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2. Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature

Author

Pacilli, Leonardo, Lo Coco, Francesco, Ramadan, Safaa Mahmoud, Giannì, Laura, Pingi, Alberto, Remotti, Daniele, and Majolino, Ignazio

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.

Published
2010
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4. Recombinant Interleukin-2 Treatment Before and After Autologous Stem Cell Transplantation in Hematologic Malignancies: Clinical and Immunologic Effects

Author

DE LAURENZI, ANTONIO, primary, IUDICONE, PAOLA, additional, ZOLI, VALERIO, additional, DE ROSA, LUCA, additional, GUGLIELMETTI, MARINA, additional, PESCAROLLO, ALESSANDRA, additional, PAPETTI, CLAUDIA, additional, PACILLI, LEONARDO, additional, LAPPONI, PAOLO, additional, PETTI, NICOLA, additional, and QUINTILIANI, LUCIA, additional

Published
1995
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8. Therapy of Acute Nonlymphocytic Leukemia in Children: A Review of 73 Patients 1

Author

Amadori, Sergio, Petti, Maria Concetta, Pacilli, Leonardo, Papa, Giuseppe, and Mandelli, Franco

Abstract

Since 1969, 73 children with acute nonlymphocytic leukemia have been admitted for evaluation and treatment at the Institute of Hematology of the University of Rome. Various drug regimens, basically including daunomycin and/or cytosine arabinoside, were employed both for induction and maintenance treatment. Overall, the incidence of complete remission was 63 %. The availability of intensive supportive measures starting in 1974 appears to be the most likely explanation for the higher response rate observed since then. Duration of remission and overall survival were disappointingly short owing to the high frequency of bone marrow relapse. Carefully controlled clinical studies will in the future be necessary to explore better methods of preventing leukemic relapse.

Published
1981
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