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2. Implementation of Zebrafish Ontologies for Toxicology Screening

Author

Thessen, Anne E, Marvel, Skylar, Achenbach, JC, Fischer, Stephan, Haendel, Melissa A, Hayward, Kimberly, Klüver, Nils, Könemann, Sarah, Legradi, Jessica, Lein, Pamela, Leong, Connor, Mylroie, J Erik, Padilla, Stephanie, Perone, Dante, Planchart, Antonio, Prieto, Rafael Miñana, Muriana, Arantza, Quevedo, Celia, Reif, David, Ryan, Kristen, Stinckens, Evelyn, Truong, Lisa, Vergauwen, Lucia, Berg, Colette Vom, Wilbanks, Mitch, Yaghoobi, Bianca, and Hamm, Jon

Subjects
Biological Sciences, Health Sciences, Genetics, Danio rerio, annotation, endpoint, ontology, phenotype, zebrafish
Abstract

Toxicological evaluation of chemicals using early-life stage zebrafish (Danio rerio) involves the observation and recording of altered phenotypes. Substantial variability has been observed among researchers in phenotypes reported from similar studies, as well as a lack of consistent data annotation, indicating a need for both terminological and data harmonization. When examined from a data science perspective, many of these apparent differences can be parsed into the same or similar endpoints whose measurements differ only in time, methodology, or nomenclature. Ontological knowledge structures can be leveraged to integrate diverse data sets across terminologies, scales, and modalities. Building on this premise, the National Toxicology Program's Systematic Evaluation of the Application of Zebrafish in Toxicology undertook a collaborative exercise to evaluate how the application of standardized phenotype terminology improved data consistency. To accomplish this, zebrafish researchers were asked to assess images of zebrafish larvae for morphological malformations in two surveys. In the first survey, researchers were asked to annotate observed malformations using their own terminology. In the second survey, researchers were asked to annotate the images from a list of terms and definitions from the Zebrafish Phenotype Ontology. Analysis of the results suggested that the use of ontology terms increased consistency and decreased ambiguity, but a larger study is needed to confirm. We conclude that utilizing a common data standard will not only reduce the heterogeneity of reported terms but increases agreement and repeatability between different laboratories. Thus, we advocate for the development of a zebrafish phenotype atlas to help laboratories create interoperable, computable data.

Published
2022

3. Characterizing sources of variability in zebrafish embryo screening protocols.

Author

Hamm, Jon, Ceger, Patricia, Allen, David, Stout, Matt, Maull, Elizabeth, Baker, Greg, Zmarowski, Amy, Padilla, Stephanie, Perkins, Edward, Planchart, Antonio, Stedman, Donald, Tal, Tamara, Tanguay, Robert, Wilbanks, Mitch, Walker, Nigel, and Volz, David

Subjects
Non-mammalian species, developmental toxicity, high-throughput screening, Animals, Chorion, Drug Evaluation, Preclinical, Embryo, Nonmammalian, Embryonic Development, High-Throughput Screening Assays, Toxicity Tests, Zebrafish
Abstract

There is a need for fast, efficient, and cost-effective hazard identification and characterization of chemical hazards. This need is generating increased interest in the use of zebrafish embryos as both a screening tool and an alternative to mammalian test methods. A Collaborative Workshop on Aquatic Models and 21st Century Toxicology identified the lack of appropriate and consistent testing protocols as a challenge to the broader application of the zebrafish embryo model. The National Toxicology Program established the Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) initiative to address the lack of consistent testing guidelines and identify sources of variability for zebrafish-based assays. This report summarizes initial SEAZIT information-gathering efforts. Investigators in academic, government, and industry laboratories that routinely use zebrafish embryos for chemical toxicity testing were asked about their husbandry practices and standard protocols. Information was collected about protocol components including zebrafish strains, feed, system water, disease surveillance, embryo exposure conditions, and endpoints. Literature was reviewed to assess issues raised by the investigators. Interviews revealed substantial variability across design parameters, data collected, and analysis procedures. The presence of the chorion and renewal of exposure media (static versus static-renewal) were identified as design parameters that could potentially influence study outcomes and should be investigated further with studies to determine chemical uptake from treatment solution into embryos. The information gathered in this effort provides a basis for future SEAZIT activities to promote more consistent practices among researchers using zebrafish embryos for toxicity evaluation.

Published
2019

6. Contributors

Author

Aggarwal, Manoj, primary, Akingbasote, James, additional, Anadón, Arturo, additional, Anger, Gregory J., additional, Archibong, Anthony E., additional, Ares, Irma, additional, Aschner, Michael, additional, Avila, Daiana S., additional, Bailey, Denise C., additional, Barlow, Norman J., additional, Beedanagari, Sudheer, additional, Beltyukov, P.P., additional, Bischoff, Karyn, additional, Boeck, Carina Rodrigues, additional, Bracken, William M., additional, Brehm, Emily, additional, Breyer, Richard M., additional, Bright-Ponte, Susan, additional, Brockett, Mirjana Milosevic, additional, Campagnolo, Luisa, additional, Carney, Edward W., additional, Charrette, Andrew, additional, Chebekoue, Sandrine Fleur, additional, Chiang, Catheryne, additional, Chou, Wei-Chun, additional, Cleal, Jane K., additional, Cole, Toby B., additional, Cook, Daniel, additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Curras-Collazo, Margarita, additional, Dai, Wanying, additional, Dao, Khoi, additional, Da Silva, Rosane Souza, additional, Davis, T. Zane, additional, Dominguez, Francisco, additional, Doss, Robin B., additional, Dziwenka, Margitta M., additional, Enright, Brian, additional, Estevan, Carmen, additional, Evans, Timothy J., additional, Fan, Anna M., additional, Farina, Marcelo, additional, Fenton, Suzanne E., additional, Filazi, Ayhan, additional, Fitsanakis, Vanessa A., additional, FitzGerald, Rex, additional, Flaskos, John, additional, Flaws, Jodi A., additional, Flora, S.J.S., additional, Ganjam, Vekataseshu K., additional, Gardner, Dale R., additional, Garg, Ramesh C., additional, Garrick, Jacqueline M., additional, Garry, Vincent F., additional, Gelineau-van Waes, Janee, additional, Godfrey, Keith M., additional, Golubentseva, Yu V., additional, González-Martín, Roberto, additional, Green, Benedict T., additional, Guerri, Consuelo, additional, Gulati, Kavita, additional, Gupta, P.K., additional, Gupta, Ramesh C., additional, Gupta, Rekha K., additional, Guthrie, Najla, additional, Hall, Jeffery O., additional, Hargreaves, Alan J., additional, Harris, Kenneth J., additional, Hill, Bridgett N., additional, Hilmas, Corey J., additional, Hoberman, Alan M., additional, Hougaard, Karin S., additional, Ince, Sinan, additional, Iyer, Poorni R., additional, Jacobsen, Nicklas R., additional, Kalpana, Starling, additional, Kandimalla, Ramesh, additional, Kanthasamy, Arthi, additional, Kanthasamy, Anumantha, additional, Khlebnikova, N.S., additional, Klüver, Nils, additional, Kodavanti, Prasada Rao S., additional, Krishnan, Kannan, additional, Kulkarni, Shaila, additional, Kuzukiran, Ozgur, additional, Lall, Rajiv, additional, Legradi, Jessica, additional, Lewis, Rohan M., additional, Lewis, Elise M., additional, Li, Xin, additional, Lin, Pinpin, additional, Loganathan, Bommanna G., additional, Machado, Ivo F., additional, Mahadevan, Brinda, additional, Makris, Susan L., additional, Malik, Jitendra K., additional, Marreilha dos Santos, Ana Paula, additional, Marsillach, Judit, additional, Martínez-Larrañaga, María Rosa, additional, Martínez, María Aránzazu, additional, Matouskova, Klara, additional, McClellan, Roger O., additional, Milatovic, Dejan, additional, Mohammed, Ali Mustafa, additional, Montine, Thomas J., additional, Møller, Peter, additional, Multani, Pushpinder Kaur, additional, Ni, Mingwei, additional, Nikolaidis, Efstathios, additional, Novilla, Meliton N., additional, Padilla, Stephanie, additional, Palmeira, Carlos M., additional, Pamies, David, additional, Panner Selvam, Manesh Kumar, additional, Pascual, María, additional, Patwa, Jayant, additional, Phillips, Ashley, additional, Piquette-Miller, Micheline, additional, Popov, V.B., additional, Pratt, M. Margaret, additional, Protasova, G.A., additional, Rai, Nishant, additional, Ramalho-Santos, João, additional, Ramesh, Aramandla, additional, Ray, Kausik, additional, Ray, Arunabha, additional, Ren, Aiguo, additional, Renaud, Stephen J., additional, Roberts, Drucilla J., additional, Rongzhu, Lu, additional, Sachana, Magdalini, additional, Sahlman, Heidi, additional, Saini, Nitin, additional, Saini, Vandna, additional, Shabasheva, L.V., additional, Sharma, Abha, additional, Sikka, Suresh C., additional, Silva, Marilyn Helen, additional, Simsek, Ilker, additional, Singh Kalra, Rajkumar, additional, Sinha, Anita, additional, Sogorb, Miguel A., additional, Soldin, Offie P., additional, Song, Chunjuan, additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Stoker, Tammy E., additional, Stonecipher, Clinton A., additional, Szlapinski, Sandra, additional, Tanabe, Shihori, additional, Tatiparthi, Arun, additional, Teixeira da Rocha, João Batista, additional, Thokchom, Suresh Kumar, additional, Tornesi, Belen, additional, Torous, Vanda, additional, Truran, Peter, additional, Valdez, Matthew C., additional, Vandenberg, Laura N., additional, Vargesson, Neil, additional, Vilanova, Eugenio, additional, Vähäkangas, Kirsi H., additional, Vulimiri, Suryanarayana V., additional, Warner, Genoa R., additional, Welch, Kevin D., additional, Williams, Daniel C., additional, Woldemeskel, Moges, additional, Yang, Jae-Ho, additional, Yin, Zhaobao, additional, Ying, Xiaoyou, additional, Yurdakok-Dikmen, Begum, additional, Zaja-Milatovic, Snjezana, additional, and Zhou, Changqing, additional

Published
2022
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8. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Author

Aschner, Michael, Ceccatelli, Sandra, Daneshian, Mardas, Fritsche, Ellen, Hasiwa, Nina, Hartung, Thomas, Hogberg, Helena T, Leist, Marcel, Li, Abby, Mundi, William R, Padilla, Stephanie, Piersma, Aldert H, Bal-Price, Anna, Seiler, Andrea, Westerink, Remco H, Zimmer, Bastian, and Lein, Pamela J

Subjects
Agricultural, Veterinary and Food Sciences, Biomedical and Clinical Sciences, Health Sciences, Pediatric, Neurosciences, Animal Testing Alternatives, Animals, Congresses as Topic, Drug Evaluation, Preclinical, Female, Hazardous Substances, Humans, Male, Neurons, Neurotoxicity Syndromes, Neurotoxins, Pregnancy, Prenatal Exposure Delayed Effects, Toxicity Tests, neurotoxicity, specificity, test development, AOP, validation, Agricultural and Veterinary Sciences, Medical and Health Sciences, Toxicology, Agricultural, veterinary and food sciences, Biomedical and clinical sciences, Health sciences
Abstract

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e., alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of > 50 endpoint-specific control compounds was identified. For further test development, an additional "test" set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the > 100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems.

Published
2017

10. Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS).

Author

Britton, Katy N., Judson, Richard S., Hill, Bridgett N., Jarema, Kimberly A., Olin, Jeanene K., Knapp, Bridget R., Lowery, Morgan, Feshuk, Madison, Brown, Jason, and Padilla, Stephanie

Subjects
PERFLUOROOCTANE sulfonate, HIGH throughput screening (Drug development), PHOSPHONIC acids, INDUSTRIAL goods, CHEMICAL species
Abstract

Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS have not been evaluated for developmental toxicity potential. A concentration–response study of 182 unique PFAS chemicals using the zebrafish medium-throughput, developmental vertebrate toxicity assay was conducted to investigate chemical structural identifiers for toxicity. Embryos were exposed to each PFAS compound (≤100 μM) beginning on the day of fertilization. At 6 days post-fertilization (dpf), two independent observers graded developmental landmarks for each larva (e.g., mortality, hatching, swim bladder inflation, edema, abnormal spine/tail, or craniofacial structure). Thirty percent of the PFAS were developmentally toxic, but there was no enrichment of any OECD structural category. PFOS was developmentally toxic (benchmark concentration [BMC] = 7.48 μM); however, other chemicals were more potent: perfluorooctanesulfonamide (PFOSA), N-methylperfluorooctane sulfonamide (N-MeFOSA), ((perfluorooctyl)ethyl)phosphonic acid, perfluoro-3,6,9-trioxatridecanoic acid, and perfluorohexane sulfonamide. The developmental toxicity profile for these more potent PFAS is largely unexplored in mammals and other species. Based on these zebrafish developmental toxicity results, additional screening may be warranted to understand the toxicity profile of these chemicals in other species. [ABSTRACT FROM AUTHOR]

Published
2024
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12. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS).

Author

Judson, Richard S., Smith, Doris, DeVito, Michael, Wambaugh, John F., Wetmore, Barbara A., Paul Friedman, Katie, Patlewicz, Grace, Thomas, Russell S., Sayre, Risa R., Olker, Jennifer H., Degitz, Sigmund, Padilla, Stephanie, Harrill, Joshua A., Shafer, Timothy, and Carstens, Kelly E.

Subjects
FLUOROALKYL compounds, PERFLUOROOCTANOIC acid, IN vivo toxicity testing, SULFONIC acids, HUMAN ecology
Abstract

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse health outcomes. Only a small fraction of the PFAS in commerce have been evaluated for toxicity using in vivo tests, which leads to a need to prioritize which compounds to examine further. Here, we demonstrate a prioritization approach that combines human biomonitoring data (blood concentrations) with bioactivity data (concentrations at which bioactivity is observed in vitro) for 31 PFAS. The in vitro data are taken from a battery of cell-based assays, mostly run on human cells. The result is a Bioactive Concentration to Blood Concentration Ratio (BCBCR), similar to a margin of exposure (MoE). Chemicals with low BCBCR values could then be prioritized for further risk assessment. Using this method, two of the PFAS, PFOA (Perfluorooctanoic Acid) and PFOS (Perfluorooctane Sulfonic Acid), have BCBCR values < 1 for some populations. An additional 9 PFAS have BCBCR values < 100 for some populations. This study shows a promising approach to screening level risk assessments of compounds such as PFAS that are long-lived in humans and other species. [ABSTRACT FROM AUTHOR]

Published
2024
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13. List of contributors

Author

Ahles, Kathleen, primary, Arantes, Leticia Priscilla, additional, Aschner, Michael, additional, Baer, Kevin N., additional, Banerjee, Atrayee, additional, Baud, Frédéric J., additional, Belden, Jason, additional, Bidwell, Joseph R., additional, Boyes, William K., additional, Bressler, Joseph Paul, additional, Brown, S.C., additional, Capdevielle, Marie, additional, Charli, Adhithiya, additional, Chen, Guangping, additional, Denslow, Nancy D., additional, Djordjevic, Aleksandra Buha, additional, Dugas, Tammy R., additional, Ehrich, Marion, additional, Fortin, Marie, additional, Franzen, Allison, additional, Freudenrich, Theresa M., additional, Gallucci, Randle, additional, Gentry, Robinan, additional, Gill, Duane A., additional, Glaberman, Scott, additional, Greene, Tracy, additional, Gupta, Ramesh C., additional, Hester, Kirstin, additional, Houzé, Pascal, additional, Hughes, Michael F., additional, Kanthasamy, Anumantha, additional, Karanth, S., additional, Kim, Hyung Sik, additional, Klaunig, James E., additional, Koehler, Gerwald, additional, Lee, Richard S., additional, Liu, Jing, additional, Liu, Lin, additional, Llorens, Jordi, additional, Lucas, Edralin A., additional, Luckett-Chastain, Lerin, additional, Luo, Jie, additional, Machado, Marina Lopes, additional, Martyniuk, Christopher J., additional, Maxwell, Lara, additional, Minghetti, Matteo, additional, Mix, Tamara L., additional, Olivier, K., additional, Padilla, Stephanie, additional, Pope, Carey N., additional, Pouyatos, Benoît, additional, Pulczinski, Jairus, additional, Ramaiah, Shashi K, additional, Ramsey, Joshua D., additional, Richardson, Rudy J., additional, Rokad, Dharmin, additional, Roper, Courtney, additional, Schlenk, Daniel, additional, Scott, Justin, additional, Shafer, Timothy J., additional, Smith, Brenda J., additional, Soares, Félix Alexandre Antunes, additional, Sutherland, Vicki, additional, Tanguay, Robyn Leigh, additional, Varner, Kurt J., additional, Wagner, Jarrad R., additional, Wallace, David R., additional, Warheit, D.B., additional, Wexler, Philip, additional, Yucesoy, Berran, additional, and Zamberlan, Daniele Coradini, additional

Published
2020
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22. Contributors

Author

Anadón, Arturo, primary, Anantharam, Vellareddy, additional, Archibong, Anthony E., additional, Ares, Irma, additional, Aulbach, Adam D., additional, Awasthee, Nikee, additional, Banerjee, Aryamitra, additional, Banks, Leah D., additional, Barile, Frank A., additional, Beedanagari, Sudheer R., additional, Belantis, Charalampos, additional, Bergamaschi, Enrico, additional, Bhandari, Sadikshya, additional, Bhatia, Sneha P., additional, Bischoff, Karyn, additional, Borts, David J., additional, Brehm, Emily, additional, Chandra Gupta, Subash, additional, Chatterjee, Saurabh, additional, Chiang, Catheryne, additional, Chintalapati, Anirudh J., additional, Cohn, P., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Damodaran, Tirupapuliyur V., additional, D'Souza, Clinton, additional, Dettbarn, Wolf-D., additional, Devlin, Amy A., additional, Doss, Robin B., additional, Dwivedi, Shiwangi, additional, Dziwenka, Margitta M., additional, Estévez, Jorge, additional, Fabricant, Daniel S., additional, Fan, A.M., additional, Fitsanakis, Vanessa A., additional, Flaskos, John, additional, Flaws, Jodi A., additional, Flora, Swaran J.S., additional, Ford, Sue M., additional, Fortin, Jessica S., additional, Fragou, Domniki, additional, Gad, Shayne C., additional, Galateanu, Bianca, additional, Gardner, Dale R., additional, Georgiadis, George, additional, Gil, Fernando, additional, Goel, Saryu, additional, Gulumian, Mary, additional, Gupta, P.K., additional, Gupta, Ramesh C., additional, Gupta, Rekha K., additional, Gwaltney-Brant, Sharon, additional, Hargreaves, Alan J., additional, Harris, Kelly L., additional, Harris, Kenneth J., additional, Hatfield, Holly E., additional, Hayes, Wallace A., additional, Heretis, Ioannis, additional, Hernández, Antonio F., additional, Hilmas, Corey J., additional, Hood, Darryl B., additional, Huuskonen, Pasi, additional, Jacobson, Stewart B., additional, James-Yi, Sandra A., additional, Jin, Huajun, additional, Kanno, Jun, additional, Kanthasamy, Arthi, additional, Kanthasamy, Anumantha G., additional, Kaore, Shilpa N., additional, Kaore, Navinchandra M., additional, Kaphalia, Bhupendra S., additional, Karttunen, Vesa, additional, Kaur, Gurjot, additional, Kaur, Ravneet, additional, Kodavanti, Prasada Rao S., additional, Kodavanti, Urmila P., additional, Kontadakis, George A., additional, Krishna, Gopala, additional, Krishna, Priya A., additional, Krishna, Kavya A., additional, Kummu, Maria, additional, Kymionis, George D., additional, Lall, Rajiv, additional, Lin, P., additional, Loganathan, Bommanna G., additional, Loikkanen, Jarkko, additional, Lotti, Marcello, additional, Lynes, Michael A., additional, Mahadevan, Brinda, additional, Malik, Jitendra K., additional, Mamoulakis, Charalampos, additional, Mantey, Jane A., additional, Martínez-Larrañaga, María Rosa, additional, Martínez, María Aránzazu, additional, Mavridis, Charalampos, additional, McClellan, Roger O., additional, Meador, Vincent P., additional, Mikkelsen, Lars Friis, additional, Milatovic, Dejan, additional, Miller Mukherjee, Ida R., additional, Mukherjee, Anupama, additional, Multani, Pushpinder Kaur, additional, Myllynen, Päivi, additional, Myöhänen, Kirsi, additional, Negga, Rekek, additional, Negrei, Carolina, additional, Novilla, Meliton N., additional, Padilla, Stephanie, additional, Palmeira, Carlos M., additional, Panter, Kip E., additional, Pasanen, Markku, additional, Patrick, Daniel J., additional, Pavanello, Sofia, additional, Pedersen, Henrik Duelund, additional, Pelkonen, Olavi, additional, Pellizzon, Michael A., additional, Pitt, Jason, additional, Plaka, Argyro, additional, Ramesh, Aramandla, additional, Rattan, Saniya, additional, Repo, Jenni, additional, Ricci, Matthew R., additional, Rolo, Anabela P., additional, Sachana, Magdalini, additional, Sahlman, Heidi, additional, Saini, Nitin, additional, Saini, Vandana, additional, Savolainen, Kai, additional, Seth, Ratanesh Kumar, additional, Sharma, Abha, additional, Sharma, Anurag, additional, Sieppi, Elina, additional, Silva, Rui, additional, Sinha, Anita, additional, Skamagkas, Iordanis, additional, Snow, Samantha J., additional, Sogorb, Miguel A., additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Storvik, Markus, additional, Szabo, David T., additional, Teodoro, João S., additional, Tsatsakis, Aristidis M., additional, Tsiaoussis, John, additional, Vähäkangas, Kirsi, additional, Verma, Sumit Singh, additional, Vilanova, Eugenio, additional, Vulimiri, Suryanarayana V., additional, Warner, Genoa R., additional, Welch, Kevin D., additional, Wilson-Frank, Christina, additional, You, S.H., additional, Zaja-Milatovic, Snjezana, additional, Zisis, Ioannis E., additional, and Zoltani, Csaba K., additional

Published
2019
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27. Palatability Can Drive Feeding Independent of AgRP Neurons

Author

Denis, Raphaël G.P., Joly-Amado, Aurélie, Webber, Emily, Langlet, Fanny, Schaeffer, Marie, Padilla, Stéphanie L., Cansell, Céline, Dehouck, Bénédicte, Castel, Julien, Delbès, Anne-Sophie, Martinez, Sarah, Lacombe, Amélie, Rouch, Claude, Kassis, Nadim, Fehrentz, Jean-Alain, Martinez, Jean, Verdié, Pascal, Hnasko, Thomas S., Palmiter, Richard D., Krashes, Michael J., Güler, Ali D., Magnan, Christophe, and Luquet, Serge

Published
2015
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28. Be Wary of the Edge: Well Position Influences Larval Zebrafish Behavior

Author

Hill, Bridgett, Hunter, Deborah, Jarema, Kimberly, Olin, Jeanene, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the Society of Toxicology 62nd Annual Meeting and ToxExpo March 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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29. Identifying Negative Control Chemicals for Use in Larval Zebrafish Behavior Assays (INA 2023)

Author

Knapp, Bridget, Hill, Bridgett, Hunter, Deborah, Lowery, Morgan, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the International Neurotoxicology Association (INA) Meeting symposium May 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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30. Development of a novel approach using the microelectrode array to measure neural activity and network function in larval zebrafish

Author

Keever, Jackson, Carpenter, Amy, Hedge, Joan, Padilla, Stephanie, Shafer, Timothy, and Martin, Melissa

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the Society of Toxicology 62nd Annual Meeting and ToxExpo March 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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31. Zebrafish Biology and Suitability for Developmental Hazard Screening

Author

Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the Developmental and Reproductive Toxicant Identification Committee (DARTIC) Meeting October 2022 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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32. Inconsistencies in Variable Reporting and Methods in Larval Zebrafish Behavioral Assays (INA 2023)

Author

Hill, Bridgett, Britton, Katy, Hunter, Deborah, Olin, Jeanene, Lowery, Morgan, Hedge, Joan, Knapp, Bridget, Jarema, Kimberly, Rowson, Zachary, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the International Neurotoxicology Association (INA) Meeting symposium May 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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33. Identifying Negative Control Chemicals for use in Larval Zebrafish Behavior Assays

Author

Knapp, Bridget, Hill, Bridgett, Hunter, Deborah, Lowery, Morgan, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the Carolinas Society of Environmental Toxicology & Chemistry (SETAC) Meeting April 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2023
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35. An expert-driven literature review of “negative” chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation

Author

Martin, Melissa M., primary, Baker, Nancy C., additional, Boyes, William K., additional, Carstens, Kelly E., additional, Culbreth, Megan E., additional, Gilbert, Mary E., additional, Harrill, Joshua A., additional, Nyffeler, Johanna, additional, Padilla, Stephanie, additional, Friedman, Katie Paul, additional, and Shafer, Timothy J., additional

Published
2022
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38. List of Contributors

Author

Aggarwal, Manoj, primary, Agrawal, Shruti, additional, Anadón, Arturo, additional, Anger, Gregory J., additional, Archibong, Anthony E., additional, Ares, Irma, additional, Aschner, Michael, additional, Avila, Daiana S., additional, Bailey, Denise C., additional, Baker, Nancy C., additional, Barlow, Norman J., additional, Beedanagari, Sudheer, additional, Bischoff, Karyn, additional, Bracken, William M., additional, Brehm, Emily, additional, Breyer, Richard M., additional, Bright-Ponte, Susan, additional, Campagnolo, Luisa, additional, Carney, Edward W., additional, Castellano, Victor, additional, Chebekoue, Sandrine Fleur, additional, Chiang, Catheryne, additional, Chou, Wei-Chun, additional, Choudhuri, Supratim, additional, Cleal, Jane K., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Curras-Collazo, Margarita, additional, da Rocha, João Batista Teixeira, additional, Da Silva, Rosane S., additional, Davis, T. Zane, additional, Doss, Robin B., additional, Dziwenka, Margitta M., additional, Enright, Brian, additional, Eriksson, Per, additional, Estevan, Carmen, additional, Evans, Timothy J., additional, Fadeel, Bengt, additional, Fan, Anna M., additional, Faqi, Ali S., additional, Farina, Marcelo, additional, Fenton, Suzanne E., additional, Feuston, Maureen H., additional, Filazi, Ayhan, additional, Fitsanakis, Vanessa A., additional, Flaskos, John, additional, Flaws, Jodi A., additional, Flora, Swaran J.S., additional, Ganjam, Vekataseshu K., additional, Gardner, Dale R., additional, Gardner, Nicole M., additional, Garg, Ramesh C., additional, Garry, Vincent F., additional, Gelineau-van Waes, Janee, additional, Godfrey, Keith M., additional, Guerri, Consuelo, additional, Guizzetti, Marina, additional, Gulati, Kavita, additional, Gulumian, Mary, additional, Gupta, Pawan K., additional, Gupta, Ramesh C., additional, Gupta, Rekha K., additional, Gwaltney-Brant, Sharon M., additional, Hall, Jeffrey O., additional, Hansen, Deborah K., additional, Hargreaves, Alan J., additional, Harris, Kenneth J., additional, Hoberman, Alan M., additional, Hougaard, Karin S., additional, Ince, Sinan, additional, Inselman, Amy L., additional, Iyer, Poorni, additional, Jacobsen, Nicklas R., additional, Kagan, Valerian E., additional, Kalpana, Starling, additional, Kaneko, Kotaro, additional, Kanthasamy, Anumantha, additional, Kanthasamy, Arthi, additional, Karttunen, Vesa, additional, Kim, Hyung Sik, additional, Knudsen, Thomas B., additional, Kodavanti, Prasada Rao S., additional, Krishnan, Kannan, additional, Kulkarni, Shaila, additional, Lall, Rajiv, additional, Lasher, Michelle A., additional, Laudert, Scott B., additional, Lee, Byung-Mu, additional, Legradi, Jessica, additional, Leung, Maxwell C.K., additional, Lewis, Elise M., additional, Lewis, Rohan M., additional, Li, Xin, additional, Lin, Pinpin, additional, Loganathan, Bommanna G., additional, Lyche, Jan Ludvig, additional, MacPhail, Robert C., additional, Mahadevan, Brinda, additional, Malik, Jitendra K., additional, Marreilha dos Santos, Ana Paula, additional, Martínez, Maria Aranzazu, additional, Martínez-Larrañaga, Maria Rosa, additional, McClary, David, additional, Menezes, Fabiano P., additional, Meyer, Jerrold S., additional, Milatovic, Dejan, additional, Miller Mukherjee, Ida R., additional, Mohammed, Ali Mustafa, additional, Møller, Peter, additional, Montine, Thomas J., additional, Ni, Mingwei, additional, Nikolaidis, Efstathios, additional, Novilla, Meliton N., additional, Padilla, Stephanie, additional, Palmeira, Carlos M., additional, Pamies, David, additional, Panter, Kip E., additional, Pascual, María, additional, Pellacani, Claudia, additional, Piper, Brian J., additional, Piquette-Miller, Micheline, additional, Popov, Vadim B., additional, Pratt, M. Margaret, additional, Protasova, Galina A., additional, Rai, Nishant, additional, Ramalho-Santos, João, additional, Ramesh, Aramandla, additional, Ray, Arunabha, additional, Ray, Kausik, additional, Ren, Aiguo, additional, Renaud, Stephen J., additional, Riley, Ronald T., additional, Roberts, Drucilla J., additional, Rongzhu, Lu, additional, Sachana, Magdalini, additional, Savolainen, Kai M., additional, Shabasheva, Lilia V., additional, Shiverick, Kathleen T., additional, Sikka, Suresh C., additional, Sogorb, Miguel A., additional, Soldin, Offie P., additional, Song, Chunjuan, additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Stoker, Tammy E., additional, Toor, Jaideep S., additional, Tornesi, Belen, additional, Truran, Peter, additional, Vähäkangas, Kirsi, additional, Valdez, Joseph, additional, Vargesson, Neil, additional, Viberg, Henrik, additional, Vilanova, Eugenio, additional, Voss, Kenneth A., additional, Vulimiri, Suryanarayana V., additional, Welch, Kevin D., additional, Williams, Daniel C., additional, Woldemeskel, Moges, additional, Yang, Jae-Ho, additional, Yin, Zhaobao, additional, Ying, Xiaoyou, additional, Yurdakok-Dikmen, Begum, additional, Zaja-Milatovic, Snjezana, additional, and Zhou, Changqing, additional

Published
2017
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39. Using zebrafish to assess developmental neurotoxicity

Author

Padilla, Stephanie, Hill, Bridgett N., Legradi, Jessica, Klüver, Nils, Gupta, Ramesh, Gupta, Ramesh, E&H: Environmental Health and Toxicology, and AIMMS

Subjects
Neurotoxicity, Screening, Alternative model, Developmental, Ecotoxicity, Zebrafish
Abstract

It is widely accepted that the developing nervous system is especially vulnerable to a variety of chemicals, including drugs and environmental contaminants; however our understanding of the risks from chemical exposures during development is rudimentary. Zebrafish have become a popular test species in toxicology, pharmacology, and biomedical research. This chapter was written as an introduction to the use of zebrafish in developmental neurotoxicology, and to encourage the use of this model either for human or ecological risk characterizations. We have endeavored to make the reader aware of significant research findings, and to offer a balanced view of the advantages and limitations in using zebrafish as a model for investigating developmental neurotoxicity.

Published
2022

43. Implementation of Zebrafish Ontologies for Toxicology Screening

Author

Thessen, Anne E., primary, Marvel, Skylar, additional, Achenbach, J. C., additional, Fischer, Stephan, additional, Haendel, Melissa A., additional, Hayward, Kimberly, additional, Klüver, Nils, additional, Könemann, Sarah, additional, Legradi, Jessica, additional, Lein, Pamela, additional, Leong, Connor, additional, Mylroie, J. Erik, additional, Padilla, Stephanie, additional, Perone, Dante, additional, Planchart, Antonio, additional, Prieto, Rafael Miñana, additional, Muriana, Arantza, additional, Quevedo, Celia, additional, Reif, David, additional, Ryan, Kristen, additional, Stinckens, Evelyn, additional, Truong, Lisa, additional, Vergauwen, Lucia, additional, Vom Berg, Colette, additional, Wilbanks, Mitch, additional, Yaghoobi, Bianca, additional, and Hamm, Jon, additional

Published
2022
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44. Evaluating the bioactivity of the ubiquitous tire preservative 6PPD and its quinone transformation product

Author

Villeneuve, Dan, Shafer, Timothy, Padilla, Stephanie, Harrill, Joshua, and Jankowski, Mark

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the National EPA Tribal Science Council, Fall 2022 Face-to-Face Meeting December 2022 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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45. Light Intensity Selected for Larval Zebrafish Behavioral Assay May Influence Ability to Detect Chemically Mediated Effects

Author

Hill, Bridgett, Hunter, Deborah, Jarema, Kimberly, Rowson, Zachary, Knapp, Bridget, Olin, Jeanene, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Poster presented to the Society of Environmental Toxicology and Chemistry SETAC North America 43rd Annual Meeting November 2022 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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46. Lack of methodological consistency impedes interpretation of developmental neurotoxicity larval zebrafish behavioral assays

Author

Hill, Bridgett, Britton, Katy, Hunter, Deborah, Olin, Jeanene, Lowery, Morgan, and Padilla, Stephanie

Subjects
Toxicology
Abstract

Presentation to the European Society of Environmental Toxicology andChemistry (Virtual meeting)(May 2021)Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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47. An inter-laboratory case study to determine the added value of the Zebrafish Light-dark transition test to predict developmental neurotoxicity: Report from OECD DNT Expert Group

Author

Hessel, Ellen, Shafer, Timothy, Padilla, Stephanie, Hill, Bridgett, Truong, Lisa, Tanguay, Robyn L., Hsieh, Jui-Hua, Ryan, Kristen, Behl, Mamta, Ellis, Lee, Schiavone, Valentina, Rubbini, Davide, Terriente, Javier, Alzualde, Ainhoa, Muriana, Arantza, Legradi, Jessica, Woodland, Cindy, Sachana, Magdalini, Price, Anna, and Klüver, Nils

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the Society of Toxicology 2021 Virtual Annual Meeting March 2021 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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48. Protocol light level effects on larval zebrafish behavior and the ability to detect chemical differences

Author

Hill, Bridgett, Hunter, Deborah, Jarema, Kimberly, Rowson, Zachary, Knapp, Bridget, Olin, Jeanene, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the North Carolina Society of Toxicology Meeting October 2022 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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49. An Inter-laboratory Case Study to Harmonize Zebrafish Light-Dark Transition Test to Predict Developmental Neurotoxicity (WC11)

Author

Muriana, Arantza, Alzualde, Ainhoa, Hsieh, Jui-Hua, Ryan, Kristen, Behl, Mamta, Terron, Andrea, Woodland, Cindy, Kl��ver, Nils, Hessel, Ellen, Ellis, Lee, Truong, Lisa, Tanguay, Robyn L., Sachana, Magdalini, Hill, Bridgett, Padilla, Stephanie, Shafer, Timothy, Legradi, Jessica, Schiavone, Valentina, Rubbini, Davide, Di Donato, Vincenzo, and Terriente, Javier

Subjects
Toxicology
Abstract

Presentation to the 11th World Congress on Alternative and Animal Use in the Life Sciences August 2021Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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50. Application of ToxCast Curve-Fitting Software to Zebrafish Larval Locomotor Response Dat

Author

Rowson, Zachary, Setzer, Woodrow, Paul-Friedman, Katie, Judson, Richard, and Padilla, Stephanie

Subjects
Toxicology (incl. clinical toxicology)
Abstract

Presentation to the DNT Journal Club April 2022. Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2022
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