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1,285 results on '"Pace, M."'

3. Quantitative predictions of neoadjuvant chemotherapy effects in breast cancer by individual patient data assimililation

Author

Castorina, P., Carco', D., Colarossi, C., Mare, M., Memeo, L., Pace, M., Puliafito, I., and Giuffrida, D.

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Neoadjuvant chemotherapy has been used for breast cancer aiming at downgrading before surgery. In this article we propose a new quantitative analysis of the effects of the neoadjuvant therapy to obtain numerical, personalized, predictions on the shrinkage of the tumor size after the drug doses, by data assimilation of the individual patient. The algorithm has been validated by a sample of 37 patients with histological diagnosis of locally advanced primary breast carcinoma. The biopsy specimen, the initial tumor size and its reduction after each treatment were known for all patients. We find that: a) the measure of tumor size at the diagnosis and after the first dose permits to predict the size reduction for the follow up; b) the results are in agreement with our data sample, within 10-20 %, for about 90% of the patients. The quantitative indications suggest the best time for surgery. The analysis is patient oriented, weakly model dependent and can be applied to other cancer phenotypes., Comment: In press on Annals of Hematology and Oncology

Published
2021

5. Is intrathecal bupivacaine plus dexmedetomidine superior to bupivacaine in spinal anesthesia for a cesarean section? A systematic review and meta-analysis.

Author

GIACCARI, L. G., COPPOLINO, F., AURILIO, C., PACE, M. C., PASSAVANTI, M. B., POTA, V., and SANSONE, P.

Abstract

OBJECTIVE: This study aimed to investigate whether the administration of intrathecal dexmedetomidine as a bupivacaine adjuvant for caesarean section can prolong the duration of analgesia compared with bupivacaine alone. Secondary outcomes included postoperative pain, the time interval to the first analgesic request, the level of sedation, the incidence of adverse effects, and the fetal outcomes. MATERIALS AND METHODS: A systematic review and meta-analysis were conducted. The study compared the intrathecal administration of bupivacaine plus dexmedetomidine (group BD) to the intrathecal administration of bupivacaine alone (group B) for cesarean sections. RESULTS: Fourteen publications were included. Among patients who underwent spinal anesthesia for a cesarean section, 514 patients received intrathecal bupivacaine alone, and 533 patients received intrathecal bupivacaine plus dexmedetomidine. The onset of sensory and motor block was essentially the same in both groups; the time for sensory and motor block regression was significantly longer in the BD group. Postoperative Visual Analogue Scale (VAS) values were similar in group BD when compared to group B. Postoperative VAS scores remained consistently low in Group BD compared to Group B, starting from 1 hour after surgery. The level of sedation measured at the end of the cesarean section in both groups was almost similar. No difference in terms of safety, adverse events, and neonatal outcomes was found between the two groups. CONCLUSIONS: Use of intrathecal dexmedetomidine for spinal anesthesia in cesarean section significantly prolongs sensory and motor block compared to using bupivacaine alone as an adjuvant. It also improves analgesia after 1 hour with no difference in the incidence of maternal and neonatal adverse effects compared to bupivacaine alone. The optimal dose of dexmedetomidine to use remains to be ingested. [ABSTRACT FROM AUTHOR]

Published
2024

7. Progress with the Upgrade of the SPS for the HL-LHC Era

Author

Goddard, B., Argyropoulos, T., Bartosik, H., Bartmann, W., Bohl, T., Caspers, F., Cornelis, K., Damerau, H., Drøsdal, L., Ducimetière, L., Garoby, R., Gourber-Pace, M., Höfle, W., Iadarola, G., Jensen, L., Kain, V., Losito, R., Meddahi, M., Mereghetti, A., Mertens, V., Mete, Ö., Montesinos, E., Müller, J. E., Papaphilippou, Y., Rumolo, G., Salvant, B., Shaposhnikova, E., Taborelli, M., Timko, H., Velotti, F., and Gianfelice-Wendt, E.

Subjects
Physics - Accelerator Physics
Abstract

The demanding beam performance requirements of the High Luminosity (HL-) LHC project translate into a set of requirements and upgrade paths for the LHC injector complex. In this paper the performance requirements for the SPS and the known limitations are reviewed in the light of the 2012 operational experience. The various SPS upgrades in progress and still under consideration are described, in addition to the machine studies and simulations performed in 2012. The expected machine performance reach is estimated on the basis of the present knowledge, and the remaining decisions that still need to be made concerning upgrade options are detailed., Comment: 3 p. Presented at 4th International Particle Accelerator Conference (IPAC 2013)

Published
2014

10. Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey

Author

Cobianchi, L, Piccolo, D, Dal Mas, F, Agnoletti, V, Ansaloni, L, Balch, J, Biffl, W, Butturini, G, Catena, F, Coccolini, F, Denicolai, S, De Simone, B, Frigerio, I, Fugazzola, P, Marseglia, G, Martellucci, J, Modenese, M, Previtali, P, Ruta, F, Venturi, A, Kaafarani, H, Loftus, T, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Angelos, P, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balague, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Bidoli, C, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Dall'Orto, R, Campos-Serra, A, Campostrini, S, Capoglu, R, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Ruiz, E, Conti, L, Coppola, A, De Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, De Beaux, A, Fernandez, S, De Luca, A, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Di Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire, M, Fare, C, Farre, R, Favi, F, Ferrario, L, Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Pizzocaro, E, Frountzas, M, Gachabayov, M, Galeiras, R, Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kluger, Y, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Leppaniemi, A, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, V, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Massaro, M, Matias-Garcia, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pegoraro, V, Pellino, G, Pelloni, M, Peloso, A, Del Pozo, E, Pereira, R, Pereira, B, Perez, S, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ucar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sartelli, M, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, R, Velmahos, G, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Woltz, S, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zanghi, S, Zantedeschi, M, Zapsalis, K, Zattoni, F, Zese, M, Cobianchi L., Piccolo D., Dal Mas F., Agnoletti V., Ansaloni L., Balch J., Biffl W., Butturini G., Catena F., Coccolini F., Denicolai S., De Simone B., Frigerio I., Fugazzola P., Marseglia G., Marseglia G. R., Martellucci J., Modenese M., Previtali P., Ruta F., Venturi A., Kaafarani H. M., Loftus T. J., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Angelos P., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., Balague C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Barranquero A. G., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Bidoli C., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Dall'Orto R. C., Campos-Serra A., Campostrini S., Capoglu R., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Ruiz E. C., Conti L., Coppola A., De Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'ambrosio G., Das K., Davies R. J., De Beaux A. C., Fernandez S. P. L., De Luca A., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Di Carlo I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire M., Fare C. N., Farre R., Favi F., Ferrario L., Vajana A. F. T., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Pizzocaro E., Frountzas M., Gachabayov M., Galeiras R., Vazquez A. A. G., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., Hodonou A. M., Huaman E. C., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kluger Y., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Leppaniemi A., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., Machain V. G. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., Manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Massaro M., Matias-Garcia B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pegoraro V., Pellino G., Pelloni M., Peloso A., Del Pozo E. P., Pereira R. G., Pereira B. M., Perez A. L., Perez S., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Picetti E., Pikoulis E. P., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ucar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sartelli M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante G. T., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Velmahos G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Woltz S., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zanghi S., Zantedeschi M., Zapsalis K., Zattoni F., Zese M., Cobianchi, L, Piccolo, D, Dal Mas, F, Agnoletti, V, Ansaloni, L, Balch, J, Biffl, W, Butturini, G, Catena, F, Coccolini, F, Denicolai, S, De Simone, B, Frigerio, I, Fugazzola, P, Marseglia, G, Martellucci, J, Modenese, M, Previtali, P, Ruta, F, Venturi, A, Kaafarani, H, Loftus, T, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Angelos, P, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balague, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Bidoli, C, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Dall'Orto, R, Campos-Serra, A, Campostrini, S, Capoglu, R, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Ruiz, E, Conti, L, Coppola, A, De Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, De Beaux, A, Fernandez, S, De Luca, A, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Di Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire, M, Fare, C, Farre, R, Favi, F, Ferrario, L, Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Pizzocaro, E, Frountzas, M, Gachabayov, M, Galeiras, R, Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kluger, Y, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Leppaniemi, A, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, V, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Massaro, M, Matias-Garcia, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pegoraro, V, Pellino, G, Pelloni, M, Peloso, A, Del Pozo, E, Pereira, R, Pereira, B, Perez, S, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ucar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sartelli, M, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, R, Velmahos, G, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Woltz, S, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zanghi, S, Zantedeschi, M, Zapsalis, K, Zattoni, F, Zese, M, Cobianchi L., Piccolo D., Dal Mas F., Agnoletti V., Ansaloni L., Balch J., Biffl W., Butturini G., Catena F., Coccolini F., Denicolai S., De Simone B., Frigerio I., Fugazzola P., Marseglia G., Marseglia G. R., Martellucci J., Modenese M., Previtali P., Ruta F., Venturi A., Kaafarani H. M., Loftus T. J., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Angelos P., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., Balague C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Barranquero A. G., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Bidoli C., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Dall'Orto R. C., Campos-Serra A., Campostrini S., Capoglu R., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Ruiz E. C., Conti L., Coppola A., De Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'ambrosio G., Das K., Davies R. J., De Beaux A. C., Fernandez S. P. L., De Luca A., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Di Carlo I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire M., Fare C. N., Farre R., Favi F., Ferrario L., Vajana A. F. T., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Pizzocaro E., Frountzas M., Gachabayov M., Galeiras R., Vazquez A. A. G., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., Hodonou A. M., Huaman E. C., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kluger Y., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Leppaniemi A., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., Machain V. G. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., Manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Massaro M., Matias-Garcia B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pegoraro V., Pellino G., Pelloni M., Peloso A., Del Pozo E. P., Pereira R. G., Pereira B. M., Perez A. L., Perez S., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Picetti E., Pikoulis E. P., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ucar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sartelli M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante G. T., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Velmahos G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Woltz S., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zanghi S., Zantedeschi M., Zapsalis K., Zattoni F., and Zese M.

Abstract

Background: Artificial intelligence (AI) is gaining traction in medicine and surgery. AI-based applications can offer tools to examine high-volume data to inform predictive analytics that supports complex decision-making processes. Time-sensitive trauma and emergency contexts are often challenging. The study aims to investigate trauma and emergency surgeons’ knowledge and perception of using AI-based tools in clinical decision-making processes. Methods: An online survey grounded on literature regarding AI-enabled surgical decision-making aids was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was advertised to 917 WSES members through the society’s website and Twitter profile. Results: 650 surgeons from 71 countries in five continents participated in the survey. Results depict the presence of technology enthusiasts and skeptics and surgeons’ preference toward more classical decision-making aids like clinical guidelines, traditional training, and the support of their multidisciplinary colleagues. A lack of knowledge about several AI-related aspects emerges and is associated with mistrust. Discussion: The trauma and emergency surgical community is divided into those who firmly believe in the potential of AI and those who do not understand or trust AI-enabled surgical decision-making aids. Academic societies and surgical training programs should promote a foundational, working knowledge of clinical AI.

Published
2023

11. Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey

Author

Cobianchi, L, Dal Mas, F, Agnoletti, V, Ansaloni, L, Biffl, W, Butturini, G, Campostrini, S, Catena, F, Denicolai, S, Fugazzola, P, Martellucci, J, Massaro, M, Previtali, P, Ruta, F, Venturi, A, Woltz, S, Kaafarani, H, Loftus, T, Aapoaylu, R, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Bidoli, C, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balaguacopyright, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Gonzalez Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Campo Dall'Orto, R, Campos-Serra, A, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colais-Ruiz, E, Colak, E, Conti, L, Coppola, A, de Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, de Beaux, A, De Lebrusant Fernandez, S, De Luca, A, De Simone, B, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire-Gamez, M, Fara, C, Farre, R, Favi, F, Ferrario, L, Ferrario di Tor Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Frigerio, I, Frountzas, M, Gachabayov, M, Galeiras, R, Garcaa, B, Garcia Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, V, G, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Marseglia, G, Martanez-Parez, A, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Mataas-Garcaa, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pellino, G, Pelloni, M, Peloso, A, del Pozo, E, Pereira, R, Pereira, B, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Piccolo, D, Picetti, E, Pikoulis Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ascar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Syed, A, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, A, Vazquez, R, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zangha, S, Zapsalis, K, Zattoni, F, Zese, M, Farre, S, Pegoraro, V, Zantedeschi, M, Reitano, E, Pizzocaro, E, Cobianchi L., Dal Mas F., Agnoletti V., Ansaloni L., Biffl W., Butturini G., Campostrini S., Catena F., Denicolai S., Fugazzola P., Martellucci J., Massaro M., Previtali P., Ruta F., Venturi A., Woltz S., Kaafarani H. M., Loftus T. J., Aapoaylu R., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Bidoli C., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Arvieux C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., BalaguaCopyright C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Gonzalez Barranquero A., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Campo Dall'Orto R., Campos-Serra A., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colais-Ruiz E., Colak E., Conti L., Coppola A., de Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'Ambrosio G., Das K., Davies R. J., de Beaux A. C., De Lebrusant Fernandez S. P., De Luca A., De Simone B., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Carlo I. -D. I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire-Gamez M., Fara C. N., Farre R., Favi F., Ferrario L., Ferrario di Tor Vajana A., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Frigerio I., Frountzas M., Gachabayov M., Galeiras R., Garcaa B. M., Garcia Vazquez A., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., hodonou A. M., huaman E., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., V G. M. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Marseglia G. R., Martanez-Parez A., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Mataas-Garcaa B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'Connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., del Pozo E. P., Pereira R. G., Pereira B. M., perez A. L., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Piccolo D., Picetti E., Pikoulis Pikoulis E., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ascar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Syed A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante Trigiante G., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zangha S., Zapsalis K., Zattoni F., Zese M., Farre S. P., Pegoraro V., Zantedeschi M., Reitano E., Pizzocaro E., Cobianchi, L, Dal Mas, F, Agnoletti, V, Ansaloni, L, Biffl, W, Butturini, G, Campostrini, S, Catena, F, Denicolai, S, Fugazzola, P, Martellucci, J, Massaro, M, Previtali, P, Ruta, F, Venturi, A, Woltz, S, Kaafarani, H, Loftus, T, Aapoaylu, R, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Bidoli, C, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balaguacopyright, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Gonzalez Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Campo Dall'Orto, R, Campos-Serra, A, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colais-Ruiz, E, Colak, E, Conti, L, Coppola, A, de Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, de Beaux, A, De Lebrusant Fernandez, S, De Luca, A, De Simone, B, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire-Gamez, M, Fara, C, Farre, R, Favi, F, Ferrario, L, Ferrario di Tor Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Frigerio, I, Frountzas, M, Gachabayov, M, Galeiras, R, Garcaa, B, Garcia Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, V, G, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Marseglia, G, Martanez-Parez, A, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Mataas-Garcaa, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pellino, G, Pelloni, M, Peloso, A, del Pozo, E, Pereira, R, Pereira, B, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Piccolo, D, Picetti, E, Pikoulis Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ascar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Syed, A, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, A, Vazquez, R, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zangha, S, Zapsalis, K, Zattoni, F, Zese, M, Farre, S, Pegoraro, V, Zantedeschi, M, Reitano, E, Pizzocaro, E, Cobianchi L., Dal Mas F., Agnoletti V., Ansaloni L., Biffl W., Butturini G., Campostrini S., Catena F., Denicolai S., Fugazzola P., Martellucci J., Massaro M., Previtali P., Ruta F., Venturi A., Woltz S., Kaafarani H. M., Loftus T. J., Aapoaylu R., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Bidoli C., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Arvieux C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., BalaguaCopyright C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Gonzalez Barranquero A., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Campo Dall'Orto R., Campos-Serra A., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colais-Ruiz E., Colak E., Conti L., Coppola A., de Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'Ambrosio G., Das K., Davies R. J., de Beaux A. C., De Lebrusant Fernandez S. P., De Luca A., De Simone B., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Carlo I. -D. I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire-Gamez M., Fara C. N., Farre R., Favi F., Ferrario L., Ferrario di Tor Vajana A., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Frigerio I., Frountzas M., Gachabayov M., Galeiras R., Garcaa B. M., Garcia Vazquez A., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., hodonou A. M., huaman E., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., V G. M. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Marseglia G. R., Martanez-Parez A., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Mataas-Garcaa B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'Connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., del Pozo E. P., Pereira R. G., Pereira B. M., perez A. L., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Piccolo D., Picetti E., Pikoulis Pikoulis E., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ascar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Syed A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante Trigiante G., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zangha S., Zapsalis K., Zattoni F., Zese M., Farre S. P., Pegoraro V., Zantedeschi M., Reitano E., and Pizzocaro E.

Abstract

Background: Shared decision-making (SDM) between clinicians and patients is one of the pillars of the modern patient-centric philosophy of care. This study aims to explore SDM in the discipline of trauma and emergency surgery, investigating its interpretation as well as the barriers and facilitators for its implementation among surgeons. Methods: Grounding on the literature on the topics of the understanding, barriers, and facilitators of SDM in trauma and emergency surgery, a survey was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was sent to all 917 WSES members, advertised through the society’s website, and shared on the society’s Twitter profile. Results: A total of 650 trauma and emergency surgeons from 71 countries in five continents participated in the initiative. Less than half of the surgeons understood SDM, and 30% still saw the value in exclusively engaging multidisciplinary provider teams without involving the patient. Several barriers to effectively partnering with the patient in the decision-making process were identified, such as the lack of time and the need to concentrate on making medical teams work smoothly. Discussion: Our investigation underlines how only a minority of trauma and emergency surgeons understand SDM, and perhaps, the value of SDM is not fully accepted in trauma and emergency situations. The inclusion of SDM practices in clinical guidelines may represent the most feasible and advocated solutions.

Published
2023

13. Reconciling carbon-cycle concepts, terminology, and methods

Author

Chapin, F. S., Woodwell, G. M., Randerson, J. T., Rastetter, E. B., Lovett, G. M., Baldocchi, D. D., Clark, D. A., Harmon, M. E., Schimel, D. S., Valentini, R., Wirth, C., Aber, J. D., Cole, J. J., Goulden, M. L., Harden, J. W., Heimann, M., Howarth, R. W., Matson, P. A., McGuire, A. D., Melillo, J. M., Mooney, H. A., Neff, J. C., Houghton, R. A., Pace, M. L., Ryan, M. G., Running, S. W., Sala, O. E., Schlesinger, W. H., and Schulze, E.

Subjects
net ecosystem production, net ecosystem carbon balance, gross primary production, ecosystem respiration, autotrophic respiration, heterotrophic respiration, net ecosystem exchange, net biome production, net primary production
Abstract

Recent projections of climatic change have focused a great deal of scientific and public attention on patterns of carbon (C) cycling as well as its controls, particularly the factors that determine whether an ecosystem is a net source or sink of atmospheric carbon dioxide (CO2). Net ecosystem production (NEP), a central concept in C-cycling research, has been used by scientists to represent two different concepts. We propose that NEP be restricted to just one of its two original definitions-the imbalance between gross primary production (GPP) and ecosystem respiration (ER). We further propose that a new term-net ecosystem carbon balance (NECB)-be applied to the net rate of C accumulation in (or loss from [negative sign]) ecosystems. Net ecosystem carbon balance differs from NEP when C fluxes other than C fixation and respiration occur, or when inorganic C enters or leaves in dissolved form. These fluxes include the leaching loss or lateral transfer of C from the ecosystem; the emission of volatile organic C, methane, and carbon monoxide; and the release of soot and CO2 from fire. Carbon fluxes in addition to NEP are particularly important determinants of NECB over long time scales. However, even over short time scales, they are important in ecosystems such as streams, estuaries, wetlands, and cities. Recent technological advances have led to a diversity of approaches to the measurement of C fluxes at different temporal and spatial scales. These approaches frequently capture different components of NEP or NECB and can therefore be compared across scales only by carefully specifying the fluxes included in the measurements. By explicitly identifying the fluxes that comprise NECB and other components of the C cycle, such as net ecosystem exchange (NEE) and net biome production (NBP), we can provide a less ambiguous framework for understanding and communicating recent changes in the global C cycle.

Published
2006

17. Structural and Functional Pulmonary Assessment in Severe COVID-19 Survivors at 12 Months after Discharge

Author

Corsi, A, Caroli, A, Bonaffini, P, Conti, C, Arrigoni, A, Mercanzin, E, Imeri, G, Anelli, M, Balbi, M, Pace, M, Zanoletti, A, Capelli, M, Di Marco, F, Sironi, S, Corsi A., Caroli A., Bonaffini P. A., Conti C., Arrigoni A., Mercanzin E., Imeri G., Anelli M., Balbi M., Pace M., Zanoletti A., Capelli M., Di Marco F., Sironi S., Corsi, A, Caroli, A, Bonaffini, P, Conti, C, Arrigoni, A, Mercanzin, E, Imeri, G, Anelli, M, Balbi, M, Pace, M, Zanoletti, A, Capelli, M, Di Marco, F, Sironi, S, Corsi A., Caroli A., Bonaffini P. A., Conti C., Arrigoni A., Mercanzin E., Imeri G., Anelli M., Balbi M., Pace M., Zanoletti A., Capelli M., Di Marco F., and Sironi S.

Abstract

Long-term pulmonary sequelae in COVID-19 patients are currently under investigation worldwide. Potential relationships between blood sampling and functional and radiological findings are crucial to guide the follow-up. In this study, we collected and evaluated clinical status, namely symptoms and patients’ reported outcome, pulmonary function tests (PFT), laboratory tests, and radiological findings at 3- and 12-months post-discharge in patients admitted between 25 February and 2 May 2020, and who survived severe COVID-19 pneumonia. A history of chronic pulmonary disease or COVID-19-unrelated complications were used as exclusion criteria. Unenhanced CTs were analyzed quantitatively (compromising lung volume %) and qualitatively, with main patterns of: ground-glass opacity (GGO), consolidation, and reticular configuration. Patients were subsequently divided into groups based on their radiological trends and according to the evolution in the percentage of compromised lung volume. At 12 months post-discharge, seventy-one patients showed significantly improved laboratory tests and PFT. Among them, 63 patients also underwent CT examination: all patients with negative CT findings at three months (n = 14) had negative CT also at 12 months; among the 49/63 patients presenting CT alterations at three months, 1/49 (2%) normalized, 40/49 (82%) improved, 7/49 (14%) remained stably abnormal, and 1/49 (2%) worsened. D-dimer values were low in patients with normal CT and higher in cases with improved or stably abnormal CT (median values 213 vs. 329 vs. 1000 ng/mL, respectively). The overall compromised lung volume was reduced compared with three months post-discharge (12.3 vs. 14.4%, p < 0.001). In stably abnormal CT, the main pulmonary pattern changed, showing a reduction in GGO and an increase in reticular configuration. To summarize, PFT are normal in most COVID-19 survivors 12 months post-discharge, but CT structural abnormalities persist (although sensibly improved over tim

Published
2022

26. Varicocele

Author

Cimador, M., Sergio, M., Di Pace, M. R., De Grazia, E., Esposito, Ciro, Hollands, Celeste, Lima, Mario, Settimi, Alessandro, and Valla, Jean-Stephan

Published
2010
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28. Lidocaine 700 mg medicated plaster for post-herpetic neuralgia: focus on Quality of Life, effectiveness and safety - a retrospective observational study

Author

Giaccari, L G, Aurilio, C, Coppolino, F, Pace, M C, Passavanti, M B, Pota, V, Sansone, P, Giaccari, L G, Aurilio, C, Coppolino, F, Pace, M C, Passavanti, M B, Pota, V, and Sansone, P

Subjects
Treatment Outcome, Quality of Life, Humans, Lidocaine, Neuralgia, Postherpetic, Neuropathic pain, Localized, Chronic Pain, Postherpetic Neuralgia, Lidocaine, Plaster, Patch, Retrospective Studies
Abstract

Objective: Postherpetic neuralgia (PHN) is a neuropathic pain syndrome following herpes zoster (HZ) infection, characterized by pain that persists for months to years after the resolution of the HZ rash. Therapeutic management remains challenging for every clinician. We report the follow-up of patients diagnosed with PHN and treated with lidocaine 700 mg medicated plaster (LMP), focusing on effectiveness, safety, and Quality of Life (QoL). Materials and methods: This study is a retrospective observational investigation of patients with PHN treated with LMP. Patients were regularly followed for pain intensity, co-analgesic consumption, adverse effects, QoL using the EQ-5D, and patient satisfaction for 8 weeks. Results: A total of 31 patients were evaluated. At enrollment, 18 patients (58.1%) were treated with at least one PHN concomitant medication, for which the number and dosing remained constant during the study. Patients had a mean average pain intensity of 6.5±1.0 at baseline, which decreased to 3.6±1.1 at week 4 and 2.8±0.9 at week 8. Four patients reported erythema, and one complained of vesicles eruption associated with pruritus. EQ-5D at weeks 4 and 8 of treatment showed persisting improvements in all domains except for the "anxiety/depression" domain. At week 8

Published
2022

31. Divergent trajectories of antiviral memory after SARS-CoV-2 infection

Author

Tomic, A, Skelly, DT, Ogbe, A, O’Connor, D, Pace, M, Adland, E, Alexander, F, Ali, M, Allott, K, Azim Ansari, M, Belij-Rammerstorfer, S, Bibi, S, Blackwell, L, Brown, A, Brown, H, Cavell, B, Clutterbuck, EA, de Silva, T, Eyre, D, Lumley, S, Flaxman, A, Grist, J, Hackstein, C-P, Halkerston, R, Harding, AC, Hill, J, James, T, Jay, C, Johnson, SA, Kronsteiner, B, Lie, Y, Linder, A, Longet, S, Marinou, S, Matthews, PC, Mellors, J, Petropoulos, C, Rongkard, P, Sedik, C, Silva-Reyes, L, Smith, H, Stockdale, L, Taylor, S, Thomas, S, Tipoe, T, Turtle, L, Vieira, VA, Wrin, T, Stafford, L, Abuelgasim, H, Alhussni, A, Arancibia-Cárcamo, CV, Borak, M, Cutteridge, J, Deeks, A, Denly, L, Dimitriadis, S, Fassih, S, Foord, T, Fordwoh, T, Holmes, J, Horsington, B, Kerneis, S, Kim, D, Lillie, K, Morrow, J, O’Donnell, D, Ritter, TG, Simmons, B, Taylor, A, Thomas, SR, Warren, Y, Watson, AJR, Weeks, E, Wilson, R, Young, R, Duncan, CJA, Moore, SC, Payne, R, Richter, A, Rowland-Jones, S, Mentzer, AJ, Cassar, MP, Dong, T, Fries, A, Gilbert-Jaramillo, J, Ho, L-P, Knight, JC, Neubauer, S, Peng, Y, Petousi, N, Raman, B, Talbot, NP, Pollard, AJ, Lambe, T, Conlon, CP, Jeffery, K, Travis, S, Goulder, P, Frater, J, Carroll, MW, James, WS, Klenerman, P, Barnes, E, Dold, C, and Dunachie, SJ

Abstract

The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants.

Published
2022

32. Incidence of acute respiratory infections in preschool children in an outpatient setting before and during Covid-19 pandemic in Lombardy Region, Italy

Author

Mameli, C., Picca, M., Buzzetti, R., Pace, M. E., Badolato, R., Cravidi, C., Zuccotti, G. V., Marchisio, P., Sala, M., and Di Cosimo, M. E.

Subjects
Male, children, COVID-19, respiratory infection, Acute Disease, Adolescent, Child, Child, Preschool, Humans, Incidence, Infant, Infant, Newborn, Outpatients, Pandemics, Prospective Studies, SARS-CoV-2, Respiratory Tract Infections, Research, Newborn, Pediatrics, RJ1-570, Preschool
Abstract

Introduction The incidence of acute respiratory tract infections (ARTIs) in children is difficult to estimate because they are typically treated in outpatient settings and the majority of epidemiological data originate from hospital settings and refer to the most severe illnesses. Therefore, the incidence of ARTIs in a real-world setting remains largely unexplored. Therefore, this study aims to estimate the incidence of ARTIs, upper respiratory tract infections (URTIs), and lower respiratory tract infections (LRTIs) in children aged 0–5 years in an outpatient setting. Methods This prospective cohort study was conducted in Lombardy, Italy, from October 1st, 2019, to March 31st, 2021, before and during the COVID-19 pandemic that began in March 2020. Caucasian healthy children aged 0–5 years were recruited from 69 Family Pediatricians (FP) and followed-up in an outpatient setting. Data were collected whenever a child was referred to FP and ARTI was diagnosed (Covid-19 related ARTI were excluded). The primary outcome was an estimate of the incidence of ARTIs. The incidence of ARTIs in different age groups and the effect of the COVID-19 pandemic on the incidence of ARTIs were secondary outcomes. Results We enrolled 484 children, 249 male (51.8%), mean age of 2.39 ± 1.68 years. The mean estimated incidence of ARTIs was 12.1/100 children × 30 days (95% CIs: 9.5–12.9), with the highest value observed in infants aged 1–12 months (24.9/100 children × 30 days; 95% CIs: 17.6–28.9). The mean estimated incidence of URTIs was higher than that of LRTIs (8.3 – CIs: 7.6–8.9 vs 3.8/100 children × 30 days – CIs: 6.4–4.3, respectively). The comparison of ARTIs, which occurred in the pre-pandemic winter, to those measured during the COVID-19 pandemic, revealed an impressive 82.1% drop in the incidence rate (CIs: 77.8–85.7). Conclusions This study showed that infants aged 1–12 months are more likely to develop ARTIs than older children and that COVID-19 pandemic has dramatically altered the epidemiology of ARTIs in children aged 0–5 years.

Published
2022

33. The clinical effectiveness of an integrated multidisciplinary evidence-based program to prevent intraoperative pressure injuries in high-risk children undergoing long-duration surgical procedures: A quality improvement study

Author

Ciprandi, G, Crucianelli, S, Zama, M, Antonielli, G, Armani, R, Aureli, S, Barra, G, Beetham, CJC, Bernardini, G, Cancani, F, Carai, A, Cajozzo, M, Carlesi, L, Cialdella, A, Ciaralli, I, Ciliento, G, Corsetti, T, De Chirico, B, Di Corato, P, Dotta, A, Filippelli, S, Franci, M, Frattaroli, J, Grussu, F, Lico, S, Losani, P, Giergji, M, Magli, S, Marino, SF, Mongelli, A, Nazzarri, M, Pace, M, Palmieri, G, Pannacci, I, Paparozzi, F, Pomponi, M, Portanova, A, Preziosi, A, Ragni, A, Raponi, M, Renzetti, T, Rizzo, M, Roberti, M, Sasso, E, Savarese, I, Secci, S, Selvaggio, D, Serafini, L, Spuntarelli, G, Urbani, U, Vanzi, V, Permatunga, R, Santamaria, N, Ciprandi, G, Crucianelli, S, Zama, M, Antonielli, G, Armani, R, Aureli, S, Barra, G, Beetham, CJC, Bernardini, G, Cancani, F, Carai, A, Cajozzo, M, Carlesi, L, Cialdella, A, Ciaralli, I, Ciliento, G, Corsetti, T, De Chirico, B, Di Corato, P, Dotta, A, Filippelli, S, Franci, M, Frattaroli, J, Grussu, F, Lico, S, Losani, P, Giergji, M, Magli, S, Marino, SF, Mongelli, A, Nazzarri, M, Pace, M, Palmieri, G, Pannacci, I, Paparozzi, F, Pomponi, M, Portanova, A, Preziosi, A, Ragni, A, Raponi, M, Renzetti, T, Rizzo, M, Roberti, M, Sasso, E, Savarese, I, Secci, S, Selvaggio, D, Serafini, L, Spuntarelli, G, Urbani, U, Vanzi, V, Permatunga, R, and Santamaria, N

Abstract

The prevention of hospital-acquired pressure injuries (HAPIs) in children undergoing long-duration surgical procedures is of critical importance due to the potential for catastrophic sequelae of these generally preventable injuries for the child and their family. Long-duration surgical procedures in children have the potential to result in high rates of HAPI due to physiological factors and the difficulty or impossibility of repositioning these patients intraoperatively. We developed and implemented a multi-modal, multi-disciplinary translational HAPI prevention quality improvement program at a large European Paediatric University Teaching Hospital. The intervention comprised the establishment of wound prevention teams, modified HAPI risk assessment tools, specific education, and the use of prophylactic dressings and fluidized positioners during long-duration surgical procedures. As part of the evaluation of the effectiveness of the program in reducing intraoperative HAPI, we conducted a prospective cohort study of 200 children undergoing long-duration surgical procedures and compared their outcomes with a matched historical cohort of 200 children who had undergone similar surgery the previous year. The findings demonstrated a reduction in HAPI in the intervention cohort of 80% (p < 0.01) compared to the comparator group when controlling for age, pathology, comorbidity, and surgical duration. We believe that the findings demonstrate that it is possible to significantly decrease HAPI incidence in these highly vulnerable children by using an evidence-based, multi-modal, multidisciplinary HAPI prevention strategy.

Published
2022

34. Congestive heart failure and comorbidity as determinants of colorectal cancer perioperative outcomes

Author

Basso, C., Gennaro, N., Dotto, M., Ferroni, E., Noale, M., Avossa, F., Schievano, E., Aceto, Paola, Tommasino, C., Crucitti, Antonio, Incalzi, R. A., Volpato, S., Petrini, F., Carron, M., Pace, M. C., Bettelli, G., Chiumiento, F., Corcione, A., Montorsi, M., Trabucchi, Marta, Maggi, S., Corti, M. C., Aceto P. (ORCID:0000-0002-0228-0603), Crucitti A. (ORCID:0000-0003-3496-4185), Trabucchi M., Basso, C., Gennaro, N., Dotto, M., Ferroni, E., Noale, M., Avossa, F., Schievano, E., Aceto, Paola, Tommasino, C., Crucitti, Antonio, Incalzi, R. A., Volpato, S., Petrini, F., Carron, M., Pace, M. C., Bettelli, G., Chiumiento, F., Corcione, A., Montorsi, M., Trabucchi, Marta, Maggi, S., Corti, M. C., Aceto P. (ORCID:0000-0002-0228-0603), Crucitti A. (ORCID:0000-0003-3496-4185), and Trabucchi M.

Abstract

There has been an increase in surgical interventions in frailer elderly with concomitant chronic diseases. The purpose of this paper was to evaluate the impact of aging and comorbidities on outcomes in patients who underwent surgery for the treatment of colorectal cancer (CRC) in Veneto Region (Northeastern Italy). This is a retrospective cohort study in patients ≥ 40 years who underwent elective or urgent CRC surgical resection between January 2013 and December 2015. Independent variables included: age, sex, and comorbidities. We analyzed variables associated with the surgical procedure, such as stoma creation, hospitalization during the year before the index surgery, the surgical approach used, the American Society of Anesthesiologists (ASA) score, and the Charlson Comorbidity Index score. Eight thousand four hundred and forty-seven patients with CRC underwent surgical resection. Patient age affected both pre- and post-resection LOS as well as the overall survival (OS); however, it did not affect the 30-day readmission and reoperation rates. Multivariate analysis showed that age represented a risk factor for longer preoperative and postoperative LOS as well as for 30-day and 365-day mortality, but it was not associated with an increased risk of 30-day reoperation and 30-day readmission. Chronic Heart Failure increased the 30-day mortality risk by four times, the preoperative LOS by 51%, and the postoperative LOS by 33%. Chronic renal failure was associated with a 74% higher 30-day readmission rate. Advanced age and comorbidities require a careful preoperative evaluation and appropriate perioperative management to improve surgical outcomes in older patients undergoing elective or urgent CRC resection.

Published
2022

37. In the shadow of the European neighbourhood: Political geographies of EU–Middle East relations

Author

Mamadouh, V., Bouris, D., Huber, Daniela, Pace, M., and Political and Economic Geographies (PEG, AISSR, FMG)

Abstract

Focusing on the spatiality of EU–Middle East relations, political geography, critical geopolitics and critical border studies provide tools to explore EU–Middle East relations and their impact on EU politics. Four sets of geographical concepts are particularly useful: (1) geopolitical representations and geographical imaginations (pertaining to EU and national discourses framing these relations), (2) scale and scaling processes (in the networks involving supranational, national and subnational entities), (3) region and region-making (foregrounding the institutionalisation of Europe, the Middle East and other relevant regions such as the European Neighbourhood, the Mediterranean, the Arab or the Muslim World, the Gulf. . .), and (4) borders, the bordering of the EU and the othering of the Middle East and the Levant. While the actorness of the EU in international politics is more often than not contested, the EU’s engagement in the Middle East is particularly fragmented. An analysis of differences and similarities between the geopolitical visions and codes of the EU, that of its Member States and that of states in the area, with particular attention to scalar, regional and border frames, enables us to grasp the enduring tensions between the foreign policies of the EU and its Member States in the Middle East.

Published
2022

41. Introduction: Entanglements in EU–Middle East Relations

Author

Bouris, D., Huber, D., Pace, M., and Transnational Configurations, Conflict and Governance (AISSR, FMG)

Abstract

Have relations between the European Union (EU) and the Middle East really changed substantially or is there actually more continuity than usually assumed? The aim of this introductory chapter is to take stock of the continuities, ruptures and entanglements in EU–Middle East relations. Since the end of the Second World War, the decolonisation process in the Middle East, the challenges of pan-Arabism, the US hegemony over the Middle East, the Venice Declaration, the aftermath of the Cold War, the intensification of US–European military presence in the Middle East and the Arab uprisings have all contributed to key moments of rupture in these relations. All these events represent flashpoints which expose vulnerabilities, weaknesses, fallacies and incoherencies in these relations. This introduction frames and presents the 41 chapters of this handbook which are organised in six parts – Historical Constructions/Perspectives; Theoretical Approaches/Perspectives; Multilateralism and Geopolitical Perspectives; MENA–EU Relations in the Contemporary World; Peace, Security and Conflict; and Development, Economics, Trade and Society. Each chapter and collectively these contributions highlight how EU–Middle East relations are multifaceted, varied and complex. This handbook provides a useful entry point for an informed exploration and nuanced understanding of the multiple themes, actors, structures and processes that mould these relations.

Published
2022

42. Migration and Refugees in EU–Middle East Relations

Author

İşleyen, B., Fakhoury, T., Bouris, D., Huber, D., Pace, M., Transnational Configurations, Conflict and Governance (AISSR, FMG), Bouris, Dimitris, Huber, Daniela, and Pace, Michelle

Abstract

The objective of this chapter is to give an overview of the politics of borders, migration and refugees in EU–Middle East relations. More specifically, the chapter looks at EU cooperation with Lebanon and Turkey, which are two major refugee hosting countries in the EU’s so-called Southern neighbourhood and main recipients of EU funds in the management of borders and displaced populations. The chapter identifies the main drivers, policies, mechanisms and practices of EU–Middle East relations in migration and border governance. Special attention will be paid to the concept of “externalisation”, which is regarded as the main legal and policy framework through which the EU transfers migration and border control to third countries. Here, we discuss “accession” and “association” as the two central ways for the operation of externalisation and relate them to our two cases. In both cases, we emphasise the legal, ethical and normative underpinnings and implications of the politics of borders, migration and refugees in EU relations with the Middle East.

Published
2022

43. Beamline ��� main components

Author

Carlsen, B., Carvalho, F., De Jesus, V., De La Gama, J., Ebn Rahmoun, A., Froeschl, R., Gourber-Pace, M., Grenier Boley, E., Lopez, R., Mompo, R., Papastergiou, K., Romagnoli, G., Tan, J., and Wilhelm, L.

Abstract

The East Area renovation will cover the refurbishment of the East Hall with its beamlines and infrastructures. A re-design of the beamlines is included to improve the magnet situation, the radiation situation, and maintainability in general. Thanks to a cycled powering mode of the magnets instead of a steady state one, considerable energy savings will be possible. Therefore, several magnet families have to be re-designed to be in accordance with the purposes of the project. The new East Area magnet system consists of 12 different designs with a total of 58 magnets among which 15 are bending magnets, 31 are quadrupoles, and 12 are correctors. In the Proton Synchrotron (PS) area (Building 352), the primary area (Building 157), and the line T08 (Building 157), the magnets will be cycled every 2.4 s. This concerns the lines F61, F62, part of F63, and T08. The other lines, T09, T10, and T11, will be cycled with a period of 4.8 s. Cycling the magnets is an important constraint for the construction of the magnetic parts (yokes). In addition, the coils have to be adapted to match the power supply specifications. The magnets have to be laminated to avoid eddy currents and large delays between the magnetic field and the current application. All laminated magnets currently used and needed in the new in the East Area layout will be refurbished, this concerns four families (or 22 units). The new magnets will be manufactured by industry according to CERN���s design. Another constraint is the magnet overall size limitations. As the layout was fixed at the beginning of the project, all new large magnet designs had to have the same length and width as the present ones. This complicates the designs, as laminated yokes need a larger mechanical structure around the yoke to maintain the laminations. The total lengths and widths have been discussed with the integration team and after few iterations a solution was found and the final designs approved., CERN Yellow Reports: Monographs, Vol. 4 (2021): CERN Proton Synchrotron East Area Facility: Upgrades and renovation during Long Shutdown 2

Published
2021
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47. Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Author

Skelly, DT, Harding, AC, Gilbert-Jaramillo, J, Knight, ML, Longet, S, Brown, A, Adele, S, Adland, E, Brown, H, Chinnakannan, S, Donnison, T, Ali, M, Rongkard, P, Pace, M, Zacharopoulou, P, Robinson, N, Csala, A, De Lara, C, Hutchings, CL, Mehta, H, Lee, LN, Edmans, M, Hackstein, C-P, Phalora, P, Li, W, Phillips, E, Malone, T, Ogbe, A, Jay, C, Tipoe, T, Tipton, T, Stafford, L, Mentzer, AJ, Johnson, SA, Amini, A, Marjot, T, Dimitriadis, S, Simmons, B, Deeks, A, Kerneis, S, Abuelgasim, H, Wilson, R, Thomas, SR, Watson, A, Alhussni, A, Cutteridge, J, Weeks, E, Denly, L, Lillie, K, Holmes, J, Matthews, PC, O’Donnell, D, Tan, TK, Schimanski, L, Huang, K-YA, Rijal, P, Turtle, L, de Silva, T, Richter, A, Duncan, CJA, Payne, RP, Moore, SC, Knight, JC, Cassar, MP, Raman, B, Neubauer, S, Fries, A, Talbot, NP, Petousi, N, Ho, L-P, Peng, Y, Dong, T, Camara, S, Marinou, S, Linder, A, Adlou, S, Kasanyinga, M, Bridges-Webb, A, Hill, J, Silva-Reyes, L, Blackwell, L, Frater, J, Goulder, P, Conlon, CP, Jeffery, K, Dold, C, Pollard, AJ, Sigal, A, de Oliveira, T, Townsend, AR, Klenerman, P, Dunachie, SJ, Barnes, E, Carroll, MW, and James, WS

Abstract

The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.

Published
2021

49. Imaging of liver fusion and vascular intra-hepatic shunts in omphalopagus conjoined twins: The role of a double CT study

Author

Barletta, A, Pace, M, D'Antiga, L, Cheli, M, Mangili, G, Sironi, S, Barletta A., Pace M., D'Antiga L., Cheli M., Mangili G., Sironi S., Barletta, A, Pace, M, D'Antiga, L, Cheli, M, Mangili, G, Sironi, S, Barletta A., Pace M., D'Antiga L., Cheli M., Mangili G., and Sironi S.

Abstract

Omphalopagus twins are joined ventrally in the umbilical region. In omphalopagus twins, liver's fusion is very frequent, being present in about 80% of cases. Two conjoined twins born in our Hospital were evaluated using plain x-rays, ultrasound (US), gastrointestinal xrays, Tc-99 hepatobiliary scintigraphy (SC) and contrast enhanced computed tomography (CT). There was no bony connection on conventional xrays, neither bowel communication on GI x-rays study. US demonstrated the fusion of left hepatic lobes and a not-quantifiable vascular shunt. Normal biliary function was demonstrated by Tc-99 SC. The first CT scan (twin A) showed irregular lobules in the site of hepatic fusion, a portoportal shunt and a venous vessel to the inferior vena cava of twin B. Only the second CT scan (twin B) showed an arterio-arterial partiallyextrahepatic shunts. The double CT scan allows to increase the probability of a correct individuation and description of vascular shunts for an effective preoperatory assessment. The omphalopagus twins in our case underwent planned surgical separation at 5 months of age. The surgery lasted 5 h and was not affected by any intraoperative complications.

Published
2019

50. Correction to: Perioperative Management of Elderly patients (PriME): recommendations from an Italian intersociety consensus (Aging Clinical and Experimental Research, (2020), 32, 9, (1647-1673), 10.1007/s40520-020-01624-x)

Author

Aceto, Paola, Antonelli Incalzi, R., Bettelli, G., Carron, M., Chiumiento, F., Corcione, A., Crucitti, Antonio, Maggi, S., Montorsi, M., Pace, M. C., Petrini, F., Tommasino, C., Trabucchi, Marta, Volpato, S., Aceto, P., Antonelli Incalzi, R., Bettelli, G., Carron, M., Chiumiento, F., Corcione, A., Crucitti, A., Maggi, S., Montorsi, M., Pace, M. C., Petrini, F., Tommasino, C., Trabucchi, M., and Volpato, S.

Subjects
Settore MED/18 - CHIRURGIA GENERALE, health care facilities, manpower, and services, perioperative management, social sciences, elderly patients, humanities
Abstract

The article Perioperative Management of Elderly patients (PriME).

Published
2020

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