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3. CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV

Author

Wanjalla, Celestine N, Gabriel, Curtis L, Fuseini, Hubaida, Bailin, Samuel S, Mashayekhi, Mona, Simmons, Joshua, Warren, Christopher M, Glass, David R, Oakes, Jared, Gangula, Rama, Wilfong, Erin, Priest, Stephen, Temu, Tecla, Newell, Evan W, Pakala, Suman, Kalams, Spyros A, Gianella, Sara, Smith, David, Harrison, David G, Mallal, Simon A, and Koethe, John R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Prevention, Infectious Diseases, Digestive Diseases, Liver Disease, Sexually Transmitted Infections, Diabetes, HIV/AIDS, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Humans, Calcium, Cardiovascular Diseases, CD4-Positive T-Lymphocytes, CX3C Chemokine Receptor 1, Cytomegalovirus, Risk Factors, HIV Infections, T-Lymphocyte Subsets, CD4 T cells, CGC, HIV, cardiometabolic disease, cytomegalovirus, Biochemistry and cell biology, Genetics
Abstract

Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, immune responses to co-infections such as cytomegalovirus (CMV) may play an unappreciated role in cardiometabolic comorbidities and offer new potential therapeutic targets in a subgroup of individuals. We assessed the relationship of CX3CR1+, GPR56+, and CD57+/- T cells (termed CGC+) with comorbid conditions in a cohort of 134 PWH co-infected with CMV on long-term ART. We found that PWH with cardiometabolic diseases (non-alcoholic fatty liver disease, calcified coronary arteries, or diabetes) had higher circulating CGC+CD4+ T cells compared to metabolically healthy PWH. The traditional risk factor most correlated with CGC+CD4+ T cell frequency was fasting blood glucose, as well as starch/sucrose metabolites. While unstimulated CGC+CD4+ T cells, like other memory T cells, depend on oxidative phosphorylation for energy, they exhibited higher expression of carnitine palmitoyl transferase 1A compared to other CD4+ T cell subsets, suggesting a potentially greater capacity for fatty acid β-oxidation. Lastly, we show that CMV-specific T cells against multiple viral epitopes are predominantly CGC+. Together, this study suggests that among PWH, CGC+ CD4+ T cells are frequently CMV-specific and are associated with diabetes, coronary arterial calcium, and non-alcoholic fatty liver disease. Future studies should assess whether anti-CMV therapies could reduce cardiometabolic disease risk in some individuals.

Published
2023

4. Cytokine and chemokine receptor profiles in adipose tissue vasculature unravel endothelial cell responses in HIV.

Author

Obare, Laventa M., Priest, Stephen, Ismail, Anas, Mashayekhi, Mona, Zhang, Xiuqi, Stolze, Lindsey K., Sheng, Quanhu, Nthenge, Kisyua, Vue, Zer, Neikirk, Kit, Beasley, Heather K., Gabriel, Curtis, Temu, Tecla, Gianella, Sara, Mallal, Simon A., Koethe, John R., Hinton, Antentor, Bailin, Samuel S., and Wanjalla, Celestine N.

Abstract

Chronic systemic inflammation significantly increases myocardial infarction risk in people living with HIV (PLWH). Endothelial cell dysfunction disrupts vascular homeostasis regulation, increasing the risk of vasoconstriction, inflammation, and thrombosis, contributing to cardiovascular disease. We aimed to characterize endothelial cell (EC) chemokines, cytokine, and chemokine receptors of PLWH, hypothesizing that in our cohort, glucose intolerance contributes to their differential expression implicated in endothelial dysfunction. Using single‐cell transcriptomic analysis, we phenotyped chemokine and cytokine receptor expression on arterial ECs, capillary ECs, venous ECs, and vascular smooth muscle cells (VSMCs) in subcutaneous adipose tissue of 59 PLWH with and without glucose intolerance. Our results show that arterial and capillary ECs express significantly higher interferon and tumor necrosis factor (TNF) receptors than venous ECs and VSMCs. Venous ECs exhibited more interleukin (IL)1R1 and ACKR1 receptors, and VSMCs showed significant IL6R expression than arterial and capillary ECs. When stratified by group, arterial ECs from PLWH with glucose intolerance expressed significantly higher IL1R1, IL6R, CXCL12, CCL14, and ICAM2 transcripts than arterial ECs from PLWH without diabetes. Of the different vascular cell types studied, arterial ECs as a proportion of all ECs in adipose tissue were positively correlated with plasma fasting blood glucose. In contrast, venous ECs and VSMCs were positively correlated with plasma IL6. To directly assess the effect of plasma from PLWH on endothelial function, we cultured human arterial ECs (HAECs) in plasma‐conditioned media from PLWH and performed bulk RNA sequencing. Plasma from PLWH stimulated ECs with the upregulation of genes that enrich for the oxidative phosphorylation and the TNF‐α via NFK‐β pathways. In conclusion, ECs in PLWH show heterogeneous cytokine and chemokine receptor expression, and arterial ECs were the most influenced by glucose intolerance. Further research must explicate cytokine and chemokine roles in EC dysfunction and identify biomarkers for disease progression and therapeutic response. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Cytokine and Chemokine Receptor Profiles in Adipose Tissue Vasculature Unravel Endothelial Cell Responses in HIV

Author

Obare, Laventa M., primary, Priest, Stephen, additional, Ismael, Anas, additional, Mashayekhi, Mona, additional, Zhang, Xiuqi, additional, Stolze, Lindsey K., additional, Sheng, Quanhu, additional, Vue, Zer, additional, Neikirk, Kit, additional, Beasley, Heather, additional, Gabriel, Curtis, additional, Temu, Tecla, additional, Gianella, Sara, additional, Mallal, Simon, additional, Koethe, John R., additional, Hinton, Antentor, additional, Bailin, Samuel, additional, and Wanjalla, Celestine N., additional

Published
2024
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6. Aligning patient values and code status: Choice of Diction's Effect (CODE) study

Author

Kota, Karthik J., primary, Chen, Catherine, additional, George, Renu, additional, Nagengast, Samantha, additional, Azab, Andrew, additional, Bhalla, Raman, additional, Dave, Payal, additional, Ji, Stephanie, additional, Lawrence, Ibiyonu, additional, Naik, Jay, additional, Noman, Sofiul, additional, Parikh, Payal, additional, Patel, Manish, additional, Patel, Sheetal, additional, Priest, Stephen O., additional, Prister, James, additional, Schaer, Daniel, additional, Theodorou Ross, Christina, additional, Shah, Rohan V., additional, Duberstein, Paul, additional, and Steinberg, Michael B., additional

Published
2024
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7. Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center

Author

Mishkin, Aaron, Abba, Abbas, Pathak, Abhijit S., Rastogi, Abhinav, Diamond, Adam, Satti, Aditi, Simon, Adria, Soliman, Ahmed, Braveman, Alan, Mamary, Albert J., Pandya, Aloknath, Goldberg, Amy, Kambo, Amy, Gangemi, Andrew, Vaidya, Anjali, Davison, Ann, Basil, Anuj, Kosmider, Beata, Bakhos, Charles T., Cornwell, Bill, Sanguily, Brianna, Corso, Brittany, Grabianowski, Carla, Sedlock, Carly, Myers, Catherine, Bakhos, Charles, Reddy Mandapati, Chenna Kesava, Erkmen, Cherie, Gangireddy, Chethan, Lin, Chih-ru, Burks, Christopher T., Raab, Claire, Crabbe, Deborah, Chen, Crystal, Edmundowicz, Daniel, Sacher, Daniel, Salerno, Daniel, Simon, Daniele, Ambrose, David, Ciccolella, David, Gillman, Debra, Fehrle, Dolores, Morano, Dominic, Bassler, Donnalynn, Cronin, Edmund, Dominguez, Eduardo, Randhawa, Ekam, Randhawa, Ekamjeet, Hamad, Eman, Male, Eneida, Narewski, Erin, Cordova, Francis, Jaffe, Frederic, Kueppers, Frederich, Dikengil, Fusun, Galli, Jonathan, Garfield, Jamie, Jones, Gayle, Calendo, Gennaro, Criner, Gerard, D'Alonzo, Gilbert, Marmolejos, Ginny, Gordon, Matthew, Millio, Gregory, Gupta, Rohit, Gustavo, Fernandez, Simborio, Hannah, Scott, Harwood, Shore-Brown, Heidi, Alvarado, Hernan, Yeung, Ho-Man, Yousef, Ibraheem, Oriaku, Ifeoma, Lee, Iris Jung-won, Whitman, Isaac, Brown, James, Garfield, Jamie L., Mokha, Janpreet, Gallagher, Jason, Stewart, Jeffrey, Murray, Jenna, Tang, Jessica, Gonzalez, Jeyssa, Wu, Jichuan, Thomas, Jiji, Murrett, Jim, Beros, Joanna, Travaline, John M., Varghese, Jolly, Senchak, Jordan, Lambert, Joseph, Ramzy, Joseph, Cooper, Joshua, Song, Jun, Chowdhury, Junad, Kennedy, Kaitlin, Bahmed, Karim, Loukmane, Karim, Shenoy, Karthik, Brennan, Kathleen, Johnson, Keith, Carney, Kevin, Schreyer, Kraftin, Criner, Kristin, Kumaran, Maruti, Miller, Lauren, Jameson, Laurie, Johnson, Laurie, Kilpatrick, Laurie, Criner, Lii-Yoong, Zhang, Lily, McGann, Lindsay K., Samuels, Llera A., Diamon, Marc, Kerper, Margaret, Sanchez, Maria Vega, Marcinkienwicz, Mariola, Pedlar, Maritza, Aksoy, Mark, Weir, Mark, Wolfson, Marla R., Wolfson, Marla, Marron, Robert, Keane, Martin, Zantah, Massa, Zheng, Mathew, Delfiner, Matthew, Patel, Maulin, Healy, Megan, Darnell, Melinda, Navaro, Melissa, Brisco-Bacik, Meredith A., Bromberg, Michael, Gannon, Michael, Jacobs, Michael, Mandal, Mira, Gou, Nanzhou, Marchetti, Nathaniel, Xander, Nathaniel, Kaur, Navjot, Nadpara, Neil, Desai, Nicole, Mills, Nicole, Shigemura, Norihisa, Rehbini, Ohoud, O'Corragain, Oisin, Sheriff, Omar, Arosarena, Oneida, Abramian, Osheen, Stanley, Paige, Desai, Parag, Rali, Parth, Mulhall, Patrick, Patil, Pravin, Varghe, Priju, Dubal, Puja, Patel, Puja, Blair, Rachael, Rengan, Rajagopalan, Alashram, Rami, Hooper, Randol, Armbruster, Rebecca A., Sheriden, Regina, Caricchio, Roberto, Thomas, Rogers, Soans, Rohit, Petrov, Roman, Prosniak, Roman, Fajardo, Romulo, Bhutani, Ruchi, Townsend, Ryan, Islam, Sabrina, Pettigrew, Samantha, Wallace, Samantha, Sehgal, Sameep, Krachman, Samuel, Dhungana, Santosh, Hoang, Sarah, Duffy, Sean, Rani, Seema, William, Shapiro, Weaver, Sheila, Benny, Shelu, George, Sheril, Sun, Shuang, Srivastava-Malhotra, Shubhra, Brictson, Stephanie, Spivack, Stephanie, Tittaferrante, Stephanie, Yerkes, Stephanie, Priest, Stephen, Codella, Steve, Kelsen, Steven G., Houser, Steven, Verga, Steven, Bolla, Sudhir, Kotnala, Sudhir, Karhadkar, Sunil, Johnson, Sylvia, Shariff, Tahseen, Jacobs, Tammy, Hooper, Thomas, Rogers, Tom, Reed, Tony S., Ku, Tse-Shuen, Sajjan, Uma, Kim, Victor, Cabey, Whitney, Chatila, Wissam, Li, Wuyan, Dorey-Stein, Zach, Dorey-Stein, Zachariah, Repanshek, Zachary D., Oresanya, Lawrence, Yu, Daohai, Weiss, Robert, Ali, Nadia, Stack, Anthony, Lubitz, Andrea L., Panaro, Joseph, Bashir, Riyaz, Lakhter, Vladimir, Dass, Chandra, Maruti, Kumaran, Lu, Xiaoning, Rao, A. Koneti, Cohen, Gary, Criner, Gerard J., and Choi, Eric T.

Published
2021
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13. Distinct blood CD3+ CD14+ T Cell-Monocyte complexes harbor HIV and are dynamic, glucose-dependent, and increased in individuals with glucose intolerance

Author

Wanjalla, Celestine N, primary, Simmons, Joshua, additional, Oakes, Jared, additional, Zhang, Xiuqi, additional, Nochowivz, Cindy, additional, Priest, Stephen, additional, Bailin, Samuel S, additional, Watten, Christopher M, additional, Mashayekhi, Mona, additional, Beasley, Heather K, additional, Wang, Jian, additional, Meenderink, Leslie M., additional, Sheng, Quanhu, additional, Stolze, Joey, additional, Gangula, Rama, additional, Chopra, Abha, additional, Gabriel, Curtis L, additional, Temu, Tecla, additional, Pakala, Suman, additional, Wilfong, Erin M, additional, Gianella, Sara, additional, Phillips, Elizabeth J, additional, Harrison, David G, additional, Hinton, Antenitor, additional, Kalams, Spyros A, additional, Mallal, Simon A, additional, and Koethe, John R, additional

Published
2023
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14. CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV

Author

Wanjalla, Celestine N., primary, Gabriel, Curtis L., additional, Fuseini, Hubaida, additional, Bailin, Samuel S., additional, Mashayekhi, Mona, additional, Simmons, Joshua, additional, Warren, Christopher M., additional, Glass, David R., additional, Oakes, Jared, additional, Gangula, Rama, additional, Wilfong, Erin, additional, Priest, Stephen, additional, Temu, Tecla, additional, Newell, Evan W., additional, Pakala, Suman, additional, Kalams, Spyros A., additional, Gianella, Sara, additional, Smith, David, additional, Harrison, David G., additional, Mallal, Simon A., additional, and Koethe, John R., additional

Published
2023
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15. Distinct CD3 CD14 T Cell-Monocytes are Dynamic Complexes that are Increased with Glucose Intolerance and Salt-Sensitive Hypertension

Author

Pitzer, Ashley, primary, Simmons, Joshua D., additional, Oakes, Jared, additional, Zhang, Xiuqi, additional, Nochowicz, Cindy, additional, Priest, Stephen, additional, Bailin, Samuel, additional, Warren, Christopher M., additional, Mashayekhi, Mona, additional, Beasley, Heather K., additional, Shao, Jianqiang, additional, Ertugulu, Lale A., additional, Meenderink, Leslie M., additional, Sheng, Quanhu, additional, Stolze, Joey, additional, Gangula, Rama, additional, Chopra, Abha, additional, Gabriel, Curtis L., additional, Temu, Tecla M., additional, Pakala, Suman B., additional, Wilfong, Erin M., additional, Gianella, Sara, additional, Phillips, Elizabeth J., additional, Harrison, David G., additional, Hinton, Antentor, additional, Kalams, Spyros A., additional, Kirabo, Annet, additional, Mallal, Simon A., additional, Koethe, John R., additional, and Wanjalla, Celestine N., additional

Published
2023
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28. Education Online: A Community Preceptor Computer Network.

Author

Gephart, Dale, Donahue, Dennis, Orgren, Rosemary, Brooks, W. Blair, and Priest, Stephen L.

Abstract

Describes and assesses the Dartmouth Medical School (New Hampshire) community preceptor computer network, using electronic mail and local area network resources to improve communication of curriculum to rural teaching sites, enhance the quality of community-based teaching experiences, support community-based preceptors in teaching, and help community preceptors engage more closely with academic medical centers. (Author/MSE)

Published
1998

30. CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV.

Author

Wanjalla, Celestine N., Gabriel, Curtis L., Fuseini, Hubaida, Bailin, Samuel S., Mashayekhi, Mona, Simmons, Joshua, Warren, Christopher M., Glass, David R., Oakes, Jared, Gangula, Rama, Wilfong, Erin, Priest, Stephen, Temu, Tecla, Newell, Evan W., Pakala, Suman, Kalams, Spyros A., Gianella, Sara, Smith, David, Harrison, David G., and Mallal, Simon A.

Subjects
FATTY liver, T cells, HEART metabolism disorders, CARNITINE palmitoyltransferase, NON-alcoholic fatty liver disease, CHEMOKINE receptors
Abstract

Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, immune responses to co-infections such as cytomegalovirus (CMV) may play an unappreciated role in cardiometabolic comorbidities and offer new potential therapeutic targets in a subgroup of individuals. We assessed the relationship of CX3CR1+, GPR56+, and CD57+/- T cells (termed CGC+) with comorbid conditions in a cohort of 134 PWH co-infected with CMV on longterm ART. We found that PWH with cardiometabolic diseases (non-alcoholic fatty liver disease, calcified coronary arteries, or diabetes) had higher circulating CGC+CD4+ T cells compared to metabolically healthy PWH. The traditional risk factor most correlated with CGC+CD4+ T cell frequency was fasting blood glucose, as well as starch/sucrose metabolites. While unstimulated CGC+CD4+ T cells, like other memory T cells, depend on oxidative phosphorylation for energy, they exhibited higher expression of carnitine palmitoyl transferase 1A compared to other CD4+ T cell subsets, suggesting a potentially greater capacity for fatty acid boxidation. Lastly, we show that CMV-specific T cells against multiple viral epitopes are predominantly CGC+. Together, this study suggests that among PWH, CGC+ CD4+ T cells are frequently CMV-specific and are associated with diabetes, coronary arterial calcium, and non-alcoholic fatty liver disease. Future studies should assess whether anti-CMV therapies could reduce cardiometabolic disease risk in some individuals. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Cover Image, Volume 239, Number 11, November 2024.

Author

Obare, Laventa M., Priest, Stephen, Ismail, Anas, Mashayekhi, Mona, Zhang, Xiuqi, Stolze, Lindsey K., Sheng, Quanhu, Nthenge, Kisyua, Vue, Zer, Neikirk, Kit, Beasley, Heather K., Gabriel, Curtis, Temu, Tecla, Gianella, Sara, Mallal, Simon A., Koethe, John R., Hinton, Antentor, Bailin, Samuel S., and Wanjalla, Celestine N.

Published
2024
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35. Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center

Author

Rali, Parth, primary, O'Corragain, Oisin, additional, Oresanya, Lawrence, additional, Yu, Daohai, additional, Sheriff, Omar, additional, Weiss, Robert, additional, Myers, Catherine, additional, Desai, Parag, additional, Ali, Nadia, additional, Stack, Anthony, additional, Bromberg, Michael, additional, Lubitz, Andrea L., additional, Panaro, Joseph, additional, Bashir, Riyaz, additional, Lakhter, Vladimir, additional, Caricchio, Roberto, additional, Gupta, Rohit, additional, Dass, Chandra, additional, Maruti, Kumaran, additional, Lu, Xiaoning, additional, Rao, A. Koneti, additional, Cohen, Gary, additional, Criner, Gerard J., additional, Choi, Eric T., additional, Mishkin, Aaron, additional, Abba, Abbas, additional, Pathak, Abhijit S., additional, Rastogi, Abhinav, additional, Diamond, Adam, additional, Satti, Aditi, additional, Simon, Adria, additional, Soliman, Ahmed, additional, Braveman, Alan, additional, Mamary, Albert J., additional, Pandya, Aloknath, additional, Goldberg, Amy, additional, Kambo, Amy, additional, Gangemi, Andrew, additional, Vaidya, Anjali, additional, Davison, Ann, additional, Basil, Anuj, additional, Kosmider, Beata, additional, Bakhos, Charles T., additional, Cornwell, Bill, additional, Sanguily, Brianna, additional, Corso, Brittany, additional, Grabianowski, Carla, additional, Sedlock, Carly, additional, Bakhos, Charles, additional, Reddy Mandapati, Chenna Kesava, additional, Erkmen, Cherie, additional, Gangireddy, Chethan, additional, Lin, Chih-ru, additional, Burks, Christopher T., additional, Raab, Claire, additional, Crabbe, Deborah, additional, Chen, Crystal, additional, Edmundowicz, Daniel, additional, Sacher, Daniel, additional, Salerno, Daniel, additional, Simon, Daniele, additional, Ambrose, David, additional, Ciccolella, David, additional, Gillman, Debra, additional, Fehrle, Dolores, additional, Morano, Dominic, additional, Bassler, Donnalynn, additional, Cronin, Edmund, additional, Dominguez, Eduardo, additional, Randhawa, Ekam, additional, Randhawa, Ekamjeet, additional, Hamad, Eman, additional, Male, Eneida, additional, Narewski, Erin, additional, Cordova, Francis, additional, Jaffe, Frederic, additional, Kueppers, Frederich, additional, Dikengil, Fusun, additional, Galli, Jonathan, additional, Garfield, Jamie, additional, Jones, Gayle, additional, Calendo, Gennaro, additional, Criner, Gerard, additional, D'Alonzo, Gilbert, additional, Marmolejos, Ginny, additional, Gordon, Matthew, additional, Millio, Gregory, additional, Gustavo, Fernandez, additional, Simborio, Hannah, additional, Scott, Harwood, additional, Shore-Brown, Heidi, additional, Alvarado, Hernan, additional, Yeung, Ho-Man, additional, Yousef, Ibraheem, additional, Oriaku, Ifeoma, additional, Lee, Iris Jung-won, additional, Whitman, Isaac, additional, Brown, James, additional, Garfield, Jamie L., additional, Mokha, Janpreet, additional, Gallagher, Jason, additional, Stewart, Jeffrey, additional, Murray, Jenna, additional, Tang, Jessica, additional, Gonzalez, Jeyssa, additional, Wu, Jichuan, additional, Thomas, Jiji, additional, Murrett, Jim, additional, Beros, Joanna, additional, Travaline, John M., additional, Varghese, Jolly, additional, Senchak, Jordan, additional, Lambert, Joseph, additional, Ramzy, Joseph, additional, Cooper, Joshua, additional, Song, Jun, additional, Chowdhury, Junad, additional, Kennedy, Kaitlin, additional, Bahmed, Karim, additional, Loukmane, Karim, additional, Shenoy, Karthik, additional, Brennan, Kathleen, additional, Johnson, Keith, additional, Carney, Kevin, additional, Schreyer, Kraftin, additional, Criner, Kristin, additional, Kumaran, Maruti, additional, Miller, Lauren, additional, Jameson, Laurie, additional, Johnson, Laurie, additional, Kilpatrick, Laurie, additional, Criner, Lii-Yoong, additional, Zhang, Lily, additional, McGann, Lindsay K., additional, Samuels, Llera A., additional, Diamon, Marc, additional, Kerper, Margaret, additional, Sanchez, Maria Vega, additional, Marcinkienwicz, Mariola, additional, Pedlar, Maritza, additional, Aksoy, Mark, additional, Weir, Mark, additional, Wolfson, Marla R., additional, Wolfson, Marla, additional, Marron, Robert, additional, Keane, Martin, additional, Zantah, Massa, additional, Zheng, Mathew, additional, Delfiner, Matthew, additional, Patel, Maulin, additional, Healy, Megan, additional, Darnell, Melinda, additional, Navaro, Melissa, additional, Brisco-Bacik, Meredith A., additional, Gannon, Michael, additional, Jacobs, Michael, additional, Mandal, Mira, additional, Gou, Nanzhou, additional, Marchetti, Nathaniel, additional, Xander, Nathaniel, additional, Kaur, Navjot, additional, Nadpara, Neil, additional, Desai, Nicole, additional, Mills, Nicole, additional, Shigemura, Norihisa, additional, Rehbini, Ohoud, additional, Arosarena, Oneida, additional, Abramian, Osheen, additional, Stanley, Paige, additional, Rali, Parth, additional, Mulhall, Patrick, additional, Patil, Pravin, additional, Varghe, Priju, additional, Dubal, Puja, additional, Patel, Puja, additional, Blair, Rachael, additional, Rengan, Rajagopalan, additional, Alashram, Rami, additional, Hooper, Randol, additional, Armbruster, Rebecca A., additional, Sheriden, Regina, additional, Thomas, Rogers, additional, Soans, Rohit, additional, Petrov, Roman, additional, Prosniak, Roman, additional, Fajardo, Romulo, additional, Bhutani, Ruchi, additional, Townsend, Ryan, additional, Islam, Sabrina, additional, Pettigrew, Samantha, additional, Wallace, Samantha, additional, Sehgal, Sameep, additional, Krachman, Samuel, additional, Dhungana, Santosh, additional, Hoang, Sarah, additional, Duffy, Sean, additional, Rani, Seema, additional, William, Shapiro, additional, Weaver, Sheila, additional, Benny, Shelu, additional, George, Sheril, additional, Sun, Shuang, additional, Srivastava-Malhotra, Shubhra, additional, Brictson, Stephanie, additional, Spivack, Stephanie, additional, Tittaferrante, Stephanie, additional, Yerkes, Stephanie, additional, Priest, Stephen, additional, Codella, Steve, additional, Kelsen, Steven G., additional, Houser, Steven, additional, Verga, Steven, additional, Bolla, Sudhir, additional, Kotnala, Sudhir, additional, Karhadkar, Sunil, additional, Johnson, Sylvia, additional, Shariff, Tahseen, additional, Jacobs, Tammy, additional, Hooper, Thomas, additional, Rogers, Tom, additional, Reed, Tony S., additional, Ku, Tse-Shuen, additional, Sajjan, Uma, additional, Kim, Victor, additional, Cabey, Whitney, additional, Chatila, Wissam, additional, Li, Wuyan, additional, Dorey-Stein, Zach, additional, Dorey-Stein, Zachariah, additional, and Repanshek, Zachary D., additional

Published
2021
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39. Husserl's concept of being: from phenomenology to metaphysics

Author

Priest, Stephen

Subjects
Philosophy, German -- History, Phenomenology -- Beliefs, opinions and attitudes, Metaphysics -- Beliefs, opinions and attitudes, Ontology -- Beliefs, opinions and attitudes, Philosophy and religion
Abstract

Husserl's transcendental phenomenology is based on unrecognized metaphysical presuppositions, as demonstrated by an examination of Husserl's concept of being. Topics discussed include individual and real being, absolute being, and the metaphysics of absolute being.

Published
1999

42. The Problem of Evil - Peter van Inwagen

Author

Priest, Stephen

Subjects
Philosophy and religion
Abstract

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1467-9213.2007.521_5.x Byline: Stephen Priest

Published
2007

45. The Emotions

Author

Priest, Stephen

Subjects
The Emotions (Book), Books -- Book reviews, Philosophy and religion
Abstract

The author defends a Belief-Desire theory of the emotions against Component and Evaluative theories. On all three theories emotions exhibit intentionality. On the Component theory emotions exhibit intentionality because beliefs [...]

Published
1995

46. Prion-like MAVS aggregation in lupus patients associates with increased interferon-I

Author

Shao, Wen-Hai, Shu, Daniel H., Zhen, Yuxuan, Hilliard, Brendan, Priest, Stephen O., Cesaroni, Matteo, Ting, Jenny P-Y., and Cohen, Philip L.

Subjects
Adult, Male, Ubiquitin-Protein Ligases, Blotting, Western, Protein Aggregation, Pathological, Article, snRNP Core Proteins, Ribonucleoprotein, U1 Small Nuclear, Arthritis, Rheumatoid, Mitochondrial Proteins, Humans, Lupus Erythematosus, Systemic, Adaptor Proteins, Signal Transducing, Autoantibodies, Membrane Glycoproteins, Membrane Proteins, Interferon-beta, Middle Aged, Receptors, Complement, Tissue Array Analysis, Antibodies, Antinuclear, Case-Control Studies, Interferon Type I, Leukocytes, Mononuclear, Intercellular Signaling Peptides and Proteins, Female, Transcriptome
Abstract

Increased levels of type I interferon (IFN) and type I IFN-regulated genes are found in patients with systemic lupus erythematosus (SLE) and may be central to its pathogenesis. Mitochondrial antiviral signaling protein (MAVS) is a key regulator of type I IFN that undergoes a dramatic prion-like aggregation and self propagates the activation signal from viral RNA to amplify downstream IFN production. We undertook this study to determine whether such MAVS aggregates might play a role in the sustained increased production of type I IFN in SLE.Peripheral blood mononuclear cells were isolated and mitochondrial extracts were prepared. MAVS aggregation was detected by semidenatured agarose gel electrophoresis and confirmed by immunofluorescence staining. MAVS-associated signaling proteins were analyzed by Western blotting. MAVS aggregation-associated gene expression signature was analyzed by microarray.In blood cells from 22 of 67 SLE patients, essentially all MAVS was in a high molecular weight aggregated form. None of 6 rheumatoid arthritis patients and only 3 of 33 healthy controls had abnormal MAVS. Compared to MAVS aggregate-negative patients, MAVS aggregate-positive SLE patients had significantly higher serum levels of IFNβ and significantly increased levels of autoantibodies against Sm and U1 RNP. Gene array data revealed a characteristic gene expression pattern in these patients, with altered expression of genes involved in IFN signaling and membrane trafficking.Persistent MAVS aggregates may lead to increased type I IFN production and result in unmitigated signals leading to autoimmunity.

Published
2016

47. Stat1 Regulates Lupus-Like Chronic GVHD Severity via Interactions with Stat3

Author

Shao, Wen-Hai, Gamero, Ana M., Zhen, Yuxuan, Lobue, Monica J., Priest, Stephen O., Albandar, Hazem J., and Cohen, Philip L.

Subjects
STAT3 Transcription Factor, B-Lymphocytes, Interleukin-6, Graft vs Host Disease, Lymphocyte Activation, Lupus Nephritis, Article, Mice, Inbred C57BL, Interferon-gamma, Mice, STAT1 Transcription Factor, immune system diseases, Chronic Disease, Animals, skin and connective tissue diseases, Autoantibodies
Abstract

Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease, characterized by a spectrum of autoantibodies that target multiple cellular components. Glomerulonephritis is a major cause of morbidity in patients with SLE. Little is known about the pathogenesis of SLE renal damage and compromised renal function. Activation of both Stat1 and Stat3 has been reported in lupus and lupus nephritis. The reciprocal activation of these two transcription factors may have a major impact on renal inflammation. To study the role of Stat1 in a lupus model, we induced lupus-like chronic graft-versus-host disease (cGVHD) in Stat1-knockout (KO) and wild-type (WT) mice by i.p. injection of class II-disparate bm12 splenocytes. WT recipients of these alloreactive cells developed anti-dsDNA autoantibodies starting at week 2 as expected, with a decline after week 4. In contrast, Stat1-KO hosts exhibited a prolonged and significant increase of anti-dsDNA autoantibody responses compared with WT mice (week 4 to week 8). Increased autoantibody titers were accompanied by increased proteinuria and mortality in the cGVHD host mice lacking Stat1. Further analysis revealed expression and activation of Stat3 in the glomeruli of Stat1-KO host mice but not WT mice with cGVHD. Glomerular Stat3 activity in the Stat1-KO mice was associated with increased IL-6 and IFN-γ secretion and macrophage infiltration. Interactions between Stat1 and Stat3 thus appear to be crucial in determining the severity of lupus-like disease in the cGVHD model.

Published
2015

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