Search

The radiosensitization potential of focused ultrasound (FUS)-induced mild hyperthermia was assessed in an allogenic subcutaneous C6 glioma tumor model in rats. Mild hyperthermia at 42 °C was induced in tumors using a single-element 350 kHz FUS transducer. Radiation was delivered with a small animal radiation research platform using a single-beam irradiation technique. The combined treatment involved 20 min of FUS hyperthermia immediately before radiation. Tumor growth changes were observed one week post-treatment. A radiation dose of 2 Gy alone showed limited tumor control (30% reduction). However, when combined with FUS hyperthermia, there was a significant reduction in tumor growth compared to other treatments (tumor volumes: control—1174 ± 554 mm3, FUS-HT—1483 ± 702 mm3, 2 Gy—609 ± 300 mm3, FUS-HT + 2 Gy—259 ± 186 mm3; ANOVA p < 0.00001). Immunohistological analysis suggested increased DNA damage as a short-term mechanism for tumor control in the combined treatment. In conclusion, FUS-induced mild hyperthermia can enhance the effectiveness of radiation in a glioma tumor model, potentially improving the outcome of standard radiation treatments for better tumor control. [ABSTRACT FROM AUTHOR]

The sensitivity of broadband ultrasonic attenuation (BUA) and speed of sound (SOS) to variations of bone strength is examined. Findings reveal the detection of a difference of 10 percent in bone strength due to bone volume fraction (BV/TV).

The application of a model-based estimation method to quantitative ultrasound (QUS) transmission measurements is discussed. Results suggest the detection of different wave types and its characterization in the trochanteric region.

A device for quantitative ultrasound (QUS) measurements at the proximal femur in vivo is presented. Findings reveal a good signal to noise ratio and proper depiction of the proximal femur on an attenuation image.

Ultrasonic velocity measured in bone provides a good assessment of osteoporotic fracture risk, however, a lack of standardization of signal processing techniques used to compute the speed of sound (SOS) complicates the comparison between data obtained with different commercial devices. 38 intact femurs are tested using a through-transmission technique and SOS determined using different techniques.

Research is presented concerning the measurement of the acoustic velocity of liquids through the use of a plate-liquid-plate acoustic resonator. The experimental results are compared with theoretical ones.

Abbreviations COVID-19 coronavirus disease 2019 CT computed tomography LIPUS low-intensity pulsed ultrasound SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 US ultrasound Since the outbreak of the new coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) infection, lung ultrasound (US) has become a relevant tool in the point-of-care evaluation and monitoring of pulmonary alterations induced by SARS-CoV-2 infection at the bedside. Can Low-Intensity Pulsed Ultrasound Treat Discrete Pulmonary Lesions in Patients With COVID-19? We suggest in this commentary that US could also be effective to reduce lung inflammation and fibrosis in moderate-to-severe coronavirus disease 2019 (COVID-19)-related pneumonia. Coronavirus disease-related pulmonary lesions, consisting of edematous tissue and fluid-filled cavities, usually in the peripheral lung areas, are visible with US imaging and are potentially amenable to treatment with therapeutic US. [Extracted from the article]