This study investigated the spatiotemporal evolution of economic development in 23 cities across Guangdong Province, Hong Kong, and Macau from 1990 to 2022. The results indicated a general growth trend in overall economic development, with substantial fluctuations in absolute differences and a significant reduction in relative differences. The economic development appeared to be balanced both within and between cities. Spatially, the study revealed an increasing agglomeration effect, evident polarization in economic levels, and a distinct core–periphery structure, with central cities in the Greater Bay Area exerting a growing influence on their peripheries. Nevertheless, the peripheral cities, despite their economic strides, necessitate augmented policy interventions and capital influx to bridge regional chasms. The study's outcomes serve as a foundational reference for sharpening policy decisions, fostering regional amalgamation, and invigorating urban blueprinting and city-to-city synergies. This research provides an in-depth analysis of economic development trends across 23 cities in Guangdong, Hong Kong, and Macau over 32 years. For policymakers, urban planners, and business leaders, the findings present a clearer picture of the region's economic landscape. Notably, while central cities within the Greater Bay Area have become influential economic hubs, surrounding cities still face challenges. These insights suggest a need for more targeted policies and investments, especially in peripheral cities, to promote more uniform growth across the region. By understanding these dynamics, governments and businesses can make more informed decisions that foster city-to-city collaborations and develop better urban and regional strategies. [ABSTRACT FROM AUTHOR]