laure, additional, Merlet, Pascale, additional, Boultwood, Jacqueline, additional, Konopleva, Marina, additional, Andreeff, Michael, additional, West, Robert, additional, Pla, Marika, additional, Adès, Lionel, additional, Fenaux, Pierre, additional, Krief, Patricia, additional, Chomienne, Christine, additional, Omidvar, Nader, additional, and Padua, Rose Ann, additional

Published
2021
Full Text
View/download PDF

26. Comparison of In vivo [18F]Fluoro-desoxyglucose and [18F]Fluoro-thymidine Positron Emission Tomography for Disease Monitoring in a Mouse Model of Higher-Risk Myelodysplastic Syndrome

Author

Sarda-Mantel, Laure, Gou, Panhong, Hontonnou, Fortune, Hosten, Benoit, Vignal, Nicolas, San, Carine, Brumpt, Caren, Fenaux, Pierre, Chomienne, Christine, Giraudier, Stephane, and Padua, Rose-Ann

Subjects
biochemistry
Abstract

Higher-risk myelodysplastic syndrome (HR-MDS) has a poor prognosis in the absence of efficient therapy. The evaluation of new therapies in animal models of HR-MDS is hampered by the absence of accurate in vivo biomarkers of the disease. In this study we compared [18F]Fluoro-desoxyglucose Positron Emission Tomography (FDG-PET) and [18F]Fluoro-thymidine (FLT)-PET imaging for disease follow-up in a triple transgenic MMTVtTA/TetoBCL-2/MRP8NRASD12 mouse model of HR-MDS. Normal control FVB/N mice (G1,n=9) and HR-MDS mice (G2,n=12) underwent both FDG- and FLT-PET procedures at 2-day intervals, on a dedicated small animal device. Blood cell counting, BCL-2 and Mac-1hi/Gr-1lo expression measurements in blood were performed before each PET procedure. Visually, PET images of G2 mice demonstrated homogeneous FDG uptake in the whole skeleton similar to that observed in G1 mice, and abnormal FLT hot spots in bone marrow not observed in G1 mice. The intensity of FLT hot spots in bone marrow was higher in 3-months old G2 mice than in 2-months old G2 mice, concordant with a higher percentage of cells expressing Mac-1hi/Gr-1lo and lower platelets counts. We conclude that FLT-PET/CT imaging is a more valuable surrogate non-invasive quantitative marker of HR-MDS bone marrow involvement than FDG-PET/CT in our mouse model of HR-MDS.

Published
2021

28. Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

Author

Fan, Alice C., Deb-Basu, Debabrita, Orban, Mathias W., Gotlib, Jason R., Natkunam, Yasodha, O'Neill, Roger, Padua, Rose-Ann, Xu, Liwen, Taketa, Daryl, Shirer, Amy E., Beer, Shelly, Yee, Ada X., Voehringer, David W., and Felsher, Dean W.

Subjects
Cellular signal transduction -- Genetic aspects, Cellular signal transduction -- Research, Chronic myeloid leukemia -- Genetic aspects, Chronic myeloid leukemia -- Drug therapy, Chronic myeloid leukemia -- Research, Lymphomas -- Drug therapy, Lymphomas -- Genetic aspects, Lymphomas -- Research, Tumor proteins -- Physiological aspects, Tumor proteins -- Genetic aspects, Tumor proteins -- Research
Abstract

Current methods of protein detection are insensitive to detecting subtle changes in oncoprotein activation that underlie key cancer signaling processes. The requirement for large numbers of cells precludes serial tumor sampling for assessing a response to therapeutics. Therefore, we have developed a nanofluidic proteomic immunoassay (NIA) to quantify total and low-abundance protein isoforms in nanoliter volumes. Our method can quantify amounts of MYC oncoprotein and B cell lymphoma protein-2 (BCL2) in Burkitt's and follicular lymphoma; identify changes in activation of extracellular signal-related kinases-1 (ERK1) and ERK2, mitogen-activated kinase-1 (MEK), signal transducer and activator of transcription protein-3 (STAT3) and STAT5, c-Jun N-terminal kinase (JNK) and caspase-3 in imatinib-treated chronic myelogeneous leukemia (CML) cells; measure an unanticipated change in the phosphorylation of an ERK2 isomer in individuals with CML who responded to imatinib; and detect a decrease in STAT3 and STAT5 phosphorylation in individuals with lymphoma who were treated with atorvastatin. Therefore, we have described a new and highly sensitive method for determining oncoprotein expression and phosphorylation in clinical specimens for the development of new therapeutics for cancer., Cancer is frequently associated with the abnormal expression and phosphorylation of oncogenes (1-4). Specific hematopoietic tumors are frequently characterized by the discrete activation of specific oncogenes such as MYC (5-7), [...]

Published
2009

29. Comparison of In vivo [18F]Fluoro-desoxyglucose and [18F]Fluoro-thymidine Positron Emission Tomography for Disease Monitoring in a Mouse Model of Higher-Risk Myelodysplastic Syndrome

Author

Sarda-Mantel, Laure, primary, Gou, Panhong, additional, Hontonnou, Fortune, additional, Hosten, Benoit, additional, Vignal, Nicolas, additional, San, Carine, additional, Brumpt, Caren, additional, Fenaux, Pierre, additional, Chomienne, Christine, additional, Giraudier, Stephane, additional, and Padua, Rose-Ann, additional

Published
2021
Full Text
View/download PDF

31. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia

Author

Padua, Rose Ann, Larghero, Jerome, Robin, Marie, Pogam, Carol le, Schlageter, Marie-Helene, Muszlak, Sacha, Fric, Jan, West, Robert, Rousselot, Philippe, Phan, Thi Hai, Mudde, Liesbeth, Teisserenc, Helene, Carpentier, Antoine F, Kogan, Scott, Degos, Laurent, Pla, Marika, Bishop, J Michael, Stevenson, Freda, Charron, Dominique, and Chomienne, Christine

Abstract

Author(s): Rose Ann Padua (corresponding author) [1, 2]; Jerome Larghero [1]; Marie Robin [1]; Carol le Pogam [1]; Marie-Helene Schlageter [1]; Sacha Muszlak [2]; Jan Fric [1]; Robert West [3]; [...]

Published
2003
Full Text
View/download PDF

32. Identification of a Patient Cohort with Relapsing Diffuse Large B-Cell Lymphoma with a Low International Prognostic Index in PET/CT Using a 2-Gene (LMO2/TNFRSF9) Scoring System

Author

Omidvar, Nader, primary, Tekin, Nilgun, additional, Conget, Paulette, additional, Bruna, Flavia, additional, Timar, Botond, additional, Gagyi, Eva, additional, Basak, Ranjan, additional, Auewarakul, Chirayu, additional, Sritana, Narongrit, additional, Cerci, Juliano Julio, additional, Dimamay, Mark Pierre, additional, Gyorke, Tamas, additional, Redondo, Francisca, additional, Nair, Reena, additional, Gorospe, Charity, additional, Paez, Diana, additional, Fanti, Stefano, additional, Ozdag, Hilal, additional, Padua, Rose Ann, additional, and Carr, Robert, additional

Published
2020
Full Text
View/download PDF

34. BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia

Author

Vidal, Valérie, Robert, Guillaume, Goursaud, Laure, Durand, Laetitia, Ginet, Clemence, Karsenti, Jean Michel, Luciano, Frederic, Gastaud, Lauris, Garnier, Georges, Braun, Thorsten, Hirsch, Pierre, Raffoux, Emmanuel, Nloga, Anne Marie, Padua, Rose Ann, Dombret, Hervé, Rohrlich, Pierre, Ades, Lionel, Chomienne, Christine, Auberger, Patrick, Fenaux, Pierre, and Cluzeau, Thomas

Subjects
Adult, Aged, 80 and over, Male, Antimetabolites, Antineoplastic, IPSS-R, IPSS, Gene Expression, Bone Marrow Cells, Middle Aged, Prognosis, Leukemia, Myeloid, Acute, Treatment Outcome, AML, BCL2L10, Proto-Oncogene Proteins c-bcl-2, Myelodysplastic Syndromes, MDS, Azacitidine, Humans, Female, Biomarkers, Research Paper, Aged, Neoplasm Staging
Abstract

Azacitidine (AZA), the reference treatment for most higher-risk myelodysplastic (MDS) patients can also improve overall survival (OS) in elderly acute myeloid leukemia (AML) patients ineligible for intensive chemotherapy, but reliable biological markers predicting response and OS in patients treated with AZA are lacking. In a preliminary study, we found that an increase of the percentage of BCL2L10, an anti-apoptotic member of the bcl-2 family, was correlated with AZA resistance. In this study, we assessed prospectively by flow cytometry the prognostic value of BCL2L10 positive bone marrow mononuclear cells in 70 patients (42 MDS and 28 AML), prior to AZA treatment. In patients with baseline marrow blasts below 30%, the baseline percentage of bone marrow BCL2L10 positive cells inversely correlated with response to AZA and OS independently of the International Prognostic Scoring System (IPSS) and IPSS-revised (IPSS-R). Specifically, OS was significantly lower in patients with more than 10% BCL2L10 positive cells (median 8.3 vs 22.9 months in patients with less than 10% positivity, p = 0,001). In summary, marrow BCL2L10 positive cells may be a biomarker for azacitidine response and OS, with a potential impact in clinical practice.

Published
2017

39. The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Author

Narayanan, Ashwin, primary, Gagliardi, Filippo, additional, Gallotti, Alberto L., additional, Mazzoleni, Stefania, additional, Cominelli, Manuela, additional, Fagnocchi, Luca, additional, Pala, Mauro, additional, Piras, Ignazio S., additional, Zordan, Paola, additional, Moretta, Nicole, additional, Tratta, Elisa, additional, Brugnara, Gianluca, additional, Altabella, Luisa, additional, Bozzuto, Giuseppina, additional, Gorombei, Petra, additional, Molinari, Agnese, additional, Padua, Rose-Ann, additional, Bulfone, Alessandro, additional, Politi, Letterio S., additional, Falini, Andrea, additional, Castellano, Antonella, additional, Mortini, Pietro, additional, Zippo, Alessio, additional, Poliani, Pietro L., additional, and Galli, Rossella, additional

Published
2018
Full Text
View/download PDF

44. BCL-2 Inhibitor Venetoclax (ABT-199) and MEK Inhibitor GDC-0973 Synergise to Target AML Progenitors and Overcome Drug Resistance with the Use of PET Scanning in a Mouse Model of HR-MDS to Monitor Response to Treatment

Author

Padua, Rose Ann, primary, Sarda-Mantel, Laure, additional, Chiquet, Mathieu, additional, Kappel, Claire, additional, Krief, Patricia, additional, Setterblad, Niclas, additional, Hontonnou, Fortune, additional, Hosten, Benoit, additional, Vignal, Nicolas, additional, Zassadowski, Fabien, additional, Cassinat, Bruno, additional, Gou, Panhong, additional, Giraudier, Stephane, additional, Konopleva, Marina Y., additional, Andreeff, Michael, additional, PLA, Marika, additional, Ades, Lionel, additional, Fenaux, Pierre, additional, and Chomienne, Christine, additional

Published
2018
Full Text
View/download PDF

45. Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis

Author

Alex, Ansu Abu, primary, Ganesan, Saravanan, additional, Palani, Hamenth Kumar, additional, Balasundaram, Nithya, additional, David, Sachin, additional, Lakshmi, Kavitha M., additional, Kulkarni, Uday P., additional, Nisham, P. N., additional, Korula, Anu, additional, Devasia, Anup J., additional, Janet, Nancy Beryl, additional, Abraham, Aby, additional, Srivastava, Alok, additional, George, Biju, additional, Padua, Rose Ann, additional, Chomienne, Christine, additional, Balasubramanian, Poonkuzhali, additional, and Mathews, Vikram, additional

Published
2018
Full Text
View/download PDF

46. Protocol for qRT-PCR analysis from formalin fixed paraffin embedded tissue sections from diffuse large b-cell lymphoma: Validation of the six-gene predictor score

Author

Tekin, Nilgun, primary, Omidvar, Nader, additional, Morris, Tim Peter, additional, Conget, Paulette, additional, Bruna, Flavia, additional, Timar, Botond, additional, Gagyi, Eva, additional, Basak, Ranjan, additional, Naik, Omkar, additional, Auewarakul, Chirayu, additional, Sritana, Narongrit, additional, Levy, Debora, additional, Cerci, Juliano Julio, additional, Bydlowski, Sergio Paulo, additional, Pereira, Juliana, additional, Dimamay, Mark Pierre, additional, Natividad, Filipinas, additional, Chung, June-Key, additional, Belder, Nevin, additional, Kuzu, Isinsu, additional, Paez, Diana, additional, Dondi, Maurizio, additional, Carr, Robert, additional, Ozdag, Hilal, additional, and Padua, Rose Ann, additional

Published
2016
Full Text
View/download PDF

47. The effect of biological heterogeneity on R-CHOP treatment outcome in diffuse large B-cell lymphoma across five international regions

Author

Carr, Robert, primary, Ozdag, Hilal, additional, Tekin, Nilgun, additional, Morris, Timothy, additional, Conget, Paulette, additional, Bruna, Flavia, additional, Timar, Botond, additional, Gagyi, Eva, additional, Basak, Ranjan, additional, Naik, Omkar, additional, Auewarakul, Chirayu, additional, Srithana, Narongrit, additional, Dimamay, Mark Pierre, additional, Natividad, Filipinas, additional, Chung, June-Key, additional, Belder, Nevin, additional, Kuzu, Isinsu, additional, Omidvar, Nader, additional, Paez, Diana, additional, and Padua, Rose Ann, additional

Published
2016
Full Text
View/download PDF

48. GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Author

Guerenne, Laura, primary, Beurlet, Stéphanie, additional, Said, Mohamed, additional, Gorombei, Petra, additional, Le Pogam, Carole, additional, Guidez, Fabien, additional, de la Grange, Pierre, additional, Omidvar, Nader, additional, Vanneaux, Valérie, additional, Mills, Ken, additional, Mufti, Ghulam J, additional, Sarda-Mantel, Laure, additional, Noguera, Maria Elena, additional, Pla, Marika, additional, Fenaux, Pierre, additional, Padua, Rose Ann, additional, Chomienne, Christine, additional, and Krief, Patricia, additional

Published
2016
Full Text
View/download PDF

50. The proneural gene ASCL1governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Author

Narayanan, Ashwin, Gagliardi, Filippo, Gallotti, Alberto L., Mazzoleni, Stefania, Cominelli, Manuela, Fagnocchi, Luca, Pala, Mauro, Piras, Ignazio S., Zordan, Paola, Moretta, Nicole, Tratta, Elisa, Brugnara, Gianluca, Altabella, Luisa, Bozzuto, Giuseppina, Gorombei, Petra, Molinari, Agnese, Padua, Rose-Ann, Bulfone, Alessandro, Politi, Letterio S., Falini, Andrea, Castellano, Antonella, Mortini, Pietro, Zippo, Alessio, Poliani, Pietro L., and Galli, Rossella

Abstract

Achaete-scute homolog 1 gene (ASCL1)is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the activation of a PN gene signature. Besides prototypical ASCL1PN target genes, the molecular effectors mediating ASCL1function in regulating GBM differentiation and, most relevantly, subgroup specification are currently unknown. Here we report that ASCL1 not only promotes the acquisition of a PN phenotype in CSCs by inducing a glial-to-neuronal lineage switch but also concomitantly represses mesenchymal (MES) features by directly downregulating the expression of N-Myc downstream-regulated gene 1 (NDRG1), which we propose as a novel gene classifier of MES GBMs. Increasing the expression of ASCL1in PN CSCs results in suppression of self-renewal, promotion of differentiation and, most significantly, decrease in tumorigenesis, which is also reproduced by NDRG1silencing. Conversely, both abrogation of ASCL1expression in PN CSCs and enforcement of NDRG1expression in either PN or MES CSCs induce proneural-to-mesenchymal transition (PMT) and enhanced mesenchymal features. Surprisingly, ASCL1overexpression in MES CSCs increases malignant features and gives rise to a neuroendocrine-like secretory phenotype. Altogether, our results propose that the fine interplay between ASCL1and its target NDRG1might serve as potential subgroup-specific targetable vulnerability in GBM; enhancing ASCL1expression in PN GBMs might reduce tumorigenesis, whereas repressing NDRG1 expression might be actionable to hamper the malignancy of GBM belonging to the MES subgroup.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results