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7. Raltegravir Plasma Concentrations in Treatment-Experienced Patients Receiving Salvage Regimens Based on Raltegravir with and without Maraviroc Coadministration

Author

Silvia Baroncelli, Paola Villani, Liliana E. Weimer, Nicoletta Ladisa, Daniela Francisci, Chiara Tommasi, Vincenzo Vullo, Roberta Preziosi, Stefania Cicalini, Maria Cusato, Clementina M. Galluzzo, Marco Floridia, Mario Regazzi, for the ISS NIA Group […, R. Bucciardini, M. Floridia, LE Weimer, V. Fragola, M. Massella, S. Baroncelli, CM Galluzzo, MF Pirillo, MG Mancini, R. Amici, A. Cara, R. Bona, P. Leone, P. Filati, M. Franco, S. Donnini, M. Mirra, M. Di Gregorio, S. Lucattini, L. Fucili, F. Baldelli, D. Francisci, L. Martinelli, G. Masini, S. Bastianelli, G. Angarano, N. Ladisa, A. Volpe, V. Vullo, G. D’Ettorre, G. Ceccarelli, M. Andreoni, L. Sarmati, D. Delle Rose, M. Montano, V. Tozzi, R. Libertone, L. Pucillo, P. Narciso, R. Bellagamba, C. Tommasi, N. Petrosillo, S. Cicalini, F. Ghinelli, L. Sighinolfi, D. Segala, O. Armignacco, R. Preziosi, C. Ferrari, A. Degli Antoni, A. Cavalli, G. Parruti, F. Sozio, L. Cosentino, D. Dionisio, A. Vivarelli, PE Manconi, F. Ortu, ML Di Martino, R. Motta, R. Del Gobbo, A. Mataloni Paggi, C. Silvestri, G. Scalise, A. Giacometti, O. Cirioni, S. Sebastianelli, E. Marchionni, E. Gabrielli, MS Mura, M. Mannazzu, G. Cattari, G. Coinu, G. Guaraldi, B. Beghetto, G. Nardini, VIALE, PIERLUIGI, VERUCCHI, GABRIELLA, BORDERI, MARCO, PIERGENTILI, BENEDETTA, Silvia Baroncelli, Paola Villani, Liliana E Weimer, Nicoletta Ladisa, Daniela Francisci, Chiara Tommasi, Vincenzo Vullo, Roberta Preziosi, Stefania Cicalini, Maria Cusato, Clementina M Galluzzo, Marco Floridia, Mario Regazzi, for the ISS-NIA Group […, R Bucciardini, M Floridia, LE Weimer, V Fragola, M Massella, S Baroncelli, CM Galluzzo, MF Pirillo, MG Mancini, R Amici, A Cara, R Bona, P Leone, P Filati, M Franco, S Donnini, M Mirra, M Di Gregorio, S Lucattini, L Fucili, F Baldelli, D Francisci, L Martinelli, G Masini, S Bastianelli, G Angarano, N Ladisa, A Volpe, V Vullo, G D’Ettorre, G Ceccarelli, M Andreoni, L Sarmati, D Delle Rose, M Montano, V Tozzi, R Libertone, L Pucillo, P Narciso, R Bellagamba, C Tommasi, N Petrosillo, S Cicalini, F Ghinelli, L Sighinolfi, D Segala, O Armignacco, R Preziosi, C Ferrari, A Degli Antoni, A Cavalli, G Parruti, F Sozio, L Cosentino, D Dionisio, A Vivarelli, PE Manconi, F Ortu, ML Di Martino, P Viale, G Verucchi, M Borderi, B Piergentili, R Motta, R Del Gobbo, A Mataloni Paggi, C Silvestri, G Scalise, A Giacometti, O Cirioni, S Sebastianelli, E Marchionni, E Gabrielli, MS Mura, M Mannazzu, G Cattari, G Coinu, G Guaraldi, B Beghetto, G Nardini, and …]

Subjects
maraviroc, HAART, Settore MED/17 - Malattie Infettive, Drug interaction, antiretroviral therapy, Plasma drug concentrations, Pharmacology, hiv infections, NO, Nucleoside Reverse Transcriptase Inhibitor, pyrrolidinones, chemistry.chemical_compound, Pharmacotherapy, male, cohort studies, Pharmacokinetics, Antiretroviral Therapy, Highly Active, Raltegravir Potassium, middle aged, Drug interactions, Maraviroc, Raltegravir, Salvage regimens, Medicine, Pharmacology (medical), Protease inhibitor (pharmacology), salvage therapy, humans, highly active, triazoles, plasma drug concentration, Reverse-transcriptase inhibitor, drug administration schedule, business.industry, adult, HIV, drug interactions, aged, anti-hiv agents, chemistry, Concomitant, salvage regimen, young adult, raltegravir, business, antiretroviral therapy, highly active, cyclohexanes, medicine.drug
Abstract

BACKGROUND: Raltegravir and maraviroc represent new, important resources for HIV-infected patients with intolerance or resistance to other antiretroviral agents. The safety and efficacy of both drugs have been investigated, but there is no information on possible pharmacokinetic interactions between these 2 drugs in clinical practice. OBJECTIVE: To evaluate raltegravir plasma concentrations in heavily treatment-experienced patients receiving salvage regimens and explore, in a preliminary assessment, the potential influence of maraviroc coadministration and other cofactors on raltegravir trough concentrations (Ctrough). METHODS: Fifty-four HIV-infected patients with triple class (nucleoside reverse transcriptase inhibitor, nonnucleoside reverse transcriptase inhibitor, protease inhibitor) treatment experience starting raltegravir 400 mg twice daily, with (n = 11) or without (n = 43) concomitant maraviroc 300 mg twice daily, were evaluated. All regimens included at least 3 drugs of at least 2 different classes. Raltegravir plasma Ctrough, after at least 1 month of treatment, were analyzed to compare groups of patients taking raltegravir only and raltegravir plus maraviroc. Immunovirological (CD4, HIV-RNA) and clinical data after 6 months of treatment were also collected and described. RESULTS: Raltegravir plasma Ctrough showed a large variability (range 0.02 μg/mL) raltegravir concentrations were observed in all patients receiving raltegravir + maraviroc and in 74% of patients receiving raltegravir alone (p = 0.060). After 6 months of treatment, the 2 groups had similar clinical, virologic, and immunologic conditions. CONCLUSIONS: Coadministration of maraviroc does not seem to have any relevant effects on raltegravir plasma Ctrough in heavily treatment-experienced patients receiving salvage regimens. Further studies should evaluate the potential additional benefits of maraviroc coadministration in terms of virologic and immunologic response.

Published
2010
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8. Incidence of Malignancies in HIV‐Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

Author

Prosperi M.C., Cozzi Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., BORDERI, MARCO, VERUCCHI, GABRIELLA, PIERGENTILI, BENEDETTA, Prosperi MC., Cozzi-Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini-Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Borderi M, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., Prosperi, M. C. F., Cozzi lepri, A., Castagna, Antonella, Mussini, C., Murri, R., Giacometti, A., Torti, C., Costantini, A., Narciso, P., Ghinelli, F., Antinori, A., and D'arminio Monforte, A.

Subjects
Adult, Male, Microbiology (medical), tumor, medicine.medical_specialty, Prognosi, Prognosis, male, cohort studies, CD4 lymphocyte count, HIV infections, female, neoplasms, Italy, incidence, adult, humans, HIV Infections, Cohort Studies, MALIGNANCIES, HIV, AIDS, CD4, Neoplasms, Immunopathology, Internal medicine, Epidemiology, medicine, Humans, HIV Infection, Sida, biology, business.industry, Incidence, Incidence (epidemiology), Settore MED/07 - Microbiologia e Microbiologia Clinica, biology.organism_classification, Confidence interval, CD4 Lymphocyte Count, Surgery, Infectious Diseases, Cohort, Neoplasm, Female, Viral disease, Cohort Studie, business, Human, Cohort study
Abstract

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and nonADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM. © 2010 by the Infectious Diseases Society of America. All rights reserved.

Published
2010
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9. Prevalence of hypovitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort

Author

Vescini F, Cozzi Lepri A, Maggiolo F, De Luca A, Cassola G, Vullo V, Carosi G, Antinori A, Tozzi V, Monforte AD, Icona Foundation Study G.r.o.u.p. Moroni M, Angarano G, Cauda R, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Von Schlosser F, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Capobianchi MR, Castagna A, Ceccherini Silberstein F, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Emilia R, Arlotti M, Ortolani P, Antonucci G, Narciso P, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., BORDERI, MARCO, RE, MARIA CARLA, VIALE, PIERLUIGI, VERUCCHI, GABRIELLA, PIERGENTILI, BENEDETTA, Vescini F, Cozzi-Lepri A, Borderi M, Re MC, Maggiolo F, De Luca A, Cassola G, Vullo V, Carosi G, Antinori A, Tozzi V, Monforte AD, Icona Foundation Study Group.Moroni M, Angarano G, Cauda R, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Viale PL, Von Schlosser F, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Capobianchi MR, Castagna A, Ceccherini-Silberstein F, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Emilia R, Arlotti M, Ortolani P, Antonucci G, Narciso P, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., Vescini, F, Cozzi Lepri, A, Borderi, M, Re, M, Maggiolo, F, De Luca, A, Cassola, G, Vullo, V, Carosi, G, Antinori, A, Tozzi, V, Monforte, A, Gori, A, Vescini, Fabio, Cozzi lepri, Alessandro, Borderi, Marco, Re, Maria Carla, Maggiolo, Franco, De Luca, Andrea, Cassola, Giovanni, Vullo, Vincenzo, Carosi, Giampiero, Antinori, Andrea, Tozzi, Valerio, Monforte, Antonella D'arminio, Icona Foundation Study, Group, and Castagna, Antonella

Subjects
Male, HIV Infections, vitamin D, Logistic regression, Risk Factors, Cardiovascular Disease, Prevalence, HIV Infection, Pharmacology (medical), Renal Insufficiency, Chronic, Vitamin D, Young adult, education.field_of_study, hiv infection, prognosis, vitamin d deficiency and insufficiency, Diabetes Mellitu, Middle Aged, Prognosis, Infectious Diseases, Anti-Retroviral Agents, Italy, Cardiovascular Diseases, Combination, Cohort, Linear Model, Drug Therapy, Combination, Female, Seasons, prognosi, Adult, Africa, Aged, Central America, Diabetes Mellitus, Drug Therapy, Humans, Linear Models, South America, Vitamin D Deficiency, Young Adult, Human, medicine.medical_specialty, Population, Infectious Disease, Settore MED/17 - MALATTIE INFETTIVE, vitamin D deficiency, Internal medicine, medicine, Vitamin D and neurology, Renal Insufficiency, Chronic, education, Survival analysis, business.industry, Risk Factor, Hypovitaminosis D, HIV, Odds ratio, medicine.disease, vitamin D deficiency and insufficiency, Immunology, Anti-Retroviral Agent, Season, business
Abstract

Background: A high prevalence of hypovitaminosis D (hypD) in HIV-infected patients has been reported, but reasons are unclear. Methods: The 25 hydroxy vitamin D (vitD) concentration was measured in a sample of HIV-positive patients from Italy enrolled in the Icona Foundation Study. The change in absolute levels of vitD pre/post combination antiretroviral treatment was modelled by linear regression controlling for confounders and seasonality. Factors associated with hypD were identified using logistic regression analysis, and survival analysis was employed to evaluate the prognostic value of vitD concentration to predict severe diseases (diabetes, cardiovascular, renal), AIDS, and death. RESULTS:: We studied 810 patients contributing 1408 vitD measures. Median age was 36 years (range: 20-69). VitD insufficiency (30-75 nmol/L) and deficiency (

Published
2011

10. Tubercular disease caused by bacillus of Calmette-Guerin administered as a local adjuvant treatment of relapsing bladder carcinoma.: Pathogenetic, diagnostic and therapeutic issues, and literature review

Author

Manfredi, Roberto, Dentale, Nicola, Piergentili, Benedetta, Pultrone, Cristian, and Brunocilla, Eugenio

Subjects
bladder carcinoma, infection dissemination, Bacillus of Calmette-Guérin, BCG-itis, differential diagnosis, pulmonary and genito-urinary localizations, local therapy
Abstract

Two exemplary case reports of respiratory granulomatous infection caused by bacillus of Calmette-Guérin (BCG) in patients who were repeatedly treated with local, intravesical adjuvant BCG therapy for a relapsing transitional bladder carcinoma, are outlined and discussed, on the ground of the cumbersome diagnostic and differential diagnostic process (especially when a prior tuberculosis and a concurrent chronic obstructive pulmonary disease are of concern), and an updated literature revision. Only four cases of respiratory BCG-itis (pulmonary tuberculosis-like forms), have been reported until now to the best of our knowledge (two of them following bladder instillation of BCG). One episode of ours represents the first described case with a dual, concomitant granulomatous localization of BCG-itis, also involving the genitourinary tract.

Published
2009

11. Measles outbreak in the city of Bologna, December 2007 to May 2008

Author

CALZA, LEONARDO, ROSSETI, NIRMALA, PIERGENTILI, BENEDETTA, CASCAVILLA, ALESSANDRA, TRAPANI, FILIPPO, POCATERRA, DARIA, VERUCCHI, GABRIELLA, MANFREDI, ROBERTO, CHIODO, FRANCESCO, Calza L, Rosseti N, Piergentili B, Cascavilla A, Trapani F, Pocaterra D, Verucchi G, Manfredi R, and Chiodo F.

Subjects
OUTBREAK, IMMUNISATION, MEASLES
Published
2009

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