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13 results on '"Padakanti Sandeep Chary"'

1. Exploration of the Topical Nanoemulgel Bearing with Ferulic Acid and Essential Oil for Diabetic Wound Healing

Author

Urati Anuradha, Valamla Bhavana, Padakanti Sandeep Chary, Nitin Pal Kalia, and Neelesh Kumar Mehra

Subjects
antioxidant, anti-inflammatory, nanoemulgel, diabetic wound healing, ferulic acid, Physiology, QP1-981
Abstract

Aim: To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of the novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)]. Methods: Ferulic acid nanoemulsion developed with lemongrass oil is investigated in diabetic wound healing. Further nanoemulsion is incorporated into 1% carbopol® 934 to obtain the DLMGO-G. Nanoemulsion was characterized for particle size, and polydispersity index (PDI) was obtained by Malvern Zetasizer (Zetasizer Nano ZS, Malvern, AL, USA), and morphology by TEM (JEM 1400, JOEL, Akishima, Japan). Furthermore, in vitro cell line and in vivo studies were carried out. Results: The developed nanoemulsion showed a globule size of 28.04 ± 0.23 nm and PDI of 0.07 ± 0.01. The morphology of nanoformulations by TEM confirmed the spherical and uniform nature. Further, the nanoformulation in in vitro cell line experiments revealed that the IC50 value was increased by 1.52 times compared to the drug solution. The treatment groups have shown that fibroblast morphologies were spindle-shaped, suggesting that nanoformulation was compatible with the cells and developed normally on nanoformulation. It also reduced ROS with improved internalization more than the control group. The in vitro wound healing model also revealed that nanoformulation had better wound healing activity. In the in vivo diabetic wound studies on male SD rats, the levels of inflammatory markers such as TNF-α, IL-6, IL-22, and IL-1β declined significantly when treated with DLMGO-G. IL-10 levels significantly increased compared to the diseased group, and MMP-9 levels were remarkably decreased compared to the diseased group. Furthermore, histopathological studies showed the regeneration and granulation of tissues. Conclusions: Thus, these findings indicate that FA-loaded nanoemulgel greatly accelerates the healing of wounds in diabetic rats.

Published
2024
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3. Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis

Author

Safiya Sulthana, Padakanti Sandeep Chary, Valamla Bhavana, Ekta Pardhi, Shashi Bala Singh, and Neelesh Kumar Mehra

Subjects
Pharmacology, Immunology, Pharmacology (medical)
Abstract

Our main aim is in the present investigation, development and evaluation of seabuckthorn oil-based Emulgel formulation for psoriasis therapy. Anti-psoriatic activity of the SeaEmulgel was studied using Imiquimod-induced psoriasis-like inflammation model Balb/c mice and parameters such as PASI score, ear thickness, spleen to body weight index including histological staining studies, enzyme-linked immune sorbent assay (ELISA), skin compliance and safety evaluation of sea buckthorn oil was performed. The globule size and PDI of sea buckthorn oil emulsion were found to be 172.70 ± 1.73 nm and 0.117 ± 0.018, respectively. In-vivo animal studies performed on male Balb/c mice and emulgel showed a reduction in redness, scaling, inflammation in psoriasis-induced mice, which was analysed by PASI scoring, body weight, spleen weight index and ear thickness. The current investigation clearly revealed the better anti-psoriatic activity of SeaEmulgel formulation against imiquimod-induced psoriasis-like skin inflammation Balb/c mice model.

Published
2022

4. Multifunctional hybrid nanoparticles in diagnosis and therapy of breast cancer

Author

Naveen Rajana, Aare Mounika, Padakanti Sandeep Chary, Valamla Bhavana, Anuradha Urati, Dharmendra Khatri, Shashi Bala Singh, and Neelesh Kumar Mehra

Subjects
Drug Carriers, Polymers, Pharmaceutical Science, Humans, Nanoparticles, Nanotechnology, Metal Nanoparticles, Female, Breast Neoplasms
Abstract

Breast cancer is the most prevalent non-cutaneous malignancy in women, with greater than a million new cases every year. In the last decennium, numerous diagnostic and treatment approaches have been enormously studied for Breast cancer. Among the different approaches, nanotechnology has appeared as a promising approach in preclinical and clinical studies for early diagnosis of primary tumors and metastases and eradicating tumor cells. Each of these nanocarriers has its particular advantages and drawbacks. Combining two or more than two constituents in a single nanocarrier system leads to the generation of novel multifunctional Hybrid Nanocarriers with improved structural and biological properties. These novel Hybrid Nanocarriers have the capability to overcome the drawbacks of individual constituents while having the advantages of those components. Various hybrid nanocarriers such as lipid polymer hybrid nanoparticles, inorganic hybrid nanoparticles, metal-organic hybrid nanoparticles, and hybrid carbon nanocarriers are utilized for the diagnosis and treatment of various cancers. Certainly, Hybrid Nanocarriers have the capability to encapsulate multiple cargos, targeting agents, enhancement in encapsulation, stability, circulation time, and structural disintegration compared to non-hybrid nanocarriers. Many studies have been conducted to investigate the utilization of Hybrid nanocarriers in breast cancer for imaging platforms, photothermal and photodynamic therapy, chemotherapy, gene therapy, and combinational therapy. In this review, we mainly discussed in detailed about of preparation techniques and toxicological considerations of hybrid nanoparticles. This review also discussed the role of hybrid nanocarriers as a diagnostic and therapeutic agent for the treatment of breast cancer along with alternative treatment approaches apart from chemotherapy including photothermal and photodynamic therapy, gene therapy, and combinational therapy.

Published
2022

8. Nanotechnology

Author

Padakanti Sandeep Chary, Naveen Rajana, Valamla Bhavana, Pankaj Kumar Singh, Saurabh Srivastava, Jitender Madan, Shashi Bala Singh, and Neelesh Kumar Mehra

Published
2022
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9. Contributors

Author

Aashruti Agrawal, Farhan Jalees Ahmad, Faria Ali, null Alka, Mohd. Aqil, M. Arockia Babu, Venkatesh Teja Banala, Sarwar Beg, Aditi Bhat, Valamla Bhavana, Padakanti Sandeep Chary, Vikas Chaudhary, Akash Chaurasiya, Manish K. Chourasia, Harshita Dalvi, Yige Fu, Amruta Gorajiya, Mimansa Goyal, Monica Gulati, Vivek Gupta, Harsha Jain, Dhara Jain, Nitin Jain, Isha Joshi, Kiran Jyoti, Manpreet Kaur, Ayesha Khan, Dharmendra Kumar Khatri, Parveen Kumar, Preeti Kush, Praveen Lakhera, Jitender Madan, Srushti Mahajan, Indrani Maji, Priyanka Maurya, Neelesh Kumar Mehra, Charu Misra, Keerti Mishra, Nidhi Mishra, Dhrubojyoti Mukherjee, Jatinder Kaur Mukker, Jayabalan Nirmal, Raquibun Nisha, Ravi Raj Pal, Vineela Parvathaneni, Ketan Patel, Manali Patki, Rakesh Kumar Paul, Purva Pingle, Ravi Shankar Prasad Singh, Abdul Qadir, Naveen Rajana, Manoj Rawat, Kaisar Raza, Vaskuri G.S. Sainaga Jyothi, Shubhini A. Saraf, Aishwarya Saraswat, Satish Sardana, Deep Shikha Sharma, null Shubhra, Snehal K. Shukla, Neelu Singh, Pankaj Kumar Singh, Priya Singh, Sachin Kumar Singh, Samipta Singh, Shashi Bala Singh, Yuvraj Singh, Rupinder Kaur Sodhi, Veerabomma Haritha Sree, Anitha Sriram, Saurabh Srivastava, Amrendra K. Tiwari, Richa Vartak, Sheetu Wadhwa, Xuechun Wang, Pavan K. Yadav, and Sobiya Zafar

Published
2022
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11. List of contributors

Author

Valamla Bhavana, Erem Bilensoy, Padakanti Sandeep Chary, Bhushan P. Chaudhari, Balak Das Kurmi, Vividha Dhapte, Nazlı Erdoğar, A. Fernandez-Carballido, A.I. Fraguas-Sanchez, Bharti Gajbe, Kavita R. Gajbhiye, Virendra Gajbhiye, Laxmikant Gautam, Pengbo Guo, Umesh Gupta, Tanweer Haider, Priyanka Jain, Rupshee Jain, Vikas Jain, Neha Jaiswal, Nan Ji, Indu Lata Kanwar, Rameshroo Kenwat, Hitesh Kumar, Vinay Kumar, Gopal C. Kundu, Ipsita G. Kundu, Akanksha Malaiya, C. Martin-Sabroso, Farhan Mazahir, Abhishesh Kumar Mehata, Neelesh Kumar Mehra, Barnalee Mishra, Vijay Mishra, Yachana Mishra, Aliesha Moudgil, Madaswamy S. Muthu, Rishi Paliwal, Shivani Rai Paliwal, Vikas Pandey, Anil T. Pawar, N.N.V. Radharani, Naveen Rajana, Sarita Rani, Rakesh Kumar Sahoo, Priya Shrivastava, Mansha Singhai, Viswas Raja Solomon, Vandana Soni, Murtaza M. Tambuwala, Chalet Tan, A.I. Torres-Suarez, Shourya Tripathi, Cem Varan, Gamze Varan, Sanjana Varma, Matte Kasi Viswanadh, S.P. Vyas, Wucheng Wen, Ho Lun Wong, Hui Yi Xue, Amit Singh Yadav, and Awesh K. Yadav

Published
2022
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12. Contributors

Author

Javed Ahmad, Mohammad Zaki Ahmad, Faraat Ali, Nabil K. Alruwaili, Sultan Alshehri, Archana Bagre, Valamla Bhavana, Padakanti Sandeep Chary, Shashank Chaturvedi, Shivani Chauhan, Akash Chaurasiya, Anuj Garg, Urvashee Gogoi, Anamika Sahu Gulbake, Syed Sarim Imam, Keerti Jain, Archita Jha, Hae-Won Kim, Pramod Kumar, Amal G. Kurian, Thiagarajan Madheswaran, Neelesh Kumar Mehra, Awanish Mishra, Nidhi Mishra, Pragya Shakti Mishra, Abdul Aleem Mohammed, Saba Naqvi, Puja Nayak, Rishi Paliwal, Shivani Rai Paliwal, Kanan Panchal, Jithendra Panneerselvam, Poonam Parashar, Nilosha Parveen, Anup K. Patel, Kapil D. Patel, Parth R. Patel, Kalyani Pathak, Yashwant Pathak, Naveen Rajana, Suraj Singh S. Rathod, Riya Saikia, Ravi Sheshala, Neelu Singh, Rajendra K. Singh, Shashi Bala Singh, Raghu Raj Singh Thakur, Ankita Tiwari, Lalitkumar Vora, and Ameeduzzafar Zafar

Published
2022
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