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With increasing competition between the products in the market, packaging design is getting maximum attention in product sale. In order to sell any product, manufacturers use marketing strategies and effective communication. The aim of this study is to perform a product packaging analysis on perfume bottles, using eye gaze tracking technology to identify most viewed and consumer-friendly packaging design. To examine visual attention and emotional arousal in reaction to packaging design features in an ecommerce environment, we had conducted an eye gaze tracking experiment with 75 female participants. In this research, we analyzed pupil and eye monitoring metrics to identify emotional and cognitive processes, with an emphasis on emotional arousal, visual attention and cognitive effort. Our findings identified prominent packaging designs that sellers can use to display product advertisements according to consumer preferences to further enhance sales and revenue for their business. This study's empirical application could be extremely beneficial to marketers, content managers and advertisers in terms of managing and designing web content. [ABSTRACT FROM AUTHOR]

Recognition memory, the ability to recognise previously encountered information, correlates with pupil diameter changes during the recognition period. This physiological response, known as the pupil old/new effect, generally reflects the variation in pupil dilation when encountering previously studied (old) stimuli compared to new stimuli. To develop a more precise understanding of the pupil old/new effect, we conducted a meta-analysis of 17 eye-tracking experiments (across 12 articles spanning from 2008 to 2023) involving 560 healthy adults with a mean age of 22.31 years. Analysis of publication bias showed a rather low risk of bias in the selected articles. The main meta-analysis revealed a significant and large pooled pupil old/new effect (Cohen's dz = 0.73, 95% CI [0.50, 0.95]). Further analysis of moderators showed that the number of participants included in the experiments and the criteria for selecting trials (only correct trials vs. all trials) had a significant impact on the meta-analytic results. In general, the analyses revealed a robust pupil old/new effect across all selected articles. This finding underscores its potential utility as a marker of recognition memory across different stimuli type, and various experimental designs. [ABSTRACT FROM AUTHOR]

Objective. The aim of this study is to quantify anterior chamber parameters to provide potential risk indicators for evaluating the progression of primary angle‐closure suspect (PACS) eyes to acute primary angle closure (APAC) and the degree of intraocular pressure elevation in patients with APAC utilizing anterior segment optical coherence tomography (AS‐OCT). Methods. Tomey CASIA2 AS‐OCT was used to quantitatively measure various anterior chamber parameters, including anterior chamber depth (ACD), anterior chamber volume (ACV), lens thickness (LT), lens vault (LV), iris‐trabecular contact index (ITC), iris thickness (IT), iris volume (IV), iris curvature (IC), iris area (IA), and iris thickness (IT), in APAC eyes (30 eyes) and contralateral PACS eyes (30 eyes) of 30 patients. The differences in these parameters between the two groups and their relationship with intraocular pressure were analyzed. Results. Compared to the PACS group, the APAC group exhibited significantly smaller IA and IC, and significantly larger pupil diameter (PD) and ITC (P < 0.05). There were no statistically significant differences in ACV, ACD, ACW, ACA, LV, IV, and IT750/2000 between the two groups. In APAC eyes, multivariable linear regression analysis showed a significant negative correlation between intraocular pressure and IV (β = −1.85; 95% confidence interval: −2.77 to −0.93; P = 0.001), while no correlation was found in PACS eyes. In all 60 eyes, LT showed a negative correlation with ACV, ACD, ACA, and nasal IT750, and a positive correlation with LV and nasal IC. Conclusion. AS‐OCT has multiple advantages in evaluating various anterior chamber parameters in patients with glaucoma. IA may serve as a predictive indicator of the progression of eyes from PAC or APAC. A significant negative correlation was found between intraocular pressure and IV during APAC attacks. LT can be considered a predictive factor for the occurrence of primary angle‐closure disease. [ABSTRACT FROM AUTHOR]

Background: Children with intellectual disability are less physically active and more sedentary than typically developing peers. To date no studies have tested the feasibility of a school‐based walking intervention for children with Intellectual Disability. Method: A clustered randomised controlled trial (cRCT), with an embedded process evaluation, was used to test the feasibility of a school‐based walking intervention. Eight schools (n = 161 pupils aged 9–13 years) were randomised into either an intervention arm or an 'exercise as usual' arm. Measures included physical activity, physical fitness and emotional wellbeing. Baseline and 3‐month follow‐up data were collected. Results: The 'Walk Buds' intervention was found to be acceptable to teaching staff and pupils, with an uptake rate of the walking sessions offered of 84%. Conclusion: A number of challenges were experienced, relating to the COVID‐19 pandemic, and difficulties collecting accelerometer data. Barriers, facilitators and required changes identified through the mixed methods process evaluation are discussed. [ABSTRACT FROM AUTHOR]

(1) Background: Defining the optimum center for laser refractive corrections is difficult, with many of the available approaches having pros and cons. Decentered ablations result in undesirable side effects like halos, glare, monocular diplopia, and a reduction in visual acuity; (2) Methods: The ideal centration in refractive corrections should fulfil three requirements: covering a scotopic pupil; respecting the visual axis; and minimizing tissue removal. The implications of different centration strategies are discussed and shown graphically; (3) Results: Oversized asymmetric offset ablation faces fewer difficulties in registering static cyclotorsion, features less tissue wastage compared to a symmetric offset, and includes a certain amount of coma (and trefoil) in the profile, benefiting eyes with a pupil offset, which typically present with relevant amounts of coma and trefoil corneal aberrations due to decentered optics; (4) Conclusions: There is a need for a flexible choice of centration in refractive procedures to design customized and non-customized treatments optimally. An ideal optical zone covering the pupil with the widest entrance may be as important as a centration reference. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder with high prevalence among the elderly, primarily manifested by progressive decline in motor function. The aging global demographic and increased life expectancy have led to a rapid surge in PD cases, imposing a significant societal burden. PD along with other neurodegenerative diseases has garnered increasing attention from the scientific community. In PD, motor symptoms are recognized when approximately 60% of dopaminergic neurons have been damaged. The irreversible feature of PD and benefits of early intervention underscore the importance of disease onset prediction and prompt diagnosis. The advent of digital health technology in recent years has elevated the role of digital biomarkers in precisely and sensitively detecting early PD clinical symptoms, evaluating treatment effectiveness, and guiding clinical medication, focusing especially on motor function, responsiveness and sleep quality assessments. This review examines prevalent digital biomarkers for PD and highlights the latest advancements. [ABSTRACT FROM AUTHOR]

Recent work demonstrates that those who regularly play action video games (AVGs) consistently outperform non‐gamer (NG) controls on tests of various cognitive abilities. AVGs place high demands on several cognitive functions and are often engaged with for long periods of time (e.g., over 2 h), predisposing players to experiencing cognitive fatigue. The detrimental effects of cognitive fatigue have been widely studied in various contexts where accurate performance is crucial, including aviation, military, and sport. Even though AVG players may be prone to experiencing cognitive fatigue, this topic has received little research attention to date. In this study, we compared the effect of a cognitively fatiguing task on the subsequent cognitive performance of action video game players and NG control participants. Our results indicated AVGs showed superior spatial working memory and complex attention abilities while showing no difference from NGs on simple attention performance. Additionally, we found that our cognitive fatigue and control interventions did not differentially affect the cognitive performance of AVGs and NGs in this study. This pre‐registered study provides evidence that AVGs show superior cognitive abilities in comparison to a non‐gaming population, but do not appear more resilient to cognitive fatigue. [ABSTRACT FROM AUTHOR]

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Introduction: This study aimed to describe the fixation location and the time of the longer fixation of expert and novice futsal coaches before the ball was in play in futsal set pieces. Methods: A total of 10 experts (ages 48 ± 5) and 10 novice coaches (ages 40 ± 7) participated in the study. They observed that 38 video clips were created to mimic the attack and defensive set-piece moments of the game. Data were collected in a standardized video analysis task using the pupil invisible eye tracker and processed through the pupil cloud platform. The Mann-Whitney test was conducted to evaluate differences in gaze duration between game moments (attack and defense set pieces) and groups (expert vs. novice). Gaze duration was also compared for gaze location between groups. For further comparisons, the game moments (attack and defense set pieces) and the gaze location were summarized in two-dimensional graphics using correspondence analysis. Results and discussion: The results revealed higher values of gaze duration for attack and defense set pieces for the group of experts than for novices. When considering gaze duration, expert coaches had higher values than novices for the attacker 3, defender 3, barrier 1st, and barrier 2nd gaze locations. The correspondence analysis showed different strategies of visual search and, consequently, gaze locations for attack and defense set pieces. In particular, there was different correspondence for free kicks between the level of expertise and gaze location, while corner and sideline kicks revealed some correspondence between the groups and the gaze location. In free kicks, coaches should be particularly concerned about the relationship between attacker and defender three and the barrier 1st and 2nd line positions. In corner and sideline kicks, coaches should be particularly aware of the relationship between attackers' and defenders' positions. [ABSTRACT FROM AUTHOR]

The assessment of mental effort is increasingly relevant in neurocognitive and life span domains. Pupillometry, the measure of the pupil size, is often used to assess effort but has disadvantages. Analysis of eye movements may provide an alternative, but research has been limited to easy and difficult task demands in younger adults. An effort measure must be sensitive to the whole effort profile, including "giving up" effort investment, and capture effort in different age groups. The current study comprised three experiments in which younger (n = 66) and older (n = 44) adults listened to speech masked by background babble at different signal-to-noise ratios associated with easy, difficult, and impossible speech comprehension. We expected individuals to invest little effort for easy and impossible speech (giving up) but to exert effort for difficult speech. Indeed, pupil size was largest for difficult but lower for easy and impossible speech. In contrast, gaze dispersion decreased with increasing speech masking in both age groups. Critically, gaze dispersion during difficult speech returned to levels similar to easy speech after sentence offset, when acoustic stimulation was similar across conditions, whereas gaze dispersion during impossible speech continued to be reduced. These findings show that a reduction in eye movements is not a byproduct of acoustic factors, but instead suggest that neurocognitive processes, different from arousal-related systems regulating the pupil size, drive reduced eye movements during high task demands. The current data thus show that effort in one sensory domain (audition) differentially impacts distinct functional properties in another sensory domain (vision). [ABSTRACT FROM AUTHOR]

The pupillary light response was long considered a brainstem reflex, outside of cognitive influence. However, newer findings indicate that pupil dilation (and eye movements) can reflect content held "in mind" with working memory (WM). These findings may reshape understanding of ocular and WM mechanisms, but it is unclear whether the signals are artifactual or functional to WM. Here, we ask whether peripheral and oculomotor WM signals are sensitive to the task-relevance or "attentional state" of WM content. During eye-tracking, human participants saw both dark and bright WM stimuli, then were retroactively cued to the item that would most likely be tested. Critically, we manipulated the attentional priority among items by varying the cue reliability across blocks. We confirmed previous findings that remembering darker items is associated with larger pupils (vs. brighter), and that gaze is biased toward cued item locations. Moreover, we discovered that pupil and eye movement responses were influenced differently by WM item relevance. Feature-specific pupillary effects emerged only for highly prioritized WM items but were eliminated when cues were less reliable, and pupil effects also increased with self-reported visual imagery strength. Conversely, gaze position consistently veered toward the cued item location, regardless of cue reliability. However, biased microsaccades occurred at a higher frequency when cues were more reliable, though only during a limited post-cue time window. Therefore, peripheral sensorimotor processing is sensitive to the task-relevance or functional state of internal WM content, but pupillary and eye movement WM signals show distinct profiles. These results highlight a potential role for early visual processing in maintaining multiple WM content dimensions. NEW & NOTEWORTHY: Here, we found that working memory (WM)-driven ocular inflections—feature-specific pupillary and saccadic biases—were muted for memory items that were less behaviorally relevant. This work illustrates that functionally informative goal signals may extend as early as the sensorimotor periphery, that pupil size may be under more fine-grained control than originally thought, and that ocular signals carry multiple dimensions of cognitively relevant information. [ABSTRACT FROM AUTHOR]

Purpose: To compare the objective visual quality of moderate-to-high myopia corrected by small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (TransPRK) at a 1,050-Hz ablation frequency, assisted by Smart-Pulse technology (SCHWIND eye-tech-solutions). Methods: This study involved 123 patients (123 eyes) with moderate-to-high myopia between July 2020 and January 2021. They were categorized into the SMILE group (67 patients, 67 eyes) and the TransPRK group (56 patients, 56 eyes). Follow-ups were conducted at 6 months postoperatively to record the logarithm of the minimum angle of resolution visual acuity, and the Strehl ratio and higher order aberrations were measured using the Sirius anterior segment analysis device (SCHWIND eye-tech-solutions) under a 6-mm pupil diameter at various postoperative intervals. Results: At 1 week and 1 month postoperatively, the uncorrected distance visual acuity (UDVA) in the SMILE group was superior to that in the TransPRK group (P <.05 for both). At 1 week and 1 month postoperatively, the Strehl ratio value in the SMILE group was higher than that in the TransPRK group (P <.05 for both). At 1, 3, and 6 months postoperatively, coma was greater in the SMILE group than in the TransPRK group (P <.05 for all). Spherical aberrations were lower in the SMILE group than in the TransPRK group at 3 and 6 months postoperatively (P <.05). At 6 months postoperatively, UDVA was −0.09 ± 0.08 and −0.11 ± 0.05 logMAR in the SMILE and TransPRK groups, respectively, which exceeded their preoperative corrected distance visual acuity of −0.05 ± 0.04 and −0.09 ± 0.08 logMAR (all P <.001). Compared with preoperative values, the Strehl ratio, total higher order, coma, and spherical aberration differences were significantly increased postoperatively in both groups (all P <.001). Conclusions: Both surgical methods improved UDVA and each had its advantages. The visual quality of SMILE was superior at 1 week and 1 month postoperatively (Strehl ratio values were higher than those of the TransPRK group), and its spherical aberration was lower than that of the TransPRK group at 3 and 6 months; TransPRK with SmartPulse technology with a 1,050-Hz ablation frequency showed that coma was significantly lower than that of the SMILE group at 1, 3, and 6 months postoperatively. [J Refract Surg. 2024;40(7):e490–e498.] [ABSTRACT FROM AUTHOR]

Purpose: There is increasing interest in the measurement of cognitive effort during listening tasks, for both research and clinical purposes. Quantification of task-evoked pupil responses (TEPRs) is a psychophysiological method that can be used to study cognitive effort. However, light level during cognitively demanding listening tasks may affect TEPRs, complicating interpretation of listening-related changes. The objective of this study was to examine the effects of light level on TEPRs during effortful listening across a range of signal-to-noise ratios (SNRs). Method: Thirty-six adults without hearing loss were asked to repeat target sentences presented in background babble noise while their pupil diameter was recorded. Light level and SNRs were manipulated in a 4 × 4 repeated-measures design. Repeated-measures analyses of variance were used to measure the effects. Results: Peak and mean dilation were typically larger in more adverse SNR conditions (except for SNR −6 dB) and smaller in higher light levels. Differences in mean and peak dilation between SNR conditions were larger in dim light than in brighter light. Conclusions: Brighter light conditions make TEPRs less sensitive to variations in listening effort across levels of SNR. Therefore, light level must be considered and reported in detail to ensure sensitivity of TEPRs and for comparisons of findings across different studies. It is recommended that TEPR testing be conducted in relatively low light conditions, considering both background illumination and screen luminance. [ABSTRACT FROM AUTHOR]

Measuring the eyebox of a near‐eye display is a complex and time‐consuming process. The recent introduction of the Draper eyebox method offers an opportunity to simplify the process and dramatically reduce the measurement time. This study compares the Draper method with the standard goniometric method with both pupil and eye rotation, and discusses its correlation. [ABSTRACT FROM AUTHOR]

Physiological measures are often used to assess the mental state of human operators in supervisory process control tasks. However, the diversity of research approaches creates a heterogeneous landscape of empirical evidence. To map existing evidence and provide guidance to researchers and practitioners, this paper systematically reviews 109 empirical studies that report relationships between peripheral nervous system measures and mental state dimensions (e.g. mental workload, mental fatigue, stress, and vigilance) of interest. Ocular and electrocardiac measures were the most prominent measures across application fields. Most studies sought to validate such measures for reliable assessments of cognitive task demands and time on task, with measures of pupil size receiving the most empirical support. In comparison, less research examined the utility of physiological measures in predicting human task performance. This approach is discussed as an opportunity to focus on operators' individual response to cognitive task demands and to advance the state of research. Physiological measures can provide the basis for dynamic operator assistance in supervisory process control tasks. This review synthesises the existing evidence, highlighting both the aggregated empirical support and the heterogeneity of the results. To advance the status quo, a larger emphasis on physiological measures as predictors of operator performance is needed. Abbreviations: HF/E: Human factors and ergonomics; CNS: Central nervous system; PNS: Peripheral nervous system; HR: Heart rate; HRV: Heart rate variability; IBI: Interbeat interval; AVNN: Average of RR intervals; SDRR: Standard deviation of RR intervals; CVRR: Coefficient of variation in RR intervals; RMSSD: Root mean square of successive; pNNX: Percentage of successive RR intervals; MAD: Median absolute deviation; LF: Power of the low-frequency; MF: Power of the mid-frequency; HF: Power of the high-frequency; TP: Total power. [ABSTRACT FROM AUTHOR]

Nowadays, eye gaze tracking of real-world people to acknowledge what they are seeing in a particular page is trending as it is emerging fast; but its complexity is also growing fast, and the accuracy is not enough. In the proposed system, the image patch of the eye region is extracted from the input image using the Viola Jones Algorithm for facial feature detection. Then SqueezeNet and U-Net are combined to train the model for pixel classification of iris and pupil from the eye image patch with a training dataset that contains manually labelled iris and pupil region. After extracting the iris and pupil features, the eye gaze tracking is formulated by using 2D pupil center extracted by applying Mean-Shift algorithm and 3D eyeball center. The system achieved an accuracy of 99.93% which is best comparable to the state-of-the-art methods. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate binocular intermediate visual acuity (IVA), depth of focus, and other visual outcomes achieved with a monofocal aspheric intraocular lens (IOL) using pooled data from 2 randomized, double-masked, controlled trials. Patients and Methods: The studies conducted at 32 sites included patients aged ≥ 22 years with bilateral cataracts, preoperative corneal astigmatism 1.0 D, and lens power 18.0– 25.0 D. Patients received bilateral AcrySof IQ IOLs (SN60WF). Primary endpoint data were collected at month 6. Binocular uncorrected and corrected distance visual acuity (UDVA and CDVA) at 4 m, binocular uncorrected and corrected IVA (UIVA and DCIVA) at 66 cm, manifest refraction spherical equivalent (MRSE), and binocular defocus curve at 4 m were assessed under photopic conditions. Validated questionnaires were used to assess spectacle use and quality of vision. Results: Of 233 patients who received SN60WF, 228 had visual acuity data at 6 months. Under photopic conditions, 51% of the eyes had pupils > 4 mm, 40% had pupils 3– 4 mm, and 9% had pupils < 3 mm. Mean ± SD UDVA and CDVA were − 0.019 ± 0.110 and − 0.088 ± 0.082 logMAR, respectively. Mean ± SD UIVA and DCIVA were 0.125 ± 0.145 and 0.196 ± 0.139 logMAR, respectively. UIVA and DCIVA of 20/32 or better were achieved by 83% (188/228) and 71% (162/228) of patients, respectively. Mean ± SD MRSE was − 0.007 ± 0.404 D for the first eye and 0.036 ± 0.371 for the second eye. The defocus curve demonstrated binocular vision of 0.24 logMAR or better from +1.2 to − 1.5 D. Spectacle independence for distance and intermediate vision was reported by 86% and 41% of the patients, respectively. Based on questionnaires, 61%, 79%, and 65% of the patients did not experience starbursts, halos, or glare. Conclusion: A monofocal aspheric IOL (SN60WF) assessed in a large, pooled study provided excellent distance vision and clinically functional intermediate vision. [ABSTRACT FROM AUTHOR]

The present study examined individual differences in levels of processing. Participants completed a cued recall task in which they made either rhyme or semantic judgements on pairs of items. Pupillary responses during encoding were recorded as a measure of the allocation of attentional effort and participants completed multiple measures of working and long-term memory. The results suggested levels of processing effect in both accuracy and pupillary responses with deeper levels of processing demonstrating higher accuracy and larger pupillary responses than shallower levels of processing. Most participants demonstrated levels of processing effect, but there was substantial variability in the size of the effect. Variation in levels of processing was positively related to individual differences in long-term memory and the magnitude of the pupillary levels of processing effect, but not working memory. These results suggest that some of the variation in levels of processing is likely due to individual differences in the allocation of attentional effort (particularly to items processed deeply) during encoding. [ABSTRACT FROM AUTHOR]

In this paper, the implementation of a new pupil detection system based on artificial intelligence techniques suitable for real-time and real-word applications is presented. The proposed AI-based pupil detection system uses a classifier implemented with slim-type neural networks, with its classes being defined according to the possible positions of the pupil within the eye image. In order to reduce the complexity of the neural network, a new parallel architecture is used in which two independent classifiers deliver the pupil center coordinates. The training, testing, and validation of the proposed system were performed using almost 40,000 eye images with a resolution of 320 × 240 pixels and coming from 20 different databases, with a high degree of generality. The experimental results show a detection rate of 96.29% at five pixels with a standard deviation of 3.38 pixels for all eye images from all databases and a processing speed of 100 frames/s. These results indicate both high accuracy and high processing speed, and they allow us to use the proposed solution for different real-time applications in variable and non-uniform lighting conditions, in fields such as assistive technology to communicate with neuromotor-disabled patients by using eye typing, in computer gaming, and in the automotive industry for increasing traffic safety by monitoring the driver's cognitive state. [ABSTRACT FROM AUTHOR]

Listening to speech in noise can require substantial mental effort, even among younger normal-hearing adults. The task-evoked pupil response (TEPR) has been shown to track the increased effort exerted to recognize words or sentences in increasing noise. However, few studies have examined the trajectory of listening effort across longer, more natural, stretches of speech, or the extent to which expectations about upcoming listening difficulty modulate the TEPR. Seventeen younger normal-hearing adults listened to 60-s-long audiobook passages, repeated three times in a row, at two different signal-to-noise ratios (SNRs) while pupil size was recorded. There was a significant interaction between SNR, repetition, and baseline pupil size on sustained listening effort. At lower baseline pupil sizes, potentially reflecting lower attention mobilization, TEPRs were more sustained in the harder SNR condition, particularly when attention mobilization remained low by the third presentation. At intermediate baseline pupil sizes, differences between conditions were largely absent, suggesting these listeners had optimally mobilized their attention for both SNRs. Lastly, at higher baseline pupil sizes, potentially reflecting overmobilization of attention, the effect of SNR was initially reversed for the second and third presentations: participants initially appeared to disengage in the harder SNR condition, resulting in reduced TEPRs that recovered in the second half of the story. Together, these findings suggest that the unfolding of listening effort over time depends critically on the extent to which individuals have successfully mobilized their attention in anticipation of difficult listening conditions. [ABSTRACT FROM AUTHOR]

Ergonomic‐centric holography is introduced, an algorithmic framework that simultaneously optimizes for realistic incoherent defocus, unrestricted pupil movements in the eye box, and high‐order diffractions for filtering‐free holography. The proposed method outperforms prior algorithms on holographic display prototypes operating in unfiltered and pupil‐mimicking modes, offering the potential to enhance next‐generation virtual and augmented reality experiences. [ABSTRACT FROM AUTHOR]

Issues with joint attention, especially avoiding eye contact with others, are considered one of the core defects found in the early stages of children with autism spectrum disorder (ASD). This study is the first to use pupil reflection technology, which can be used to present an image of the participants within the virtual character's eyes on the screen, thereby arousing their interest and promoting eye contact with the character during the interaction. The study evaluated the efficacy of pupil reflection as an internal cue to improve a participant's joint attention. A total of 63 children with ASD were asked to participate in the study. The stimuli materials were combined with internal cues and external cues. We found that, first, both the internal and external cues attracted the attention of the ASD participants and can play a prompting role in the intervention training. Second, the internal cues appeared to successfully simulate the real world in that the ASD participants paid more attention to the eyes. It can be used to improve eye contact with others. Third, there was no obvious interaction between the internal and external cues. This demonstrated that pupil reflection had a positive impact on the visual processing and joint attention of children with ASD. [ABSTRACT FROM AUTHOR]

Background: Tinnitus is a conscious perception of an auditory sensation in the absence of a corresponding external stimulus. Tinnitus can have a strong impact on the quality of life. The cause of tinnitus is not exactly known. Objectives: To assess the reliability of portable infrared pupillometry. To study the hypothesis that enlarged anterior osteophytes of cervical vertebras influences the parasympathetic nervous system. Methods: Nineteen tinnitus patients were examined with a portable infrared pupillometer and had X-ray examination of the cervical spine. The control patient population included 79 patients who visited the pain clinic for non-tinnitus complaints. Five different pupillometry values were estimated. The intraclass correlation coefficient was used to measure the inter-observer reliability. A multiple linear regression model was used to examine the association between the size of anterior osteophytes of cervical vertebras and pupillometry measurements. Results: Inter-observer reliability was excellent for baseline pupil diameter and maximum constriction amplitude (values>= 0.75), moderate to good for pupillary constriction rate and maximum constriction velocity (values 0.41 - 0.74) and poor for latency constriction. Baseline pupil diameter, maximum constriction amplitude and maximum constriction velocity were significant lower in tinnitus patients. Multiple linear regression showed a significant effect of the size of anterior osteophyte of the sixth and third cervical vertebra and the intervertebral disc space between the third and fourth cervical vertebra on maximum constriction amplitude of the pupillometry measurement. In tinnitus patients a significant effect was found of hearing loss of 8 kHz on maximum constriction amplitude. Conclusion: Inter-observer reliability was excellent for pupil diameter and maximum constriction amplitude (values>= 0.75) measured with a pupillometer. Pupil diameter, maximum constriction amplitude and maximum constriction velocity were significant lower in tinnitus patients. These results indicate that the parasympathetic nervous system is impaired. Large anterior osteophytes on the sixth and third cervical vertebra had a significant effect on maximum constriction amplitude, which we interpreted as an effect on the autonomous nervous system by activating the glossopharyngeal and vagal nerves. Pupillometry is valuable diagnostic measurement for tinnitus patients. [ABSTRACT FROM AUTHOR]

Conventional evaluation of fish freshness based on physiological and biochemical methods was destructive, complicated and costly. In this study, the new model was trained on the eye images of 100 large yellow croakers along with their total volatile basic nitrogen (TVB-N) value as freshness indicators in the storage of nine consecutive days at 4 °C. The experiment was divided into three stages (0–2 days, 3–6 days, and 7–8 days) based on TVB-N value, about 1000 images in each stage were used for freshness classification. A non-destructive and rapid fish freshness detection method based on the eye region images of large yellow croaker was proposed by mathematical modeling. The features of large yellow croaker images were extracted automatically by ResNet-34 structure, and then the key extracted feature was focused on the pupil of the fish eye by mixed attention mechanism. Finally, the features of pupil were used to classify the freshness of large yellow croaker. The results showed the accuracy of the model to classify the fish freshness was reached to 99.4%. The model constructed based on the eye images was non-destructive, and could well monitor and distinguish the freshness of large yellow croakers at different storage stages. [ABSTRACT FROM AUTHOR]

Background: In some cases of patients with out-of-hospital cardiac arrest (OHCA) who underwent extracorporeal cardiopulmonary resuscitation (ECPR), negative pupillary light reflex (PLR) and mydriasis upon hospital arrival serve as common early indicator of poor prognosis. However, in certain patients with poor prognoses inferred by pupil findings upon hospital arrival, pupillary findings improve before and after the establishment of ECPR. The association between these changes in pupillary findings and prognosis remains unclear. This study aimed to clarify the association of pupillary examinations before and after the establishment of ECPR in patients with OHCA showing poor pupillary findings upon hospital arrival with their outcomes. To this end, we analysed retrospective multicentre registry data involving 36 institutions in Japan, including all adult patients with OHCA who underwent ECPR between January 2013 and December 2018. We selected patients with poor prognosis inferred by pupillary examinations, negative pupillary light reflex (PLR) and pupil mydriasis, upon hospital arrival. The primary outcome was favourable neurological outcome, defined as Cerebral Performance Category 1 or 2 at hospital discharge. Multivariable logistic regression analysis was performed to evaluate the association between favourable neurological outcome and pupillary examination after establishing ECPR. Results: Out of the 2,157 patients enrolled in the SAVE-J II study, 723 were analysed. Among the patients analysed, 74 (10.2%) demonstrated favourable neurological outcome at hospital discharge. Multivariable analysis revealed that a positive PLR at ICU admission (odds ration [OR] = 11.3, 95% confidence intervals [CI] = 5.17–24.7) was significantly associated with favourable neurological outcome. However, normal pupil diameter at ICU admission (OR = 1.10, 95%CI = 0.52–2.32) was not significantly associated with favourable neurological outcome. Conclusion: Among the patients with OHCA who underwent ECPR and showed poor pupillary examination findings upon hospital arrival, 10.2% had favourable neurological outcome at hospital discharge. A positive PLR after the establishment of ECPR was significantly associated with favourable neurological outcome. [ABSTRACT FROM AUTHOR]

Background: Eye movement tests remain significantly underutilized in emergency departments and primary healthcare units, despite their superior diagnostic sensitivity compared to neuroimaging modalities for the differential diagnosis of acute vertigo. This underutilization may be attributed to a potential lack of awareness regarding these tests and the absence of appropriate tools for detecting nystagmus. This study aimed to develop a nystagmus measurement algorithm using a lightweight deep-learning model that recognizes the ocular regions. Method: The deep learning model was used to segment the eye regions, detect blinking, and determine the pupil center. The model was trained using images extracted from video clips of a clinical battery of eye movement tests and synthesized images reproducing real eye movement scenarios using virtual reality. Each eye image was annotated with segmentationmasks of the sclera, iris, and pupil, with gaze vectors of the pupil center for eye tracking. We conducted a comprehensive evaluation of model performance and its execution speeds in comparison to various alternative models using metrics that are suitable for the tasks. Results: The mean Intersection over Union values of the segmentation model ranged from 0.90 to 0.97 for different classes (sclera, iris, and pupil) across types of images (synthetic vs. real-world images). Additionally, the mean absolute error for eye tracking was 0.595 for real-world data and the F1 score for blink detection was = 0.95, which indicates our model is performing at a very high level of accuracy. Execution speed was also the most rapid for ocular object segmentation under the same hardware condition as compared to alternative models. The prediction for horizontal and vertical nystagmus in real eye movement video revealed high accuracy with a strong correlation between the observed and predicted values (r = 0.9949 for horizontal and r = 0.9950 for vertical; both p < 0.05). Conclusion: The potential of our model, which can automatically segment ocular regions and track nystagmus in real time from eye movement videos, holds significant promise for emergency settings or remote intervention within the field of neurotology. [ABSTRACT FROM AUTHOR]

The Framework for Effortful Listening (FUEL) suggests five input-related demands can alter listening effort: source, transmission, listener, message and context factors. We hypothesised that vocoded sentences represented a source factor degradation and sentences in speech-shaped noise represented a transmission factor degradation. We used pupillometry and a subjective scale to examine our hypothesis. Participants listened to vocoded sentences and sentences in speech-shaped noise at several difficulty levels designed to produce similar word recognition abilities; they also listened to unprocessed sentences. Within-participant pupillometrics and subjective listening effort were analysed. Post-hoc analyses were performed to examine if word recognition accuracy differentially influenced pupil responses. Twenty young adults with normal hearing. Baseline pupil diameter was significantly smaller, peak pupil dilation was significantly larger, peak pupil dilation latency was significantly shorter, and subjective listening effort was significantly greater for the vocoded sentences than the sentences-in-noise. Word recognition ability also affected pupillometrics, but only for the vocoded sentences. Our findings suggest that source factor degradations result in greater listening effort than transmission factor degradations. Future research should address how clinical interventions tailored towards different input-related demands may lead to reduced listening effort and improve patient outcomes. [ABSTRACT FROM AUTHOR]

The pupil of the eye provides a rich source of information for cognitive scientists, as it can index a variety of bodily states (e.g., arousal, fatigue) and cognitive processes (e.g., attention, decision-making). As pupillometry becomes a more accessible and popular methodology, researchers have proposed a variety of techniques for analyzing pupil data. Here, we focus on time series-based, signal-to-signal approaches that enable one to relate dynamic changes in pupil size over time with dynamic changes in a stimulus time series, continuous behavioral outcome measures, or other participants' pupil traces. We first introduce pupillometry, its neural underpinnings, and the relation between pupil measurements and other oculomotor behaviors (e.g., blinks, saccades), to stress the importance of understanding what is being measured and what can be inferred from changes in pupillary activity. Next, we discuss possible pre-processing steps, and the contexts in which they may be necessary. Finally, we turn to signal-to-signal analytic techniques, including regression-based approaches, dynamic time-warping, phase clustering, detrended fluctuation analysis, and recurrence quantification analysis. Assumptions of these techniques, and examples of the scientific questions each can address, are outlined, with references to key papers and software packages. Additionally, we provide a detailed code tutorial that steps through the key examples and figures in this paper. Ultimately, we contend that the insights gained from pupillometry are constrained by the analysis techniques used, and that signal-to-signal approaches offer a means to generate novel scientific insights by taking into account understudied spectro-temporal relationships between the pupil signal and other signals of interest. [ABSTRACT FROM AUTHOR]

Objective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease (PD). Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 2022 were included. Hoehn-Yahr staging was used to evaluate stage of the disease, Unified Parkinson's Disease Rating Scale III (UPDRS III) was used to evaluate the severity of motor disorders, Scales for Outcomes in Parkinson's Disease - Autonomic (SCOPA - AUT) was used to evaluate autonomic nervous function, Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function, Non-Motor Symptoms Scale (NMSS) was used to evaluate the severity of nonmotor symptoms. Results According to whether the patients were accompanied by Alzheimer's disease (AD), they were divided into a group with AD (n = 82) and a group without AD (n = 48). The proportion of Hoehn-Yahr staging 3 to 5 (χ² = 5.689, P = 0.017), UPDRS III score (t = 21.490, P = 0.000), SCOPA-AUT score (t = 21.330, P = 0.000), dysregulation of body temperature (χ² = 8.512, P = 0.004), urinary dysfunction (χ² = 17.270, P = 0.000), gastrointestinal dysfunction (χ² = 24.471, P = 0.000), dysregulation of pupil (χ² = 5.299, P = 0.021), cardiovascular dysfunction (χ² = 15.355, P = 0.000) and NMSS score (t = 32.309, P = 0.000) in the group with AD were higher than those in the group without AD, the MMSE (t = 4.730, P = 0.000) and MoCA (t = 6.840, P = 0.000) total scores and subtype scores (P = 0.000, for all) in the group with AD were lower than those in the group without AD. Correlation analysis showed that the SCOPA-AUT score of PD patients with AD was negatively correlated with MMSE and MoCA total scores and subtype scores (P = 0.000, for all). Conclusions The autonomic dysfunction of elderly PD patients with AD is more serious, and the autonomic nervous function is closely related to cognitive function. [ABSTRACT FROM AUTHOR]

This study explores the effects of different perceptual and cognitive information processing stages on mental workload by assessing multimodal indicators of mental workload such as the NASA-TLX, task performance, ERPs and eye movements. Repeated measures ANOVA of the data showed that among ERP indicators, P1, N1 and N2 amplitudes were sensitive to perceptual load (P-load), P3 amplitude was sensitive to P-load only in the prefrontal region during high cognitive load (C-load) states, and P3 amplitude in the occipital and parietal regions was sensitive to C-load. Among the eye movement indicators, blink frequency was sensitive to P-load in all C-load states, but to C-load in only low P-load states; pupil diameter and blink duration were sensitive to both P-load and C-load. Based on the above indicators, the k-nearest neighbours (KNN) algorithm was used to propose a classification method for the four different mental workload states with an accuracy of 97.89%. Practitioner summary: Based on the results of this study, it is possible to implement the monitoring of mental workload states and optimise brain task allocation in operations involving high mental workload, such as human-computer interaction. [ABSTRACT FROM AUTHOR]

(1) Background: Our previous research provides evidence that vergence eye movements may significantly influence cognitive processing and could serve as a reliable measure of cognitive issues. The rise of consumer-grade eye tracking technology, which uses sophisticated imaging techniques in the visible light spectrum to determine gaze position, is noteworthy. In our study, we explored the feasibility of using webcam-based eye tracking to monitor the vergence eye movements of patients with Mild Cognitive Impairment (MCI) during a visual oddball paradigm. (2) Methods: We simultaneously recorded eye positions using a remote infrared-based pupil eye tracker. (3) Results: Both tracking methods effectively captured vergence eye movements and demonstrated robust cognitive vergence responses, where participants exhibited larger vergence eye movement amplitudes in response to targets versus distractors. (4) Conclusions: In summary, the use of a consumer-grade webcam to record cognitive vergence shows potential. This method could lay the groundwork for future research aimed at creating an affordable screening tool for mental health care. [ABSTRACT FROM AUTHOR]

The ability to readily detect and recognize biological motion (BM) is fundamental to survival and interpersonal communication. However, perception of BM is strongly disrupted when it is shown upside down. This well-known inversion effect is proposed to be caused by a life motion detection mechanism highly tuned to gravity-compatible motion cues. In the current study, we assessed the inversion effect in BM perception using a no-report pupillometry. We found that the pupil size was significantly enlarged when observers viewed upright BMs (gravity-compatible) compared with the inverted counterparts (gravity-incompatible). Importantly, such an effect critically depended on the dynamic biological characteristics, and could be extended to local feet motion signals. These findings demonstrate that the eye pupil can signal gravity-dependent life motion perception. More importantly, with the convenience, objectivity, and noninvasiveness of pupillometry, the current study paves the way for the potential application of pupillary responses in detecting the deficiency of life motion perception in individuals with socio-cognitive disorders. [ABSTRACT FROM AUTHOR]

The pupil of the eye responds to various salient signals from different modalities, but there is no consensus on how these pupillary responses are integrated when multiple signals appear simultaneously. Both linear and nonlinear integration have been found previously. The current study aimed to reexamine the nature of pupillary integration, and specifically focused on the early, transient pupillary responses due to its close relationship with orienting. To separate the early pupillary responses out of the pupil time series, we adopted a pupil oscillation paradigm in which sensory stimuli were periodically presented. The simulation analysis confirmed that the amplitude of the pupil oscillation, induced by stimuli repeatedly presented at relatively high rates, can precisely reflect the early, transient pupillary responses without involving the late and sustained pupillary responses. The experimental results then showed that the amplitude of pupil oscillation induced by a series of simultaneous audiovisual stimuli equaled to a linear summation of the oscillatory amplitudes when unisensory stimuli were presented alone. Moreover, the tonic arousal levels, indicated by the baseline pupil size, cannot shift the summation from linear to nonlinear. These findings together support the additive nature of multisensory pupillary integration for the early, orienting‐related pupillary responses. The additive nature of pupillary integration further implies that multiple pupillary responses may be independent of each other, irrespective of their potential cognitive and neural drivers. The current study tapped into the controversial issue of how pupillary responses to multisensory signals are integrated, and specifically focused on the early, transient pupillary responses due to its close relationship with orienting. Using a simulation analysis and a pupil oscillation paradigm, we demonstrated a linear integration of the early pupillary responses. [ABSTRACT FROM AUTHOR]

The bull shark (Carcharhinus leucas) is an apex predator with a wide distribution in tropical and warm temperate waters. This species is known to utilise freshwater systems and estuaries as nursery grounds. During a wider bull shark tagging survey in the Rewa River, Fiji, in 2017 and 2018, 27 neonate bull sharks with red eye pupils were recorded. This opportunistic observation prompted an examination of water quality parameters in the Rewa River to collect preliminary data on the potential cause of pollution. Water samples were analysed for faecal indicator bacteria (Escherichia coli), ammonia, total nitrogen, and various metals. Results indicated high levels of E. coli contamination, as well as elevated ammonia and total nitrogen concentrations. However, due to the limited sample size and the likelihood of additional underlying causes, a definitive causal relationship could not be established. Hence, this finding stands as an opportunistic observation, detailed here for documentation and stimulation of discourse. Field observations of 27 neonate bull sharks with red eyes in the Rewa River, Fiji, raised concerns about water quality. Analysis indicated high levels of Escherichia coli contamination, ammonia, and total nitrogen. However, the definitive causal relationship is yet to be investigated. [ABSTRACT FROM AUTHOR]

Eye movements offer precious information about persons’ state. Video surveillance, marketing, driver fatigue as well as medical diagnosis assistance applications manage eye behavior. We propose a new method for efficiently detecting eye movement. In this paper, we combine circle eye model with eye feature method to improve the accuracy. A set of detectors estimate the eyes centers to increase the localization rate. As a pre-processing stage, the mean of the edges yields the center of the two eye regions. Image treatment operations reduce the ROI. A Circle Hough Transform (CHT) algorithm is adopted in a modified version as a detector to find the circle eye in the image; the circle center found represents the eye's pupil estimation. We introduced the Maximally Stable Extremal Region (MSER) as a second detector, which has never been used for eye localization. Invariant to continuous geometric transformations and affine intensity changes and detected at several scales, MSERs efficiently detect regions of interest, in our case eye regions, and precisely, their centers. Ellipses fit MSERs, and their centroid estimation match eyes center. We demonstrate that the true eye centers can be found by combining these methods. The validation of the proposed method is performed on a very challenging BioID base. The proposed approach compares well with existing state-of-the-art techniques and achieves an accuracy of 82.53% on the BioID database when the normalized error is less than 0.05, without prior knowledge or any learning model. [ABSTRACT FROM AUTHOR]

The exact factors predicting outcomes following traumatic brain injury (TBI) remain elusive. In this systematic review and meta-analysis, we examined factors influencing outcomes in adult patients with TBI, from 3 months to 1 year after injury. A search of four electronic databases--PubMed, Scopus, Web of Science, and ScienceDirect--yielded 29 studies for review and 16 for meta-analysis, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. In patients with TBI of any severity, mean differences were observed in age (8.72 years; 95% confidence interval [CI], 4.77-12.66 years), lymphocyte count (â?'0.15Ã--109/L; 95% CI, â?'0.18 to â?'0.11), glucose levels (1.20 mmol/L; 95% CI, 0.73-1.68), and hemoglobin levels (â?'0.91 g/dL; 95% CI, â?'1.49 to â?'0.33) between those with favorable and unfavorable outcomes. The prevalence rates of unfavorable outcomes were as follows: abnormal cisterns, 65.7%; intracranial pressure above 20 mmHg, 52.9%; midline shift of 5 mm or more, 63%; hypotension, 71%; hypoxia, 86.8%; blood transfusion, 70.3%; and mechanical ventilation, 90%. Several predictors were strongly associated with outcome. Specifically, age, lymphocyte count, glucose level, hemoglobin level, severity of TBI, pupillary reaction, and type of injury were identified as potential predictors of long-term outcomes. [ABSTRACT FROM AUTHOR]

Purpose. To investigate the long-term changes in visual quality and pupil size after small incision lenticule extraction (SMILE) for eyes without preoperative cylinder refraction. Methods. Thirty-three myopic eyes (33 patients) without preoperative cylinder refraction were corrected using SMILE. Refractive outcomes, corneal curvature, aberrations, contrast sensitivity (CS), and pupil diameter were evaluated preoperatively, and 30 months postoperatively. Results. The 30-month postoperative uncorrected and corrected distance visual acuity (UDVA and CDVA, LogMAR) were −0.10 ± 0.09 and −0.14 ± 0.06, respectively, whereas the preoperative CDVA (LogMAR) was −0.07 ± 0.05. Cylinder refraction of −0.11 ± 0.21 D (ranging from −0.50 to 0.00) was observed at 30 months postoperatively, increasing from the preoperative cylinder refraction of 0.00 ± 0.00 D (P = 0.004). Moreover, the centroid coordinates x, y of corneal anterior astigmatic vectors were −0.19 ± 0.22, 0.81 ± 0.33 at 30 months postoperatively, and 0.02 ± 0.28, 0.76 ± 0.51 preoperatively ( P x < 0.001 and P y = 0.810 , respectively). Furthermore, a 15° axis change in the mean anterior corneal astigmatic vector was observed at 30 months postoperatively from the preoperative state, as measured by Pentacam. At 30 months postoperatively, the photopic Log CS reduced significantly with glare at three and six cycles/degrees (P < 0.001 and P = 0.015 , respectively), a decreased photopic pupil diameter (3.27 ± 0.55 mm vs. 3.10 ± 0.66 mm, P = 0.030), and an increased Coma ( Z 3 1 ) and Trefoil ( Z 3 − 3 ) at 4 mm diameter area analysis. However, a significant linear regression relationship was only observed between changes in photopic pupil diameter and changes in photopic Log CS with glare at 12 cycles/degree (P = 0.038 and β = 0.282). Conclusion. Slight cylinder regression was observed with thicker corneal lenticular extraction after SMILE correction of nonastigmatic eyes 30 months postoperatively. This regression was mainly because of the axis changes in anterior corneal astigmatism power. Therefore, a cylinder nomogram modification of 0.25 to 0.50 D is considerable for correcting nonastigmatic myopic eyes with a predicted spherical lenticular thickness over 100 µm. [ABSTRACT FROM AUTHOR]

''Using eye-tracking technology, this study examined hazard detection at night. Using a 2 (younger versus older) x 2 (simulator versus on road) repeated-measures mixed design, 16 older adults and 17 younger adults drove their own vehicle and on a driving simulator under nighttime conditions wearing eye tracking technology. Both driving conditions had three roadway hazards of pedestrians looking at their cell phone while posed to cross the roadway. Pupil glances were recorded using outcome measures of total fixation duration, number of fixations, and time to first fixation. Results showed older adults detected hazards similarly to younger adults, especially during on-road performance. Night hazard detection was similar across driving conditions except for time to first fixation, which was faster on-road for both age groups. Results support potential use of driving simulators as a proxy for on-road with night driving needed for research and practice. [ABSTRACT FROM AUTHOR]

Objective: This study aims to examine the effects of virtual reality (VR) usage on the eyes and investigate the parameters responsible for the subsequent discomfort sensation. Materials and Methods: This prospective study enrolled 20 healthy volunteers who were engaged in a 10-minute VR game session. Refractive errors, kappa angles, phoria presence, accommodative responses, and scotopic, mesopic, and photopic pupillometry values were recorded before and after using VR. A Virtual Reality Sickness Questionnaire (VRSQ) was applied to assess discomfort, and the relation with evaluated parameters was investigated. Results: Twenty volunteers (mean age 29.80±0.57 years) included 11 females (55%) and 9 males (45%). The mean spherical equivalent refractive error was -- 1.94±0.28 diopters and 5 (25%) volunteers had phoria. Average kappa angles were 0.23±0.02 mm (x-axis) and 0.11±0.01 mm (y-axis). Post-VR, the median [(interquartile range (IQR)] stereopsis decreased from 30 (30-60) to 60 (60-60) arc seconds (P<0.001). Pupil sizes increased significantly across all lighting conditions (P<0.001). Accommodation did not significantly change post-VR (P>0.05). VRSQ scores correlated positively with phoria and kappa-x angle (r=0.458, P=0.003 and r=0.330, P=0.038) while negatively with stereopsis and kappa-y angle (r=-0.375, P=0.017 and r=-0.326, P=0.04). Conclusion: Virtual reality use reduces depth perception and induces significant mydriasis across lighting conditions. Post-VR discomfort feeling may be related to phoria, kappa angle, and stereopsis. [ABSTRACT FROM AUTHOR]

Purpose: Newborn and infant vision screening is an essential component of the health promotion visit, where the provider screens for ocular risk factors and abnormalities that may cause future impairment or vision loss. Providers may underestimate the importance of screening or find neonatal vision assessments difficult due to poor patient cooperation or time‐consuming exams, but the reversibility of vision impairment in infants makes early detection paramount to proper treatment. This article provides a clinical review of evidence‐based, practical guidance to providers who care for infants from birth through 6 months of age in the primary care setting. Conclusions: The comprehensive eye exam in infants should include a thorough history and physical examination of eye structures, visual acuity, evaluation of extraocular movements and alignment, and assessment of the red reflex. Recommended exam maneuvers differ with age as visual acuity improves and development advances through infancy. Practice Implications: Early detection of ocular pathology is critical to avoid permanent vision loss, serious morbidity, and even mortality. The seemingly complex vision screening exam can be completed with little to no cooperation from the patient when a competent pediatric healthcare provider prioritizes opportunistic exam maneuvers. The opportunistic exam allows providers to maximize efficiency while maintaining thorough technique during vision exams and screenings. [ABSTRACT FROM AUTHOR]

A space occupant's real-time exposure to light reaching his/her eyes has been a concern in lighting research and design practice. This study assumed a schematic eye to estimate the luminous flux received by the entrance pupil from the visible luminous environment. As the first part of this study, this paper focused on the fundamentals of luminous flux calculation that considers real-time human eye reactions. The research work includes: (a) developing a dynamic binocular/monocular visual field model that takes the eye movement into account, based on a conventional visual field model in orthomode, (b) retrieving the apparent area of the entrance pupil of the schematic eye, and (c) quantifying the light passing through the entrance pupil from the luminous environment fallen in the binocular/monocular visual field. The fundamental theory was tested in a theoretical uniform lighting scene to calculate the luminous flux emitted from the human visual field along multiple gaze directions at different light levels. A foundation was thus laid to estimate the real-time luminous flux passing through the entrance pupil with the aid of the camera as disclosed in Part 2 of the present study. [ABSTRACT FROM AUTHOR]

With vision being our most powerful sense and cerebral vision impairment (CVI) being a growing concern in our special schools, it is crucial that support staff working with children have a thorough understanding of both CVI and how to support their individual levels of functional vision. Creating an inspiring new innovation to support learners with profound and multiple learning difficulties (PMLD) was the focus of this research. Using an approach provided by the Education Endowment Foundation, questionnaires were given to all 49 support staff; training via PowerPoint was then provided to volunteer participants who also spent time using the innovation in the classroom. The main findings were that the training increased participants' overall confidence in CVI and how to support learners with a visual impairment. Using the innovation in the classroom also positively impacted the participants' daily practice. Potential challenges such as ensuring staff all have a thorough understanding of the innovation and having a suitable learning environment for visual work were identified. [ABSTRACT FROM AUTHOR]

A 30-year-old male patient presented to the eye department with complaints of blurring of vision of right eye at distance and near for a duration of 1.5 months. Ocular examination revealed Anisocoria with enlarged pupil in the right eye. On instillation of 0.1% pilocarpine, there was a pronounced miosis in the dilated pupil seen at 30 min associated with an improvement in distance and near vision. On slit lamp examination, vermiform movements were seen in the affected pupil on shining the slit from temporal aspect. Fundus examination was within normal limits. Systemic examination revealed absent deep tendon reflexes. Based on the clinical features, a diagnosis of Holmes-Adie syndrome was reached and the patient was started on 0.1% pilocarpine eye drops. This case highlights the importance of thorough systemic examination and investigations in all cases of anisocoria. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate and compare the accuracy of iTrace and CASIA2 in measuring the postoperative orientation of toric intraocular lens (IOL) without mydriasis. Setting: Tianjin Medical University Eye Hospital, Tianjin, China. Design: Prospective cohort study. Methods: Patients with SN6AT toric IOLs implanted after cataract surgery were enrolled. 1 month after surgery, the toric IOL orientation were measured by iTrace and CASIA2 in nonmydriatic, semi-dark conditions. Then, the toric axis was directly reviewed using the slit-lamp under full mydriasis. Axis measurement differences between each of the 2 devices and the slit-lamp, described as their relative differences (RDs), were calculated and compared. The percentage of RDs within 5 degrees, within 10 degrees and greater than 30 degrees were analyzed. Results: 77 eyes of 70 patients were included. Generally, the mean toric axis measurement RDs of CASIA2 and iTrace were 9.24 ± 10.53 degrees and 13.89 ± 15.47 degrees respectively (P = .04). For CASIA2 (72 eyes), 54.17% (39), 72.22% (52), and 4.17% (3) of eyes had RDs within 5 degrees, within 10 degrees and greater than 30 degrees, compared with 40.00% (28), 61.43% (43) and 12.86% (9) for iTrace (70 eyes). The 95% limits of agreements of CASIA2 with slit-lamp was narrower than that of iTrace with slit-lamp. The median RD of CASIA2 was significantly smaller in eyes with pupil =4mmunder dark condition compared with eyes with pupil <4 mm (P = .03). Conclusions: CASIA2 demonstrates greater precision in measuring toric IOL orientation under non-mydriatic conditions compared with iTrace. Moreover, the accuracy of CASIA2 is enhanced in cases of pupil >4 mm. [ABSTRACT FROM AUTHOR]

Adaptive optics (AO) has been widely used to measure and regulate human eye aberrations in real time. However, involuntary eye movement will restrict the working ability of the AO system severely. Thus, we propose a dual-camera three-dimensional (3D) automatic tracking technique for the AO system. In this paper, the basic principle of 3D tracking eye positioning and pupil tracking was introduced. The accuracy and feasibility were verified by practical experiments. The results show that the averaged root mean square error of higher-order aberrations from eight subjects is decreased by 11.5%, and the fluctuation variance is decreased significantly. [ABSTRACT FROM AUTHOR]

Anthropomorphic appearance is a key factor to affect users' attitudes and emotions. This research aimed to measure emotional experience caused by robots' anthropomorphic appearance with three levels – high, moderate, and low – using multimodal measurement. Fifty participants' physiological and eye-tracker data were recorded synchronously while they observed robot images that were displayed in random order. Afterward, the participants reported subjective emotional experiences and attitudes towards those robots. The results showed that the images of the moderately anthropomorphic service robots induced higher pleasure and arousal ratings, and yielded significantly larger pupil diameter and faster saccade velocity, than did the low or high robots. Moreover, participants' facial electromyography, skin conductance, and heart-rate responses were higher when observing moderately anthropomorphic service robots. An implication of the research is that service robots' appearance should be designed to be moderately anthropomorphic; too many human-like features or machine-like features may disturb users' positive emotions and attitudes. Practitioner Summary: This research aimed to measure emotional experience caused by three types of anthropomorphic service robots using a multimodal measurement experiment. The results showed that moderately anthropomorphic service robots evoked more positive emotion than high and low anthropomorphic robots. Too many human-like features or machine-like features may disturb users' positive emotions. [ABSTRACT FROM AUTHOR]