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1. Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Author

Jarius, Sven, Pache, Florence, Körtvelyessy, Peter, Jelčić, Ilijas, Stettner, Mark, Franciotta, Diego, Keller, Emanuela, Neumann, Bernhard, Ringelstein, Marius, Senel, Makbule, Regeniter, Axel, Kalantzis, Rea, Willms, Jan F., Berthele, Achim, Busch, Markus, Capobianco, Marco, Eisele, Amanda, Reichen, Ina, Dersch, Rick, Rauer, Sebastian, Sandner, Katharina, Ayzenberg, Ilya, Gross, Catharina C., Hegen, Harald, Khalil, Michael, Kleiter, Ingo, Lenhard, Thorsten, Haas, Jürgen, Aktas, Orhan, Angstwurm, Klemens, Kleinschnitz, Christoph, Lewerenz, Jan, Tumani, Hayrettin, Paul, Friedemann, Stangel, Martin, Ruprecht, Klemens, and Wildemann, Brigitte

Published
2022
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4. Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Author

Tsymala, Irina, Nigritinou, Magdalini, Zeka, Bleranda, Schulz, Rouven, Niederschick, Felix, Matković, Mia, Bauer, Isabel J., Szalay, Michael, Schanda, Kathrin, Lerch, Magdalena, Misu, Tatsuro, Fujihara, Kazuo, Bennett, Jeffrey L., Dahle, Charlotte, Pache, Florence, Rommer, Paulus, Leutmezer, Fritz, Illes, Zsolt, Leite, Maria Isabel, Palace, Jacqueline, Scholze, Petra, Reindl, Markus, Lassmann, Hans, and Bradl, Monika

Published
2020
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5. Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations

Author

Otto, Carolin, primary, Schwarz, Tatjana, additional, Jeworowski, Lara M, additional, Schmidt, Marie L, additional, Walper, Felix, additional, Pache, Florence, additional, Schindler, Patrick, additional, Niederschweiberer, Moritz, additional, Krumbholz, Andi, additional, Rose, Ruben, additional, Drosten, Christian, additional, Ruprecht, Klemens, additional, and Corman, Victor M, additional

Published
2023
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6. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, Albrecht, P., Ayzenberg, I., Bayas, A., Bellmann-Strobl, J., Bischof, F., Bittner, S., Böttcher, T., Brettschneider, J., Buttmann, M., DSouza, M., Ettrich, B., Frank, B., Gass, A., Grothe, M., Guthke, K., Haarmann, A., Habedank, E., Hoffmann, F., Hoffmann, O., Hümmert, M.W., Junghans, J., Kaste, M., Kaulen, B., Kermer, P., Kern, P., Klotz, L., Köhler, W., Kolesilova, E., Korsen, M., Kowarik, M., Langel, S., Lee, D.H., Liebetrau, M., Luessi, F., Marouf, W., Meister, S., Melms, A., Metz, I., Münch, C., Niehaus, S., Pawlitzki, M., Pellkofer, H., Puhlmann, H.U., Pul, R., Retzlaf, N., Riedlinger, A., Rommer, P., Röpke, L., Rostásy, K., Rückriem, L., Ruschil, C., Schippling, S., Senel, M., Sieb, J.P., Sommer, C., Spreer, A., Steinbrecher, A., Stephanik, H., Stoppe, M., Süße, M., Tackenberg, B., Tünnerhoff, J., Veauthier, C., Walter, A., Wandinger, K.P., Warnke, C., Weber, M.S., Weissert, R., Wiendl, H., Wilke, C., Winkelmann, A., Yalachkov, Y., Young, K., Zentner, C., and Zipp, F.

Published
2018
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9. sj-docx-1-msj-10.1177_13524585231161253 – Supplemental material for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations

Author

Otto, Carolin, Schwarz, Tatjana, Jeworowski, Lara M, Schmidt, Marie L, Walper, Felix, Pache, Florence, Schindler, Patrick, Niederschweiberer, Moritz, Krumbholz, Andi, Rose, Ruben, Drosten, Christian, Ruprecht, Klemens, and Corman, Victor M

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585231161253 for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations by Carolin Otto, Tatjana Schwarz, Lara M Jeworowski, Marie L Schmidt, Felix Walper, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Andi Krumbholz, Ruben Rose, Christian Drosten, Klemens Ruprecht and Victor M Corman in Multiple Sclerosis Journal

Published
2023
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13. Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study

Author

Ayzenberg, Ilya, Schöllhammer, Joanna, Hoepner, Robert, Hellwig, Kerstin, Ringelstein, Marius, Aktas, Orhan, Kümpfel, Tania, Krumbholz, Markus, Trebst, Corinna, Paul, Friedemann, Pache, Florence, Obermann, Mark, Zeltner, Lena, Schwab, Matthias, Berthele, Achim, Jarius, Sven, Kleiter, Ingo, and Neuromyelitis Optica Study Group (NEMOS)

Published
2016
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14. Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

Author

Mossakowski, Agata A., Pohlan, Julian, Bremer, Daniel, Lindquist, Randall, Millward, Jason M., Bock, Markus, Pollok, Karolin, Mothes, Ronja, Viohl, Leonard, Radbruch, Moritz, Gerhard, Jenny, Bellmann-Strobl, Judith, Behrens, Janina, Infante-Duarte, Carmen, Mähler, Anja, Boschmann, Michael, Rinnenthal, Jan Leo, Füchtemeier, Martina, Herz, Josephine, Pache, Florence C., Bardua, Markus, Priller, Josef, Hauser, Anja E., Paul, Friedemann, Niesner, Raluca, and Radbruch, Helena

Published
2015
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15. Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20 treated patients with multiple sclerosis after three or four COVID-19 vaccinations

Author

Otto, Carolin, primary, Schwarz, Tatjana, additional, Jeworowski, Lara M., additional, Schmidt, Marie L., additional, Walper, Felix, additional, Pache, Florence, additional, Schindler, Patrick, additional, Niederschweiberer, Moritz, additional, Krumbholz, Andi, additional, Rose, Ruben, additional, Drosten, Christian, additional, Ruprecht, Klemens, additional, and Corman, Victor M, additional

Published
2022
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16. Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder

Author

Otto, Carolin, primary, Radbruch, Helena, additional, Wilken, Diana, additional, Lietzow, Tatjana, additional, Steinhagen, Katja, additional, Grage-Griebenow, Evelin, additional, von Brünneck, Ann-Christin, additional, Jarius, Sven, additional, Hofmann, Jörg, additional, Pache, Florence, additional, and Ruprecht, Klemens, additional

Published
2022
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18. Additional file 1 of Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Author

Jarius, Sven, Pache, Florence, K��rtvelyessy, Peter, Jel��i��, Ilijas, Stettner, Mark, Franciotta, Diego, Keller, Emanuela, Neumann, Bernhard, Ringelstein, Marius, Senel, Makbule, Regeniter, Axel, Kalantzis, Rea, Willms, Jan F., Berthele, Achim, Busch, Markus, Capobianco, Marco, Eisele, Amanda, Reichen, Ina, Dersch, Rick, Rauer, Sebastian, Sandner, Katharina, Ayzenberg, Ilya, Gross, Catharina C., Hegen, Harald, Khalil, Michael, Kleiter, Ingo, Lenhard, Thorsten, Haas, J��rgen, Aktas, Orhan, Angstwurm, Klemens, Kleinschnitz, Christoph, Lewerenz, Jan, Tumani, Hayrettin, Paul, Friedemann, Stangel, Martin, Ruprecht, Klemens, and Wildemann, Brigitte

Abstract

Additional file 1. Table S1. Patient and subgroup characteristics.

Published
2022
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19. sj-docx-6-msj-10.1177_13524585221094478 – Supplemental material for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis

Author

Schwarz, Tatjana, Otto, Carolin, Jones, Terry C, Pache, Florence, Schindler, Patrick, Niederschweiberer, Moritz, Schmidt, Felix A, Drosten, Christian, Corman, Victor M, and Ruprecht, Klemens

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-6-msj-10.1177_13524585221094478 for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis by Tatjana Schwarz, Carolin Otto, Terry C Jones, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Felix A Schmidt, Christian Drosten, Victor M Corman and Klemens Ruprecht in Multiple Sclerosis Journal

Published
2022
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20. sj-doc-5-msj-10.1177_13524585221094478 – Supplemental material for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis

Author

Schwarz, Tatjana, Otto, Carolin, Jones, Terry C, Pache, Florence, Schindler, Patrick, Niederschweiberer, Moritz, Schmidt, Felix A, Drosten, Christian, Corman, Victor M, and Ruprecht, Klemens

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-doc-5-msj-10.1177_13524585221094478 for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis by Tatjana Schwarz, Carolin Otto, Terry C Jones, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Felix A Schmidt, Christian Drosten, Victor M Corman and Klemens Ruprecht in Multiple Sclerosis Journal

Published
2022
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21. sj-doc-1-msj-10.1177_13524585221094478 – Supplemental material for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis

Author

Schwarz, Tatjana, Otto, Carolin, Jones, Terry C, Pache, Florence, Schindler, Patrick, Niederschweiberer, Moritz, Schmidt, Felix A, Drosten, Christian, Corman, Victor M, and Ruprecht, Klemens

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-doc-1-msj-10.1177_13524585221094478 for Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis by Tatjana Schwarz, Carolin Otto, Terry C Jones, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Felix A Schmidt, Christian Drosten, Victor M Corman and Klemens Ruprecht in Multiple Sclerosis Journal

Published
2022
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22. Neuromyelitis Optica: Evaluation of 871 Attacks and 1,153 Treatment Courses

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Wegner, Brigitte, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Krumbholz, Markus, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Winkelmann, Alexander, Marouf, Wael, Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, and Trebst, Corinna

Published
2016
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25. A cohort of 222 anti-CD20 treated patients with multiple sclerosis followed through the COVID-19 pandemic: Attenuated humoral but robust cellular immune responses after vaccination and infection

Author

Schwarz, Tatjana, primary, Otto, Carolin, additional, Jones, Terry C, additional, Pache, Florence, additional, Schindler, Patrick, additional, Niederschweiberer, Moritz, additional, Schmidt, Felix, additional, Drosten, Christian, additional, Corman, Victor M, additional, and Ruprecht, Klemens, additional

Published
2021
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26. Successful plasmapheresis and immunoglobulin treatment for severe lipid storage myopathy: Doing the right thing for the wrong reason

Author

Kleefeld, Felix, primary, Renesse, Anja, additional, Dittmayer, Carsten, additional, Harms, Lutz, additional, Radke, Josefine, additional, Radbruch, Helena, additional, Goebel, Hans‐Hilmar, additional, Pache, Florence, additional, Schneider, Udo, additional, Schuelke, Markus, additional, Uruha, Akinori, additional, and Stenzel, Werner, additional

Published
2021
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27. Additional file 1 of Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Author

Tsymala, Irina, Nigritinou, Magdalini, Bleranda Zeka, Schulz, Rouven, Niederschick, Felix, Matković, Mia, Bauer, Isabel J., Szalay, Michael, Schanda, Kathrin, Lerch, Magdalena, Tatsuro Misu, Fujihara, Kazuo, Bennett, Jeffrey L., Dahle, Charlotte, Pache, Florence, Rommer, Paulus, Leutmezer, Fritz, Illes, Zsolt, Leite, Maria Isabel, Palace, Jacqueline, Scholze, Petra, Reindl, Markus, Lassmann, Hans, and Bradl, Monika

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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28. Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

Author

Faissner, Simon, primary, Graz, Florian, additional, Reinehr, Sabrina, additional, Petrikowski, Laura, additional, Haupeltshofer, Steffen, additional, Ceylan, Ulaş, additional, Stute, Gesa, additional, Winklmeier, Stephan, additional, Pache, Florence, additional, Paul, Friedemann, additional, Ruprecht, Klemens, additional, Meinl, Edgar, additional, Dick, H. Burkhard, additional, Gold, Ralf, additional, Kleiter, Ingo, additional, and Joachim, Stephanie C., additional

Published
2020
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29. Successful plasmapheresis and immunoglobulin treatment for severe lipid storage myopathy: Doing the right thing for the wrong reason.

Author

Kleefeld, Felix, von Renesse, Anja, Dittmayer, Carsten, Harms, Lutz, Radke, Josefine, Radbruch, Helena, Goebel, Hans‐Hilmar, Pache, Florence, Schneider, Udo, Schuelke, Markus, Uruha, Akinori, and Stenzel, Werner

Subjects
GLUCOSE-6-phosphate dehydrogenase, VITAMIN B2, MUSCLE diseases, PLASMAPHERESIS, LIPIDS, SCANNING transmission electron microscopy
Abstract

Multiple acyl coenzyme A dehydrogenase deficiency, mitochondrial myopathy, electron microscopy, lipid storage myopathy Of note, sarcoplasmic lipid storage compatible with lipid-storage myopathy was only observed in the muscle biopsy specimen taken at the height of her symptoms (second biopsy) by Oil-Red-O staining and on ultrastructural examination. Keywords: multiple acyl coenzyme A dehydrogenase deficiency; mitochondrial myopathy; lipid storage myopathy; electron microscopy EN multiple acyl coenzyme A dehydrogenase deficiency mitochondrial myopathy lipid storage myopathy electron microscopy 1 5 5 01/19/22 20220201 NES 220201 Three consecutive skeletal muscle biopsies during a several months time-frame, showing different degrees of neutral lipid storage. [Extracted from the article]

Published
2022
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30. Apheresis therapies for NMOSD attacks : a retrospective study of 207 therapeutic interventions

Author

NEMOS (Neuromyelitis Optica Study Group), Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen Hartmut, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, NEMOS (Neuromyelitis Optica Study Group), Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen Hartmut, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, and Trebst, Corinna

Abstract

Objective: To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR). Methods: This retrospective cohort study was based on the registry of the German Neuromyelitis Optica Study Group, a nationwide network established in 2008. It recruited patients with neuromyelitis optica diagnosed according to the 2006 Wingerchuk criteria or with aquaporin-4 (AQP4-ab)-antibody–seropositive NMOSD treated at 6 regional hospitals and 16 tertiary referral centers until March 2013. Besides descriptive data analysis of patient and attack characteristics, generalized estimation equation (GEE) analyses were applied to compare the effectiveness of the 2 apheresis techniques. A GEE model was generated to assess predictors of outcome. Results: Two hundred and seven attacks in 105 patients (87% AQP4-ab-antibody seropositive) were treated with at least 1 apheresis therapy. Neither PE nor IA was proven superior in the therapy of NMOSD attacks. CR was only achieved with early apheresis therapy. Strong predictors for CR were the use of apheresis therapy as first-line therapy (OR 12.27, 95% CI: 1.04–144.91, p = 0.047), time from onset of attack to start of therapy in days (OR 0.94, 95% CI: 0.89–0.99, p = 0.014), the presence of AQP4-ab-antibodies (OR 33.34, 95% CI: 1.76–631.17, p = 0.019), and monofocal attack manifestation (OR 4.71, 95% CI: 1.03–21.62, p = 0.046). Conclusions: Our findings suggest early use of an apheresis therapy in NMOSD attacks, particularly in AQP4-ab-seropositive patients. No superiority was shown for one of the 2 apheresis techniques. Classification of evidence: This study provides Class IV evidence that for patients with NMOSD, neither PE nor IA is superior in the treatment of attacks.

Published
2018

32. Neuromyelitis optica

Author

Pache, Florence, additional, Wildemann, Brigitte, additional, Paul, Friedemann, additional, and Jarius, Sven, additional

Published
2018
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33. Additional file 1: Table S1. of MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients

Author

Pache, Florence, Zimmermann, Hanna, Mikolajczak, Janine, Schumacher, Sophie, Lacheta, Anna, Oertel, Frederike, Bellmann-Strobl, Judith, Jarius, Sven, Wildemann, Brigitte, Reindl, Markus, Waldman, Amy, Soelberg, Kerstin, Asgari, Nasrin, Ringelstein, Marius, Aktas, Orhan, Gross, Nikolai, Buttmann, Mathias, Ach, Thomas, Ruprecht, Klemens, Paul, Friedemann, and Brandt, Alexander

Subjects
genetic structures, sense organs, eye diseases
Abstract

Demographic, clinical and serological data. a) Early stage dry macular degeneration in both eyes; b) Suspected early stage glaucoma. c) Visual assessments were performed during acute ON OS. Abbreviations: ON: optic neuritis. VEP P100: visually evoked potential P100 latency. n.e.: not evocable; pRNFL: peripapillary retinal nerve fiber layer thickness. GCIP: combined ganglion cell and inner plexiform layer volume. INL: inner nuclear layer volume. ORL: outer retinal layers volume including layers from outer plexiform layer to Bruchâ s membrane. (DOCX 21 kb)

Published
2016
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34. Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response

Author

Stellmann, Jan-Patrick, primary, Krumbholz, Markus, additional, Friede, Tim, additional, Gahlen, Anna, additional, Borisow, Nadja, additional, Fischer, Katrin, additional, Hellwig, Kerstin, additional, Pache, Florence, additional, Ruprecht, Klemens, additional, Havla, Joachim, additional, Kümpfel, Tania, additional, Aktas, Orhan, additional, Hartung, Hans-Peter, additional, Ringelstein, Marius, additional, Geis, Christian, additional, Kleinschnitz, Christoph, additional, Berthele, Achim, additional, Hemmer, Bernhard, additional, Angstwurm, Klemens, additional, Young, Kim Lea, additional, Schuster, Simon, additional, Stangel, Martin, additional, Lauda, Florian, additional, Tumani, Hayrettin, additional, Mayer, Christoph, additional, Zeltner, Lena, additional, Ziemann, Ulf, additional, Linker, Ralf Andreas, additional, Schwab, Matthias, additional, Marziniak, Martin, additional, Then Bergh, Florian, additional, Hofstadt-van Oy, Ulrich, additional, Neuhaus, Oliver, additional, Zettl, Uwe, additional, Faiss, Jürgen, additional, Wildemann, Brigitte, additional, Paul, Friedemann, additional, Jarius, Sven, additional, Trebst, Corinna, additional, and Kleiter, Ingo, additional

Published
2017
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35. Contribution of blood vessels to retinal nerve fiber layer thickness in NMOSD

Author

Oertel, Frederike C., primary, Zimmermann, Hanna, additional, Mikolajczak, Janine, additional, Weinhold, Maria, additional, Kadas, Ella Maria, additional, Oberwahrenbrock, Timm, additional, Pache, Florence, additional, Bellmann-Strobl, Judith, additional, Ruprecht, Klemens, additional, Paul, Friedemann, additional, and Brandt, Alexander U., additional

Published
2017
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36. Neuromyelitis optica

Author

Pache, Florence, additional, Wildemann, Brigitte, additional, Paul, Friedemann, additional, and Jarius, Sven, additional

Published
2017
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37. Longitudinal Intravital Imaging of the Retina Reveals Long-term Dynamics of Immune Infiltration and Its Effects on the Glial Network in Experimental Autoimmune Uveoretinitis, without Evident Signs of Neuronal Dysfunction in the Ganglion Cell Layer

Author

Bremer, Daniel, primary, Pache, Florence, additional, Günther, Robert, additional, Hornow, Jürgen, additional, Andresen, Volker, additional, Leben, Ruth, additional, Mothes, Ronja, additional, Zimmermann, Hanna, additional, Brandt, Alexander U., additional, Paul, Friedemann, additional, Hauser, Anja E., additional, Radbruch, Helena, additional, and Niesner, Raluca, additional

Published
2016
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38. Differentielle Aktivierung des NLRP3-Inflammasoms durch Pneumolysin

Author

Pache, Florence

Subjects
streptococcus pneumoniae, ply, NLRP3, Pneumolysin, inflammasome, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
Abstract

Pneumokokken-Infektionen, wie z.B. Pneumonien, stellen weltweit eine häufige Todesursache dar. Die Interaktion der Pneumokokken mit den Wirtszellen und insbesondere die Mechanismen der Erkennung durch das angeborene Immunsystem sind immer noch nur unvollständig aufge-klärt. Vor dem Hintergrund der weiterhin relativ hohen Mortalität der Pneumokokkeninfektionen sowie der zunehmenden Antibiotika-Resistenz ist ein grundlegendes Verständnis dieser Mecha-nismen von essentieller Bedeutung. Am Anfang der Immunantwort gegen Bakterien einschließlich von Pneumokokken steht die Er-kennung dieser Bakterien. Erste Zielzellen, die im Rahmen der Pneumokokkeninfektion betrof- fen sind und für eine frühe Verteidigung des Organismus sorgen, sind Makrophagen. Nachfol-gend spielt die Produktion von Zytokinen, unter ihnen IL-1eine wichtige Rolle. IL-1 ist Schlüsselzytokin der frühen Immunantwort, verantwortlich für die Aktivierung und Regulation weitere Wirtszellen und Abwehrmechanismen. In der vorliegenden Arbeit sollte untersucht werden, über welche Mechanismen Makrophagen welche Pneumokokkenbestandteile erkennen, um die wichtige IL-1-Produktion zu aktivieren. Es konnte gezeigt werden, dass ausschließlich vollständiges, Poren-bildendes Zytotoxin Pneumolysin zu einer Ausschüttung von reifem IL-1β führt. Dabei war unerheblich, ob lebende Bakterien oder aufgereinigtes Pneumolysin verwendet wurden. Wichtig hierbei war außerdem, dass unterschiedliche Ply-Varianten dargebracht wurden, die nach derzeitigem Kenntnisstand eine Besonderheit der Pneumokokken innerhalb der Gruppe der Gram-positiven Bakterien (sehr unterschiedliche immunologische Reaktionen, je nach Ausprägung des Virulenzfaktors Ply) auf-zeigt. Auf Seiten des Wirts war für die Prozessierung und Ausschüttung von IL-1β das Vorhan-densein des NLRP3-Inflammasoms essentiell. Sowohl die Entstehung radikaler Sauerstoffspe- zies, als auch Kalium-Efflux aus dem Intrazellularraum, sind mögliche Mechanismen, die für die Ply-abhängige Aktivierung des NLRP3-Inflammasoms ursächlich sein können. Es konnte gezeigt werden, dass die Inhibierung des Proteinkomplexes NLRP3 eine stark verminderte IL-1β-Produktion zur Folge hat, ebenso führt eine Aufhebung des Kaliumgradienten sowie der Inhibie-rung von ROS-Bildung zu einer Inhibierung der IL-1β-Produktion. Insgesamt zeigt die Studie, dass dem NLRP3-Inflammasom eine kritische Rolle in der Bildung des pro-inflammatorischen Zytokins IL-1β bei einer Infektion mit S. pneumoniae zukommt und dass die Expression von hämolytischen Pneumolysins auf Seiten des Bakteriums hierfür notwen-dig ist. Es wird darüber hinaus die Besonderheit in der Pneumokokkeninfektion gezeigt, dass ein bakterieller Virulenzfaktor- Polymorphismus zu einer veränderten Bakterien-Erkennung durch das angeborene Immunsystem führt., Globaly infections with Streptococcus pneumonia account for a high mortality and morbidity rate through infectious diseases. Mechanisms of host-pathogen interaction especially routes of pneumococcal recognition via the host’s innate immune system are not well understood. Alt-hough different vaccinations against pneumococci are available a general protection against all different pneumococcal serotypes is not given. Furthermore increasing resistency of pneumococci towards antibiotic therapy reveals the urgency of a more complete understanding of the patho-gen’s virulence mechanisms and the host’s defense strategy. For the initiation of the host’s immune response a reliable recognition of pathogens is key. Mac-rophages play a major role in early recognition of pneumococcal infection and thereby provide a first line of defense. Cytokines, notably IL-1 are produced and secreted subsequently to patho-gen recognition. IL-1is an important cytokine of the early innate immune system. It both in-duces the activation of the host’s cellular immune response and orchestrates defense mechanisms. The present dissertation identifies and discusses the key factors of pneumococcal recognition that are used by macrophages in order to activate the production of IL-1β. Important results pre-sented here are the following: The release of mature IL-1β is only stimulated by the complete, pore-forming cytotoxine pneumolysine. In this context, it is irrelevant whether living bacteria or cleaned-up pneumolysin are the triggering factor. Furthermore it has to be noted that different ply variants were used as stimuli. By doing so, it could be demonstrated that pneumococci have a special status within the group of Gram-positive bacteria, with different immunological reactions depending on the polymorphism of the virulence factor ply. For the host, the presence of NLRP3-inflammasome was a necessary factor for the processing and release of IL-1β. The ply-dependent activation of NLRP3 inflammasome turns out to be triggered by the emergence of radical oxygen species, as well as by an efflux of potassium from the intracellular compartment. As a further result, it was demonstrated that the inhibition of the NLRP3 proteine complex pro-voked a stronly decreased production of IL-1β. Furthermore, the production of IL-1β diminished when the protein complex NLRP3 was inhibited. Upon elimination of the potassium gradient or inhibition of ROS production after pneumococcal stimulation of macrophages IL-1β production was strongly decreased. As a general result, the dissertation demonstrates that the NLRP3 inflammasome plays an im-portant role for the production of the pro inflammatory cytokine IL-1β in the context of an infec-tion with S. pneumonia that expresses hemolytic full length pneumolysin. Furthermore, it is demonstrated that in the context of an infection with pneumococci, a bacterial virulence factor polymorphism causes a modified identification of bacteria by the innate immune system.

Published
2014

40. Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder

Author

Streitberger, Kaspar-Josche, primary, Fehlner, Andreas, additional, Pache, Florence, additional, Lacheta, Anna, additional, Papazoglou, Sebastian, additional, Bellmann-Strobl, Judith, additional, Ruprecht, Klemens, additional, Brandt, Alexander, additional, Braun, Jürgen, additional, Sack, Ingolf, additional, Paul, Friedemann, additional, and Wuerfel, Jens, additional

Published
2016
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41. Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

Author

Kreye, Jakob, primary, Wenke, Nina K., additional, Chayka, Mariya, additional, Leubner, Jonas, additional, Murugan, Rajagopal, additional, Maier, Nikolaus, additional, Jurek, Betty, additional, Ly, Lam-Thanh, additional, Brandl, Doreen, additional, Rost, Benjamin R., additional, Stumpf, Alexander, additional, Schulz, Paulina, additional, Radbruch, Helena, additional, Hauser, Anja E., additional, Pache, Florence, additional, Meisel, Andreas, additional, Harms, Lutz, additional, Paul, Friedemann, additional, Dirnagl, Ulrich, additional, Garner, Craig, additional, Schmitz, Dietmar, additional, Wardemann, Hedda, additional, and Prüss, Harald, additional

Published
2016
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42. MRI phase changes in multiple sclerosis vs neuromyelitis optica lesions at 7T

Author

Sinnecker, Tim, primary, Schumacher, Sophie, additional, Mueller, Katharina, additional, Pache, Florence, additional, Dusek, Petr, additional, Harms, Lutz, additional, Ruprecht, Klemens, additional, Nytrova, Petra, additional, Chawla, Sanjeev, additional, Niendorf, Thoralf, additional, Kister, Ilya, additional, Paul, Friedemann, additional, Ge, Yulin, additional, and Wuerfel, Jens, additional

Published
2016
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44. Neuronal Afferent Visual System Damage in MOG-Antibody Associated Optic Neuritis Is as Severe as in AQP4-Antibody Positive NMOSD (P4.275)

Author

Zimmermann, Hanna, primary, Pache, Florence, additional, Mikolajczak, Janine, additional, Schumacher, Sophie, additional, Lacheta, Anna, additional, Jarius, Sven, additional, Wildemann, Brigitte, additional, Reindl, Markus, additional, Waldman, Amy, additional, Ruprecht, Klemens, additional, Asgari, Nasrin, additional, Soelberg, Kerstin, additional, Ringelstein, Marius, additional, Aktas, Orhan, additional, Paul, Friedemann, additional, and Brandt, Alexander, additional

Published
2016
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46. Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

Author

Metz, Imke, primary, Beißbarth, Tim, additional, Ellenberger, David, additional, Pache, Florence, additional, Stork, Lidia, additional, Ringelstein, Marius, additional, Aktas, Orhan, additional, Jarius, Sven, additional, Wildemann, Brigitte, additional, Dihazi, Hassan, additional, Friede, Tim, additional, Brück, Wolfgang, additional, Ruprecht, Klemens, additional, and Paul, Friedemann, additional

Published
2016
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47. Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis

Author

Keller, Andreas, primary, Leidinger, Petra, additional, Meese, Eckart, additional, Haas, Jan, additional, Backes, Christina, additional, Rasche, Ludwig, additional, Behrens, Janina R., additional, Pfuhl, Catherina, additional, Wakonig, Katharina, additional, Gieß, René M., additional, Jarius, Sven, additional, Meder, Benjamin, additional, Bellmann-Strobl, Judith, additional, Paul, Friedemann, additional, Pache, Florence C., additional, and Ruprecht, Klemens, additional

Published
2015
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49. Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue

Author

Fatykhova, Diana, primary, Rabes, Anne, additional, Machnik, Christoph, additional, Guruprasad, Kunchur, additional, Pache, Florence, additional, Berg, Johanna, additional, Toennies, Mario, additional, Bauer, Torsten T., additional, Schneider, Paul, additional, Schimek, Maria, additional, Eggeling, Stephan, additional, Mitchell, Timothy J., additional, Mitchell, Andrea M., additional, Hilker, Rolf, additional, Hain, Torsten, additional, Suttorp, Norbert, additional, Hippenstiel, Stefan, additional, Hocke, Andreas C., additional, and Opitz, Bastian, additional

Published
2015
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50. Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

Author

Hertwig, Laura, primary, Pache, Florence, additional, Romero-Suarez, Silvina, additional, Stürner, Klarissa H, additional, Borisow, Nadja, additional, Behrens, Janina, additional, Bellmann-Strobl, Judith, additional, Seeger, Bibiane, additional, Asselborn, Natascha, additional, Ruprecht, Klemens, additional, Millward, Jason M, additional, Infante-Duarte, Carmen, additional, and Paul, Friedemann, additional

Published
2015
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