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5. Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments

Subjects
GERMINAL-CENTERS, MULTIPLE-MYELOMA, B-CELLS, BCL-6 PROTEIN, TH2 CELLS, REED-STERNBERG CELLS, C-MAF, PROGRESSIVE TRANSFORMATION, EXPRESSION PATTERN, GENE-EXPRESSION
Abstract

Background: Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4(+) T-cells.Aims: To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T-H immune response in HL.Methods and results: By immunohistochemistry, GATA3 was strongly and T-bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance of T-bet(+) T-cells and lesser amounts of GATA3(+) and cMaf(+) T-cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c-Maf was observed mostly in T-lymphocytes within the germinal centres (GCs). Nodular lymphocyte predominance type of Hodgkin's lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c-Maf(+) T-cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c-Maf(+)/CD57(+) T-cell rosettes around the neoplastic cells; these rosettes were absent in "paragranuloma-type'' T-cell/histiocyte rich B-cell lymphoma.Conclusions: T-cell TF expression profiles of the reactive T-cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments.

Published
2007

6. Cytokine gene expression profile distinguishes CD4+/CD57+T cells of the nodular lymphocyte predominance type of Hodgkin's lymphoma from their tonsillar counterparts

Author

Lydia Visser, Sibrand Poppema, Anke van den Berg, Cigdem Atayar, Faculteit Medische Wetenschappen/UMCG, Stem Cell Aging Leukemia and Lymphoma (SALL), and Translational Immunology Groningen (TRIGR)

Subjects
CD4-Positive T-Lymphocytes, Male, Pathology, nodular lymphocyte predominance type of Hodgkin's lymphoma, Lymphocyte, T-Lymphocytes, Palatine Tonsil, DISEASE, CD57 Antigens, Progressive transformation of germinal centres, INDUCED CYTIDINE DEAMINASE, PROGRESSIVE TRANSFORMATION, Oligonucleotide Array Sequence Analysis, Interleukin-13, Hodgkin's lymphoma, IMMUNE-RESPONSES, Middle Aged, Flow Cytometry, Hodgkin Disease, progressive transformation of germinal centres, medicine.anatomical_structure, B-CELLS, Female, Adult, medicine.medical_specialty, Adolescent, T cell, T cells, Biology, Pathology and Forensic Medicine, Interferon-gamma, medicine, Humans, REED-STERNBERG CELLS, Interleukin 4, Aged, Hyperplasia, Gene Expression Profiling, Germinal center, BCL-6 PROTEIN, T lymphocyte, medicine.disease, Molecular biology, cytokines, Reed–Sternberg cell, GERMINAL-CENTERS, T-CELLS, Interleukin-2, Interleukin-4, INTERLEUKIN-13 RECEPTOR, CD4(+)/CD57(+) T cells
Abstract

Little is known about the cytokine profile of nodular lymphocyte predominance Hodgkin's lymphoma (NLPHL) and the significance of the characteristic rosetting CD4(+)/CD57(+) T cells. We analysed the T lymphocyte populations isolated from lymph node suspensions from five patients with NLPHL, two with follicular hyperplasia and progressive transformation of germinal centres (PTGC), three with classical Hodgkin's lymphoma (CHL) and five with hyperplasia of the tonsil. We sorted the T cells based on expression of CD3, CD4 and CD57 by flow cytometry and evaluated the cytokine mRNA profiles of the T cells with quantitative RT-PCR. NLPHL cases were as rich in T cells as the CHL cases, but all NLPHL cases had a much higher frequency of CD4(+)/CD57(+) T cells. In contrast to the CD4(+)/CD57(+) T cells from tonsils, IL2 and IL4 mRNAs were consistently absent from the CD4(+)/CD57(+) T cells of NLPHL. Even after stimulation, no IL4 transcripts could be detected in the CD4(+)/CD57(+) T cells of NLPHL. On the other hand, IFN gamma transcripts were elevated in NLPHL and PTGC T cell subsets as compared to tonsillar T cell subsets. IL13 mRNA was exclusively produced by the T cells of CHL cases, indicating that IL13 may be a key cytokine in CHL. In conclusion, elevated levels of CD4(+)/CD57(+) T cells are characteristic of NLPHL and these T cells display a distinct cytokine mRNA profile. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Published
2006
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9. Adapting to a Virtual Learning Environment

Author

Maddox, Winston H.

Subjects
Community College Education, Community Colleges, Education, Educational Technology, Educational Software, Information Technology, Pedagogy, Teaching, higher education, community colleges, online teaching, professors, college teachers, pedagogy, virtual learning, PAR, participatory action research, disorienting dilemmas, progressive transformation, paradigm shifts, leadership, change
Abstract

This participatory action research (PAR) dissertation examines the experiences of five experienced faculty transitioning from teaching in a traditional classroom to a virtual learning environment. The research participants used technology to deliver course material and reflected on the changes in their pedagogical practice. Data were collected using four phased sessions, including the completion of interview questions, individual interview video sessions, and group video sessions and the review of participant video validation postings. Research participants used journaling to reflect on their values, beliefs, assumptions, and experiences associated with teaching and learning. Research participants teaching in virtual learning environments were provided an avenue to develop an understanding of previous encounters with technology, attitudes toward technology, and the relationship they envisioned for the use of technology in their classrooms. The study concluded with the development of an “Introduction to Online Teaching for Experienced Faculty Workshop.” The results of this dissertation substantiated that faculty experience various disorienting dilemmas that correlate with a progressive transformation, resulting in at least one case in a paradigm shift. The study also highlights the faculty participants’ concerns, issues, and perspectives of positivist versus constructivist teaching styles as a function of their participation. This dissertation is accompanied by 22 MP4 videos of the participants in this study (see List of Supplemental Files). This dissertation is available in open access in AURA http:/aura.antioch.edu and OhioLink ETD Center, www.ohiolink.edu/etd

Published
2015

10. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Surovec, Martin, Ponešová, Barbora, Eichlerová, Eva, and Surovec, Martin

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

11. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Surovec, Martin, Ponešová, Barbora, Eichlerová, Eva, and Surovec, Martin

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

12. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Ponešová, Barbora, and Eichlerová, Eva

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

13. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Ponešová, Barbora, and Eichlerová, Eva

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

14. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Ponešová, Barbora, and Eichlerová, Eva

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

15. Obnova areálu Tasovického mlýna

Author

Ponešová, Barbora, Eichlerová, Eva, Surovec, Martin, Ponešová, Barbora, Eichlerová, Eva, and Surovec, Martin

Abstract

Projekt se zabývá obnovou areálu Tasovického mlýna. Navržená strategie je rozdělena do několika fází, které reagují na nedokonalosti direktivního programování a nejistotu výsledku konvenční rekonstrukce. Důraz je kladen na postupnou transformaci pomocí různé doby trvání jednotlivých zásahů. Projekt se snaží pochopit a tlumočit rozdíly mezi dobou vzniku stavby a současnými potřebami., Project deals with renewal of the Mill Grounds In Tasovice. Designed strategy is divided into several steps which respond to imperfections of directive approach and doubts about result of conventional renovation. Emphasis is on gradual transformation which is achieved by flexible duation of each phase. Projects is trying to understand and articulate difference between medieval and modern needs.

16. Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments

Author

Tjasso Blokzijl, Sibrand Poppema, Randy D. Gascoyne, Lydia Visser, Cigdem Atayar, M Boot, Anke van den Berg, Stem Cell Aging Leukemia and Lymphoma (SALL), and Translational Immunology Groningen (TRIGR)

Subjects
Adult, Male, GABA Plasma Membrane Transport Proteins, Pathology, medicine.medical_specialty, Adolescent, Lymphocyte, Biology, C-MAF, Pathology and Forensic Medicine, T-Lymphocyte Subsets, MULTIPLE-MYELOMA, medicine, Humans, Child, REED-STERNBERG CELLS, PROGRESSIVE TRANSFORMATION, Histiocyte, Aged, EXPRESSION PATTERN, GENE-EXPRESSION, Aged, 80 and over, GATA3, Germinal center, BCL-6 PROTEIN, T-Lymphocytes, Helper-Inducer, General Medicine, Middle Aged, Germinal Center, medicine.disease, Hodgkin's lymphoma, Hodgkin Disease, Molecular biology, Neoplasm Proteins, Lymphoma, Lymphatic system, medicine.anatomical_structure, Reed–Sternberg cell, Proto-Oncogene Proteins c-maf, GERMINAL-CENTERS, B-CELLS, Original Article, Female, TH2 CELLS, T-Box Domain Proteins, Transcription Factors
Abstract

Background: Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4(+) T-cells. Aims: To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T-H immune response in HL. Methods and results: By immunohistochemistry, GATA3 was strongly and T-bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance of T-bet(+) T-cells and lesser amounts of GATA3(+) and cMaf(+) T-cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c-Maf was observed mostly in T-lymphocytes within the germinal centres (GCs). Nodular lymphocyte predominance type of Hodgkin's lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c-Maf(+) T-cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c-Maf(+)/CD57(+) T-cell rosettes around the neoplastic cells; these rosettes were absent in "paragranuloma-type'' T-cell/histiocyte rich B-cell lymphoma. Conclusions: T-cell TF expression profiles of the reactive T-cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments.

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