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3. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry.

Author

Harahsheh, Ashraf, Shah, Samay, Dallaire, Frederic, Manlhiot, Cedric, Khoury, Michael, Lee, Simon, Fabi, Marianna, Mauriello, Daniel, Tierney, Elif, Sabati, Arash, Dionne, Audrey, Dahdah, Nagib, Choueiter, Nadine, Thacker, Deepika, Giglia, Therese, Truong, Dongngan, Jain, Supriya, Portman, Michael, Orr, William, Harris, Tyler, Szmuszkovicz, Jacqueline, Farid, Pedrom, and McCrindle, Brian

Abstract

BACKGROUND: Patients with multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) have overlapping clinical features. We compared demographics, clinical presentation, management, and outcomes of patients according to evidence of previous SARS-CoV-2 infection. METHODS: The International Kawasaki Disease Registry (IKDR) enrolled KD and MIS-C patients from sites in North, Central, and South America, Europe, Asia, and the Middle East. Evidence of previous infection was defined as: Positive (household contact or positive polymerase chain reaction [PCR]/serology), Possible (suggestive clinical features of MIS-C and/or KD with negative PCR or serology but not both), Negative (negative PCR and serology and no known exposure), and Unknown (incomplete testing and no known exposure). RESULTS: Of 2345 enrolled patients SARS-CoV-2 status was Positive for 1541 (66%) patients, Possible for 89 (4%), Negative for 404 (17%) and Unknown for 311 (13%). Clinical outcomes varied significantly among the groups, with more patients in the Positive/Possible groups presenting with shock, having admission to intensive care, receiving inotropic support, and having longer hospital stays. Regarding cardiac abnormalities, patients in the Positive/Possible groups had a higher prevalence of left ventricular dysfunction, and patients in the Negative and Unknown groups had more severe coronary artery abnormalities. CONCLUSIONS: There appears to be a spectrum of clinical features from MIS-C to KD with a great deal of heterogeneity, and one primary differentiating factor is evidence for previous acute SARS-CoV-2 infection/exposure. SARS-CoV-2 Positive/Possible patients had more severe presentations and required more intensive management, with a greater likelihood of ventricular dysfunction but less severe coronary artery adverse outcomes, in keeping with MIS-C.

Published
2023

4. Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Author

Walton, Mollie, Raghuveer, Geetha, Harahsheh, Ashraf, Portman, Michael A., Lee, Simon, Khoury, Michael, Dahdah, Nagib, Fabi, Marianna, Dionne, Audrey, Harris, Tyler H., Choueiter, Nadine, Garrido-Garcia, Luis Martin, Jain, Supriya, Dallaire, Frédéric, Misra, Nilanjana, Hicar, Mark D., Giglia, Therese M., Truong, Dongngan T., Tierney, Elif Seda Selamet, Thacker, Deepika, Nowlen, Todd T., Szmuszkovicz, Jacqueline R., Norozi, Kambiz, Orr, William B., Farid, Pedrom, Manlhiot, Cedric, and McCrindle, Brian W.

Published
2023
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5. Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension

Author

Abbate, Antonio, Abo-Auda, Wael, Akhtar, Asif, Arad, Michael, Atar, Shaul, Baibhav, Bipul, Brucato, Antonio, Collins, Sean, Colquhoun, David, Cremer, Paul, Cross, David, Dwivedi, Girish, Eisen, Alon, Freedberg, Nahum, Fuchs, Shmuel, Gaddam, Eliyazar, Gattorno, Marco, Gelfand, Eli, Grena, Paul, Halabi, Majdi, Harris, David, Imazio, Massimo, Insalaco, Antonella, Karim, Amin, Klein, Allan, Knowlton, Kirk, Kontzias, Apostolos, Kornberg, Robert, Latif, Faisal, Leibowitz, David, LeWinter, Martin, Lou, Pey Wen, Lin, David, Luis, S. Allen, Nicholls, Stephen, Petersen, John, Portman, Michael, Roberts-Thomson, Philip, Schiff, Elad, Siegel, Robert, Stokes, Michael, Sutej, Paul, Wittekind, Samuel, Witzling, Valentin, Zukermann, Robert, Trotta, Lucia, Cremer, Paul C., Klutstein, Marc, Luis, Sushil A., Wasserstrum, Yishay, Clair, JoAnn, Wang, Sheldon, Klein, Allan L., and Paolini, John F.

Published
2024
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6. COVID-19 Positive Versus Negative Complete Kawasaki Disease: A Study from the International Kawasaki Disease Registry

Author

Jose, Jerin, Tierney, Elif Seda Selamet, Harahsheh, Ashraf S., Dahdah, Nagib, Raghuveer, Geetha, Friedman, Kevin G., Khoury, Michael, Hicar, Mark D., Merves, Shae A., Dallaire, Frederic, Farid, Pedrom, Manlhiot, Cedric, Runeckles, Kyle, Misra, Nilanjana, Portman, Michael, Ballweg, Jean A., Lee, Simon, Jain, Supriya S., Harris, Tyler H., Szmuszkovicz, Jacqueline R., Orr, William, Larios, Guillermo, and McCrindle, Brian W.

Published
2023
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7. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Truong, Dongngan T, Trachtenberg, Felicia L, Pearson, Gail D, Dionne, Audrey, Elias, Matthew D, Friedman, Kevin, Hayes, Kerri H, Mahony, Lynn, McCrindle, Brian W, Oster, Matthew E, Pemberton, Victoria, Powell, Andrew J, Russell, Mark W, Shekerdemian, Lara S, Son, Mary Beth, Taylor, Michael, Newburger, Jane W, Investigators, for the MUSIC Study, Giglia, Therese M, McHugh, Kimberly E, Atz, Andrew M, Pletzer, Scott A, Lang, Sean M, Payne, R Mark, Patel, Jyoti K, Pignatelli, Ricardo H, Sexson, Kristen, Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R, Farooqi, Kanwal M, Shakti, Divya, Parnell, Aimee S, Osakwe, Onyekachukwu J, Sykes, Michelle C, Morgan, Lerraughn, Owada, Carl Y, Forsha, Daniel, Carr, Michael R, Watanabe, Kae, Portman, Michael A, Dummer, Kristen B, Burns, Jane C, Tremoulet, Adriana H, Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L, Szmuszkovicz, Jacqueline R, Wong, Pierre C, Cheng, Andrew L, Votava-Smith, Jodie K, Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K, Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T, Muniz, Juan Carlos G, Li, Jennifer S, Campbell, Michael Jay, Handler, Stephanie S, Shea, J Ryan, Hoffman, Timothy M, Franklin, Wayne J, Sabati, Arash A, Nowlen, Todd T, and Chrisant, Maryanne

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Biomedical Imaging, Clinical Trials and Supportive Activities, Cardiovascular, Clinical Research, Prevention, Pediatric, Patient Safety, Adult, COVID-19, Child, Heart, Humans, Magnetic Resonance Imaging, National Heart, Lung, and Blood Institute (U.S.), SARS-CoV-2, Stroke Volume, Systemic Inflammatory Response Syndrome, United States, Ventricular Function, Left, Young Adult, MUSIC Study Investigators, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients

Published
2022

8. Temporal clustering of Kawasaki disease cases around the world.

Author

Burney, Jennifer A, DeHaan, Laurel L, Shimizu, Chisato, Bainto, Emelia V, Newburger, Jane W, DeBiasi, Roberta L, Dominguez, Samuel R, Portman, Michael A, Melish, Marian, Bratincsak, Andras, Fabi, Marianna, Corinaldesi, Elena, Yu, Jeong Jin, Gee, Paul, Kitano, Naomi, Tremoulet, Adriana H, Cayan, Daniel R, Burns, Jane C, and Kawasaki Disease Climate Study Group

Subjects
Kawasaki Disease Climate Study Group, Humans, Mucocutaneous Lymph Node Syndrome, Incidence, Cluster Analysis, Linear Models, Monte Carlo Method, Time Factors, Child, Hospitals, United States, Italy, New Zealand, Republic of Korea, Global Health
Abstract

In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This finding raised the question of whether other locations around the world experience similar temporal clusters of KD that might offer clues to disease etiology. Here we combine data from San Diego and nine additional sites around the world with hospitals that care for large numbers of KD patients, as well as two multi-hospital catchment regions. We found that across these sites, KD cases clustered at short time scales and there were anomalously long quiet periods with no cases. Both of these phenomena occurred more often than would be expected given local trends and seasonality. Additionally, we found unusually frequent temporal overlaps of KD clusters and quiet periods between pairs of sites. These findings suggest that regional and planetary range environmental influences create periods of higher or lower exposure to KD triggers that may offer clues to the etiology of KD.

Published
2021

9. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Alsalehi, Mahmoud, Ballweg, Jean A., Barnes, Benjamin, Braunlin, Elizabeth, Buffone, Ashley, Bustamante-Ogando, Juan Carlos, Chang, Arthur J., Corral, Nicolas, Dancey, Paul, El-Ganzoury, Mona, El-Samman, Nora, Elias, Matthew, Fernandez-Cooke, Elisa, Friedman, Kevin, Garrido-Garcia, Luis Martin, Garrido, Luis Martin, Goldenberg, Guillermo Larios, Grcic, Michelle M., Harris, Kevin C., Hicar, Mark D., Hindt, Bridgette, Jone, Pei-Ni, Kajimoto, Hidemi, Kaneta, Kelli, Khare, Manaswitha, Knutson, Stacie, Kutty, Shelby, Lanari, Marcello, Maksymiuk, Victoria, McHugh, Kimberly E., Merves, Shae, Misra, Nilanjana, Mohandas, Sindhu, Mondal, Tapas, Norozi, Kambiz, Nowlen, Todd, Pagano, Joseph J., Prasad, Deepa, Raghuveer, Geetha, Ravi, Prasad, Sundaram, Balasubramanian, Sehgal, Anupam, Shah, Ashish, Vázquez, Belén Toral, Tremoulet, Adriana H., Venkataraman, Aishwarya, Watelle, Laurence, Yamazaki-Naksahimada, Marco Antonio, Yetman, Anji T., Harahsheh, Ashraf S., Shah, Samay, Dallaire, Frederic, Manlhiot, Cedric, Khoury, Michael, Lee, Simon, Fabi, Marianna, Mauriello, Daniel, Tierney, Elif Seda Selamet, Sabati, Arash A., Dionne, Audrey, Dahdah, Nagib, Choueiter, Nadine, Thacker, Deepika, Giglia, Therese M., Truong, Dongngan T., Jain, Supriya, Portman, Michael, Orr, William B., Harris, Tyler H., Szmuszkovicz, Jacqueline R., Farid, Pedrom, and McCrindle, Brian W.

Published
2024
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10. Edoxaban for Thromboembolism Prevention in Pediatric Patients With Cardiac Disease

Author

Brothers, Matthew, Marino, Bradley, Canter, Charles, Law, Mark, Nguyen, Nguyenvu, Sang, Charlie, Shimano, Kristin, Gupta, Dipankar, Portman, Michael, Williams, Derek, Glass, Lauren, Sperrazza, Charles, Herold, Steven, Garg, Ruchira, Vranicar, Mark, Awad, Sawsan, Asante-Korang, Alfred, Druzgal, Colleen, Ozment, Caroline, Del Toro, Kamill, Roses, Ferran, Jux, Christian, Gravenhorst, Verena, Schweigmann, Ulrich, Bhatt, Mihir, Sabapathy, Christine, Dahdah, Nagib, Bartonicek, Dototea, Tulzer, Gerald, Basargina, Elena, Zvereva, Tatiana, Pertels, Tatiana, Plotnikova, Irina, Pierre-Emmanuel, S.E.G.U.E.L.A., Amedro, Pascal, Yves, Dulac, BONNET, Damien, Saraco, Paola, Rimini, Alessandro, Digtiar, Valerii, Gonchar, Margaryta, Kryuchko, Tetyana, Yablon, Olga, Bedi, Varinder Singh, Patel, Jashvant, Mitra, Monjori, Kusa, Jacek, Domagala, Kowalczyk, KÖRNYEI, László, BERECZKI, Csaba, ABLONCZY, László, Levitas, Vivianne Aviva, Mishali, David, Revel-Vilk, Shoshana, Harlev, Dan, Sasmaz, Hatice Ilgen, Ozbek, Namik Yasar, Unal, Sule, Patıroglu, Türkan, Malbora, Baris, Agin, Hasan, Karakas, Zeynep, Kavakli, Ramazan Kaan, Chalmers, Elizabeth, Bu'Lock, Frances, Daubeney, Piers, Hamza, Hala, Badr, Mohamed, Elalfy, Mohsen, Mansour, Ahmed, Hassab, Hoda, Sabry, Ayman, Daou, Linda, Bitar, Fadi, Portman, Michael A., Jacobs, Jeffrey P., Newburger, Jane W., Berger, Felix, Grosso, Michael A., Duggal, Anil, Tao, Ben, and Goldenberg, Neil A.

Published
2022
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11. Shear stress associated with cardiopulmonary bypass induces expression of inflammatory cytokines and necroptosis in monocytes.

Author

Tu, Lan, Hsieh, Lance, Kajimoto, Masaki, Charette, Kevin, Kibiryeva, Nataliya, Forero, Adriana, Hampson, Sarah, Marshall, Jennifer, OBrien, James, Scatena, Marta, Portman, Michael, Savan, Ram, Benner, Chris, Aliseda, Alberto, Nuri, Muhammad, Bittel, Douglas, Pastuszko, Peter, and Nigam, Vishal

Subjects
Calcium signaling, Cardiology, Cytokines, Inflammation, Surgery, Animals, Animals, Newborn, Calcium Signaling, Cardiopulmonary Bypass, Cytokines, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Inflammation Mediators, Interleukin-8, Male, Models, Animal, Monocytes, Necroptosis, RNA-Seq, Stress, Mechanical, Sus scrofa, Systemic Inflammatory Response Syndrome, THP-1 Cells, Tumor Necrosis Factor-alpha, Up-Regulation
Abstract

Cardiopulmonary bypass (CPB) is required during most cardiac surgeries. CBP drives systemic inflammation and multiorgan dysfunction that is especially severe in neonatal patients. Limited understanding of molecular mechanisms underlying CPB-associated inflammation presents a significant barrier to improve clinical outcomes. To better understand these clinical issues, we performed mRNA sequencing on total circulating leukocytes from neonatal patients undergoing CPB. Our data identify myeloid cells, particularly monocytes, as the major cell type driving transcriptional responses to CPB. Furthermore, IL-8 and TNF-α were inflammatory cytokines robustly upregulated in leukocytes from both patients and piglets exposed to CPB. To delineate the molecular mechanism, we exposed THP-1 human monocytic cells to CPB-like conditions, including artificial surfaces, high shear stress, and cooling/rewarming. Shear stress was found to drive cytokine upregulation via calcium-dependent signaling pathways. We also observed that a subpopulation of THP-1 cells died via TNF-α-mediated necroptosis, which we hypothesize contributes to post-CPB inflammation. Our study identifies a shear stress-modulated molecular mechanism that drives systemic inflammation in pediatric CPB patients. These are also the first data to our knowledge to demonstrate that shear stress causes necroptosis. Finally, we observe that calcium and TNF-α signaling are potentially novel targets to ameliorate post-CPB inflammation.

Published
2021

12. Emerging Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome Associated With COVID-19 in Children

Author

Lin, Justin, Harahsheh, Ashraf S., Raghuveer, Geetha, Jain, Supriya, Choueiter, Nadine F., Garrido-Garcia, Luis Martin, Dahdah, Nagib, Portman, Michael A., Misra, Nilanjana, Khoury, Michael, Fabi, Marianna, Elias, Matthew D., Dionne, Audrey, Lee, Simon, Tierney, Elif Seda Selamet, Ballweg, Jean A., Manlhiot, Cedric, and McCrindle, Brian W.

Published
2023
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14. Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease

Author

Teitel, David F, Newburger, Jane W, Sutton, Nicole, Tani, Lloyd Y, Harahsheh, Ashraf S, Jone, Pei-Ni, Mensch, Deborah J, Cotts, Timothy, Davidson, Alex, Dahdah, Nagib, Johnson, Walter H, and Portman, Michael A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Pediatric, Ambulatory Care, Cardiology, Child, Humans, Mucocutaneous Lymph Node Syndrome, Pediatrics, Quality Assurance, Health Care, Quality Indicators, Health Care, United States, Kawasaki disease, quality metrics, ambulatory pediatrics, pediatrics, pediatric cardiology, Paediatrics and Reproductive Medicine, Paediatrics
Abstract

The Adult Congenital and Pediatric Cardiology (ACPC) Section of the American College of Cardiology sought to develop quality indicators/metrics for ambulatory pediatric cardiology practice. The objective of this study was to report the creation of metrics for patients with Kawasaki disease. Over a period of 5 months, 12 pediatric cardiologists developed 24 quality metrics based on the most relevant statements, guidelines, and research studies pertaining to Kawasaki disease. Of the 24 metrics, the 8 metrics deemed the most important, feasible, and valid were sent on to the ACPC for consideration. Seven of the 8 metrics were approved using the RAND method by an expert panel. All 7 metrics approved by the ACPC council were accepted by ACPC membership after an "open comments" process. They have been disseminated to the pediatric cardiology community for implementation by the ACPC Quality Network.

Published
2020

15. Abstract 16216: Sociodemographic Disparities in Severity of Multisystem Inflammatory Syndrome in Children: The National MUSIC Study

Author

Lopez, Keila N, Truong, Dongngan, Anderson, Brett R, Baker-Smith, Carissa M, Bradford, Tamara T, Dionne, Audrey, Dummer, Kirsten, Forsha, Daniel E, Franklin, Wayne J, Handler, Stephanie, Harahsheh, Ashraf S, Hasbani, Keren, hu, Chenwei, Jone, Pei-Ni, Lang, Sean, McHugh, Kimberly E, Oster, Matthew, Pearson, Gail D, Portman, Michael A, Preminger, Tamar, Russell, Mark, Sanil, Yamuna, Sexson Tejtel, S, Shakti, Divya, Shea, Ryan, Trachtenberg, Felicia, Wang, Shuo, Wong, Jonathan P. P, and Newburger, Jane W

Published
2023
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16. Abstract 15506: Pattern of Use of Anakinra for Patients With Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Author

Portman, Michael A, Harahsheh, Ashraf S, Raghuveer, Geetha, Sundraram, Balasubramanian, Venkataraman, Aishwarya, Yamazaki-Naksahimada, Marco, Park, Susan, El Ganzoury, Mona, Dionne, Audrey, Thacker, Deepika, Chang, Arthur J, Choueiter, Nadine, Braunlin, Elizabeth A, Orr, William, McHugh, Kimberly E, Farid, Pedrom, Manlhiot, Cedric, and McCrindle, Brian W

Published
2023
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17. Abstract 15148: How Reassuring is an Initial Echocardiogram With Normal Coronary Arteries for Patients Presenting With Acute Kawasaki Disease?

Author

Khoury, Michael, Nelson, Jennifer A, Lee, Simon, Portman, Michael A, Yetman, Angela T, Dahdah, Nagib, Misra, Nilanjana, Nowlen, Todd, Jone, Pei-Ni, Fabi, Marianna, Tierney, Seda S, Fernandez-Cooke, Elisa, Elias, Matthew, Mauriello, Daniel, Dallaire, Frederic, Norozi, Kambiz, Dancey, Paul, Farid, Pedrom, Manlhiot, Cedric, and McCrindle, Brian W

Published
2023
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20. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Dionne, Audrey, Elias, Matthew D., Giglia, Therese M., McHugh, Kimberly E., Atz, Andrew M., Pletzer, Scott A., Truong, Dongngan T., Russell, Mark W., Lang, Sean M., Payne, R. Mark, Patel, Jyoti K., Oster, Matthew E., Shekerdemian, Lara S., Pignatelli, Ricardo H., Sexson, Kristen, McCrindle, Brian W., Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R., Farooqi, Kanwal M., Shakti, Divya, Parnell, Aimee S., Osakwe, Onyekachukwu J, Sykes, Michelle C., Morgan, Lerraughn, Owada, Carl Y., Forsha, Daniel, Carr, Michael R., Watanabe, Kae, Portman, Michael A., Dummer, Kristen B., Burns, Jane C., Tremoulet, Adriana H., Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L., Szmuszkovicz, Jacqueline R., Wong, Pierre C., Cheng, Andrew L., Votava-Smith, Jodie K., Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K., Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T., Muniz, Juan Carlos G., Li, Jennifer S., Campbell, Michael Jay, Handler, Stephanie S., Shea, J Ryan, Hoffman, Timothy M., Franklin, Wayne J., Sabati, Arash A., Nowlen, Todd T., Chrisant, Maryanne, Trachtenberg, Felicia L., Pearson, Gail D., Friedman, Kevin, Hayes, Kerri H., Mahony, Lynn, Pemberton, Victoria, Powell, Andrew J., Son, Mary Beth, Taylor, Michael, and Newburger, Jane W.

Published
2022
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21. Absence of Pericarditis Recurrence in Rilonacept-Treated Patients with COVID-19 and SARS-CoV-2 Vaccination: Results from RHAPSODY Long-Term Extension

Author

Brucato, Antonio, primary, Trotta, Lucia, additional, Arad, Michael, additional, Cremer, Paul C., additional, Insalaco, Antonella, additional, Klutstein, Marc, additional, LeWinter, Martin, additional, Lin, David, additional, Luis, Sushil A., additional, Wasserstrum, Yishay, additional, Clair, JoAnn, additional, Wang, Sheldon, additional, Klein, Allan L., additional, Imazio, Massimo, additional, Paolini, John F., additional, Abbate, Antonio, additional, Abo-Auda, Wael, additional, Akhtar, Asif, additional, Atar, Shaul, additional, Baibhav, Bipul, additional, Bhalla, Karan, additional, Brucato, Antonio, additional, Collins, Sean, additional, Colquhoun, David, additional, Cremer, Paul, additional, Cross, David, additional, Dwivedi, Girish, additional, Eisen, Alon, additional, Freedberg, Nahum, additional, Fuchs, Shmuel, additional, Gaddam, Eliyazar, additional, Gattorno, Marco, additional, Gelfand, Eli, additional, Grena, Paul, additional, Halabi, Majdi, additional, Harris, David, additional, Karim, Amin, additional, Klein, Allan, additional, Knowlton, Kirk, additional, Kontzias, Apostolos, additional, Kornberg, Robert, additional, Latif, Faisal, additional, Leibowitz, David, additional, Lou, Pey Wen, additional, Luis, S. Allen, additional, Nicholls, Stephen, additional, Petersen, John, additional, Portman, Michael, additional, Roberts-Thomson, Philip, additional, Schiff, Elad, additional, Siegel, Robert, additional, Stokes, Michael, additional, Sutej, Paul, additional, Wittekind, Samuel, additional, Witzling, Valentin, additional, and Zukermann, Robert, additional

Published
2024
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26. Abstract 11816: Association of Increased Adiposity and Presentation and Outcomes for Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With Covid-19

Author

Khoury, Michael, Venkataraman, Aishwarya, Portman, Michael A, Fabi, Marianna, Dahdah, Nagib, Jain, Supriya, Jone, Pei-Ni, Raghuveer, Geetha, Lee, Simon, Prasad, Deepa, El Ganzoury, Mona, Yetman, Angela T, Friedman, Kevin G, Martin Garrido, Luis, Norozi, Kambiz, Sehgal, Anupam, Serrano, Ryan M, Kutty, Shelby, Farid, Pedrom, and McCrindle, Brian W

Published
2022
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28. Abstract 11464: Spectrum and Associated Factors for Coronary Artery Involvement in Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With Covid-19

Author

Lee, Simon, Harahsheh, Ashraf S, Portman, Michael A, Fabi, Marianna, Jain, Supriya, El Ganzoury, Mona, Dionne, Audrey, Misra, Nilanjana, Nowlen, Todd, Elias, Matthew, Fernandez-Cooke, Elisa, Szmuszkovicz, Jacqueline R, Orr, William, Truong, Dongngan, McHugh, Kimberly E, Choueiter, Nadine, Shah, Surya, Manlhiot, Cedric, Farid, Pedrom, and McCrindle, Brian W

Published
2022
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30. Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children With Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial

Author

Altman, Carolyn A., Anderson, Brett R., Braunlin, Elizabeth, Burns, Jane C., Carr, Michael R., Choueiter, Nadine F., Colyer, Jessica H., Crean, Andrew, Dempsey, Adam, Desjardins, Laurent, Dillenburg, Rejane, Dionne, Audrey, Ferris, Anna, Gewitz, Michael, Grcic, Michelle M., Greenway, Steven C., Hamel-Perrault, Elodie, Harris, Kevin C., Hayden-Rush, Christina, Hill, Kevin D., Jain, Supriya, Jone, Pei-Ni, Kimball, Thomas R., Lang, Sean M., Li, Jennifer S., Lin, Ming-Tai, Mahle, William T., McHugh, Kimberly E., Portman, Michael A., Renaud, Claudia, Sexson Tejitel, S. Kristen, Szmuszkovicz, Jacqueline R., Texter, Karen M., Thacker, Deepika, Selamet Tierney, Elif Seda, Thomas, Thomas, Tremoulet, Adriana H., Wagner-Lees, Sharon, Warren, Andrew, Manlhiot, Cedric, Newburger, Jane W., Low, Tisiana, Dahdah, Nagib, Mackie, Andrew S., Raghuveer, Geetha, Giglia, Therese M., Dallaire, Frederic, Mathew, Mathew, Runeckles, Kyle, Pahl, Elfriede, Harahsheh, Ashraf S., Norozi, Kambiz, de Ferranti, Sarah D., Friedman, Kevin, Yetman, Anji T., Kutty, Shelby, Mondal, Tapas, and McCrindle, Brian W.

Published
2020
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32. Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults

Author

Truong, Dongngan T., Dionne, Audrey, Muniz, Juan Carlos, McHugh, Kimberly E., Portman, Michael A., Lambert, Linda M., Thacker, Deepika, Elias, Matthew D., Li, Jennifer S., Toro-Salazar, Olga H., Anderson, Brett R., Atz, Andrew M., Bohun, C. Monique, Campbell, M. Jay, Chrisant, Maryanne, D’Addese, Laura, Dummer, Kirsten B., Forsha, Daniel, Frank, Lowell H., Frosch, Olivia H., Gelehrter, Sarah K., Giglia, Therese M., Hebson, Camden, Jain, Supriya S., Johnston, Pace, Krishnan, Anita, Lombardi, Kristin C., McCrindle, Brian W., Mitchell, Elizabeth C., Miyata, Koichi, Mizzi, Trent, Parker, Robert M., Patel, Jyoti K., Ronai, Christina, Sabati, Arash A., Schauer, Jenna, Tejtel, S. Kristen Sexson, Shea, J. Ryan, Shekerdemian, Lara S., Srivastava, Shubhika, Votava-Smith, Jodie K., White, Sarah, and Newburger, Jane W.

Published
2021
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33. Pharmacogenomics of Coronary Artery Response to Intravenous Gamma Globulin in Kawasaki Disease

Author

Shrestha, Sadeep, primary, Wiener, Howard W, additional, Chowdhury, Sabrina, additional, Kajimoto, Hidemi, additional, Srinivasasainagendra, Vinodh, additional, Mamaeva, Olga A, additional, Brahmbhatt, Ujval N, additional, Ledee, Dolena, additional, Lau, Yung, additional, Padilla, Luz A, additional, Chen, Jake, additional, Dahdah, Nagib, additional, Tiwari, Hemant K, additional, and Portman, Michael A, additional

Published
2024
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35. Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease

Author

Shrestha, Sadeep, primary, Wiener, Howard W., additional, Kajimoto, Hidemi, additional, Srinivasasainagendra, Vinodh, additional, Ledee, Dolena, additional, Chowdhury, Sabrina, additional, Cui, Jinhong, additional, Chen, Jake Y., additional, Beckley, Mikayla A, additional, Padilla, Luz A., additional, Dahdah, Nagib, additional, Tiwari, Hemant K., additional, and Portman, Michael A., additional

Published
2024
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37. Objective Comparison of Clinical and Cardiac Magnetic Resonance Biomarkers in Adolescents Presenting With Acute Chest Pain and Elevated Troponins Pre‐COVID and Post‐COVID Vaccination.

Author

Gulhane, Avanti, Soriano, Brian, Stanescu, Luana, Schauer, Jenna, Ferguson, Mark, Romberg, Erin, Bhutta, Sadaf, Otto, Randolph, Caris, Elizabeth, Mallenahalli, Sathish, Portman, Michael, Litt, Harold, and Buddhe, Sujatha

Subjects
CHEST pain, CARDIAC magnetic resonance imaging, COVID-19 pandemic, COVID-19, GLOBAL longitudinal strain, SARS disease
Abstract

A recent study compared the prevalence and severity of myocarditis in adolescents before and after COVID-19 vaccination. The study found that vaccine-induced myocarditis was more common and severe than myocarditis caused by COVID-19 infection. The study analyzed clinical biomarkers and MRI characteristics of patients with acute chest pain and elevated troponins. The results showed that patients who developed myocarditis after vaccination had higher body surface area and B-type natriuretic peptide levels compared to those with pre-COVID myocarditis. MRI findings revealed myocardial edema and subepicardial late gadolinium enhancement as the most frequent abnormalities in both groups. The study suggests that further research is needed to understand the prognostic implications of abnormal MRI imaging biomarkers in children with post-COVID vaccine myocarditis. [Extracted from the article]

Published
2024
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39. Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Author

Walton, Mollie, primary, Raghuveer, Geetha, additional, Harahsheh, Ashraf, additional, Portman, Michael A., additional, Lee, Simon, additional, Khoury, Michael, additional, Dahdah, Nagib, additional, Fabi, Marianna, additional, Dionne, Audrey, additional, Harris, Tyler H., additional, Choueiter, Nadine, additional, Garrido-Garcia, Luis Martin, additional, Jain, Supriya, additional, Dallaire, Frédéric, additional, Misra, Nilanjana, additional, Hicar, Mark D., additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Tierney, Elif Seda Selamet, additional, Thacker, Deepika, additional, Nowlen, Todd T., additional, Szmuszkovicz, Jacqueline R., additional, Norozi, Kambiz, additional, Orr, William B., additional, Farid, Pedrom, additional, Manlhiot, Cedric, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin T., additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Cowles, Heather, additional, Dancey, Paul, additional, de Ferranti, Sarah D, additional, Ganzoury, Mona El, additional, Elias, Matthew, additional, Elsamman, Nora, additional, Cooke, Elisa Fernández, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Khare, Manaswitha, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Mauriello, Daniel, additional, McHugh, Kimberly E., additional, Merves, Shae A., additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, and Ravi, Prasad, additional

Published
2023
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44. Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

Author

Ahuja, Preeti, Zhao, Peng, Angelis, Ekaterini, Ruan, Hongmei, Korge, Paavo, Olson, Aaron, Wang, Yibin, Jin, Eunsook S, Jeffrey, F Mark, Portman, Michael, and MacLellan, W Robb

Subjects
Heart Disease, Cardiovascular, Genetics, Biotechnology, Nutrition, Underpinning research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Aetiology, Animals, Cell Proliferation, Fatty Acids, Gene Expression Regulation, Glucose, Hemodynamics, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Myocardial Ischemia, Myocytes, Cardiac, Neoplasms, Oxygen, Proto-Oncogene Proteins c-myc, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Medical and Health Sciences, Immunology
Abstract

In the adult heart, regulation of fatty acid oxidation and mitochondrial genes is controlled by the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators. However, in response to pathological stressors such as hemodynamic load or ischemia, cardiac myocytes downregulate PGC-1 activity and fatty acid oxidation genes in preference for glucose metabolism pathways. Interestingly, despite the reduced PGC-1 activity, these pathological stressors are associated with mitochondrial biogenesis, at least initially. The transcription factors that regulate these changes in the setting of reduced PGC-1 are unknown, but Myc can regulate glucose metabolism and mitochondrial biogenesis during cell proliferation and tumorigenesis in cancer cells. Here we have demonstrated that Myc activation in the myocardium of adult mice increases glucose uptake and utilization, downregulates fatty acid oxidation by reducing PGC-1alpha levels, and induces mitochondrial biogenesis. Inactivation of Myc in the adult myocardium attenuated hypertrophic growth and decreased the expression of glycolytic and mitochondrial biogenesis genes in response to hemodynamic load. Surprisingly, the Myc-orchestrated metabolic alterations were associated with preserved cardiac function and improved recovery from ischemia. Our data suggest that Myc directly regulates glucose metabolism and mitochondrial biogenesis in cardiac myocytes and is an important regulator of energy metabolism in the heart in response to pathologic stress.

Published
2010

45. Objective Comparison of Clinical and Cardiac Magnetic Resonance Biomarkers in Adolescents Presenting With Acute Chest Pain and Elevated Troponins Pre‐COVID and Post‐COVID Vaccination

Author

Gulhane, Avanti, primary, Soriano, Brian, additional, Stanescu, Luana, additional, Schauer, Jenna, additional, Ferguson, Mark, additional, Romberg, Erin, additional, Bhutta, Sadaf, additional, Otto, Randolph, additional, Caris, Elizabeth, additional, Mallenahalli, Sathish, additional, Portman, Michael, additional, Litt, Harold, additional, and Buddhe, Sujatha, additional

Published
2023
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46. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Harahsheh, Ashraf S., primary, Shah, Samay, additional, Dallaire, Frederic, additional, Manlhiot, Cedric, additional, Khoury, Michael, additional, Lee, Simon, additional, Fabi, Marianna, additional, Mauriello, Daniel, additional, Tierney, Elif Seda Selamet, additional, Sabati, Arash A., additional, Dionne, Audrey, additional, Dahdah, Nagib, additional, Choueiter, Nadine, additional, Thacker, Deepika, additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Jain, Supriya, additional, Portman, Michael, additional, Orr, William B., additional, Harris, Tyler H., additional, Szmuszkovicz, Jacqueline R., additional, Farid, Pedrom, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin, additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Dancey, Paul, additional, El-Ganzoury, Mona, additional, El-Samman, Nora, additional, Elias, Matthew, additional, Fernandez-Cooke, Elisa, additional, Friedman, Kevin, additional, Garrido-Garcia, Luis Martin, additional, Garrido, Luis Martin, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Hicar, Mark D., additional, Hindt, Bridgette, additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Kaneta, Kelli, additional, Khare, Manaswitha, additional, Knutson, Stacie, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Maksymiuk, Victoria, additional, McHugh, Kimberly E., additional, Merves, Shae, additional, Misra, Nilanjana, additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Norozi, Kambiz, additional, Nowlen, Todd, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, Raghuveer, Geetha, additional, Ravi, Prasad, additional, Sundaram, Balasubramanian, additional, Sehgal, Anupam, additional, Shah, Ashish, additional, Vázquez, Belén Toral, additional, Tremoulet, Adriana H., additional, Venkataraman, Aishwarya, additional, Watelle, Laurence, additional, Yamazaki-Naksahimada, Marco Antonio, additional, and Yetman, Anji T., additional

Published
2023
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47. Edoxaban for Thromboembolism Prevention in Pediatric Patients With Cardiac Disease

Author

Portman, Michael A., primary, Jacobs, Jeffrey P., additional, Newburger, Jane W., additional, Berger, Felix, additional, Grosso, Michael A., additional, Duggal, Anil, additional, Tao, Ben, additional, Goldenberg, Neil A., additional, Brothers, Matthew, additional, Marino, Bradley, additional, Canter, Charles, additional, Law, Mark, additional, Nguyen, Nguyenvu, additional, Sang, Charlie, additional, Shimano, Kristin, additional, Gupta, Dipankar, additional, Portman, Michael, additional, Williams, Derek, additional, Glass, Lauren, additional, Sperrazza, Charles, additional, Herold, Steven, additional, Garg, Ruchira, additional, Vranicar, Mark, additional, Awad, Sawsan, additional, Asante-Korang, Alfred, additional, Druzgal, Colleen, additional, Ozment, Caroline, additional, Del Toro, Kamill, additional, Roses, Ferran, additional, Jux, Christian, additional, Gravenhorst, Verena, additional, Schweigmann, Ulrich, additional, Bhatt, Mihir, additional, Sabapathy, Christine, additional, Dahdah, Nagib, additional, Bartonicek, Dototea, additional, Tulzer, Gerald, additional, Basargina, Elena, additional, Zvereva, Tatiana, additional, Pertels, Tatiana, additional, Plotnikova, Irina, additional, Pierre-Emmanuel, S.E.G.U.E.L.A., additional, Amedro, Pascal, additional, Yves, Dulac, additional, BONNET, Damien, additional, Saraco, Paola, additional, Rimini, Alessandro, additional, Digtiar, Valerii, additional, Gonchar, Margaryta, additional, Kryuchko, Tetyana, additional, Yablon, Olga, additional, Bedi, Varinder Singh, additional, Patel, Jashvant, additional, Mitra, Monjori, additional, Kusa, Jacek, additional, Domagala, Kowalczyk, additional, KÖRNYEI, László, additional, BERECZKI, Csaba, additional, ABLONCZY, László, additional, Levitas, Vivianne Aviva, additional, Mishali, David, additional, Revel-Vilk, Shoshana, additional, Harlev, Dan, additional, Sasmaz, Hatice Ilgen, additional, Ozbek, Namik Yasar, additional, Unal, Sule, additional, Patıroglu, Türkan, additional, Malbora, Baris, additional, Agin, Hasan, additional, Karakas, Zeynep, additional, Kavakli, Ramazan Kaan, additional, Chalmers, Elizabeth, additional, Bu'Lock, Frances, additional, Daubeney, Piers, additional, Hamza, Hala, additional, Badr, Mohamed, additional, Elalfy, Mohsen, additional, Mansour, Ahmed, additional, Hassab, Hoda, additional, Sabry, Ayman, additional, Daou, Linda, additional, and Bitar, Fadi, additional

Published
2022
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48. SARS-CoV-2 Variants and Multisystem Inflammatory Syndrome in Children

Author

McCrindle, Brian W., primary, Harahsheh, Ashraf S., additional, Handoko, Ryan, additional, Raghuveer, Geetha, additional, Portman, Michael A., additional, Khoury, Michael, additional, Newburger, Jane W., additional, Lee, Simon, additional, Jain, Supriya S., additional, Khare, Manaswitha, additional, Dahdah, Nagib, additional, and Manlhiot, Cedric, additional

Published
2023
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