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4. Chronic lymphocytic leukaemia.

Author

Stevenson, Freda, Wu, Catherine, Croce, Carlo, Packham, Graham, Wierda, William, Gribben, John, Rai, Kanti, OBrien, Susan, and Kipps, Thomas

Subjects
Humans, Leukemia, Lymphocytic, Chronic, B-Cell
Abstract

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and lymphoid tissues. Signalling via surface immunoglobulin, which constitutes the major part of the B cell receptor, and several genetic alterations play a part in CLL pathogenesis, in addition to interactions between CLL cells and other cell types, such as stromal cells, T cells and nurse-like cells in the lymph nodes. The clinical progression of CLL is heterogeneous and ranges from patients who require treatment soon after diagnosis to others who do not require therapy for many years, if at all. Several factors, including the immunoglobulin heavy-chain variable region gene (IGHV) mutational status, genomic changes, patient age and the presence of comorbidities, should be considered when defining the optimal management strategies, which include chemotherapy, chemoimmunotherapy and/or drugs targeting B cell receptor signalling or inhibitors of apoptosis, such as BCL-2. Research on the biology of CLL has profoundly enhanced our ability to identify patients who are at higher risk for disease progression and our capacity to treat patients with drugs that selectively target distinctive phenotypic or physiological features of CLL. How these and other advances have shaped our current understanding and treatment of patients with CLL is the subject of this Primer.

Published
2017

5. Chronic lymphocytic leukaemia

Author

Kipps, Thomas J, Stevenson, Freda K, Wu, Catherine J, Croce, Carlo M, Packham, Graham, Wierda, William G, O'Brien, Susan, Gribben, John, and Rai, Kanti

Subjects
Genetics, Hematology, Rare Diseases, Cancer, Lymphoma, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Clinical Sciences
Abstract

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and lymphoid tissues. Signalling via surface immunoglobulin, which constitutes the major part of the B cell receptor, and several genetic alterations play a part in CLL pathogenesis, in addition to interactions between CLL cells and other cell types, such as stromal cells, T cells and nurse-like cells in the lymph nodes. The clinical progression of CLL is heterogeneous and ranges from patients who require treatment soon after diagnosis to others who do not require therapy for many years, if at all. Several factors, including the immunoglobulin heavy-chain variable region gene (IGHV) mutational status, genomic changes, patient age and the presence of comorbidities, should be considered when defining the optimal management strategies, which include chemotherapy, chemoimmunotherapy and/or drugs targeting B cell receptor signalling or inhibitors of apoptosis, such as BCL-2. Research on the biology of CLL has profoundly enhanced our ability to identify patients who are at higher risk for disease progression and our capacity to treat patients with drugs that selectively target distinctive phenotypic or physiological features of CLL. How these and other advances have shaped our current understanding and treatment of patients with CLL is the subject of this Primer.

Published
2017

10. BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

Author

Smith, Lindsay D., Minton, Annabel R., Blunt, Matthew D., Karydis, Laura I., Dutton, David A., Rogers-Broadway, Karly-Rai, Dobson, Rachel, Liu, Rena, Norster, Faith, Hogg, Elizabeth, Ashton-Key, Margaret, Strefford, Jonathan C., Jia, Li, Efremov, Dimitar G., Helgason, G. Vignir, Johnson, Peter W. M., Stevenson, Freda K., Forconi, Francesco, Cragg, Mark S., Tumbarello, David A., Packham, Graham, and Steele, Andrew J.

Published
2020
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13. Data from Isolation of a Novel Thioflavin S–Derived Compound That Inhibits BAG-1–Mediated Protein Interactions and Targets BRAF Inhibitor–Resistant Cell Lines

Author

Enthammer, Marion, primary, Papadakis, Emmanouil S., primary, Salomé Gachet, Maria, primary, Deutsch, Martin, primary, Schwaiger, Stefan, primary, Koziel, Katarzyna, primary, Ashraf, Muhammad Imtiaz, primary, Khalid, Sana, primary, Wolber, Gerhard, primary, Packham, Graham, primary, Cutress, Ramsey I., primary, Stuppner, Hermann, primary, and Troppmair, Jakob, primary

Published
2023
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17. Supplementary Methods, Tables 1 - 4, Figures 1 - 10 from Isolation of a Novel Thioflavin S–Derived Compound That Inhibits BAG-1–Mediated Protein Interactions and Targets BRAF Inhibitor–Resistant Cell Lines

Author

Enthammer, Marion, primary, Papadakis, Emmanouil S., primary, Salomé Gachet, Maria, primary, Deutsch, Martin, primary, Schwaiger, Stefan, primary, Koziel, Katarzyna, primary, Ashraf, Muhammad Imtiaz, primary, Khalid, Sana, primary, Wolber, Gerhard, primary, Packham, Graham, primary, Cutress, Ramsey I., primary, Stuppner, Hermann, primary, and Troppmair, Jakob, primary

Published
2023
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21. Supplementary methods and Figures from The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

Author

Blunt, Matthew D., primary, Koehrer, Stefan, primary, Dobson, Rachel C., primary, Larrayoz, Marta, primary, Wilmore, Sarah, primary, Hayman, Alice, primary, Parnell, Jack, primary, Smith, Lindsay D., primary, Davies, Andrew, primary, Johnson, Peter W.M., primary, Conley, Pamela B., primary, Pandey, Anjali, primary, Strefford, Jonathan C., primary, Stevenson, Freda K., primary, Packham, Graham, primary, Forconi, Francesco, primary, Coffey, Greg P., primary, Burger, Jan A., primary, and Steele, Andrew J., primary

Published
2023
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22. Supplementary Figures from Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity

Author

Peters, Tara L., primary, Tillotson, Joseph, primary, Yeomans, Alison M., primary, Wilmore, Sarah, primary, Lemm, Elizabeth, primary, Jiménez-Romero, Carlos, primary, Amador, Luis A., primary, Li, Lingxiao, primary, Amin, Amit D., primary, Pongtornpipat, Praechompoo, primary, Zerio, Christopher J., primary, Ambrose, Andrew J., primary, Paine-Murrieta, Gillian, primary, Greninger, Patricia, primary, Vega, Francisco, primary, Benes, Cyril H., primary, Packham, Graham, primary, Rodríguez, Abimael D., primary, Chapman, Eli, primary, and Schatz, Jonathan H., primary

Published
2023
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23. Supplementary Data from Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

Author

Lemm, Elizabeth A., primary, Valle-Argos, Beatriz, primary, Smith, Lindsay D., primary, Richter, Johanna, primary, Gebreselassie, Yohannes, primary, Carter, Matthew J., primary, Karolova, Jana, primary, Svaton, Michael, primary, Helman, Karel, primary, Weston-Bell, Nicola J., primary, Karydis, Laura, primary, Williamson, Chris T., primary, Lenz, Georg, primary, Pettigrew, Jeremy, primary, Harwig, Curtis, primary, Stevenson, Freda K., primary, Cragg, Mark, primary, Forconi, Francesco, primary, Steele, Andrew J., primary, Cross, Jennifer, primary, Mackenzie, Lloyd, primary, Klener, Pavel, primary, and Packham, Graham, primary

Published
2023
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24. CCR Translation on this Article from The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation

Author

Conti, John A., primary, Kendall, Timothy J., primary, Bateman, Adrian, primary, Armstrong, Thomas A., primary, Papa-Adams, Andrew, primary, Xu, Qian, primary, Packham, Graham, primary, Primrose, John N., primary, Benyon, R. Christopher, primary, and Iredale, John P., primary

Published
2023
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27. Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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28. Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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29. Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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30. Supplementary Figure Legends from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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31. Data from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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32. Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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33. Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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34. Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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35. Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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36. Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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37. Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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39. IL-4 enhances expression and function of surface IgM in CLL cells

Author

Aguilar-Hernandez, Maria M., Blunt, Matthew D., Dobson, Rachel, Yeomans, Alison, Thirdborough, Stephen, Larrayoz, Marta, Smith, Lindsay D., Linley, Adam, Strefford, Jonathan C., Davies, Andrew, Johnson, Peter M.W., Savelyeva, Natalia, Cragg, Mark S., Forconi, Francesco, Packham, Graham, Stevenson, Freda K., and Steele, Andrew J.

Published
2016
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43. The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

Author

Blunt, Matthew D., Carter, Matthew J., Larrayoz, Marta, Smith, Lindsay D., Aguilar-Hernandez, Maria, Cox, Kerry L., Tipton, Thomas, Reynolds, Mark, Murphy, Sarah, Lemm, Elizabeth, Dias, Samantha, Duncombe, Andrew, Strefford, Jonathan C., Johnson, Peter.W.M., Forconi, Francesco, Stevenson, Freda K., Packham, Graham, Cragg, Mark S., and Steele, Andrew J.

Published
2015
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45. MicroRNA, Disease and Therapy

Author

Sreekumar, Rahul, Bullock, Marc, Sayan, Emre, Packham, Graham, Mirnezami, Alex, Dubitzky, Werner, editor, Wolkenhauer, Olaf, editor, Cho, Kwang-Hyun, editor, and Yokota, Hiroki, editor

Published
2013
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