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Your search keyword '"Padberg, Jan-Sören"' showing total 9 results
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9 results on '"Padberg, Jan-Sören"'

3. Complications and Outcomes in 39,864 Patients Receiving Standard Care Plus Mechanical Circulatory Support or Standard Care Alone for Infarct-Associated Cardiogenic Shock

Author

Padberg, Jan-Sören, primary, Feld, Jannik, additional, Padberg, Leonie, additional, Köppe, Jeanette, additional, Makowski, Lena, additional, Gerß, Joachim, additional, Dröge, Patrik, additional, Ruhnke, Thomas, additional, Günster, Christian, additional, Lange, Stefan Andreas, additional, and Reinecke, Holger, additional

Published
2024
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6. Damage of the endothelial glycocalyx in chronic kidney disease

Author

Padberg, Jan-Sören, primary, Wiesinger, Anne, additional, di Marco, Giovana Seno, additional, Reuter, Stefan, additional, Grabner, Alexander, additional, Kentrup, Dominik, additional, Lukasz, Alexander, additional, Oberleithner, Hans, additional, Pavenstädt, Hermann, additional, Brand, Marcus, additional, and Kümpers, Philipp, additional

Published
2014
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9. Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

Author

Padberg, Jan-Sören, Van Meurs, Matijs, Kielstein, Jan T, Martens-Lobenhoffer, Jens, Bode-Böger, Stefanie M, Zijlstra, Jan G, Kovesdy, Csaba P, Kümpers, Philipp, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Vascular Ageing Programme (VAP), and Groningen Kidney Center (GKC)

Subjects
Cognitive Neuroscience, Neuroscience (miscellaneous)
Abstract

UNLABELLED: BACKGROUND: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia. However, its relevance in human endotoxemia has not been investigated so far. We thus aimed to study changes in blood pressure in parallel with tryptophan and kynurenine levels during experimental endotoxemia in humans. FINDINGS: Six healthy male volunteers were given E. coli lipopolysaccharide (LPS; 4 ng/kg) as a 1-min intravenous infusion. They had levels of soluble E-Selectin and soluble vascular cell adhesion molecule-1 as well as IDO activity assessed as the kynurenine-to-tryptophan plasma ratio by liquid chromatography-tandem mass spectrometry at various time points during a 24 h time course. During endotoxemia, IDO activity significantly increased, reaching peak levels at 8 h after LPS infusion (44.0 ± 15.2 vs. 29.4 ± 6.8 at baseline, P

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