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Introduction: Hypertensive disorders remain the most significant and unsolved problems in obstetrics. 5 to 10 percent of all pregnancies are complicated by hypertensive disorders. Hypertensive disorders, hemorrhage and infection-are the three most common reasons behind maternal morbidity and maternal mortality which form the lethal triad of maternal mortality. Among hypertensive disorders the preeclampsia either alone or superimposed on chronic hypertension, is the most dangerous. Materials and Methods: Study conducted at Department of Obstetrics and Gynaecology, Andhra Medical College, Vishakhapatnam from March 2022 to February 2023. 100 cases were taken those with blood pressure 140/90mmHg and above are divided in to three groups. The non severe PREECLAMPSIA group consists of 59 pregnant women with blood pressure between 140/90mmHg and 160/110mmHg. The severe PRE-ECLAMPSIA group consists of 22 pregnant women with systolic blood pressure above 160mmHg and diastolic blood pressure above 110mmHg with symptoms like vomiting, headache, Visual Disturbances, Upper abdominal Pain. Other 19 cases were Eclampsia cases i.e which had atleast 1 episode of seizures in PRE-ECLAMPSIA cases. Results: Of the 100 cases allotted in the study 45 cases (45%) belong to 21-25 years of age, 36 cases (36%) belong to 18 -20 years of age, and only 7 (7%) are above 31years of age of which only 1 case is of 40 years of age. Of the total 100 cases, 63 cases (63%) belong to Term gestation i.e above 37weeks of gestation, of which 60 cases are between 37-40 weeks and 3 cases above 40 weeks of gestation. 24 cases (24%) belong to 34-36 weeks, 10 cases (10%) belong to 32-34 weeks. Most of the cases i.e 57 cases (57%) are primi gravida and only 43% are multi gravida, of which 31% had only one previous pregnancy i.e second gravida. Of the 22 cases of severe preeclampsia, 13 cases (59.1%) had APTT 31-36 seconds, 6 cases (27.3%) had APTT 36-40 seconds, 2 cases (9.1%) had APTT 28-31 seconds and only 1case (4.5%) had APTT >40 seconds and no case had APTT <28 seconds. Conclusion: Coagulation abnormalities include HELLP syndrome and disseminated intra vascular coagulation contribute the causes for maternal deaths in Pre-Eclampsia. Present study can be helpful in identifying the coagulation abnormalities in relation to Pre-Eclampsia in earlier stage and can be helpful for the management of complications in relation to Pre-Eclampsia. Severe pre eclampsia and eclampsia can be associated with normal platelet counts; therefore, present study shows that platelet count alone cannot be relied upon to assess the severity of Pre-Eclampsia. Maternal and fetal mortality and morbidity can be reduced with the help of this study. [ABSTRACT FROM AUTHOR]

Introduction: Acute Kidney Injury (AKI) poses life-threatening risks in pregnancy, leading to adverse perinatal and maternal outcomes. Aim: To estimate the incidence of Pregnancy-Related Acute Kidney Injury (PRAKI) and describe maternal and foetal outcomes in cases of Acute Renal Failure (ARF) at a tertiary care institute. Materials and Methods: A prospective descriptive study was conducted on 104 antenatal women with ARF attending King George Hospital, Visakhapatnam, Andhra Pradesh, India, from January to December 2020. A total of 7,409 deliveries occurred during the study period, and antenatal women with evidence of pre-existing renal disease were excluded. A detailed history was obtained, and evaluation included renal function tests and a total abdominal scan. Mode of delivery, foetal deaths, stillbirths, maternal deaths, and APGAR scores were analysed. Laboratory findings were also reported. Data analysis was performed using coGuide statistical software, and results were expressed in terms of frequency and percentages. Results: The incidence of PRAKI was 14 per 1,000 deliveries (1.4%). The mean age of the participants was 24.05±4.11 years. The majority (78 out of 104, 75%) were in the third trimester. Out of the 104 cases of PRAKI, 77 (74%) were due to hypertension. There were 16 (15.4%) maternal deaths and 19 (21.8%) perinatal deaths. Results: The incidence of PRAKI was 14 per 1,000 deliveries (1.4%). The mean age of the participants was 24.05±4.11 years. The majority (78 out of 104, 75%) were in the third trimester. Out of the 104 cases of PRAKI, 77 (74%) were due to hypertension. There were 16 (15.4%) maternal deaths and 19 (21.8%) perinatal deaths. [ABSTRACT FROM AUTHOR]