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Your search keyword '"PEREZ-TRUJILLO, JOSE J."' showing total 10 results
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10 results on '"PEREZ-TRUJILLO, JOSE J."'

7. An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model

Author

Martinez-Perez, Alejandra G., primary, Perez-Trujillo, Jose J., additional, Garza-Morales, Rodolfo, additional, Ramirez-Avila, Norma E., additional, Loera-Arias, Maria J., additional, Gomez-Gutierrez, Jorge G., additional, Saucedo-Cardenas, Odila, additional, Garcia-Garcia, Aracely, additional, Rodriguez-Rocha, Humberto, additional, and Montes-de-Oca-Luna, Roberto, additional

Published
2021
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8. DNA vaccine encoding human papillomavirus antigens flanked by a signal peptide and a KDEL sequence induces a potent therapeutic antitumor effect

Author

Perez-Trujillo, Jose J., primary, Garza-Morales, Rodolfo, additional, Barron-Cantu, Jose A., additional, Figueroa-Parra, Gabriel, additional, Garcia-Garcia, Aracely, additional, Rodriguez-Rocha, Humberto, additional, Garcia-Juarez, Jaime, additional, Muñoz-Maldonado, Gerardo E., additional, Saucedo-Cardenas, Odila, additional, Montes-De-Oca-Luna, Roberto, additional, and Loera-Arias, Maria De Jesus, additional

Published
2017
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9. CXCL10/XCL1 fusokine elicits in vitro and in vivo chemotaxis

Author

Sanchez-Lugo, Yessica E., primary, Perez-Trujillo, Jose J., additional, Gutierrez-Puente, Yolanda, additional, Garcia-Garcia, Aracely, additional, Rodriguez-Rocha, Humberto, additional, Barboza-Quintana, Oralia, additional, Muñoz-Maldonado, Gerardo E., additional, Saucedo-Cardenas, Odila, additional, de Oca-Luna, Roberto Montes, additional, and Loera-Arias, Maria J., additional

Published
2014
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10. A DNA Vaccine Encoding SA-4-1BBL Fused to HPV-16 E7 Antigen Has Prophylactic and Therapeutic Efficacy in a Cervical Cancer Mouse Model.

Author

Garza-Morales, Rodolfo, Perez-Trujillo, Jose J., Martinez-Jaramillo, Elvis, Saucedo-Cardenas, Odila, Loera-Arias, Maria J., Garcia-Garcia, Aracely, Rodriguez-Rocha, Humberto, Yolcu, Esma, Shirwan, Haval, Gomez-Gutierrez, Jorge G., and Montes-de-Oca-Luna, Roberto

Subjects
*PEPTIDES, *RECOMBINANT proteins, *ANIMAL experimentation, *CALCIUM-binding proteins, *INTERFERONS, *MICE, *PAPILLOMAVIRUSES, *VACCINES, *VIRAL antigens, *TREATMENT effectiveness, *THERAPEUTICS, TUMOR prevention, CERVIX uteri tumors
Abstract

The SA-4-1BBL, an oligomeric novel form of the natural ligand for the 4-1BB co-stimulatory receptor of the tumor necrosis factor (TNF) superfamily, as a recombinant protein has potent pleiotropic effects on cells of innate, adaptive, and regulatory immunity with demonstrated therapeutic efficacy in several tumor models. However, the production of soluble form of SA-4-1BBL protein and quality control is time and resource intensive and face various issues pertinent to clinical development of biologics. The present study sought to take advantage of the simplicity and translatability of DNA-based vaccines for the production and delivery of SA-4-1BBL for cancer immune prevention and therapy. A chimeric HPV-16 E7 DNA vaccine (SP-SA-E7-4-1BBL) was constructed that contains the signal peptide (SP) of calreticulin (CRT), streptavidin (SA) domain of SA-4-1BBL, HPV-16 E7 double mutant gene, and the extracellular domain of mouse 4-1BBL. Immunization by gene gun with SP-SA-E7-4-1BBL induced greater prophylactic as well as therapeutic effects in C57BL/6 mice against TC-1 tumor model compared with immunization with E7wt, SP-SA-4-1BBL or reference-positive control CRT-E7wt. The therapeutic efficacy of the DNA vaccine was associated with increased frequency of E7-specific T cells producing interferon (IFN)-γ. Overall, our data suggest that this DNA-based vaccine strategy might represent a translational approach because it provides a simpler and versatile alternative to a subunit vaccine based on SA-4-1BBL and E7 proteins. [ABSTRACT FROM AUTHOR]

Published
2019
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