1. IMPORTANCE OF TOTAL SERUM IGE FOR IMPROVEMENT IN AIRWAYS HYPERRESPONSIVENESS WITH INHALED CORTICOSTEROIDS IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
- Author
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Huib Kerstjens, Jan Schouten, Paul Brand, DFME SCHOONBROOD, PJ STERK, Dirkje Postma, KF KERREBIJN, PH QUANJER, HJ SLUITER, EM POUW, CM ROOS, HM JANSEN, Degooyer, A., TW VANDERMARK, GH KOETER, PM DELONG, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELEERS, BAHA VANDERBRUGGENBOGAARTS, Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, NJ ROBINSON, ER BLEECKER, DA MEYERS, and Groningen Research Institute for Asthma and COPD (GRIAC)
- Subjects
LUNG-FUNCTION ,ALLERGY ,SKIN-TEST REACTIVITY ,INFLAMMATION ,BUDESONIDE ,HYPERREACTIVITY ,REVERSIBILITY ,AIR-FLOW LIMITATION ,respiratory system ,BRONCHODILATOR RESPONSE ,respiratory tract diseases ,RESPONSIVENESS - Abstract
Airways hyperresponsiveness is a hallmark of asthma, and many patients with COPD also demonstrate hyperresponsiveness. Inhaled corticosteroids improve hyperresponsiveness, but the extent of improvement may vary considerably between patients. This study was designed to determine which patient characteristics predict these differences in response. Patients with mild to moderately severe obstructive airways disease (asthma and COPD) were selected if PC20 less than or equal to 8 mg/ml and FEV(1)
- Published
- 1995