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El tratamiento temprano de las alteraciones oclusales y esqueléticas devuelve la armonía y funcionalidad al complejo craneofacial, simplifica los procedimientos correctivos, reduce las necesidades de exodoncias de dientes permanentes y trae beneficios psicológicos a los pacientes, así mismo provee las condiciones necesarias para que cada paciente exprese su potencial de crecimiento. Es importante el tratamiento de estas maloclusiones tan pronto se identifican, puesto que ayudaran a un mejor manejo. La máscara facial de protracción es una excelente opción para el tratamiento de la maloclusión clase III especialmente si se combina con expansión rápida del maxilar y se continua con AOF. En este artículo presentamos la terapia realizada a un paciente de 7 años con maloclusión clase III esquelética y la evolución del caso durante seis años.

Purpose: Radiation therapy is an integral part of the preoperative treatment of rectal cancers. However, only a minority of patients achieve a complete pathologic response to therapy because of resistance of these tumors to radiation therapy. This resistance may be mediated by constitutively active pro-survival signaling pathways or by inducible/acquired mechanisms in response to radiation therapy. Simultaneous inhibition of these pathways can sensitize these tumors to radiation therapy.Methods and Materials: Human colorectal cancer cells were exposed to clinically relevant doses of gamma rays, and the mechanism of their radioresistance was investigated. We characterized the transcription factor nuclear factor-kappaB (NF-kappaB) activation as a mechanism of inducible radioresistance in colorectal cancer and used curcumin, the active ingredient in the yellow spice turmeric, to overcome this resistance.Results: Curcumin inhibited the proliferation and the post-irradiation clonogenic survival of multiple colorectal cancer cell lines. Radiation stimulated NF-kappaB activity in a dose- and time-dependent manner, whereas curcumin suppressed this radiation-induced NF-kappaB activation via inhibition of radiation-induced phosphorylation and degradation of inhibitor of kappaB alpha, inhibition of inhibitor of kappaB kinase activity, and inhibition of Akt phosphorylation. Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).Conclusions: Our results suggest that transient inducible NF-kappaB activation provides a prosurvival response to radiation that may account for development of radioresistance. Curcumin blocks this signaling pathway and potentiates the antitumor effects of radiation therapy. [ABSTRACT FROM AUTHOR]