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Your search keyword '"PETRY, M. E."' showing total 8 results
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8 results on '"PETRY, M. E."'

1. ChemInform Abstract: 6,9-Bis((aminoalkyl)amino)benzo(g)isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations.

Author

KRAPCHO, A. P., primary, PETRY, M. E., additional, GETAHUN, Z., additional, LANDI, J. J. JUN., additional, STALLMAN, J., additional, POLSENBERG, J. F., additional, GALLAGHER, C. E., additional, MARESCH, M. J., additional, HACKER, M. P., additional, GIULIANI, F. C., additional, BEGGIOLIN, G., additional, PEZZONI, G., additional, MENTA, E., additional, MANZOTTI, C., additional, OLIVA, A., additional, SPINELLI, S., additional, and TOGNELLA, S., additional

Published
2010
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2. ChemInform Abstract: The Synthesis of 6,9-Difluorobenzo(g)quinoline-5,10-dione. Displacements of the Fluorides by Diamines Which Lead to 6,9-Bis(( aminoalkyl)amino)benzo(g)quinoline-5,10-diones.

Author

KRAPCHO, A. P., primary, PETRY, M. E., additional, LANDI, J. J. JUN., additional, STALLMAN, J., additional, POLSENBERG, J. F., additional, HACKER, M. P., additional, SPINELLI, S., additional, OLIVA, A., additional, DI DOMENICO, R., additional, and MENTA, E., additional

Published
2010
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7. 6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: synthesis and antitumor evaluations.

Author

Krapcho AP, Petry ME, Getahun Z, Landi JJ Jr, Stallman J, Polsenberg JF, Gallagher CE, Maresch MJ, Hacker MP, and Giuliani FC

Subjects
Adenocarcinoma drug therapy, Animals, Antineoplastic Agents therapeutic use, Colonic Neoplasms drug therapy, Humans, Leukemia L1210 drug therapy, Leukemia P388 drug therapy, Male, Mice, Mice, Inbred DBA, Mitoxantrone analogs & derivatives, Mitoxantrone therapeutic use, Structure-Activity Relationship, Anthraquinones chemical synthesis, Anthraquinones therapeutic use, Antineoplastic Agents chemical synthesis, Isoquinolines chemical synthesis, Isoquinolines therapeutic use, Tumor Cells, Cultured drug effects
Abstract

Synthetic procedures have been developed which lead to the 2-aza congeners 3 and several related N-oxides 4. The analogues 3 exhibited a wide range of in vitro cytotoxicity against L1210 leukemia, the human colon adenocarcinoma cell line LoVo, and the doxorubicin resistant LoVo/DX cell line. Selected analogues of 3 showed significant P388 antileukemic activity in mice with 3c exhibiting high activity. This activity was also retained in the related N-oxide 4a. These heterocyclic bioisosteric models are representative of the first anthracene-9,10-diones which display antileukemic activity comparable to mitoxantrone.

Published
1994
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8. Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.

Author

Krapcho AP, Petry ME, and Hacker MP

Subjects
Animals, Antineoplastic Agents therapeutic use, Chemical Phenomena, Chemistry, Leukemia L1210 drug therapy, Mice, Naphthalenes therapeutic use, Structure-Activity Relationship, Thiophenes therapeutic use, Antineoplastic Agents chemical synthesis, Naphthalenes chemical synthesis, Thiophenes chemical synthesis
Abstract

A number of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4, 9-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone.

Published
1990
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