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4. PURPOSE AND PERSPECTIVE IN OPHTHALMOLOGY

Author

Packer, Mark

Subjects
Ophthalmology, Health
Abstract

Have you taken any time recently to remember why you decided to become an ophthalmologist and how that relates to what you do every day? Given the confusing world in [...]

Published
2024

5. Effectiveness and safety of a novel crosslinked hyaluronate canalicular gel occlusive device for dry eye.

Author

Packer, Mark, Lindstrom, Richard, Thompson, Vance, Parekh, Jai G., Gupta, Preeya, Nijm, Lisa M., and Donnenfeld, Eric

Abstract

Purpose: To evaluate the effectiveness and safety of a crosslinked hyaluronate (HA) canalicular filler (Lacrifill Canalicular Gel) compared with a commercially available hydrogel canalicular plug (Form Fit). Setting: 5 sites in the United States. Design: Prospective, multicenter, controlled, double-masked, randomized 2:1 (filler:plug). Methods: Adults (=22 years) with the Schirmer test (with anesthesia) =10 mm/5 minutes, presence of corneal staining, ocular surface disease index (OSDI) of =23 with =3 responses of "not applicable," patent lacrimal drainage system, and bilateral corrected distance visual acuity of 20/40 or better. Filler or plugs were instilled bilaterally in the inferior canaliculi. Primary effectiveness endpoint was noninferiority of the mean within subject change from baseline to month 3 in Schirmer score for patients receiving filler compared with plugs. The key secondary effectiveness endpoint was noninferiority of the proportion of patients with filler achieving improvement from baseline to month 3 in OSDI by a minimal clinically important difference. Additional endpoints included the mean change from baseline to 3 and 6 months in tear meniscus height, OSDI, corneal staining, tear breakup time, and safety. Results: 157 patients were randomized; 99 patients with crosslinked HA filler and 52 patients with hydrogel plugs completed the study. Filler was noninferior to plugs in the mean Schirmer score change from baseline and in the proportion of patients achieving a clinically important improvement in OSDI. Conclusions: Crosslinked HA filler is a safe, well-tolerated, and effective method to treat dry eye. Clinically and statistically significant improvements in signs and symptoms of dry eye were sustained through 6 months. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Wearable Technology With Head-Mounted Displays and Visual Function

Author

Ianchulev, Tsontcho, Minckler, Donald S, Hoskins, H Dunbar, Packer, Mark, Stamper, Robert, Pamnani, Ravinder D, and Koo, Edward Y

Subjects
Adult, Data Display, Equipment Design, Eyeglasses, Head, Humans, Internet, Male, Photography, Safety, Scotoma, Task Performance and Analysis, User-Computer Interface, Visual Fields, Medical and Health Sciences, General & Internal Medicine
Published
2014

19. The Staar Sonic Wave

Author

Hoffman, Richard S., Fine, I. Howard, Packer, Mark, Fine, I. Howard, editor, Packer, Mark, editor, and Hoffman, Richard. S., editor

Published
2005
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21. The Millennium

Author

Braga-Mele, Rosa, Devine, Terrence, Packer, Mark, Fine, I. Howard, editor, Packer, Mark, editor, and Hoffman, Richard. S., editor

Published
2005
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22. The Light-Adjustable Lens

Author

Hoffman, Richard S., Fine, I. Howard, Packer, Mark, Fine, I. Howard, editor, Packer, Mark, editor, and Hoffman, Richard. S., editor

Published
2005
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23. The Tecnis Multifocal IOL

Author

Packer, Mark, Fine, I. Howard, Hoffman, Richard S., Fine, I. Howard, editor, Packer, Mark, editor, and Hoffman, Richard. S., editor

Published
2005
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26. Evolution of Cataract Surgery

Author

Packer, Mark, Lindstrom, Richard L., Davis, Elizabeth A., Krueger, Ronald R., editor, Talamo, Jonathan H., editor, and Lindstrom, Richard L., editor

Published
2013
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35. Incisions

Author

Fine, I. Howard, Hoffman, Richard S., Packer, Mark, Alió, Jorge L., editor, and Fine, I. Howard, editor

Published
2010
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38. Pterygium

Author

Fine, I Howard, Hoffman, Richard S, Packer, Mark, Fine, I. Howard, editor, and Mojon, Daniel S., editor

Published
2010
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