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3. Antiviral and Cytotoxic Activities of Ilex aquifolium Silver Queen in the Context of Chemical Profiling of Two Ilex Species.

Author

Pachura, Natalia, Włodarczyk, Maciej, Bażanów, Barbara, Pogorzelska, Aleksandra, Gębarowski, Tomasz, Kupczyński, Robert, and Szumny, Antoni

Subjects
*ANTIVIRAL agents, *CAFFEINE, *CANCER cell growth, *GASTROINTESTINAL cancer, *COMPOSITION of leaves, *URSOLIC acid, *SILVER
Abstract

The leaves of Ilex paraguariensis (known as Yerba mate), used as a popular beverage, are a very well-recognized plant material with various biological activities, including analeptic (because of caffeine), anti-obesity (phenolics, saponins), antimicrobial, and antiviral (phenolics, saponins). Here, the chemical compositions of the leaves of two European Ilex species (× meserveae and aquifolium) with three varieties each were investigated. The terpenoid, saponin, and polyphenolic fractions were submitted for LC-MS or GC-MS analysis against a standard Mate leaf. In addition, the aroma profiles of all the species were analysed using HS-SPME-Arrow prior to GC-MS analysis. All fractions were subjected to antiviral and cytotoxic assays. We found 86 compounds in all accessions, with limonene, linalool, and p-cymene being predominant. There were minor similarities between the volatile compositions of the European and South American species. We found ursolic and oleanolic acid to be the main compounds in the terpenoid fraction. Mono-caffeoylquinic acids and di-caffeoylquinic acids were the main constituents of the polar fractions. About 180 compounds from the saponin group were tentatively identified, of which 9 and 3 were selected as distinctive markers for I. meserveae and I. aquifolium, respectively. Based on chemical screening, I. aquifolium Silver Queen was chosen as the source of terpenoid and saponin fractions and polyphenol extracts. The most substantial inhibition of cancer cell growth was observed with saponin in the case of the MCF7 (human breast cancer) cell line, while for LoVo and L929 cell lines (human colorectal cancer and reference mouse fibroblasts), it was slightly weaker. These results should be analysed further as a promising chemoprevention of colorectal and gastrointestinal cancers. Saponin and polyphenolic extracts exhibited similar activities against HSV-1 and HAdV-5, with 4-log reduction in virus titres. This study focuses our attention on a field of potential antiviral formulations derived from European holly. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Biochemical and Molecular Investigation of the Effect of Saponins and Terpenoids Derived from Leaves of Ilex aquifolium on Lipid Metabolism of Obese Zucker Rats

Author

Pachura, Natalia, primary, Kupczyński, Robert, additional, Lewandowska, Kamila, additional, Włodarczyk, Maciej, additional, Klemens, Marta, additional, Kuropka, Piotr, additional, Nowaczyk, Renata, additional, Krzystek-Korpacka, Małgorzata, additional, Bednarz-Misa, Iwona, additional, Sozański, Tomasz, additional, Pogoda-Sewerniak, Krystyna, additional, and Szumny, Antoni, additional

Published
2022
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12. Biological Potential and Chemical Profile of European Varieties of Ilex

Author

Pachura, Natalia, primary, Kupczyński, Robert, additional, Sycz, Jordan, additional, Kuklińska, Agata, additional, Zwyrzykowska-Wodzińska, Anna, additional, Wińska, Katarzyna, additional, Owczarek, Aleksandra, additional, Kuropka, Piotr, additional, Nowaczyk, Renata, additional, Bąbelewski, Przemysław, additional, and Szumny, Antoni, additional

Published
2021
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17. Volatile Composition and Sensory Properties as Quality Attributes of Fresh and Dried Hemp Flowers (Cannabis sativa L.)

Author

Kwaśnica, Andrzej, primary, Pachura, Natalia, additional, Masztalerz, Klaudia, additional, Figiel, Adam, additional, Zimmer, Aleksandra, additional, Kupczyński, Robert, additional, Wujcikowska, Katarzyna, additional, Carbonell-Barrachina, Angel A., additional, Szumny, Antoni, additional, and Różański, Henryk, additional

Published
2020
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20. Biological Potential and Chemical Profile of European Varieties of Ilex.

Author

Pachura, Natalia, Kupczyński, Robert, Sycz, Jordan, Kuklińska, Agata, Zwyrzykowska-Wodzińska, Anna, Wińska, Katarzyna, Owczarek, Aleksandra, Kuropka, Piotr, Nowaczyk, Renata, Bąbelewski, Przemysław, and Szumny, Antoni

Subjects
CHEMICAL potential, LABORATORY rats, FATTY liver, PHENOLIC acids, METABOLIC regulation
Abstract

Plants of the genus Ilex are widespread throughout the world, with its best-known representative being Ilex paraguraiensis from South America. The European species Ilex aquifolium shows similarities in its terpenoid, sugar and phenolic acid profiles. Using aqueous extracts of Ilex aquifolium as a supplement in Wistar rats showed that, despite the lack of caffeine, it had strong hypocholesterolemic effects. In addition, a reduction in oxidative lipid degradation and a decrease in hepatic steatosis in histopathological studies were observed. The results of this study suggest that extracts from the European species Ilex aquifolium may have potential as an alternative treatment for hyperlipidemia. [ABSTRACT FROM AUTHOR]

Published
2022
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