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9 results on '"Pacciani, Valentina"'

7. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Author

Caruso, Roberta, Botti, Elisabetta, Sarra, Massimiliano, Esposito, Maria, Stolfi, Carmine, Diluvio, Laura, Giustizieri, Maria Laura, Pacciani, Valentina, Mazzotta, Annamaria, Campione, Elena, MacDonald, Thomas T., Chimenti, Sergio, Pallone, Francesco, Costanzo, Antonio, and Monteleone, Giovanni

Subjects
Inflammation -- Causes of, Hyperplasia -- Development and progression, Hyperplasia -- Causes of, Psoriasis -- Development and progression, Psoriasis -- Care and treatment, Interleukin-21 -- Health aspects
Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis., Psoriasis is a chronic, inflammatory skin disorder affecting up to 3% of the world's population (1). Histologically, psoriasis is characterized by increased proliferation of keratinocytes in the interfollicular epidermis, elongated [...]

Published
2009

8. Dendritic cells modifi cation during sublingual immunotherapy in children with allergic symptoms to house dust mites

Author

Angelini, Federica, primary, Pacciani, Valentina, additional, Corrente, Stefania, additional, Silenzi, Romina, additional, Di Pede, Alessandra, additional, Polito, Antonella, additional, Riccardi, Carla, additional, Di Cesare, Silvia, additional, Yammine, Marie Laure, additional, Rossi, Paolo, additional, Moschese, Viviana, additional, and Chini, Loredana, additional

Published
2010
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9. Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection

Author

Guglietta, Silvia, primary, Garbuglia, Anna Rosa, additional, Pacciani, Valentina, additional, Scottà, Cristiano, additional, Perrone, Maria Paola, additional, Laurenti, Luca, additional, Spada, Enea, additional, Mele, Alfonso, additional, Capobianchi, Maria Rosaria, additional, Taliani, Gloria, additional, Folgori, Antonella, additional, Vitelli, Alessandra, additional, Ruggeri, Lionello, additional, Nicosia, Alfredo, additional, Piccolella, Enza, additional, and Del Porto, Paola, additional

Published
2005
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